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  1. Article ; Online: GABA

    Cook, Daniel C / Ryan, Timothy A

    eLife

    2023  Volume 12

    Abstract: Control of neurotransmission efficacy is central to theories of how the brain computes and stores information. Presynaptic G-protein coupled receptors (GPCRs) are critical in this problem as they locally influence synaptic strength and can operate on a ... ...

    Abstract Control of neurotransmission efficacy is central to theories of how the brain computes and stores information. Presynaptic G-protein coupled receptors (GPCRs) are critical in this problem as they locally influence synaptic strength and can operate on a wide range of time scales. Among the mechanisms by which GPCRs impact neurotransmission is by inhibiting voltage-gated calcium (Ca
    MeSH term(s) Synapses ; Presynaptic Terminals/physiology ; Synaptic Transmission/physiology ; Action Potentials/physiology ; gamma-Aminobutyric Acid ; Calcium
    Chemical Substances gamma-Aminobutyric Acid (56-12-2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.83530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Implementing shared ventilation must be scientific and ethical, or it risks harm.

    Cook, Daniel C

    British journal of anaesthesia

    2020  Volume 125, Issue 1, Page(s) e181–e183

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/therapy ; Humans ; Pandemics/ethics ; Pneumonia, Viral/therapy ; Resource Allocation/ethics ; Resource Allocation/methods ; SARS-CoV-2 ; Ventilators, Mechanical/ethics
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country England
    Document type Letter ; Review
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.04.061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.80: Show issues Location:
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  3. Article ; Online: Occipital Neuralgia May Be a Possible Limitation on the Utility of the Buffalo Treadmill Test for Concussion Assessments: 2 Case Reports.

    Cook, Laura / Herman, Daniel C

    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

    2022  Volume 32, Issue 5, Page(s) e550–e552

    Abstract: Abstract: Two female athletes presented to clinic following a head injury and exhibited signs of concussion. Both athletes experienced exacerbation of symptoms secondary to dysautonomia related to concussion injury on the Buffalo Concussion Treadmill ... ...

    Abstract Abstract: Two female athletes presented to clinic following a head injury and exhibited signs of concussion. Both athletes experienced exacerbation of symptoms secondary to dysautonomia related to concussion injury on the Buffalo Concussion Treadmill Test (BCTT). On repeat evaluation, both athletes exhibited neck pain with symptoms immediately provoked by palpation of the occipital nerves. After a third occipital nerve block, both athletes had complete resolution of symptoms and subsequently tolerated BCTT to the maximum rate of perceived exertion with no provoked symptoms. The athletes were cleared for return to sport without issue. These cases indicate a potential limitation in the utility of the BCTT for determining the etiology and management of concussion and postconcussion syndrome.
    MeSH term(s) Athletes ; Athletic Injuries/complications ; Athletic Injuries/diagnosis ; Brain Concussion/complications ; Brain Concussion/diagnosis ; Exercise Test ; Female ; Humans ; Neck Pain/diagnosis ; Neck Pain/etiology ; Neuralgia ; Neuropsychological Tests
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1062530-6
    ISSN 1536-3724 ; 1050-642X
    ISSN (online) 1536-3724
    ISSN 1050-642X
    DOI 10.1097/JSM.0000000000001022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3120: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Providing rigor in bee colony strength auditing methods.

    Cook, Daniel / Hauxwell, Caroline

    Journal of economic entomology

    2024  Volume 117, Issue 2, Page(s) 410–416

    Abstract: The primary method used to audit honey bee (Apis mellifera Linnaeus, 1758 [Hymenoptera: Apidae]) colony strength for almond pollination services, Nasr et al.'s (1990) frame-top cluster count method, is a subjective visual audit that relies on an auditor' ... ...

    Abstract The primary method used to audit honey bee (Apis mellifera Linnaeus, 1758 [Hymenoptera: Apidae]) colony strength for almond pollination services, Nasr et al.'s (1990) frame-top cluster count method, is a subjective visual audit that relies on an auditor's spot assessment and may lack rigor and repeatability. We created novel, open-source software for the analysis of frame-top cluster count photographic assessments to improve methodological rigor and repeatability. We evaluated 2 existing visual audit methods, created 3 novel audit method variations, and determined between-method conversion factors using linear modeling. The software has potential applications in apiological research, apiarist and orchardist colony auditing, as well as training future generations of apiarists in auditing techniques. The software enhances the rigor and repeatability of Nasr et al.'s (1990) frame-top cluster count population assessment. In this article, we introduce the novel open-source software and between-method regression equations and review the tested visual assessment methods and their application.
    MeSH term(s) Bees ; Animals ; Hymenoptera ; Pollination ; Prunus dulcis
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 3031-4
    ISSN 1938-291X ; 0022-0493
    ISSN (online) 1938-291X
    ISSN 0022-0493
    DOI 10.1093/jee/toae032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1118: Show issues Location:
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  6. Article ; Online: GABABR silencing of nerve terminals

    Daniel C Cook / Timothy A Ryan

    eLife, Vol

    2023  Volume 12

    Abstract: Control of neurotransmission efficacy is central to theories of how the brain computes and stores information. Presynaptic G-protein coupled receptors (GPCRs) are critical in this problem as they locally influence synaptic strength and can operate on a ... ...

    Abstract Control of neurotransmission efficacy is central to theories of how the brain computes and stores information. Presynaptic G-protein coupled receptors (GPCRs) are critical in this problem as they locally influence synaptic strength and can operate on a wide range of time scales. Among the mechanisms by which GPCRs impact neurotransmission is by inhibiting voltage-gated calcium (Ca2+) influx in the active zone. Here, using quantitative analysis of both single bouton Ca2+ influx and exocytosis, we uncovered an unexpected non-linear relationship between the magnitude of action potential driven Ca2+ influx and the concentration of external Ca2+ ([Ca2+]e). We find that this unexpected relationship is leveraged by GPCR signaling when operating at the nominal physiological set point for [Ca2+]e, 1.2 mM, to achieve complete silencing of nerve terminals. These data imply that the information throughput in neural circuits can be readily modulated in an all-or-none fashion at the single synapse level when operating at the physiological set point.
    Keywords synapse ; calcium channel ; exocytosis ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Fast and Versatile Functionalization of Glassy Carbon.

    Ainsworth, Jasper / Cook, Thomas C / Stack, T Daniel P

    Langmuir : the ACS journal of surfaces and colloids

    2022  Volume 38, Issue 45, Page(s) 13814–13821

    Abstract: A rapid procedure for the functionalization of glassy carbon surfaces (GCSs) is disclosed. A three-step sequence of bromomethylation, azide displacement, and copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) allows ethynylated molecules to be ... ...

    Abstract A rapid procedure for the functionalization of glassy carbon surfaces (GCSs) is disclosed. A three-step sequence of bromomethylation, azide displacement, and copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) allows ethynylated molecules to be attached covalently to the carbon surface through a methylene functional group. Redox-active ethynyl ferrocene and [Ru
    Language English
    Publishing date 2022-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.2c01964
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  8. Article ; Online: Dietary Intakes of Long-Chain Polyunsaturated Fatty Acids and Impulsivity: Comparing Non-Restricted, Vegetarian, and Vegan Diets.

    Byrne, Mitchell K / Cook, Rebecca / Murta, Janina C D / Bressington, Daniel / Meyer, Barbara J

    Nutrients

    2024  Volume 16, Issue 6

    Abstract: Background: Research suggests a link between deficiencies in omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) and impulsivity among psychiatric populations. However, this association is less evident in non-clinical populations. As omega-3 ... ...

    Abstract Background: Research suggests a link between deficiencies in omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) and impulsivity among psychiatric populations. However, this association is less evident in non-clinical populations. As omega-3 LCPUFAs are predominantly sourced through fish consumption, non-fish dieters may be more vulnerable to higher impulsivity.
    Methods: This cross-sectional observational study explored the association between lower intakes of omega-3 LCPUFA food sources and higher self-reported measures of impulsivity among healthy adults consuming non-restricted, vegetarian, and vegan diets.
    Results: The results from the validated Food Frequency Questionnaire showed significantly lower estimated omega-3 LCPUFA intakes among vegans and vegetarians when compared with people consuming non-restricted diets. Furthermore, although all groups scored within the normal range of impulsivity measures, vegans scored comparatively higher. Vegans also scored significantly higher in impulsivity control relating to attention than those consuming non-restricted diets.
    Conclusions: The significantly lower omega-3 LCPUFA dietary intakes in the vegan diets were associated with higher scores in the second-order attentional aspect of self-reported impulsiveness.
    MeSH term(s) Adult ; Humans ; Cross-Sectional Studies ; Diet ; Diet, Vegan ; Diet, Vegetarian ; Eating ; Fatty Acids ; Fatty Acids, Omega-3 ; Vegetarians
    Chemical Substances Fatty Acids ; Fatty Acids, Omega-3
    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Observational Study ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16060875
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  9. Article ; Online: Non-canonical Molecular Targets for Novel Analgesics: Intracellular Calcium and HCN Channels.

    Cook, Daniel C / Goldstein, Peter A

    Current neuropharmacology

    2021  Volume 19, Issue 11, Page(s) 1937–1951

    Abstract: Pain is a prevalent biopsychosocial condition that poses a significant challenge to healthcare providers, contributes substantially to a disability, and is a major economic burden worldwide. An overreliance on opioid analgesics, which primarily target ... ...

    Abstract Pain is a prevalent biopsychosocial condition that poses a significant challenge to healthcare providers, contributes substantially to a disability, and is a major economic burden worldwide. An overreliance on opioid analgesics, which primarily target the μ-opioid receptor, has caused devastating morbidity and mortality in the form of misuse and overdose-related death. Thus, novel analgesic medications are needed that can effectively treat pain and provide an alternative to opioids. A variety of cellular ion channels contribute to nociception, the response of the sensory nervous system to a noxious stimulus that commonly leads to pain. Ion channels involved in nociception may provide a suitable target for pharmacologic modulation to achieve pain relief. This narrative review summarizes the evidence for two ion channels that merit consideration as targets for non-opioid pain medications: ryanodine receptors (RyRs), which are intracellular calcium channels, and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which belong to the superfamily of voltage-gated K+ channels. The role of these channels in nociception and neuropathic pain is discussed and suitability as targets for novel analgesics and antihyperalgesics is considered.
    MeSH term(s) Analgesics/pharmacology ; Analgesics/therapeutic use ; Calcium ; Humans ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ; Neuralgia
    Chemical Substances Analgesics ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-04-12
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X19666210119153047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: An automated approach to quantify chemotaxis index in

    Crombie, Timothy A / Chikuturudzi, Chido / Cook, Daniel E / Andersen, Erik C

    microPublication biology

    2022  Volume 2022

    Abstract: Chemotaxis assays are used extensively to study behavioral responses ... ...

    Abstract Chemotaxis assays are used extensively to study behavioral responses of
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000567
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