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  1. Book ; Conference proceedings: Abstracts for the XIth World Congress of Psychiatric Genetics

    Barden, Nicholas

    Quebec City, October 4 - 8, 2003

    (American journal of medical genetics : B ; 122,1)

    2003  

    Title variant Neuropsychiatric genetics
    Institution World Congress of Psychiatric Genetics
    International Society of Psychiatric Genetics
    Author's details sponsored by the International Society of Psychiatric Genetics. Abstracts org. and ed. by Nicholas Barden
    Series title American journal of medical genetics : B ; 122,1
    American journal of medical genetics
    American journal of medical genetics ; B
    Collection American journal of medical genetics
    American journal of medical genetics ; B
    Language English
    Size S. [1] - 190
    Publisher Wiley-Liss
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT013835306
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1376/B -122- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: A perceptual approach to address complex water management issues in lowland permeable catchments.

    Homan, Thomas / Howden, Nicholas J K / Barden, Ruth / Kasprzyk-Hordern, Barbara / Hofman, Jan

    Water research

    2024  Volume 254, Page(s) 121406

    Abstract: Water quality management is a pressing global concern, and an increasingly complex issue due to climate and land-use change, legacy pollution, and the persistent release of well-known and emerging contaminants from diffuse and point sources. The ... ...

    Abstract Water quality management is a pressing global concern, and an increasingly complex issue due to climate and land-use change, legacy pollution, and the persistent release of well-known and emerging contaminants from diffuse and point sources. The increasing availability of high-frequency monitoring data is leading existing, often heuristic approaches, to be judged inadequate. Water managers frequently rely on simple qualitative and/or quantitative approaches for decision-making, but a lack of tangible improvement in freshwater quality outcomes is demanding new and innovative approaches that rely more on physical process understanding, rather than precedent. In this study, we drew upon local geological, hydrogeological, and hydrological data to infer a high-level perceptual model of surface/groundwater interactions in a chalk stream in Dorset, UK. We used the perceptual model to interrogate spatial and temporal trends in historical water quality data and to construct reach-scale nutrient mass balances. Through novel representation with Sankey diagrams, the perceptual model highlighted the relative importance of different hydrological features. Surface/groundwater interactions were found to occur predominantly by spring flow. We demonstrate that river flow accretion was dominated by the Chalk aquifer despite only occupying ca. 15 % of the surface bedrock area, and that spring sources, whilst vital to dilute treated sewage inputs in baseflow conditions, were also major sources of legacy nitrate. Nutrient mass balances showed that sewage treatment works contributed ca. 13 % to soluble reactive phosphorus load, with groundwater accounting for ca. 48 %. Thus, a determinand often associated with point-source pollution was shown to be diffuse dominated in this river. The study demonstrated how a multi-disciplinary approach to water management, based on a comprehensive perceptual modelling approach, could identify hitherto unknown sources and relative contributors to freshwater pollution and allow flow and load apportionment studies to provide useful decision-support to manage nutrient pollution. The novel application of perceptual modelling tools, such as the Sankey diagram, allows different source attributions to be presented in an accessible manner, and can be readily transferred to other study areas.
    MeSH term(s) Environmental Monitoring ; Sewage ; Water Quality ; Rivers ; Calcium Carbonate ; Water Supply ; Water Pollutants, Chemical/analysis
    Chemical Substances Sewage ; Calcium Carbonate (H0G9379FGK) ; Water Pollutants, Chemical
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2024.121406
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  3. Article ; Online: Test-Retest Reliability and the Effects of Walking Speed on Stride Time Variability During Continuous, Overground Walking in Healthy Young Adults.

    Ryan, Nicholas S / Bruno, Paul A / Barden, John M

    Journal of applied biomechanics

    2020  Volume 37, Issue 2, Page(s) 102–108

    Abstract: Studies have investigated the reliability and effect of walking speed on stride time variability during walking trials performed on a treadmill. The objective of this study was to investigate the reliability of stride time variability and the effect of ... ...

    Abstract Studies have investigated the reliability and effect of walking speed on stride time variability during walking trials performed on a treadmill. The objective of this study was to investigate the reliability of stride time variability and the effect of walking speed on stride time variability, during continuous, overground walking in healthy young adults. Participants completed: (1) 2 walking trials at their preferred walking speed on 1 day and another trial 2 to 4 days later and (2) 1 trial at their preferred walking speed, 1 trial approximately 20% to 25% faster than their preferred walking speed, and 1 trial approximately 20% to 25% slower than their preferred walking speed on a separate day. Data from a waist-mounted accelerometer were used to determine the consecutive stride times for each trial. The reliability of stride time variability outcomes was generally poor (intraclass correlations: .167-.487). Although some significant differences in stride time variability were found between the preferred walking speed, fast, and slow trials, individual between-trial differences were generally below the estimated minimum difference considered to be a real difference. The development of a protocol to improve the reliability of stride time variability outcomes during continuous, overground walking would be beneficial to improve their application in research and clinical settings.
    MeSH term(s) Accelerometry ; Adult ; Exercise Test ; Female ; Humans ; Male ; Reproducibility of Results ; Walking Speed ; Young Adult
    Language English
    Publishing date 2020-12-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1145288-2
    ISSN 1543-2688 ; 1065-8483
    ISSN (online) 1543-2688
    ISSN 1065-8483
    DOI 10.1123/jab.2020-0138
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    Zs.B 2776: Show issues Location:
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  4. Article: Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression.

    Barden, Nicholas

    Journal of psychiatry & neuroscience : JPN

    2004  Volume 29, Issue 3, Page(s) 185–193

    Abstract: Major alterations of the hypothalamic-pituitary-adrenocortical (HPA) system that can be reversed by successful antidepressant therapy are often seen in depressed patients. Persuasive evidence points to the involvement of a dysfunctional glucocorticoid ... ...

    Abstract Major alterations of the hypothalamic-pituitary-adrenocortical (HPA) system that can be reversed by successful antidepressant therapy are often seen in depressed patients. Persuasive evidence points to the involvement of a dysfunctional glucocorticoid receptor (GR) system in these changes. Support for this also comes from studies of transgenic mice that express an antisense RNA, complementary to the GR mRNA, and have numerous neuroendocrine characteristics of human depression as well as altered behaviour. Many of these neuroendocrine and behavioural characteristics of the transgenic mice can be reversed by antidepressants. A possible explanation for this is that the antidepressant-induced increase in GRs renders the HPA axis more sensitive to glucocorticoid feedback. This new insight into antidepressant drug action suggests a novel approach to the development of antidepressant drugs.
    MeSH term(s) Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Major/genetics ; Depressive Disorder, Major/physiopathology ; Humans ; Hypothalamo-Hypophyseal System/drug effects ; Hypothalamo-Hypophyseal System/physiopathology ; Hypothalamus/drug effects ; Hypothalamus/physiopathology ; Mutation, Missense/genetics ; Pituitary-Adrenal System/drug effects ; Pituitary-Adrenal System/physiopathology ; RNA, Antisense/genetics
    Chemical Substances Antidepressive Agents ; RNA, Antisense
    Language English
    Publishing date 2004-06-01
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 1077443-9
    ISSN 1180-4882
    ISSN 1180-4882
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2105: Show issues Location:
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  5. Article ; Online: Postcardiac Arrest Neuroprognostication Practices: A Survey of Brazilian Physicians.

    Zhou, Sonya E / Barden, Mary M / Gilmore, Emily J / Pontes-Neto, Octavio M / Sampaio Silva, Gisele / Kurtz, Pedro / Oliveira-Filho, Jamary / Cougo-Pinto, Pedro Telles / Zampieri, Fernando G / Napoli, Nicholas J / Theriot, Jeremy J / Greer, David M / Maciel, Carolina B

    Critical care explorations

    2021  Volume 3, Issue 1, Page(s) e0321

    Abstract: End-of-life care and decisions on withdrawal of life-sustaining therapies vary across countries, which may affect the feasibility of future multicenter cardiac arrest trials. In Brazil, withdrawal of life-sustaining therapy is reportedly uncommon, ... ...

    Abstract End-of-life care and decisions on withdrawal of life-sustaining therapies vary across countries, which may affect the feasibility of future multicenter cardiac arrest trials. In Brazil, withdrawal of life-sustaining therapy is reportedly uncommon, allowing the natural history of postcardiac arrest hypoxic-ischemic brain injury to present itself. We aimed to characterize approaches to neuroprognostication of cardiac arrest survivors among physicians in Brazil.
    Design: Cross-sectional study.
    Setting: Between August 2, 2019, and July 31, 2020, we distributed a web-based survey to physicians practicing in Brazil.
    Subjects: Physicians practicing in Brazil and members of the Brazilian Association of Neurointensive Care, who care for patients resuscitated following cardiac arrest.
    Interventions: Not applicable.
    Measurements and main results: Responses from 185 physicians were obtained. Pupillary reflexes, corneal reflexes, and motor responses were considered critical to prognostication, whereas neuroimaging and electroencephalography were also regarded as important. For patients without targeted temperature management, absent pupillary and corneal reflexes at 24 hours postarrest were considered strongly predictive of poor neurologic outcome by 31.8% and 33.0%, respectively. For targeted temperature management-treated patients, absent pupillary and corneal reflexes at 24-hour postrewarming were considered prognostic by 22.9% and 20.0%, respectively. Physicians felt comfortable making definitive prognostic recommendations at day 6 postarrest or later (34.2%) for nontargeted temperature management-treated patients, and at day 6 postrewarming (20.4%) for targeted temperature management-treated patients. Over 90% believed that improving neuroprognostic accuracy would affect end-of-life decision-making.
    Conclusions: There is significant variability in neuroprognostic approaches to postcardiac arrest patients and timing of prognostic studies among Brazilian physicians, with practices frequently deviating from current guidelines, underscoring a need for greater neuroprognostic accuracy. Nearly all physicians believed that improving neuroprognostication will impact end-of-life decision-making. Given the tendency to delay prognostic recommendations while using similar neuroprognostic tools, Brazil offers a unique cohort in which to examine the natural history of hypoxic-ischemic brain injury in future studies.
    Language English
    Publishing date 2021-01-11
    Publishing country United States
    Document type Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000321
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  6. Article: Ecological Restoration of an Oak Woodland within the Forest-Prairie Ecotone of Kansas

    Galgamuwa, G A Pabodha / Barden, Charles J / Hartman, Jason / Rhodes, Thad / Bloedow, Nicholas / Osorio, Raúl J

    Forest science. 2019 Jan. 30, v. 65, no. 1

    2019  

    Abstract: Conversion of mature oak (Quercus spp.) dominated woodlands to shade-tolerant species is a well-documented problem across the eastern United States. However, oak woodland restoration within the woodland-prairie ecotone of Kansas at the western edge of ... ...

    Abstract Conversion of mature oak (Quercus spp.) dominated woodlands to shade-tolerant species is a well-documented problem across the eastern United States. However, oak woodland restoration within the woodland-prairie ecotone of Kansas at the western edge of the eastern deciduous forests has not been systematically studied before. Hence, an oak-dominated woodland is being used to study the effects of prescribed burning and mechanical thinning to encourage oak regeneration within this region. A repeated measures design is employed with burn and thin treatments, administered in 2015 after conducting a pretreatment stand inventory. Resampling was done after two growing seasons. Pretreatment inventory revealed oak dominance in the tree class, while competitive species such as Cercis canadensis, Ulmus americana, and Juniperus virginiana collectively dominated the seedling and sapling classes. Thinning reduced the tree density significantly, but when thinning was not followed by a burn, both total and Cercis canadensis seedling densities increased significantly. The burn treatment, on the other hand, controlled Juniperus virginiana seedlings successfully while oak regeneration increased. Hence, the most promising results were observed when thinning and burning were combined. However, control of C. canadensis seedlings remains the major challenge in the future given its vigorous recovery two growing seasons after burning.
    Keywords Cercis canadensis ; Juniperus virginiana ; Quercus ; Ulmus americana ; deciduous forests ; density ; design ; ecological restoration ; ecotones ; forest inventory ; growing season ; prescribed burning ; pretreatment ; seedlings ; shade tolerance ; trees ; woodlands ; Eastern United States ; Kansas
    Language English
    Dates of publication 2019-0130
    Size p. 48-58.
    Publishing place Oxford University Press
    Document type Article
    Note NAL-light
    ISSN 1938-3738
    DOI 10.1093/forsci/fxy034
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Heterotopic Ossification Prophylaxis After Total Hip Arthroplasty: Randomized Trial of 400 vs 700 cGy.

    Liu, Jane Z / Frisch, Nicholas B / Barden, Regina M / Rosenberg, Aaron G / Silverton, Craig D / Galante, Jorge O

    The Journal of arthroplasty

    2017  Volume 32, Issue 4, Page(s) 1328–1334

    Abstract: Background: Heterotopic ossification (HO) is a known complication following total hip arthroplasty. Radiation is an effective prophylaxis, but an optimal protocol has yet to be determined. We performed a randomized, double-blinded clinical trial in high- ...

    Abstract Background: Heterotopic ossification (HO) is a known complication following total hip arthroplasty. Radiation is an effective prophylaxis, but an optimal protocol has yet to be determined. We performed a randomized, double-blinded clinical trial in high-risk patients to determine the efficacy of 400 vs 700 cGy doses of radiation.
    Methods: One hundred forty-seven patients undergoing total hip arthroplasty and at high risk for HO at an urban medical center were randomized to receive either a single 400 or 700 cGy dose of radiation postoperatively. High risk was defined as a diagnosis of diffuse idiopathic skeletal hyperostosis, hypertrophic osteoarthritis, ankylosing spondylitis, or history of previous HO. Radiation was administered on the first or second postoperative day. A single blinded reviewer graded radiographs taken immediately postoperatively and at a minimum of 6 months postoperatively using the Brooker classification. Progression was defined as an increase in Brooker classification. Operative data including surgical approach, implant fixation, revision surgery, and postoperative range of motion data were also collected.
    Results: A significantly greater portion of patients who received the 400 cGy dose demonstrated progression of HO than patients who received the 700 cGy dose. There were no wound complications. No preoperative factors were associated with a higher rate of progression. Patients who progressed had less flexion on physical examination than patients who did not progress, but this was not clinically significant.
    Conclusion: Seven hundred centigray was superior to 400 cGy in preventing HO formation following total hip arthroplasty in high-risk patients and may be the more effective treatment in this population. Further studies comparing 700 cGy to dosages between 400 and 700 cGy may help to clarify if a more optimal dose can be identified.
    MeSH term(s) Adult ; Aged ; Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Hip/statistics & numerical data ; Disease Progression ; Double-Blind Method ; Female ; Hip Joint/surgery ; Humans ; Male ; Middle Aged ; Ossification, Heterotopic/etiology ; Ossification, Heterotopic/prevention & control ; Osteoarthritis/complications ; Physical Examination ; Postoperative Period ; Radiography ; Radiotherapy ; Radiotherapy Dosage ; Range of Motion, Articular ; Reoperation/statistics & numerical data ; Spondylitis, Ankylosing/complications ; Treatment Outcome
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2016.10.030
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2134: Show issues Location:
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  8. Article ; Online: Contagious caprine pleuropneumonia in Mauritius.

    Srivastava, A K / Meenowa, D / Barden, G / Salguero, F J / Churchward, C / Nicholas, R A J

    The Veterinary record

    2010  Volume 167, Issue 8, Page(s) 304–305

    MeSH term(s) Animals ; Disease Outbreaks/veterinary ; Female ; Goat Diseases/diagnosis ; Goat Diseases/epidemiology ; Goats ; Male ; Mauritius/epidemiology ; Mycoplasma capricolum ; Pleuropneumonia, Contagious/diagnosis ; Pleuropneumonia, Contagious/epidemiology
    Language English
    Publishing date 2010-08-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 390015-0
    ISSN 2042-7670 ; 0042-4900
    ISSN (online) 2042-7670
    ISSN 0042-4900
    DOI 10.1136/vr.c3816
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    Zs.B 645: Show issues Location:
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  9. Article ; Online: Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator.

    Rennie, Glen R / Barden, Timothy C / Bernier, Sylvie G / Carvalho, Andrew / Deming, Renee / Germano, Peter / Hudson, Colleen / Im, G-Yoon J / Iyengar, Rajesh R / Jia, Lei / Jung, Joon / Kim, Elise / Lee, Thomas W-H / Mermerian, Ara / Moore, Joel / Nakai, Takashi / Perl, Nicholas R / Tobin, Jenny / Zimmer, Daniel P /
    Renhowe, Paul A

    Bioorganic & medicinal chemistry letters

    2021  Volume 40, Page(s) 127886

    Abstract: Soluble guanylate cyclase (sGC) is a clinically validated therapeutic target in the treatment of pulmonary hypertension. Modulators of sGC have the potential to treat diseases that are affected by dysregulation of the NO-sGC-cGMP signal transduction ... ...

    Abstract Soluble guanylate cyclase (sGC) is a clinically validated therapeutic target in the treatment of pulmonary hypertension. Modulators of sGC have the potential to treat diseases that are affected by dysregulation of the NO-sGC-cGMP signal transduction pathway. This letter describes the SAR efforts that led to the discovery of CYR715, a novel carboxylic acid-containing sGC stimulator, with an improved metabolic profile relative to our previously described stimulator, IWP-051. CYR715 addressed potential idiosyncratic drug toxicity (IDT) liabilities associated with the formation of reactive, migrating acyl glucuronides (AG) found in related carboxylic acid-containing analogs and demonstrated high oral bioavailability in rat and dose-dependent hemodynamic pharmacology in normotensive Sprague-Dawley rats.
    MeSH term(s) Administration, Oral ; Animals ; Carboxylic Acids/chemistry ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Glucuronides/administration & dosage ; Glucuronides/chemistry ; Glucuronides/pharmacokinetics ; Humans ; Hypertension, Pulmonary/drug therapy ; Male ; Metabolome ; Models, Molecular ; Nitric Oxide/metabolism ; Oxidative Stress/drug effects ; Protein Binding ; Rats, Sprague-Dawley ; Signal Transduction ; Soluble Guanylyl Cyclase/metabolism ; Structure-Activity Relationship ; Vasodilator Agents/administration & dosage ; Vasodilator Agents/chemistry ; Vasodilator Agents/pharmacokinetics ; Rats
    Chemical Substances Carboxylic Acids ; Glucuronides ; Vasodilator Agents ; Nitric Oxide (31C4KY9ESH) ; Soluble Guanylyl Cyclase (EC 4.6.1.2)
    Language English
    Publishing date 2021-03-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2021.127886
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  10. Article: Gene interactions in depression: pathways out of darkness.

    Harvey, Mario / Belleau, Pascal / Barden, Nicholas

    Trends in genetics : TIG

    2007  Volume 23, Issue 11, Page(s) 547–556

    Abstract: Mood disorders, including major depressive disorder and bipolar disorder, are influenced by both genetic and environmental factors. Hypotheses about the neurobiology of mood disorders have been postulated and putatively associated genes identified. ... ...

    Abstract Mood disorders, including major depressive disorder and bipolar disorder, are influenced by both genetic and environmental factors. Hypotheses about the neurobiology of mood disorders have been postulated and putatively associated genes identified. Recently, the immune-related gene encoding purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7) has been genetically associated with major depressive disorder and bipolar disorder. New candidate genes and emerging gene networks and pathways involved in the aetiology of mood disorders point to a major role for neuronal survival and the adaptive immune systems.
    MeSH term(s) Bipolar Disorder/genetics ; Databases, Genetic ; Depressive Disorder, Major/genetics ; Gene Regulatory Networks ; Humans ; Models, Genetic ; PubMed ; Receptors, Purinergic P2/genetics ; Receptors, Purinergic P2X7
    Chemical Substances P2RX7 protein, human ; Receptors, Purinergic P2 ; Receptors, Purinergic P2X7
    Language English
    Publishing date 2007-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2007.08.011
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