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  1. Article: Potential of Cricket (

    Pasqualin Cavalheiro, Carlos / Ruiz-Capillas, Claudia / Herrero, Ana M / Pintado, Tatiana / Avelar de Sousa, Camila Cristina / Sant'Ana Falcão Leite, Juliana / Costa Alves da Silva, Maurício

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: This study examined the incorporation of cricket ( ...

    Abstract This study examined the incorporation of cricket (
    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13020286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Network Toxicology and Molecular Docking to Investigate the Non-AChE Mechanisms of Organophosphate-Induced Neurodevelopmental Toxicity.

    Souza, Juliana Alves da Costa Ribeiro / Souza, Terezinha / Quintans, Isadora Louise Alves da Costa Ribeiro / Farias, Davi

    Toxics

    2023  Volume 11, Issue 8

    Abstract: Organophosphate pesticides (OPs) are toxic substances that contaminate aquatic environments, interfere with the development of the nervous system, and induce Neurodevelopmental Toxicity (NDT) in animals and humans. The canonical mechanism of OP ... ...

    Abstract Organophosphate pesticides (OPs) are toxic substances that contaminate aquatic environments, interfere with the development of the nervous system, and induce Neurodevelopmental Toxicity (NDT) in animals and humans. The canonical mechanism of OP neurotoxicity involves the inhibition of acetylcholinesterase (AChE), but other mechanisms non-AChE are also involved and not fully understood. We used network toxicology and molecular docking to identify molecular targets and toxicity mechanisms common to OPs. Targets related to diazinon-oxon, chlorpyrifos oxon, and paraoxon OPs were predicted using the Swiss Target Prediction and PharmMapper databases. Targets related to NDT were compiled from GeneCards and OMIM databases. In order to construct the protein-protein interaction (PPI) network, the common targets between OPs and NDT were imported into the STRING. Network topological analyses identified EGFR, MET, HSP90AA1, and SRC as hub nodes common to the three OPs. Using the Reactome pathway and gene ontology, we found that signal transduction, axon guidance, cellular responses to stress, and glutamatergic signaling activation play key roles in OP-induced NDT.
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11080710
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  3. Article ; Online: Deletion of the lipid droplet protein kinase gene affects lipid droplets biogenesis, parasite infectivity, and resistance to trivalent antimony in Leishmania infantum

    Juliana Martins Ribeiro / Paula Alves Silva / Héllida Marina Costa-Silva / Ana Maria Murta Santi / Silvane Maria Fonseca Murta

    PLoS Neglected Tropical Diseases, Vol 18, Iss

    2024  Volume 1

    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Antifungal Susceptibility and

    Alves, Anelise Maria Costa Vasconcelos / de Brito, Érika Helena Salles / de Araújo, Márcio Flávio Moura / de Hollanda Celestino, Juliana Jales / Leite, Ana Caroline Rocha de Melo / Cruz, Gabriela Silva / Azevedo, Nuno Filipe / Rodrigues, Célia Fortuna

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: The aim of the present study was to characterize biofilms formed ... ...

    Abstract The aim of the present study was to characterize biofilms formed by
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020310
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  5. Article: A

    Barreto-Peixoto, Juliana A / Silva, Cláudia / Costa, Anabela S G / Álvarez-Rivera, Gerardo / Cifuentes, Alejandro / Ibáñez, Elena / Oliveira, M Beatriz P P / Alves, Rita C / Martel, Fátima / Andrade, Nelson

    Antioxidants (Basel, Switzerland)

    2023  Volume 13, Issue 1

    Abstract: Sweet cherry ( ...

    Abstract Sweet cherry (
    Language English
    Publishing date 2023-12-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13010059
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  6. Article ; Online: Characterisation of bioactive compounds from leaves of

    Azevedo, Lucas Santos / Fonseca, Juliana Costa / Castro, Ana Hortência Fonsêca / Farias, Katyuce de Souza / Zanuncio, Vanessa Samúdio Santos / Silva, Denise Brentan / Lima, Luciana Alves Rodrigues Dos Santos

    Natural product research

    2024  , Page(s) 1–9

    Abstract: ... Smilax ... ...

    Abstract Smilax fluminensis
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2324375
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  7. Article ; Online: Deletion of the lipid droplet protein kinase gene affects lipid droplets biogenesis, parasite infectivity, and resistance to trivalent antimony in Leishmania infantum.

    Ribeiro, Juliana Martins / Silva, Paula Alves / Costa-Silva, Héllida Marina / Santi, Ana Maria Murta / Murta, Silvane Maria Fonseca

    PLoS neglected tropical diseases

    2024  Volume 18, Issue 1, Page(s) e0011880

    Abstract: The Lipid Droplet Protein Kinase (LDK) facilitates lipid droplet (LD) biogenesis, organelles involved in various metabolic and signaling functions in trypanosomatids. As LDK's function has not been previously explored in Leishmania spp., we utilized ... ...

    Abstract The Lipid Droplet Protein Kinase (LDK) facilitates lipid droplet (LD) biogenesis, organelles involved in various metabolic and signaling functions in trypanosomatids. As LDK's function has not been previously explored in Leishmania spp., we utilized CRISPR/Cas9 technology to generate LDK-knockout lines of Leishmania infantum to investigate its role in this parasite. Our findings demonstrate that LDK is not an essential gene for L. infantum, as its deletion did not impede parasite survival. Furthermore, removing LDK did not impact the growth of promastigote forms of L. infantum lacking LDK. However, a noticeable reduction in LDs occurred during the stationary phase of parasite growth following LDK deletion. In the presence of myriocin, a LD inducer, LDK-knockout parasites displayed reduced LD abundance during both logarithmic and stationary growth phases compared to control parasites. Moreover, an infection analysis involving THP-1 cells revealed that 72 h post-infection, LDK-knockout L. infantum lines exhibited fewer infected macrophages and intracellular amastigotes than control parasites. LDK-knockout L. infantum lines also displayed 1.7 to 1.8 -fold greater resistance to trivalent antimony than control parasites. There were no observed alterations in susceptibility to amphotericin B, miltefosine, or menadione in LDK-knockout L. infantum lines. Our results suggest that LDK plays a crucial role in the biogenesis and/or maintenance of LDs in L. infantum, as well as in parasite infectivity and resistance to trivalent antimony.
    MeSH term(s) Animals ; Leishmania infantum/physiology ; Parasites ; Antimony/pharmacology ; Lipid Droplets ; Parasitic Diseases ; Protein Kinases
    Chemical Substances Antimony (9IT35J3UV3) ; Protein Kinases (EC 2.7.-)
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011880
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  8. Article ; Online: Biochemical Markers for Liver Injury in Zebrafish Larvae.

    Martins, Rafael Xavier / Souza, Juliana Alves Costa Ribeiro / Maia, Maria Eduarda / Carvalho, Matheus / Souza, Terezinha / Farias, Davi

    Methods in molecular biology (Clifton, N.J.)

    2024  Volume 2753, Page(s) 469–482

    Abstract: Liver plays a crucial role in detoxification processes and metabolism of xenobiotics, and therefore, it is a target organ of toxicity of different classes of chemicals. In this context, some key enzymes present in liver are considered to be good ... ...

    Abstract Liver plays a crucial role in detoxification processes and metabolism of xenobiotics, and therefore, it is a target organ of toxicity of different classes of chemicals. In this context, some key enzymes present in liver are considered to be good biochemical markers of hepatic damage and can have their activities determined via spectrophotometry. Aspartate and alanine aminotransferases, alkaline phosphatase, lactate dehydrogenase, and glutathione peroxidase are enzymes that have activities often changed in response to hepatotoxic compounds and can be accessed through the larval period of zebrafish (Danio rerio). In this chapter, we described methodologies for analyses of these five biomarkers in pooled zebrafish larvae through spectrophotometry.
    MeSH term(s) Animals ; Zebrafish ; Liver ; Alanine Transaminase ; Biomarkers ; Larva ; Perciformes
    Chemical Substances Alanine Transaminase (EC 2.6.1.2) ; Biomarkers
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3625-1_29
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Regional and social inequalities in food insecurity in Brazil, 2013-2018.

    Cherol, Camilla Christine de Souza / Ferreira, Aline Alves / Lignani, Juliana de Bem / Salles-Costa, Rosana

    Cadernos de saude publica

    2023  Volume 38, Issue 12, Page(s) e00083822

    Abstract: This study aims to analyze the association between social indicators and the worsening of food insecurity in 2013 and 2018 in different regions of Brazil. Data from the Brazilian National Household Sample Survey (2013) and Brazilian Household Budgets ... ...

    Abstract This study aims to analyze the association between social indicators and the worsening of food insecurity in 2013 and 2018 in different regions of Brazil. Data from the Brazilian National Household Sample Survey (2013) and Brazilian Household Budgets Survey (2018) were analyzed, considering nationally representative samples of 110,750 and 57,920 households, respectively. Food insecurity was assessed using the Brazilian Food Insecurity Scale by estimating the percentage changes in food insecurity levels between 2013 and 2018, according to sociodemographic variables. The association between social indicators and food insecurity disaggregated by region was estimated using multinomial logistic regression models. Although North and Northeast regions had higher proportions of food insecurity, the Southeast and Central-West regions had the highest increase in food insecurity in the same periods. Income was the indicator with the highest association with food insecurity both in 2013 and 2018. We also observed the association between the presence of three or more residents aged under 18 in a household and a higher risk of food insecurity in North and South regions. Food insecurity increased unevenly among regions during the Brazilian economic crisis, which reinforced regional inequality. Moreover, food insecurity was greater among households with worse social and economic living conditions, contributing to social inequality in the country. Thus, strengthening public policies to promote food security and nutrition according to regional social inequities is necessary.
    MeSH term(s) Humans ; Aged ; Brazil ; Food Supply ; Socioeconomic Factors ; Family Characteristics ; Food Insecurity
    Language English
    Publishing date 2023-01-06
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 1115730-6
    ISSN 1678-4464 ; 0102-311X
    ISSN (online) 1678-4464
    ISSN 0102-311X
    DOI 10.1590/0102-311XEN083822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4981: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: Supplementation with Moringa oleifera Lam leaf and seed flour during the pregnancy and lactation period of Wistar rats: Maternal evaluation of initial and adult neurobehavioral development of the rat progeny.

    Dantas, Danilo Lima / Alves, Maciel da Costa / Dantas, Gabriel Magno Santos / Campos, Ana Regina Nascimento / Santana, Renato Alexandre Costa de / Soares, Juliana Késsia Barbosa / Freitas, Juliano Carlo Rufino

    Journal of ethnopharmacology

    2024  Volume 325, Page(s) 117904

    Abstract: Ethnopharmacological relevance: Moringa oleifera Lam. (M. oleifera) is a tree species of Indian origin popularly known as the "tree of life". In various cultures, it is used by pregnant women to increase milk production, yet studies on its effects ... ...

    Abstract Ethnopharmacological relevance: Moringa oleifera Lam. (M. oleifera) is a tree species of Indian origin popularly known as the "tree of life". In various cultures, it is used by pregnant women to increase milk production, yet studies on its effects during pregnancy and lactation are lacking.
    Aim of the study: To evaluate the nutraceutical aspects of flours produced from the leaves and seeds of M. oleifera, and to evaluate the effect of supplementation of pregnant Wistar rats during the gestation and lactation period, with the aim of studying the weight gain and neonatal parameters of the pregnant rats, as well as effects on the neurobehavioral development and memory in their offspring.
    Materials and methods: The flour supplementation was conducted at a concentration of 100 mg per kg of animal body weight. For the memory tests, the Open Field Habituation test was performed and repeated after seven days. The Object Recognition test was conducted with the animal exposed to the open field in short and long familiarization sessions. The data obtained were analyzed using Kruskal-Wallis tests for non-parametric data and one-way and two-way ANOVA for parametric data.
    Results: Flour produced from both the leaf and seed of M. oleifera was found to contain significant amounts of nutrients (protein, fibre, carbohydrates, etc.), making them suitable for supplementation. The exposure of pregnant rats to M. oleifera leaf and seed flours did not affect weight gain, did not have harmful effects on the birth of offspring, and did not result in abortions or mutations in the offspring. Regarding the supplemented group's offspring, early maturation of the senses in the offspring compared to the control group was observed in all tests were conducted; indicating that supplementation positively impacted cognitive development. Further, the offspring of the supplemented rats presented reduced locomotion and greater exploration of new objects compared to the control group offspring, indicating positive effects on learning.
    Conclusion: This study describes for the first time the beneficial effects on pregnant Wistar rats and their offspring of maternal supplementation with flour products from the leaves and seeds of M. oleifera.
    MeSH term(s) Humans ; Adult ; Rats ; Pregnancy ; Female ; Animals ; Rats, Wistar ; Moringa oleifera ; Flour ; Plant Extracts/pharmacology ; Lactation ; Dietary Supplements ; Seeds ; Plant Leaves ; Weight Gain
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2024-02-09
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.117904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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