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Article ; Online: Grain boundary-induced premelting and solid ↔ melt phase transformations: effect of interfacial widths and energies and triple junctions at the nanoscale.

Basak, Anup

Physical chemistry chemical physics : PCCP

2021 Volume 23, Issue 33, Page(s) 17953–17972

Abstract: The strong effect of dry grain boundary (GB) and isolated solid-melt interface widths and energies and the triple junction energy on GB-induced premelting and the transformations between solid, premelt, and melt at the nanoscale are studied using a ... ...

Abstract	The strong effect of dry grain boundary (GB) and isolated solid-melt interface widths and energies and the triple junction energy on GB-induced premelting and the transformations between solid, premelt, and melt at the nanoscale are studied using a thermodynamically consistent original phase field approach of Ginzburg-Landau type. One order parameter is considered for describing solid ↔ melt transformation and another N- 1 independent order parameters are used to describe N grains in the samples. A variable energy of the GB regions is assumed which depends on the order parameter related to solid ↔ melt transformation, and the energy of the GBs reduces from their dry state energy γ
Language	English
Publishing date	2021-08-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d1cp02085d
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Article ; Online: Proteins and proteases of Prader-Willi syndrome: a comprehensive review and perspectives.

Basak, Sanjukta / Basak, Ajoy

Bioscience reports

2022 Volume 42, Issue 6

Abstract: Prader-Willi Syndrome (PWS) is a rare complex genetic disease that is associated with pathological disorders that include endocrine disruption, developmental, neurological, and physical problems as well as intellectual, and behavioral dysfunction. In ... ...

Abstract	Prader-Willi Syndrome (PWS) is a rare complex genetic disease that is associated with pathological disorders that include endocrine disruption, developmental, neurological, and physical problems as well as intellectual, and behavioral dysfunction. In early stage, PWS is characterized by respiratory distress, hypotonia, and poor sucking ability, causing feeding concern and poor weight gain. Additional features of the disease evolve over time. These include hyperphagia, obesity, developmental, cognitive delay, skin picking, high pain threshold, short stature, growth hormone deficiency, hypogonadism, strabismus, scoliosis, joint laxity, or hip dysplasia. The disease is associated with a shortened life expectancy. There is no cure for PWS, although interventions are available for symptoms management. PWS is caused by genetic defects in chromosome 15q11.2-q13, and categorized into three groups, namely Paternal deletion, Maternal uniparental disomy, and Imprinting defect. PWS is confirmed through genetic testing and DNA-methylation analysis. Studies revealed that at least two key proteins namely MAGEL-2 and NECDIN along with two proteases PCSK1 and PCSK2 are linked to PWS. Herein, we summarize our current understanding and knowledge about the role of these proteins and enzymes in various biological processes associated with PWS. The review also describes how loss and/or impairment of functional activity of these macromolecules can lead to hormonal disbalance by promoting degradation of secretory granules and via inhibition of proteolytic maturation of precursor-proteins. The present review will draw attention of researchers, scientists, and academicians engaged in PWS study and will help to identify potential targets and molecular pathways for PWS intervention and treatment.
MeSH term(s)	Endopeptidases ; Genetic Testing ; Humans ; Obesity/genetics ; Peptide Hydrolases ; Prader-Willi Syndrome/diagnosis ; Prader-Willi Syndrome/genetics
Chemical Substances	Endopeptidases (EC 3.4.-) ; Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2022-06-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	764946-0
ISSN	1573-4935 ; 0144-8463
ISSN (online)	1573-4935
ISSN	0144-8463
DOI	10.1042/BSR20220610
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Zs.A 1676: Show issues

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Article ; Online: Efficacy of coenzyme Q10 and curcumin on antioxidant enzyme activity and hippocampal alteration following exposure to cyclophosphamide in male rat.

Yahyazadeh, Ahmad / Başak, Feyza / Demirel, Mürşide Ayşe

Tissue & cell

2023 Volume 86, Page(s) 102296

Abstract: Coenzyme Q10 (KQ10) and curcumin (KUR) supplements are extensively used for their potential antioxidant, anticancer, and antiapoptotic properties. The present study investigated the neuroprotective potential of KQ10 and KUR against the side effect of ... ...

Abstract	Coenzyme Q10 (KQ10) and curcumin (KUR) supplements are extensively used for their potential antioxidant, anticancer, and antiapoptotic properties. The present study investigated the neuroprotective potential of KQ10 and KUR against the side effect of cyclophosphamide (SF) (150 mg/kg) on the hippocampus of male Wistar albino rats. Forty-nine 10-12 weeks old rats were randomly divided into seven groups: control, olive oil (OL), SF, KQ10, KUR, SF+KQ10, and SF+KUR. Our biochemical finding showed a significant decrease in superoxide dismutase (SOD) level in the SF group compared to the control group (p < 0.05). There was also a significant reduction in the total number of the hippocampal pyramidal neurons in the CA1, CA2, and CA1-3 regions in the SF group compared to the control group (p < 0.05). In the SF+KQ10 group, we found a significant increase in serum SOD level and the total number of the hippocampal pyramidal neurons in the CA1, CA2, and CA1-3 regions compared to the SF group (p < 0.05). Immunohistochemical and histopathological examination exhibited noteworthy findings in the hippocampus tissues. Our findings showed that KQ10 administration significantly mitigated the hippocampal alteration caused by SF through enhancing antioxidant enzyme activity and reducing apoptosis. However, we found no protective activity of KUR on the hippocampus tissue, which may be due to its weak antioxidative activity.
MeSH term(s)	Rats ; Male ; Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Curcumin/pharmacology ; Rats, Wistar ; Hippocampus ; Superoxide Dismutase/metabolism ; Cyclophosphamide/toxicity ; Oxidative Stress ; Ubiquinone/analogs & derivatives
Chemical Substances	Antioxidants ; coenzyme Q10 (EJ27X76M46) ; Curcumin (IT942ZTH98) ; Superoxide Dismutase (EC 1.15.1.1) ; Cyclophosphamide (8N3DW7272P) ; Ubiquinone (1339-63-5)
Language	English
Publishing date	2023-12-29
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	204424-9
ISSN	1532-3072 ; 0040-8166
ISSN (online)	1532-3072
ISSN	0040-8166
DOI	10.1016/j.tice.2023.102296
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Zs.A 1016: Show issues

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Book ; Online: Grain boundary-induced martensitic transformations

Basak, Anup

A phase-field study of nucleation, size-effect, triple junction-effect, microstructures, and compatibility at the nanoscale

2022

Abstract: An original thermodynamically consistent large strains-based multiphase phase-field (PF) approach of Ginzburg-Landau type is developed for studying the grain boundary (GB)-induced martensitic transformations (MTs) in polycrystalline materials at the ... ...

Abstract	An original thermodynamically consistent large strains-based multiphase phase-field (PF) approach of Ginzburg-Landau type is developed for studying the grain boundary (GB)-induced martensitic transformations (MTs) in polycrystalline materials at the nanoscale considering the structural stresses within the interfaces. In this general PF approach, N independent order parameters are used for describing the austenite (A)<->martensite (M) transformations and N(>1) martensitic variants, and another M independent order parameters are considered for describing M(>1) grains in the polycrystalline samples. The change in the GB energy due to its structural rearrangement during MTs is considered using variable energy for the GB(s) as a function of the order parameter related to the A<->M transformation. A rich plot for the temperatures of transformations between the A, premartensite, and M in a bicrystal with a symmetric planar tilt GB are plotted for the varying austenitic GB width. The strong effects of the parameters, including the austenitic GB width, change in GB energy due to MTs, GB misorientation, applied strains, and sample size on heterogeneous nucleation of the phases and the subsequent complex martensitic microstructures evolution are explored in various bicrystals with symmetric or asymmetric planar or circular tilt GBs during the forward and reverse transformations. The triple junction (TJ) energy and the energy and width of the adjacent GBs are also shown to strongly influence the nucleation and microstructures using the tricrystals having three symmetric planar tilt GBs. The compatibility of the microstructures across the GBs is studied. The elastic and structural stresses across the GBs and TJ regions are plotted, which is essential for understanding the role of GBs and TJs in materials failure.
Keywords	Condensed Matter - Materials Science
Subject code	669
Publishing date	2022-06-18
Publishing country	us
Document type	Book ; Online
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Article: Single-Fraction Gamma-Knife Radiosurgery with or without Previous Surgery for Cavernous Sinus Meningiomas: A Single-Center Experience and Systematic Literature Review.

Basak, A T / Ozbek, M A

Nigerian journal of clinical practice

2023 Volume 26, Issue 5, Page(s) 545–551

Abstract: Background: The most effective treatment method for meningiomas is surgical treatment. However, complete resection of cavernous sinus meningiomas is quite difficult. The biggest reasons for this are; narrow surgical corridor, the optic chiasm is the ... ...

Abstract	Background: The most effective treatment method for meningiomas is surgical treatment. However, complete resection of cavernous sinus meningiomas is quite difficult. The biggest reasons for this are; narrow surgical corridor, the optic chiasm is the close relationship between the cranial nerves and anterior cerebral and internal carotid arteries. Gamma knife radiosurgery (GKRS) may be a good option in these lesions with high mortality and morbidity. Aim: This study aimed to evaluate and compare the early effects at a mean of 6 months and 3 years and outcomes between surgery followed by gamma knife radiosurgery (GKRS) and GKRS alone for cavernous sinus meningiomas. Methods: We included 20 patients with cavernous sinus meningioma treated via single fraction Leksell Gamma Knife Perfexion (Elekta Instruments; Stockholm, Sweden) between 2015 and 2018. The mean age of the patients was 54.95 (range: 32-77) years. Nine patients underwent primary surgery (for the resection of extracavernous components of the tumor) followed by GKRS (for the resection of intracavernous components of the tumor) (group A). Meanwhile, 11 patients were managed with GKRS alone (group B). The tumor volume ranged from 2.8 to 32.8 (mean: 14.76) cm3 and the isodose to the tumor margin from 10 to 13.5 (mean: 11.65) Gy. Results: In total, 20 patients were followed up at a mean time of 18.95 (range: 6-36) months. The mean Karnofsky Performance Score of the patients was 95.2%. The mean follow up times of groups A and B were 23.6 and 15 months, respectively. Meanwhile, only patients with a follow up time of at least 6 months were included in the study. The mean follow up time after GKRS in group A was 17.6 months. There was no change in the tumor volume in 15% of patients. In the remaining cases, the tumor volume decreased. The mean tumor regression rates were 82.2% in Group A and 17.7% in Group B. The tumor volume did not decrease in three patients (n = 1, group A and n = 2, group B). Cranial nerve deficits improved, worsened, and remained stable in 46.6%, 26.6%, and 26.6% of cases, respectively. The temporary morbidity rate was 10%. In group A, transient postoperative diabetes insipidus was observed in one patient and atelectasis in another. None of these complications affected the final status of patients. The mortality rate after treatment was 0%. Conclusion: Volume staged GKRS is safe and effective for cavernous sinus meningioma. GKRS is effective for long term tumor growth control and has a low complication rate. Hence, it is the preferred management strategy for tumors with a suitable volume (average tumor diameter: 3 cm or volume: 10 cm3 ). In tumors with a volume of more than 10 mL and/or without a 3 mm safety margin with the optical system, it is recommended to prepare for radiosurgery by cytoreducing the tumor volume surgically. Based on our opinion, the best results were obtained by GKRS to the intracavernous.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Aged ; Meningioma/surgery ; Meningioma/pathology ; Meningeal Neoplasms/surgery ; Meningeal Neoplasms/pathology ; Radiosurgery/adverse effects ; Radiosurgery/methods ; Cavernous Sinus/surgery ; Cavernous Sinus/pathology ; Treatment Outcome ; Follow-Up Studies ; Retrospective Studies
Language	English
Publishing date	2023-06-25
Publishing country	India
Document type	Systematic Review ; Journal Article
ZDB-ID	1458330-6
ISSN	1119-3077
ISSN	1119-3077
DOI	10.4103/njcp.njcp_2033_21
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Zs.A 4975: Show issues

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Article ; Online: GRASP negatively regulates the secretion of the virulence factor gp63 in Leishmania.

Kumar, Kamal / Basak, Rituparna / Rai, Aakansha / Mukhopadhyay, Amitabha

Molecular microbiology

2024

Abstract: Metalloprotease-gp63 is a virulence factor secreted by Leishmania. However, secretory pathway in Leishmania is not well defined. Here, we cloned and expressed the GRASP homolog from Leishmania. We found that Leishmania expresses one GRASP homolog of 58 ... ...

Abstract	Metalloprotease-gp63 is a virulence factor secreted by Leishmania. However, secretory pathway in Leishmania is not well defined. Here, we cloned and expressed the GRASP homolog from Leishmania. We found that Leishmania expresses one GRASP homolog of 58 kDa protein (LdGRASP) which localizes in LdRab1- and LPG2-positive Golgi compartment in Leishmania. LdGRASP was found to bind with COPII complex, LdARF1, LdRab1 and LdRab11 indicating its role in ER and Golgi transport in Leishmania. To determine the function of LdGRASP, we generated LdGRASP knockout parasites using CRISPR-Cas9. We found fragmentation of Golgi in Ld:GRASPKO parasites. Our results showed enhanced transport of non-GPI-anchored gp63 to the cell surface leading to higher secretion of this form of gp63 in Ld:GRASPKO parasites in comparison to Ld:WT cells. In contrast, we found that transport of GPI-anchored gp63 to the cell surface is blocked in Ld:GRASPKO parasites and thereby inhibits its secretion. The overexpression of dominant-negative mutant of LdRab1 or LdSar1 in Ld:GRASPKO parasites significantly blocked the secretion of non-GPI-anchored gp63. Interestingly, we found that survival of transgenic parasites overexpressing Ld:GRASP-GFP is significantly compromised in macrophages in comparison to Ld:WT and Ld:GRASPKO parasites. These results demonstrated that LdGRASP differentially regulates Ldgp63 secretory pathway in Leishmania.
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	619315-8
ISSN	1365-2958 ; 0950-382X
ISSN (online)	1365-2958
ISSN	0950-382X
DOI	10.1111/mmi.15255
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Article ; Online: Antioxidative and Antibacterial Hydro-Ethanolic Fraction from an Asian Edible Mushroom Lentinus sajor-caju (Agaricomycetes) Suppresses Inflammatory Responses by Downregulating COX-2 and iNOS Expression.

Naskar, Arghya / Dasgupta, Adhiraj / Basak, Gouri / Acharya, Krishnendu

International journal of medicinal mushrooms

2024 Volume 26, Issue 1, Page(s) 1–15

Abstract: Mushrooms are prevalently important sources of pharmaceutically active metabolites. Various mushroom species belonging to the Lentinus genus are recognized for their nutritional and therapeutic properties. One such species is L. sajor-caju, which is ... ...

Abstract	Mushrooms are prevalently important sources of pharmaceutically active metabolites. Various mushroom species belonging to the Lentinus genus are recognized for their nutritional and therapeutic properties. One such species is L. sajor-caju, which is renowned in Southeast Asian nations for its culinary value. The primary goal of this study is to investigate the potential medicinal properties of L. sajor-caju, specifically its antioxidant, antibacterial, and anti-inflammatory effects. A hydroethanolic extract was formulated using dried basidiocarps, which exhibited a high phenolic content of approximately 14% and a flavonoid content of approximately 2.7%. The extract demonstrated significant antioxidant potential in in vitro reactions. The extract is sufficiently capable of scavenging free radicals (DPPH and ABTS) and chelate Fe2+ with EC50 values spanning from 186 to 390 μg/mL. In addition, considerable antimicrobial activity against tested pathogenic microorganisms was observed, as indicated by low MIC50 values (256-358 μg/mL). Moreover, the fraction was found to prevent heat-induced protein denaturation which signifies its anti-inflammatory potential. When tested on the RAW 264.7 cell line, reduction in the nitrite production, and downregulation of COX-2 and iNOS mRNA expression was observed which are the key regulator of inflammatory signalling systems. The study, therefore, recommends the use of L. sajor-caju in the medical and pharmaceutical industries for the benefit of humanity.
MeSH term(s)	Agaricales/chemistry ; Anti-Bacterial Agents ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Basidiomycota ; Cyclooxygenase 2/genetics ; Ethanol ; Lentinula ; Animals ; Mice ; RAW 264.7 Cells
Chemical Substances	Anti-Bacterial Agents ; Anti-Inflammatory Agents ; Antioxidants ; Cyclooxygenase 2 (EC 1.14.99.1) ; Ethanol (3K9958V90M)
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2108803-2
ISSN	1940-4344 ; 1521-9437
ISSN (online)	1940-4344
ISSN	1521-9437
DOI	10.1615/IntJMedMushrooms.2023051138
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Article: Another

Bayraktar, Elif / Çiftçi, Vildan / Uysal, Hilmi / Başak, A Nazlı

Frontiers in genetics

2023 Volume 14, Page(s) 1208673

Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease of motor neurons. Most ALS cases are considered sporadic due to the presence of a combination of environmental and complex genetic risk factors, while approximately 10% ...

Abstract	Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease of motor neurons. Most ALS cases are considered sporadic due to the presence of a combination of environmental and complex genetic risk factors, while approximately 10% of cases have a family history. Pathogenic variants in the
Language	English
Publishing date	2023-08-25
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1208673
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Article: Editorial: Volume II: fibrotic tissue remodeling as a driver of disease pathogenesis.

Mitra, Arkadeep / Saraswati, Sarika / Basak, Trayambak

Frontiers in molecular biosciences

2024 Volume 11, Page(s) 1356591

Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2024.1356591
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Article ; Online: Examining the changes in women's lives after the hysterectomy operation: Experiences of women from Turkey.

Turan, Ayşenur / Karabayır, Hilal Başak / Kaya, İffet Güler

Archives of women's mental health

2024

Abstract: Purpose: The aim of the study is to examine what kind of changes the operation has brought about in the social and psychological life of women.: Methods: The study was a hermeneutic-phenomenological research conducted using qualitative research ... ...

Abstract	Purpose: The aim of the study is to examine what kind of changes the operation has brought about in the social and psychological life of women. Methods: The study was a hermeneutic-phenomenological research conducted using qualitative research methods. It took place between May and July 2023 at a university hospital located in Istanbul, Turkey. Following ethical approval, the study included a total of 24 women who had undergone a 'total abdominal hysterectomy, bilateral salpingo-oophorectomy.' These participants were selected using a combination of maximum diversity sampling and random sampling methods. Data collection was carried out using a semi-structured interview form. The interviews were conducted using face-to-face interview techniques and in-depth interview methods. Qualitative data analysis involved using the coding paradigm of Grounded Theory and Straus and Corbin's coding framework. For the analysis of quantitative data, SPSS version 28.0 was employed, while qualitative data were analyzed using MaxQDA Analytics Pro 2022. Results: The study found that the participants had a mean age of 47 ± 7.53, and the majority, 66.7%, had not reached menopause before the operation. The qualitative analysis of the semi-structured interviews revealed five main themes, which were identified as follows: 'hysterectomy experiences', 'the impact of hysterectomy on sexual life', 'the significance attributed to the uterus', 'the significance attributed to femininity', and 'self-efficacy after hysterectomy'. Conclusions: The study revealed that women experienced changes in self-perception, body image, a sense of organ loss, and developed negative attitudes towards menopause following a hysterectomy. Additionally, there was a noticeable connection between the meanings attributed to the uterus and femininity, which was often influenced by cultural and social factors. In light of these findings, it is recommended that women receive counseling from healthcare professionals before undergoing a hysterectomy. This guidance can help women better understand and cope with the physical, emotional, and cultural aspects of the procedure.
Language	English
Publishing date	2024-01-06
Publishing country	Austria
Document type	Journal Article
ZDB-ID	1463529-X
ISSN	1435-1102 ; 1434-1816
ISSN (online)	1435-1102
ISSN	1434-1816
DOI	10.1007/s00737-024-01419-3
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