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Article ; Online: Commentary on: Peng, Y et al., Structured recurrent inhibition in the presubiculum could improve information processing.

Baccini, Gilda / Wulff, Peer

Pflugers Archiv : European journal of physiology

2021 Volume 473, Issue 11, Page(s) 1691–1693

MeSH term(s)	Humans ; Interneurons/physiology ; Parahippocampal Gyrus/physiology
Language	English
Publishing date	2021-10-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	6380-0
ISSN	1432-2013 ; 0031-6768
ISSN (online)	1432-2013
ISSN	0031-6768
DOI	10.1007/s00424-021-02626-y
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Article ; Online: Hippocampal cholecystokinin-expressing interneurons regulate temporal coding and contextual learning.

Rangel Guerrero, Dámaris K / Balueva, Kira / Barayeu, Uladzislau / Baracskay, Peter / Gridchyn, Igor / Nardin, Michele / Roth, Chiara Nina / Wulff, Peer / Csicsvari, Jozsef

Neuron

2024

Abstract: Cholecystokinin-expressing interneurons (CCKIs) are hypothesized to shape pyramidal cell-firing patterns and regulate network oscillations and related network state transitions. To directly probe their role in the CA1 region, we silenced their activity ... ...

Abstract	Cholecystokinin-expressing interneurons (CCKIs) are hypothesized to shape pyramidal cell-firing patterns and regulate network oscillations and related network state transitions. To directly probe their role in the CA1 region, we silenced their activity using optogenetic and chemogenetic tools in mice. Opto-tagged CCKIs revealed a heterogeneous population, and their optogenetic silencing triggered wide disinhibitory network changes affecting both pyramidal cells and other interneurons. CCKI silencing enhanced pyramidal cell burst firing and altered the temporal coding of place cells: theta phase precession was disrupted, whereas sequence reactivation was enhanced. Chemogenetic CCKI silencing did not alter the acquisition of spatial reference memories on the Morris water maze but enhanced the recall of contextual fear memories and enabled selective recall when similar environments were tested. This work suggests the key involvement of CCKIs in the control of place-cell temporal coding and the formation of contextual memories.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2024.03.019
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 92: Show issues

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Article ; Online: A novel mouse model for N-terminal truncated Aβ2-x generation through meprin β overexpression in astrocytes.

Armbrust, Fred / Bickenbach, Kira / Altmeppen, Hermann / Foggetti, Angelica / Winkelmann, Anne / Wulff, Peer / Glatzel, Markus / Pietrzik, Claus U / Becker-Pauly, Christoph

Cellular and molecular life sciences : CMLS

2024 Volume 81, Issue 1, Page(s) 139

Abstract: Neurotoxic amyloid-β (Aβ) peptides cause neurodegeneration in Alzheimer's disease (AD) patients' brains. They are released upon proteolytic processing of the amyloid precursor protein (APP) extracellularly at the β-secretase site and intramembranously at ...

Abstract	Neurotoxic amyloid-β (Aβ) peptides cause neurodegeneration in Alzheimer's disease (AD) patients' brains. They are released upon proteolytic processing of the amyloid precursor protein (APP) extracellularly at the β-secretase site and intramembranously at the γ-secretase site. Several AD mouse models were developed to conduct respective research in vivo. Most of these classical models overexpress human APP with mutations driving AD-associated pathogenic APP processing. However, the resulting pattern of Aβ species in the mouse brains differs from those observed in AD patients' brains. Particularly mutations proximal to the β-secretase cleavage site (e.g., the so-called Swedish APP (APPswe) fostering Aβ1-x formation) lead to artificial Aβ production, as N-terminally truncated Aβ peptides are hardly present in these mouse brains. Meprin β is an alternative β-secretase upregulated in brains of AD patients and capable of generating N-terminally truncated Aβ2-x peptides. Therefore, we aimed to generate a mouse model for the production of so far underestimated Aβ2-x peptides by conditionally overexpressing meprin β in astrocytes. We chose astrocytes as meprin β was detected in this cell type in close proximity to Aβ plaques in AD patients' brains. The meprin β-overexpressing mice showed elevated amyloidogenic APP processing detected with a newly generated neo-epitope-specific antibody. Furthermore, we observed elevated Aβ production from endogenous APP as well as AD-related behavior changes (hyperlocomotion and deficits in spatial memory). The novel mouse model as well as the established tools and methods will be helpful to further characterize APP cleavage and the impact of different Aβ species in future studies.
MeSH term(s)	Humans ; Mice ; Animals ; Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/metabolism ; Astrocytes/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Amyloid beta-Peptides/metabolism ; Alzheimer Disease/metabolism ; Proteolysis ; Brain/metabolism
Chemical Substances	Amyloid Precursor Protein Secretases (EC 3.4.-) ; Amyloid beta-Protein Precursor ; Amyloid beta-Peptides
Language	English
Publishing date	2024-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-024-05139-w
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Article ; Online: Regional and interhemispheric differences of neuronal representations in dentate gyrus and CA3 inferred from expression of zif268.

Schmill, Lars-Patrick / Bohle, Katharina / Röhrdanz, Niels / Schiffelholz, Thomas / Balueva, Kira / Wulff, Peer

Scientific reports

2023 Volume 13, Issue 1, Page(s) 18443

Abstract: The hippocampal formation is one of the best studied brain regions for spatial and mnemonic representations. These representations have been reported to differ in their properties for individual hippocampal subregions. One approach that allows the ... ...

Abstract	The hippocampal formation is one of the best studied brain regions for spatial and mnemonic representations. These representations have been reported to differ in their properties for individual hippocampal subregions. One approach that allows the detection of neuronal representations is immediate early gene imaging, which relies on the visualization of genomic responses of activated neuronal populations, so called engrams. This method permits the within-animal comparison of neuronal representations across different subregions. In this work, we have used compartmental analysis of temporal activity by fluorescence in-situ hybridisation (catFISH) of the immediate early gene zif268/erg1 to compare neuronal representations between subdivisions of the dentate gyrus and CA3 upon exploration of different contexts. Our findings give an account of subregion-specific ensemble sizes. We confirm previous results regarding disambiguation abilities in dentate gyrus and CA3 but in addition report novel findings: Although ensemble sizes in the lower blade of the dentate gyrus are significantly smaller than in the upper blade both blades are responsive to environmental change. Beyond this, we show significant differences in the representation of familiar and novel environments along the longitudinal axis of dorsal CA3 and most interestingly between CA3 regions of both hemispheres.
MeSH term(s)	Animals ; Dentate Gyrus/physiology ; Hippocampus/metabolism ; Neurons/metabolism ; Memory ; Brain
Language	English
Publishing date	2023-10-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45304-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice.

Baccini, Gilda / Brandt, Sören / Wulff, Peer

Journal of visualized experiments : JoVE

2021 , Issue 170

Abstract: Although the general architecture of the hippocampus is similar along its longitudinal axis, recent studies have revealed prominent differences in molecular, anatomical and functional criteria suggesting a division into different sub-circuits along its ... ...

Abstract	Although the general architecture of the hippocampus is similar along its longitudinal axis, recent studies have revealed prominent differences in molecular, anatomical and functional criteria suggesting a division into different sub-circuits along its rostro-caudal extent. Owing to differential connectivity and function the most fundamental distinction is made between the dorsal and the ventral hippocampus, which are preferentially involved in spatial and emotional processing, respectively. Accordingly, in vivo work regarding spatial memory formation has focused on the dorsal hippocampus. In contrast, electro-physiological in vitro recordings have been preferentially performed on intermediate-ventral hippocampus, largely motivated by factors like slice viability and circuit integrity. To allow for direct correlation of in vivo data on spatial processing with in vitro data we have adapted previous sectioning methods to obtain highly viable transverse brain slices from the dorsal-intermediate hippocampus for long-term recordings of principal cells and interneurons in the dentate gyrus. As spatial behavior is routinely analyzed in adult mice, we have combined this transversal slicing procedure with the use of protective solutions to enhance viability of brain tissue from mature animals. We use this approach for mice of about 3 months of age. The method offers a good alternative to the coronal preparation which is frequently used for in vitro studies on dorsal hippocampus. We compare these two preparations in terms of quality of recordings and preservation of morphological features of recorded neurons.
MeSH term(s)	Animals ; Female ; Hippocampus/physiology ; Male ; Mice ; Neurons/physiology ; Patch-Clamp Techniques ; Spatial Behavior/physiology
Language	English
Publishing date	2021-04-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/61980
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Article ; Online: Regional and interhemispheric differences of neuronal representations in dentate gyrus and CA3 inferred from expression of zif268

Lars-Patrick Schmill / Katharina Bohle / Niels Röhrdanz / Thomas Schiffelholz / Kira Balueva / Peer Wulff

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 11

Abstract: Abstract The hippocampal formation is one of the best studied brain regions for spatial and mnemonic representations. These representations have been reported to differ in their properties for individual hippocampal subregions. One approach that allows ... ...

Abstract	Abstract The hippocampal formation is one of the best studied brain regions for spatial and mnemonic representations. These representations have been reported to differ in their properties for individual hippocampal subregions. One approach that allows the detection of neuronal representations is immediate early gene imaging, which relies on the visualization of genomic responses of activated neuronal populations, so called engrams. This method permits the within-animal comparison of neuronal representations across different subregions. In this work, we have used compartmental analysis of temporal activity by fluorescence in-situ hybridisation (catFISH) of the immediate early gene zif268/erg1 to compare neuronal representations between subdivisions of the dentate gyrus and CA3 upon exploration of different contexts. Our findings give an account of subregion-specific ensemble sizes. We confirm previous results regarding disambiguation abilities in dentate gyrus and CA3 but in addition report novel findings: Although ensemble sizes in the lower blade of the dentate gyrus are significantly smaller than in the upper blade both blades are responsive to environmental change. Beyond this, we show significant differences in the representation of familiar and novel environments along the longitudinal axis of dorsal CA3 and most interestingly between CA3 regions of both hemispheres.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online ; Thesis: Inhibition von TRESK K2P-Kanälen durch Pharmaka und endogene Lipide

Mert, Ümit Verfasser] / [Baukrowitz, Thomas [Akademischer Betreuer] / Wulff, Peer Christian [Gutachter]

2022

Author's details	Ümit Mert ; Gutachter: Peer Christian Wulff ; Betreuer: Thomas Baukrowitz
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek Kiel
Publishing place	Kiel
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Task-specific oscillatory synchronization of prefrontal cortex, nucleus reuniens, and hippocampus during working memory.

de Mooij-van Malsen, Johanne Gertrude / Röhrdanz, Niels / Buschhoff, Anna-Sophia / Schiffelholz, Thomas / Sigurdsson, Torfi / Wulff, Peer

iScience

2023 Volume 26, Issue 9, Page(s) 107532

Abstract: Working memory requires maintenance of and executive control over task-relevant information on a timescale of seconds. Spatial working memory depends on interactions between hippocampus, for the representation of space, and prefrontal cortex, for ... ...

Abstract	Working memory requires maintenance of and executive control over task-relevant information on a timescale of seconds. Spatial working memory depends on interactions between hippocampus, for the representation of space, and prefrontal cortex, for executive control. A monosynaptic hippocampal projection to the prefrontal cortex has been proposed to serve this interaction. However, connectivity and inactivation experiments indicate a critical role of the nucleus reuniens in hippocampal-prefrontal communication. We have investigated the dynamics of oscillatory coherence throughout the prefrontal-hippocampal-reuniens network in a touchscreen-based working memory task. We found that coherence at distinct frequencies evolved depending on phase and difficulty of the task. During choice, the reuniens did not participate in enhanced prefrontal-hippocampal theta but in gamma coherence. Strikingly, the reuniens was strongly embedded in performance-related increases in beta coherence, suggesting the execution of top-down control. In addition, we show that during working memory maintenance the prefrontal-hippocampal-reuniens network displays performance-related delay activity.
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.107532
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A brainstem-hypothalamus neuronal circuit reduces feeding upon heat exposure.

Benevento, Marco / Alpár, Alán / Gundacker, Anna / Afjehi, Leila / Balueva, Kira / Hevesi, Zsofia / Hanics, János / Rehman, Sabah / Pollak, Daniela D / Lubec, Gert / Wulff, Peer / Prevot, Vincent / Horvath, Tamas L / Harkany, Tibor

Nature

2024 Volume 628, Issue 8009, Page(s) 826–834

Abstract: Empirical evidence suggests that heat exposure reduces food intake. However, the neurocircuit architecture and the signalling mechanisms that form an associative interface between sensory and metabolic modalities remain unknown, despite primary ... ...

Abstract	Empirical evidence suggests that heat exposure reduces food intake. However, the neurocircuit architecture and the signalling mechanisms that form an associative interface between sensory and metabolic modalities remain unknown, despite primary thermoceptive neurons in the pontine parabrachial nucleus becoming well characterized
MeSH term(s)	Animals ; Hypothalamus/metabolism ; Hypothalamus/cytology ; Mice ; Male ; Hot Temperature ; Neurons/metabolism ; Eating ; Vascular Endothelial Growth Factor A/metabolism ; Parabrachial Nucleus/cytology ; Parabrachial Nucleus/metabolism ; Parabrachial Nucleus/physiology ; Ependymoglial Cells/metabolism ; Ependymoglial Cells/cytology ; Dopamine/metabolism ; Brain Stem/cytology ; Brain Stem/metabolism ; Brain Stem/physiology ; Agouti-Related Protein/metabolism ; Female ; Thermosensing/physiology ; Neural Pathways/metabolism ; Arcuate Nucleus of Hypothalamus/metabolism ; Arcuate Nucleus of Hypothalamus/cytology ; Feeding Behavior/physiology
Chemical Substances	Vascular Endothelial Growth Factor A ; Dopamine (VTD58H1Z2X) ; Agouti-Related Protein
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07232-3
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

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Article: Preparation of acute slices from dorsal hippocampus for whole-cell recording and neuronal reconstruction in the dentate gyrus of adult mice

Baccini, Gilda / Brandt, Sören / Wulff, Peer

Journal of visualized experiments. 2021 Apr. 03, , no. 170

2021

Abstract	Although the general architecture of the hippocampus is similar along its longitudinal axis, recent studies have revealed prominent differences in molecular, anatomical and functional criteria suggesting a division into different sub-circuits along its rostro-caudal extent. Owing to differential connectivity and function the most fundamental distinction is made between the dorsal and the ventral hippocampus, which are preferentially involved in spatial and emotional processing, respectively. Accordingly, in vivo work regarding spatial memory formation has focused on the dorsal hippocampus. In contrast, electro-physiological in vitro recordings have been preferentially performed on intermediate-ventral hippocampus, largely motivated by factors like slice viability and circuit integrity. To allow for direct correlation of in vivo data on spatial processing with in vitro data we have adapted previous sectioning methods to obtain highly viable transverse brain slices from the dorsal-intermediate hippocampus for long-term recordings of principal cells and interneurons in the dentate gyrus. As spatial behavior is routinely analyzed in adult mice, we have combined this transversal slicing procedure with the use of protective solutions to enhance viability of brain tissue from mature animals. We use this approach for mice of about 3 months of age. The method offers a good alternative to the coronal preparation which is frequently used for in vitro studies on dorsal hippocampus. We compare these two preparations in terms of quality of recordings and preservation of morphological features of recorded neurons.
Keywords	adults ; hippocampus ; interneurons ; spatial memory ; viability
Language	English
Dates of publication	2021-0403
Size	p. e61980.
Publishing place	Journal of Visualized Experiments
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2259946-0
ISSN	1940-087X
ISSN	1940-087X
DOI	10.3791/61980
Database	NAL-Catalogue (AGRICOLA)

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