LIVIVO - Search results -

Search results

Result 1 - 10 of total 29

Book ; Online: MOTO

Rafailov, Rafael / Hatch, Kyle / Kolev, Victor / Martin, John D. / Phielipp, Mariano / Finn, Chelsea

Offline Pre-training to Online Fine-tuning for Model-based Robot Learning

2024

Abstract: We study the problem of offline pre-training and online fine-tuning for reinforcement learning from high-dimensional observations in the context of realistic robot tasks. Recent offline model-free approaches successfully use online fine-tuning to either ... ...

Abstract	We study the problem of offline pre-training and online fine-tuning for reinforcement learning from high-dimensional observations in the context of realistic robot tasks. Recent offline model-free approaches successfully use online fine-tuning to either improve the performance of the agent over the data collection policy or adapt to novel tasks. At the same time, model-based RL algorithms have achieved significant progress in sample efficiency and the complexity of the tasks they can solve, yet remain under-utilized in the fine-tuning setting. In this work, we argue that existing model-based offline RL methods are not suitable for offline-to-online fine-tuning in high-dimensional domains due to issues with distribution shifts, off-dynamics data, and non-stationary rewards. We propose an on-policy model-based method that can efficiently reuse prior data through model-based value expansion and policy regularization, while preventing model exploitation by controlling epistemic uncertainty. We find that our approach successfully solves tasks from the MetaWorld benchmark, as well as the Franka Kitchen robot manipulation environment completely from images. To the best of our knowledge, MOTO is the first method to solve this environment from pixels. Comment: This is an updated version of a manuscript that originally appeared at CoRL 2023. The project website is here https://sites.google.com/view/mo2o
Keywords	Computer Science - Machine Learning ; Computer Science - Artificial Intelligence ; Computer Science - Robotics
Subject code	004
Publishing date	2024-01-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: With complements: C3 inhibition in the clinic

Kolev, Martin / Barbour, Tara / Baver, Scott / Francois, Cedric / Deschatelets, Pascal

Immunological Reviews 2023 Jan., v. 313, no. 1, p. 358-375

2023 , Page(s) 358–375

Abstract: C3 is a key complement protein, located at the nexus of all complement activation pathways. Extracellular, tissue, cell‐derived, and intracellular C3 plays critical roles in the immune response that is dysregulated in many diseases, making it an ... ...

Abstract	C3 is a key complement protein, located at the nexus of all complement activation pathways. Extracellular, tissue, cell‐derived, and intracellular C3 plays critical roles in the immune response that is dysregulated in many diseases, making it an attractive therapeutic target. However, challenges such as very high concentration in blood, increased acute expression, and the elevated risk of infections have historically posed significant challenges in the development of C3‐targeted therapeutics. This is further complicated because C3 activation fragments and their receptors trigger a complex network of downstream effects; therefore, a clear understanding of these is needed to provide context for a better understanding of the mechanism of action (MoA) of C3 inhibitors, such as pegcetacoplan. Because of C3's differential upstream position to C5 in the complement cascade, there are mechanistic differences between pegcetacoplan and eculizumab that determine their efficacy in patients with paroxysmal nocturnal hemoglobinuria. In this review, we compare the MoA of pegcetacoplan and eculizumab in paroxysmal nocturnal hemoglobinuria and discuss the complement‐mediated disease that might be amenable to C3 inhibition. We further discuss the current state and outlook for C3‐targeted therapeutics and provide our perspective on which diseases might be the next success stories in the C3 therapeutics journey.
Keywords	blood ; complement ; hemoglobinuria ; immune response ; mechanism of action ; risk ; therapeutics
Language	English
Dates of publication	2023-01
Size	p. 358-375.
Publishing place	John Wiley & Sons, Inc
Document type	Article ; Online
Note	REVIEW
DOI	10.1111/imr.13138
Database	NAL-Catalogue (AGRICOLA)

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Brain-based treatment-A new approach or a well-forgotten old one?

Matanova, Vanya / Kostova, Zlatomira / Kolev, Martin

Journal of evaluation in clinical practice

2018 Volume 24, Issue 4, Page(s) 859–863

Abstract: For a relatively long period of time, mental functioning was mainly associated with personal profile while brain functioning went by the wayside. After the 90s of the 20th century, or the so called "Decade of the Brain", today, contemporary specialists ... ...

Abstract	For a relatively long period of time, mental functioning was mainly associated with personal profile while brain functioning went by the wayside. After the 90s of the 20th century, or the so called "Decade of the Brain", today, contemporary specialists work on the boundary between fundamental science and medicine. This brings neuroscience, neuropsychology, psychiatry, and psychotherapy closer to each other. Today, we definitely know that brain structures are being built and altered thanks to experience. Psychotherapy can be more effective when based on a neuropsychological approach-this implies identification of the neural foundations of various disorders and will lead to specific psychotherapeutic conclusions. The knowledge about the brain is continually enriched, which leads to periodic rethinking and updating of the therapeutic approaches to various diseases of the nervous system and brain dysfunctions. The aim of translational studies is to match and combine scientific areas, resources, experience and techniques to improve prevention, diagnosis and therapies, and "transformation" of scientific discoveries into potential treatments of various diseases done in laboratory conditions. Neuropsychological studies prove that cognition is a key element that links together brain functioning and behaviour. According to Dr. Kandel, all experimental events, including psychotherapeutic interventions, affect the structure and function of neuronal synapses. The story of why psychotherapy works is a story of understanding the brain mechanisms of psychic processes, a story of how the brain has been evolving to ensure learning, forgetting, and the mechanisms of permanent psychological change. The new evidence on brain functioning necessitates the integration of neuropsychological achievements in the psychotherapeutic process. An integrative approach is needed to take into account the dynamic interaction between brain functioning, psyche, soul, spirit, and social interaction, ie, development of a model of psychotherapeutic work based on cerebral plasticity! Brain-based psychotherapy aims at changing brain functioning not directly, but through experiences. This is neuro-psychologically informed psychotherapy.
MeSH term(s)	Brain/physiopathology ; Cognitive Neuroscience/methods ; Cognitive Neuroscience/trends ; Evaluation Studies as Topic ; Humans ; Mental Processes/physiology ; Neuropsychiatry/methods ; Neuropsychiatry/trends ; Neuropsychology/methods ; Neuropsychology/trends ; Psychotherapeutic Processes ; Psychotherapy/methods
Language	English
Publishing date	2018-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1327355-3
ISSN	1365-2753 ; 1356-1294
ISSN (online)	1365-2753
ISSN	1356-1294
DOI	10.1111/jep.12915
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4464: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Book ; Online: Makroökonomische Effekte einer paritätischen Beitragsfinanzierung

Beznoska, Martin / Kolev, Galina V / Pimpertz, Jochen

eine Analyse aktueller Reformvorschläge für die Gesetzliche Kranken- und die soziale Pflegeversicherung

(IW policy paper ; 2017, 15)

2017

Abstract: Im Vorfeld der Bundestagswahl wird unter anderem eine Rückkehr zur vollständig paritätischen Beitragsfinanzierung der Gesetzlichen Krankenversicherung gefordert. Der bislang allein von den Mitgliedern zu zahlende Zusatzbeitrag würde damit abgeschafft und ...

Author's details	Autoren: Martin Beznoska, Galina Kolev, Jochen Pimpertz
Series title	IW policy paper ; 2017, 15
Abstract	Im Vorfeld der Bundestagswahl wird unter anderem eine Rückkehr zur vollständig paritätischen Beitragsfinanzierung der Gesetzlichen Krankenversicherung gefordert. Der bislang allein von den Mitgliedern zu zahlende Zusatzbeitrag würde damit abgeschafft und je zur Hälfte auf den bisherigen Beitragssatzanteil der Arbeitnehmer und Arbeitgeber aufgeschlagen. Allerdings entpuppt sich die damit verbundene Hoffnung auf eine nachhaltige Entlastung der Beitragszahler als Irrweg. Denn letztlich müssen die Arbeitnehmer sämtliche Arbeitskosten, also auch die Arbeitgeberbeiträge zur Sozialversicherung, mit ihrer Leistung erwirtschaften, damit ihre Beschäftigung nachhaltig gesichert ist. Die hälftige Teilung des bisherigen Zusatzbeitrags belastet die Arbeitgeber in der ersten Runde um 6 Milliarden Euro pro Jahr zusätzlich. Für die Ruheständler muss die Gesetzliche Rentenversicherung einen um 1,4 Milliarden Euro höheren Beitragszuschuss zahlen. Im Gegenzug werden die privaten Haushalte der Arbeitnehmer und Rentenbezieher um 7,4 Milliarden Euro entlastet. Dennoch eignet sich die Maßnahme nicht als sozialpolitisches Instrument. Denn die Verteilung der Nettoeinkommen der sozialversicherungspflichtig Beschäftigten lässt sich damit kaum verändern. Sowohl der Gini-Koeffizient als auch die Relation der Nettoeinkommen zwischen oberem und unterem Zehntel (90/10-Verhältnis) sinken lediglich um 0,2 Prozent. Dafür drohen aber Anpassungsreaktionen, die die Gesellschaft teuer zu stehen kämen. Denn die Unternehmen werden versuchen, die höheren Arbeitskosten bereits kurzfristig über steigende Güterpreise auszugleichen. Damit verschlechtert sich aber deren Wettbewerbsfähigkeit. In der Folge wachsen die Exporte langsamer und mittelbar leidet auch die Beschäftigung. Eine Simulation mithilfe des Global Economic Model von Oxford Economics zeigt, dass zehn Jahre nach der Abschaffung des Zusatzbeitrags das Bruttoinlandsprodukt um 0,4 Prozent niedriger ausfallen würde als unter dem heutigen Beitragsrecht - in Preisen des Jahres 2010 gerechnet minus 13 Milliarden Euro. Die Erwerbslosenquote läge um 0,8 Prozentpunkte über dem Szenario ohne Reform. One of the topics debated in the run-up to the Bundestag election refers to a return to full parity contribution of statutory health insurance. The supplementary contribution paid up to now by the employees and retirees insured should be abolished and re-placed by a contribution on a parity basis by the employees and their employers. The present analysis shows that the associated hopes for a sustained relief of the contributors are not justified, since the employers have to compensate the additional costs associated with this reform. With the split of the previous supplementary contribution, employers would be burdened by 6 billion euros per year in the first round. The statutory pension insurance would also have to pay a pension subsidy worth 1.4 billion euros for retirees. In return, the private budgets of workers and pensioners are relieved by 7.4 billion euros. However, the distribution of the net social security contributions among the employees could hardly be offset. Both the Gini coefficient and the ratio of net income between the upper and lower tenths (90/10 ratio) fall by only 0.2 per cent. In the medium and long term, however, there are threats of adjustment which would make the reform expensive. A simulation using the Oxford Economic Model shows that the gross domestic product would be 0.4 per cent lower ten years after the abolition of the supplementary contribution - at 2010 prices a minus of 13 billion euros. The unemployment rate would be 0.8 percentage points higher. Even if at the same time the threshold for contributions would be raised to the level of statutory pension insurance, the distribution effects remained small. The Gini coefficient drops by almost one per cent in the first round, while the 90/10 ratio drops by 2 per cent. The macroeconomic effects weigh heavily. Although the asymmetric distribution of the higher labor costs in the Oxford Economic Model cannot be replicated, model simulations assuming equal distribution of the labor costs show that the gross domestic product would be 0.9 per cent lower after ten years - at 2010 prices it would be 29 billion euros less than with the additional contribution. The unemployment rate would be by 1.8 percentage points higher.
Keywords	Einkommensverteilung ; makroökonomische Modelle ; Gesundheitspolitik
Language	German
Size	1 Online-Ressource (circa 21 Seiten), Illustrationen
Publisher	Institut der Deutschen Wirtschaft Köln
Publishing place	Köln
Document type	Book ; Online
Note	Zusammenfassung in englischer Sprache
Database	ECONomics Information System

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Asparaginyl Endopeptidase (Legumain) Supports Human Th1 Induction via Cathepsin L-Mediated Intracellular C3 Activation.

Freeley, Simon / Cardone, John / Günther, Sira C / West, Erin E / Reinheckel, Thomas / Watts, Colin / Kemper, Claudia / Kolev, Martin V

Frontiers in immunology

2018 Volume 9, Page(s) 2449

Abstract: Autocrine activation of the complement receptors C3aR and CD46 by complement activation components C3a and C3b produced through C3 cleavage by the protease cathepsin L (CTSL) during T cell stimulation is a requirement for IFN-γ production and Th1 ... ...

Abstract	Autocrine activation of the complement receptors C3aR and CD46 by complement activation components C3a and C3b produced through C3 cleavage by the protease cathepsin L (CTSL) during T cell stimulation is a requirement for IFN-γ production and Th1 induction in human CD4
MeSH term(s)	Animals ; Cathepsin L/metabolism ; Cell Proliferation ; Complement C3a/immunology ; Complement C3b/immunology ; Cysteine Endopeptidases/genetics ; Cysteine Endopeptidases/metabolism ; Humans ; Interferon-gamma/biosynthesis ; Interferon-gamma/metabolism ; Lymphocyte Activation/genetics ; Lymphocyte Activation/immunology ; Membrane Cofactor Protein/metabolism ; Mice ; Mice, Knockout ; Receptors, Complement/metabolism ; Th1 Cells/immunology ; Thymalfasin/metabolism
Chemical Substances	IFNG protein, human ; IFNG protein, mouse ; Mcp protein, mouse ; Membrane Cofactor Protein ; Receptors, Complement ; complement C3a receptor ; Complement C3a (80295-42-7) ; Complement C3b (80295-43-8) ; Interferon-gamma (82115-62-6) ; Cysteine Endopeptidases (EC 3.4.22.-) ; Cathepsin L (EC 3.4.22.15) ; asparaginylendopeptidase (EC 3.4.22.34) ; Thymalfasin (W0B22ISQ1C)
Language	English
Publishing date	2018-10-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.02449
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Book ; Online: Gewaltiger Einbruch und nur allmähliche Erholung

Bardt, Hubertus / Beznoska, Martin / Demary, Markus / Grömling, Michael / Hüther, Michael / Kolev, Galina V. / Matthes, Jürgen / Pimpertz, Jochen / Schäfer, Holger

IW-Konjunkturprognose Frühsommer 2020

2020

Abstract: Die Corona-Pandemie trifft die Welt mit multiplen Angebots- und Nachfrageschocks zugleich. Das gab es in dieser Breite, Heftigkeit und Schnelligkeit noch nie. Eine schnelle Rückkehr auf die vorherigen Wachstumsspuren ist in allen Weltregionen nicht zu ... ...

Abstract	Die Corona-Pandemie trifft die Welt mit multiplen Angebots- und Nachfrageschocks zugleich. Das gab es in dieser Breite, Heftigkeit und Schnelligkeit noch nie. Eine schnelle Rückkehr auf die vorherigen Wachstumsspuren ist in allen Weltregionen nicht zu erwarten. Im Jahr 2020 wird die globale Wirtschaftsleistung um über 4 Prozent unter dem Vorjahresniveau liegen. Dies markiert den stärksten Einbruch in der Nachkriegszeit. Das Vorkrisenniveau dürfte erst gegen Ende des Jahres 2021 erreicht werden. Dies setzt voraus, dass es zu keiner zweiten Welle der Virusaus-breitung und einem 'second lockdown' kommt. Das globale Wirtschaftswachstum im Jahr 2021 dürfte dann in der Größenordnung von etwa 6 Prozent liegen. Der Einbruch der weltweiten Wirtschaftsaktivitäten hat gravierende Folgen für die Dynamik des Welthandels. Dieser bricht 2020 um 9 Prozent ein. 2021 ist ein Plus beim globalen Güteraustausch in Höhe von 8 Prozent zu erwarten. Die Erholung der deutschen Konjunktur wird sich nach den starken Beeinträchtigungen im zwei-ten Quartal 2020 auf weite Teile des kommenden Jahres erstrecken. Beim Export wirkt - trotz der sich wieder stabilisierenden Weltkonjunktur - die stark beeinträchtigte globale Investitions-tätigkeit hemmend. Beim Konsum deckeln zunächst fehlende Nachholmöglichkeiten, zum Teil sich nur allmählich auflösende Angebotsrestriktionen und Verunsicherungen die Dynamik. Mit der Festigung der konjunkturellen Erholung trägt der private Konsum mit seinem hohen Gewicht an der Inlandsnachfrage maßgeblich zum Aufschwung bei. Bei den Inlandsinvestitionen ist eine längere Erholungsphase zu erwarten. Eine entscheidende Rolle spielen dabei die Perspektiven für die Weltwirtschaft, denn das schwache globale Umfeld dämpft auch die Investitionsanreize in Deutschland. Anziehende Insolvenzzahlen können zusätzlich die Investitionen bremsen. Durch das Zusammenspiel dieser derzeit retardierenden Momente geht das reale Bruttoinlands-produkt in Deutschland im Jahr 2020 um 9 Prozent zurück. Unter der Annahme, dass es keinen ...
Keywords	ddc:330 ; E2 ; E3 ; E5 ; E6 ; Coronavirus ; Wirtschaftlicher Wiederaufbau ; Europäische Finanzpolitik ; EU-Staaten ; Europäischer Stabilitätsmechanismus ; Italien
Subject code	331
Language	German
Publisher	Köln: Institut der deutschen Wirtschaft (IW)
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Retraction. Targeting neural-restrictive silencer factor sensitizes tumor cells to antibody-based cancer immunotherapy in vitro via multiple mechanisms.

Kolev, Martin V / Morgan, B Paul / Ruseva, Marieta M / Donev, Rossen M

Journal of immunology (Baltimore, Md. : 1950)

2012 Volume 187, Issue 12, Page(s) 6581

Language	English
Publishing date	2012-02-29
Publishing country	United States
Document type	Retraction of Publication
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1190073
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Synchronization of fronto-parietal beta and theta networks as a signature of visual awareness in neglect.

Yordanova, Juliana / Kolev, Vasil / Verleger, Rolf / Heide, Wolfgang / Grumbt, Michael / Schürmann, Martin

NeuroImage

2017 Volume 146, Page(s) 341–354

Abstract: In the neglect syndrome, the perceptual deficit for contra-lesional hemi-space is increasingly viewed as a dysfunction of fronto-parietal cortical networks, the disruption of which has been described in neuroanatomical and hemodynamic studies. Here we ... ...

Abstract	In the neglect syndrome, the perceptual deficit for contra-lesional hemi-space is increasingly viewed as a dysfunction of fronto-parietal cortical networks, the disruption of which has been described in neuroanatomical and hemodynamic studies. Here we exploit the superior temporal resolution of electroencephalography (EEG) to study dynamic transient connectivity of fronto-parietal circuits at early stages of visual perception in neglect. As reflected by inter-regional phase synchronization in a full-field attention task, two functionally distinct fronto-parietal networks, in beta (15-25Hz) and theta (4-8Hz) frequency bands, were related to stimulus discrimination within the first 200 ms of visual processing. Neglect pathology was specifically associated with significant suppressions of both beta and theta networks engaging right parietal regions. These connectivity abnormalities occurred in a pattern that was distinctly different from what was observed in right-hemisphere lesion patients without neglect. Also, both beta and theta abnormalities contributed additively to visual awareness decrease, quantified in the Behavioural Inattention Test. These results provide evidence for the impairment of fast dynamic fronto-parietal interactions during early stages of visual processing in neglect pathology. Also, they reveal that different modes of fronto-parietal dysfunction contribute independently to deficits in visual awareness at the behavioural level.
MeSH term(s)	Aged ; Awareness/physiology ; Beta Rhythm ; Cortical Synchronization ; Electroencephalography ; Female ; Frontal Lobe/physiopathology ; Humans ; Male ; Middle Aged ; Neural Pathways/physiopathology ; Parietal Lobe/physiopathology ; Perceptual Disorders/physiopathology ; Theta Rhythm ; Visual Perception/physiology
Language	English
Publishing date	2017--01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2016.11.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 7: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Targeting neural-restrictive silencer factor sensitizes tumor cells to antibody-based cancer immunotherapy in vitro via multiple mechanisms.

Kolev, Martin V / Ruseva, Marieta M / Morgan, B Paul / Donev, Rossen M

publication RETRACTED

Journal of immunology (Baltimore, Md. : 1950)

2010 Volume 184, Issue 11, Page(s) 6035–6042

Abstract: Tumor cells escape clearance by complement by abundantly expressing CD59 and other membrane complement regulators. Recently, we designed a peptide derived from the neural-restrictive silencer factor (REST), REST68, which we showed to inhibit expression ... ...

Abstract	Tumor cells escape clearance by complement by abundantly expressing CD59 and other membrane complement regulators. Recently, we designed a peptide derived from the neural-restrictive silencer factor (REST), REST68, which we showed to inhibit expression of CD59 in tumors lacking the full-length REST and proposed a detailed model for regulation of CD59 expression via interplay between REST and nucleolin (NCL) transcription factors. In this paper, we study in detail the mechanisms for sensitization of malignant cells to Ab-based cancer immunotherapy by the REST68 peptide and the implications of the REST/NCL model for the design of treatment resulting in higher tumor susceptibility. REST68 inhibited CD59 expression in malignant cells expressing either truncated or full-length REST, but not in nonmalignant cells. However, activation of protein kinase C (PKC) in nonmalignant cells, a process that contributes to cellular transformation, phosphorylated NCL and enabled suppression of CD59 expression by the REST68. Combined treatment of different tumor types with REST68 and PKC inhibitor synergized to further suppress CD59 expression and reduce resistance to complement lysis. The combined treatment also increased susceptibility of tumors expressing either of the REST isoforms to PBMC-mediated killing, which, at least in part, accounted for the strong promotion of apoptosis by the REST68/PKC inhibitor. These data demonstrate that REST68 sensitizes tumors to Ab-based cancer immunotherapy via multiple mechanisms. Furthermore, the REST/NCL interplay model for regulation of expression of cd59 and other genes involved in cell survival enables the design of treatments for different tumor types to achieve more efficient tumor clearance.
MeSH term(s)	Antibodies, Monoclonal/pharmacology ; Antineoplastic Agents/pharmacology ; Apoptosis/physiology ; Blotting, Western ; CD59 Antigens/genetics ; CD59 Antigens/immunology ; CD59 Antigens/metabolism ; Cell Line, Tumor ; Cell Separation ; Cytotoxicity, Immunologic ; Flow Cytometry ; Gene Expression ; Humans ; Immunotherapy/methods ; In Vitro Techniques ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/therapy ; Phosphoproteins/genetics ; Phosphoproteins/immunology ; Phosphoproteins/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/immunology ; RNA-Binding Proteins/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/immunology ; Nucleolin
Chemical Substances	Antibodies, Monoclonal ; Antineoplastic Agents ; CD59 Antigens ; Phosphoproteins ; RE1-silencing transcription factor ; RNA-Binding Proteins ; Repressor Proteins
Language	English
Publishing date	2010-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1000045
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Adult form of Langerhans cell histiocytosis with pulmonary and hepatic involvement mimicking malignancy in a patient with chronic hepatitis C infection.

Moullet, Barbara / Kolev, Mirjam / Ebner, Lukas / Langer, Rupert / Gräni, Christoph / Obmann, Verena / Maurer, Martin / Semmo, Nasser / Christe, Andreas / Huber, Adrian Thomas

Radiology case reports

2020 Volume 16, Issue 2, Page(s) 327–333

Abstract: Langerhans cell histiocytosis (LCH) is a myeloid neoplasm with inflammatory properties. There are few published reports of adult LCH with liver involvement, which is still poorly understood, but shows high morbidity and mortality. We report a case of a ... ...

Abstract	Langerhans cell histiocytosis (LCH) is a myeloid neoplasm with inflammatory properties. There are few published reports of adult LCH with liver involvement, which is still poorly understood, but shows high morbidity and mortality. We report a case of a 37-year-old woman suffering from hepatitis C showing a LCH affecting the lung as well as the liver. Consistent with histology, we found an early stage of a proliferative/granulomatous phase of hepatobiliary LCH, whereas pulmonary findings showed a nodular stage of adult pulmonary LCH. Although hepatocellular carcinoma is a common malignancy in patients suffering from hepatitis C, it is crucial to keep in mind differential diagnosis for newly appearing liver lesions.
Language	English
Publishing date	2020-12-03
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2020.11.022
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito