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  1. Article ; Online: Editorial: Autoimmune complications of modern cancer therapies.

    Möhn, Nora / Renovanz, Mirjam / Hagin, David / Skripuletz, Thomas

    Frontiers in immunology

    2024  Volume 14, Page(s) 1357825

    MeSH term(s) Humans ; Neoplasms/therapy ; Autoimmune Diseases/etiology
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1357825
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  2. Article: Progressive multifokale Leukenzephalopathie: Diagnostik und Therapieoptionen

    Grote-Levi, Lea / Möhn, Nora / Wattjes, Mike P. / Skripuletz, Thomas

    Neurologie up2date

    2023  Volume 06, Issue 02, Page(s) 165–178

    Language German
    Publishing date 2023-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2511-3658 ; 2511-3453
    ISSN (online) 2511-3658
    ISSN 2511-3453
    DOI 10.1055/a-1527-3322
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  3. Article: Diagnose und Therapie der Multiplen Sklerose

    Möhn, Nora / Grote-Levi, Lea / Skripuletz, Thomas

    Neurologie up2date

    2022  Volume 05, Issue 04, Page(s) 292–300

    Language German
    Publishing date 2022-12-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2511-3658 ; 2511-3453
    ISSN (online) 2511-3658
    ISSN 2511-3453
    DOI 10.1055/a-1724-2083
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  4. Article ; Online: Neuroimmunologie von COVID‑19.

    Skripuletz, Thomas / Möhn, Nora / Franke, Christiana / Prüß, Harald

    Der Nervenarzt

    2021  Volume 92, Issue 6, Page(s) 521–530

    Abstract: Many neuroimmunological diseases, such as encephalopathy, encephalitis, myelitis and acute disseminated encephalomyelitis (ADEM) have occurred more frequently after infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which ... ...

    Title translation Neuroimmunology of COVID-19.
    Abstract Many neuroimmunological diseases, such as encephalopathy, encephalitis, myelitis and acute disseminated encephalomyelitis (ADEM) have occurred more frequently after infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which indicates a parainfectious or postinfectious association. The most likely underlying mechanisms include virus-triggered overactivation of the immune system with hyperinflammation and cytokine storm but potentially also the development of specific autoantibodies against central nervous system (CNS) tissue. These were predominantly detected in the cerebrospinal fluid of severely ill coronavirus disease 2019 (COVID-19) patients. In contrast, direct damage after invasion of SARS-CoV‑2 into the brain and spinal cord does not seem to play a relevant role. Susceptibility to infection with SARS-CoV‑2 in patients with multiple sclerosis, myasthenia or other neuroimmunological diseases including the risk for severe disease courses, is not determined by the administered immunotherapy but by known risk factors, such as age, comorbidities and the disease-related degree of disability. Therefore, immunotherapy in these patients should not be delayed or discontinued. The contribution of neuroimmunological mechanisms to long-term sequelae after survival of a COVID-19 illness, such as fatigue, impairment of memory, sleep dysfunction or anxiety, will require long-term clinical follow-up, preferentially in COVID-19 register studies.
    MeSH term(s) Brain Diseases ; COVID-19 ; Encephalitis ; Humans ; Neuroimmunomodulation ; SARS-CoV-2
    Language German
    Publishing date 2021-03-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 123291-5
    ISSN 1433-0407 ; 0028-2804
    ISSN (online) 1433-0407
    ISSN 0028-2804
    DOI 10.1007/s00115-021-01077-1
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  5. Article ; Online: Brief research report: in-depth immunophenotyping reveals stability of CD19 CAR T-cells over time.

    Odak, Ivan / Bayir, Lâle M / Riemann, Lennart / Sikora, Ruth / Schneider, Jessica / Xiao, Yankai / Möhn, Nora / Skripuletz, Thomas / Beutel, Gernot / Eder, Matthias / Ganser, Arnold / Förster, Reinhold / Schultze-Florey, Christian R / Koenecke, Christian

    Frontiers in immunology

    2024  Volume 15, Page(s) 1298598

    Abstract: Variability or stability might have an impact on treatment success and toxicity of CD19 CAR T-cells. We conducted a prospective observational study of 12 patients treated with Tisagenlecleucel for ... ...

    Abstract Variability or stability might have an impact on treatment success and toxicity of CD19 CAR T-cells. We conducted a prospective observational study of 12 patients treated with Tisagenlecleucel for CD19
    MeSH term(s) Humans ; Adaptor Proteins, Signal Transducing ; Antigens, CD19 ; Immunophenotyping ; T-Lymphocytes ; Prospective Studies
    Chemical Substances Adaptor Proteins, Signal Transducing ; Antigens, CD19
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1298598
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  6. Article ; Online: Influence of hormones in multiple sclerosis: focus on the most important hormones.

    Soleimani, Alireza / Ezabadi, Sajjad Ghane / Möhn, Nora / Esfandabadi, Zahra Moghimi / Khosravizadeh, Zahra / Skripuletz, Thomas / Azimzadeh, Maryam

    Metabolic brain disease

    2023  Volume 38, Issue 3, Page(s) 739–747

    Abstract: Hormonal imbalance may be an important factor in the severity of multiple sclerosis (MS) disease. In this context, hormone therapy has been shown to have immunoregulatory potential in various experimental approaches. There is increasing evidence of ... ...

    Abstract Hormonal imbalance may be an important factor in the severity of multiple sclerosis (MS) disease. In this context, hormone therapy has been shown to have immunoregulatory potential in various experimental approaches. There is increasing evidence of potentially beneficial effects of thyroid, melatonin, and sex hormones in MS models. These hormones may ameliorate the neurological impairment through immunoregulatory and neuroprotective effects, as well as by reducing oxidative stress. Expanding our knowledge of hormone therapy may be an effective step toward identifying additional molecular/cellular pathways in MS disease. In this review, we discuss the role of several important hormones in MS pathogenesis in terms of their effects on immunoregulatory aspects and neuroprotection.
    MeSH term(s) Humans ; Multiple Sclerosis/metabolism ; Gonadal Steroid Hormones/metabolism ; Gonadal Steroid Hormones/pharmacology ; Neuroprotective Agents/pharmacology ; Melatonin/therapeutic use ; Oxidative Stress
    Chemical Substances Gonadal Steroid Hormones ; Neuroprotective Agents ; Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632824-6
    ISSN 1573-7365 ; 0885-7490
    ISSN (online) 1573-7365
    ISSN 0885-7490
    DOI 10.1007/s11011-022-01138-7
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  7. Book ; Online ; Thesis: Effekte synthetischer Retinoid-Rezeptor-Liganden auf IL-17 produzierende γδ T-Zellen in der experimentellen Gallengangatresie

    Möhn, Nora [Verfasser] / Petersen, Claus [Akademischer Betreuer]

    2020  

    Author's details Nora Möhn ; Akademischer Betreuer: Claus Petersen ; Arbeitsgruppe des Forschungslabors der Kinderchirurgie
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Bibliothek der Medizinischen Hochschule Hannover
    Publishing place Hannover
    Document type Book ; Online ; Thesis
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  8. Article ; Online: IgG4-related hypertrophic pachymeningitis with tumor-like intracranial and intracerebral lesions.

    Esmaeilzadeh, Majid / Dadak, Mete / Atallah, Oday / Möhn, Nora / Skripuletz, Thomas / Hartmann, Christian / Banan, Rozbeh / Krauss, Joachim K

    Acta neurochirurgica

    2022  Volume 164, Issue 10, Page(s) 2781–2787

    Abstract: Objective: IgG4-related hypertrophic pachymeningitis is a rare fibroinflammatory disorder that may cause localized or diffused thickening of the dura mater. Misinterpretations of the clinical and imaging findings are common. Clinical manifestations ... ...

    Abstract Objective: IgG4-related hypertrophic pachymeningitis is a rare fibroinflammatory disorder that may cause localized or diffused thickening of the dura mater. Misinterpretations of the clinical and imaging findings are common. Clinical manifestations depend on the location of the inflammatory lesion and on compression of neural structures leading to functional deficits. A dural biopsy is commonly needed for a definitive diagnosis. Immunomodulatory therapy is considered the therapy of choice.
    Methods: Four patients with IgG4-related hypertrophic pachymeningitis were identified over a 5-year period. Patient-related characteristics including age, preoperative workup, signs and symptoms of patients, and diagnostic procedures were evaluated. Furthermore, the surgical treatment and 5-year follow-up outcomes were analyzed.
    Results: There were two adults and two adolescents (mean age 32 years; range 15 to 67 years). Two patients were male, and two were female. No history of disease was known in any of the patients. Clinical symptoms were epilepsy (n = 2), ataxia and nausea (n = 1), and facial nerve palsy (n = 1). MR imaging studies showed contrast enhancing lesions in the temporal region in two patients, and in the cerebellar region in the other two patients. Subtotal resection was performed in two instances and a biopsy via a suboccipital retrosigmoid approach was obtained in the other two patients. Histochemical and immunohistochemical investigations revealed an IgG 4 disease in all of these patients. Immunomodulatorry therapy led to clinical stability during follow-up of 5 years in all four cases.
    Conclusion: The diagnosis of IgG4-related hypertrophic pachymeningitis is challenging, but is of great relevance as treatment differs significantly from other forms of pachymeningitis and a specific therapeutic approach may avoid long-term neurological complications. Our series contributes to a better clinical characterization of this rare disease.
    MeSH term(s) Adolescent ; Adult ; Dura Mater/diagnostic imaging ; Dura Mater/pathology ; Dura Mater/surgery ; Female ; Humans ; Hypertrophy ; Immunoglobulin G/therapeutic use ; Magnetic Resonance Imaging/adverse effects ; Male ; Meningitis/diagnosis ; Meningitis/etiology ; Neoplasms/complications
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2022-08-17
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-022-05340-5
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  9. Article ; Online: Adoptive Allogeneic T-Cell Therapy Improves the Clinical Outcome of JC Virus Granule Cell Neuronopathy: A Case Report.

    Grote-Levi, Lea / Möhn, Nora / Bonifacius, Agnes / Tischer-Zimmermann, Sabine / Schweitzer, Finja / Mahmoudi, Nima / Silling, Steffi / Warnke, Clemens / Maecker-Kolhoff, Britta / Wattjes, Mike P / Eiz-Vesper, Britta / Höglinger, Günter U / Skripuletz, Thomas

    Neurology(R) neuroimmunology & neuroinflammation

    2023  Volume 10, Issue 5

    Abstract: Objectives: JC virus granule cell neuronopathy is a potentially fatal otherwise highly disabling disease without an approved therapeutic option. This case report presents the positive record to T-cell therapy in JC virus granule cell neuronopathy.: ... ...

    Abstract Objectives: JC virus granule cell neuronopathy is a potentially fatal otherwise highly disabling disease without an approved therapeutic option. This case report presents the positive record to T-cell therapy in JC virus granule cell neuronopathy.
    Methods: The patient represented with subacute cerebellar symptoms. Diagnosis of JC virus granule cell neuronopathy was made because of infratentorially accentuated brain volume atrophy shown by brain MRI and the detection of JC virus DNA in the CSF.
    Results: Six doses of virus-specific T cells were administered. Within 12 months after therapy initiation, the patient showed clear clinical benefit with improvement of symptoms, and JC viral DNA load significantly declined.
    Discussion: We present the case report of a positive response to T-cell therapy in JC virus granule cell neuronopathy, leading to an improvement of symptoms.
    MeSH term(s) Humans ; JC Virus ; Cerebellum ; Atrophy ; Cell- and Tissue-Based Therapy ; Hematopoietic Stem Cell Transplantation
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2767740-0
    ISSN 2332-7812 ; 2332-7812
    ISSN (online) 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000200138
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  10. Article ; Online: The relevance of NMDA receptor antibody-specific index for diagnosis and prognosis in patients with anti-NMDA receptor encephalitis.

    Hümmert, Martin W / Jendretzky, Konstantin F / Fricke, Karin / Gingele, Marina / Ratuszny, Dominica / Möhn, Nora / Trebst, Corinna / Skripuletz, Thomas / Gingele, Stefan / Sühs, Kurt-Wolfram

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 12696

    Abstract: The clinical implications of the presence of anti-N-methyl-D-aspartate receptor (NMDAR)-specific intrathecal immunoglobulin G synthesis and whether it determines the diagnosis of anti-NMDAR encephalitis have not been thoroughly investigated yet. Thus, ... ...

    Abstract The clinical implications of the presence of anti-N-methyl-D-aspartate receptor (NMDAR)-specific intrathecal immunoglobulin G synthesis and whether it determines the diagnosis of anti-NMDAR encephalitis have not been thoroughly investigated yet. Thus, the aim of this study was to investigate whether the detection of intrathecal anti-NMDAR-specific IgG synthesis contributes to the diagnostic confirmation of anti-NMDAR encephalitis, to disease severity, and to prognosis in patients with positive serum anti-NMDAR-IgG. In this study, patients with detectable anti-NMDAR IgG in serum and/or cerebrospinal fluid (CSF) were included and separated into two groups that either met the 2016 criteria by Graus et al. of definite anti-NMDAR encephalitis (n = 27) or did not (n = 15). In a total, of 80 paired CSF/serum samples, antibody titers were titrated manually and end-point titer levels were carefully determined in a blinded manner to the subgroup attribution. The disease course was assessed via the modified Rankin Scale (mRS) and prognosis was estimated by the anti-NMDAR Encephalitis One-Year Functional Status (NEOS) score. With respect to whether the diagnostic Graus criteria for definite anti-NMDAR encephalitis were fulfilled, a significantly unequal distribution of intrathecal anti-NMDAR antibody-specific synthesis could be shown with a high negative predictive value in case of a negative anti-NMDAR antibody-specific index (NMDAR AI, p = .008. OR = 23.9, sensitivity = 1.0, specificity = 0.4, negative predictive value = 1). A weak correlation was found between the CSF antibody titer and mRS value at the time of sample collection (r
    MeSH term(s) Humans ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis ; Receptors, N-Methyl-D-Aspartate ; Prognosis ; Antibodies ; Disease Progression
    Chemical Substances Receptors, N-Methyl-D-Aspartate ; Antibodies
    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-38462-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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