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  1. Article ; Online: Ratiometric Fluorescence Sensing System for Lead Ions Based on Self-Assembly of Bioprobes Triggered by Specific Pb

    Mehta, Pramod Kumar / Lee, JaeYoon / Oh, Eun-Taex / Park, Heon Joo / Lee, Keun-Hyeung

    ACS applied materials & interfaces

    2023  

    Abstract: Lead is one of the most toxic substances. However, there are few ratiometric fluorescent probes for sensing ... ...

    Abstract Lead is one of the most toxic substances. However, there are few ratiometric fluorescent probes for sensing Pb
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c00567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A strategy to prevent atherosclerosis via TNF receptor regulation.

    Kim, Chan Woo / Oh, Eun-Taex / Park, Heon Joo

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2021  Volume 35, Issue 3, Page(s) e21391

    Abstract: Atherosclerosis is a chronic inflammatory disease of the arterial wall. It has been known that development of atherosclerosis is closely related to activation of tumor necrosis factor α (TNF-α). The objective of this study was to elucidate the effects of ...

    Abstract Atherosclerosis is a chronic inflammatory disease of the arterial wall. It has been known that development of atherosclerosis is closely related to activation of tumor necrosis factor α (TNF-α). The objective of this study was to elucidate the effects of TNF-α blockade with brusatol on endothelial activation under pro-atherosclerotic conditions. To this end, we examined the effects of brusatol on TNF-α-induced intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) expression in human aortic endothelial cells (HAECs) using western blot and THP-1 adhesion assays. Brusatol induced a decrease in TNF-α-induced ICAM-1 and VCAM-1 expression through inhibiting TNFR1 expression, leading to suppression of endothelial inflammation independently of the NRF2 (nuclear factor erythroid 2-related factor 2) pathway. The mechanism underlying brusatol-induced TNF receptor 1 (TNFR1) inhibition was investigated with the aid of protein synthesis, co-immunoprecipitation, and cytokine arrays. Notably, brusatol inhibited TNFR1 protein synthesis and suppressed both the canonical nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) signaling pathway and TNF-α-induced cytokine secretion. We further tested the functional effect of brusatol on atherosclerosis development in vivo using two different atherosclerosis mouse models, specifically, acute partial carotid ligation and conventional chronic high-fat diet-fed mouse models. Administration of brusatol led to significant suppression of atherosclerosis development in both mouse models. Our finding that brusatol prevents atherosclerosis via inhibition of TNFR1 protein synthesis supports the potential of downregulation of cell surface TNFR1 as an effective therapeutic approach to inhibit development of atherosclerosis.
    MeSH term(s) Animals ; Atherosclerosis/prevention & control ; Cells, Cultured ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Humans ; Intercellular Adhesion Molecule-1/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Proteasome Endopeptidase Complex/physiology ; Quassins/therapeutic use ; Receptors, Tumor Necrosis Factor, Type I/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Vascular Cell Adhesion Molecule-1/genetics
    Chemical Substances Quassins ; Receptors, Tumor Necrosis Factor, Type I ; Tumor Necrosis Factor-alpha ; Vascular Cell Adhesion Molecule-1 ; Intercellular Adhesion Molecule-1 (126547-89-5) ; brusatol (14907-98-3) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202000764R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 296: Show issues

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  3. Article ; Online: NQO1 regulates cell cycle progression at the G2/M phase.

    Oh, Eun-Taex / Kim, Ha Gyeong / Kim, Chul Hoon / Lee, Jeonghun / Kim, Chulhee / Lee, Jae-Seon / Cho, Yunmi / Park, Heon Joo

    Theranostics

    2023  Volume 13, Issue 3, Page(s) 873–895

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Humans ; Cell Cycle ; Cell Division ; Cell Line, Tumor ; G2 Phase ; NAD(P)H Dehydrogenase (Quinone)/genetics ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Proto-Oncogene Proteins c-fos/metabolism ; Neoplasms/genetics
    Chemical Substances NAD(P)H Dehydrogenase (Quinone) (EC 1.6.5.2) ; NQO1 protein, human (EC 1.6.5.2) ; Proto-Oncogene Proteins c-fos ; CKS1B protein, human
    Language English
    Publishing date 2023-01-10
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.77444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tuning of Peptide Cytotoxicity with Cell Penetrating Motif Activatable by Matrix Metalloproteinase-2.

    Lee, Jeonghun / Oh, Eun-Taex / Lee, Hae-June / Lee, Eunkyoung / Kim, Ha Gyeong / Park, Heon Joo / Kim, Chulhee

    ACS omega

    2022  Volume 7, Issue 34, Page(s) 29684–29691

    Abstract: Although diverse cell penetrating motifs not only from naturally occurring proteins but also from synthetic peptides have been discovered and developed, the selectivity of cargo delivery connected to these motifs into the desired target cells is ... ...

    Abstract Although diverse cell penetrating motifs not only from naturally occurring proteins but also from synthetic peptides have been discovered and developed, the selectivity of cargo delivery connected to these motifs into the desired target cells is generally low. Here, we demonstrate the selective cytotoxicity tuning of an anticancer KLA peptide with a cell penetrating motif activatable by matrix metalloproteinase-2 (MMP2). The anionic masking sequence introduced at the end of the KLA peptide through an MMP2-cleavable linker is selectively cleaved by MMP2 and the cationic cell penetrating motif is activated. Upon treatment of the peptide to H1299 cells (high MMP2 level), it is selectively internalized into the cells by MMP2, which consequently induces membrane disruption and cell death. In contrast, the peptide shows negligible cytotoxicity toward A549 cancer cells with low MMP2 levels. Furthermore, the selective therapeutic efficacy of the peptide induced by MMP2 is also corroborated using in vivo study.
    Language English
    Publishing date 2022-08-16
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c02127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Implications of NQO1 in cancer therapy.

    Oh, Eun-Taex / Park, Heon Joo

    BMB reports

    2015  Volume 48, Issue 11, Page(s) 609–617

    Abstract: Nad(p)h: quinone oxidoreductase (NQO1), an obligatory two-electron reductase, is a ubiquitous cytosolic enzyme that catalyzes the reduction of quinone substrates. The NQO1- mediated two-electron reduction of quinones can be either chemoprotection/ ... ...

    Abstract Nad(p)h: quinone oxidoreductase (NQO1), an obligatory two-electron reductase, is a ubiquitous cytosolic enzyme that catalyzes the reduction of quinone substrates. The NQO1- mediated two-electron reduction of quinones can be either chemoprotection/detoxification or a chemotherapeutic response, depending on the target quinones. When toxic quinones are reduced by NQO1, they are conjugated with glutathione or glucuronic acid and excreted from the cells. Based on this protective effect of NQO1, the use of dietary compounds to induce the expression of NQO1 has emerged as a promising strategy for cancer prevention. On the other hand, NQO1-mediated two-electron reduction converts certain quinone compounds (such as mitomycin C, E09, RH1 and -lapachone) to cytotoxic agents, leading to cell death. It has been known that NQO1 is expressed at high levels in numerous human cancers, including breast, colon, cervix, lung, and pancreas, as compared with normal tissues. This implies that tumors can be preferentially damaged relative to normal tissue by cytotoxic quinone drugs. Importantly, NQO1 has been shown to stabilize many proteins, including p53 and p33ING1b, by inhibiting their proteasomal degradation. This review will summarize the biological roles of NQO1 in cancer, with emphasis on recent findings and the potential of NQO1 as a therapeutic target for the cancer therapy.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Humans ; NAD(P)H Dehydrogenase (Quinone)/biosynthesis ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; NAD(P)H Dehydrogenase (Quinone)/pharmacology ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Quinones/metabolism
    Chemical Substances Antineoplastic Agents ; Quinones ; NAD(P)H Dehydrogenase (Quinone) (EC 1.6.5.2)
    Language English
    Publishing date 2015-09-29
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2410389-5
    ISSN 1976-670X ; 1976-6696
    ISSN (online) 1976-670X
    ISSN 1976-6696
    DOI 10.5483/bmbrep.2015.48.11.190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4202: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Multi-Layer Nanofibrous PCL Scaffold-Based Colon Cancer Cell Cultures to Mimic Hypoxic Tumor Microenvironment for Bioassay.

    Oh, Eun-Taex / Kim, Ha Gyeong / Choi, Min-Ho / Lee, Jae-Seon / Kim, Sang Jeong / Kwak, Jong-Young / Park, Heon Joo

    Cancers

    2021  Volume 13, Issue 14

    Abstract: Three-dimensional (3D) cancer cell culture systems have been developed to aid the study of molecular mechanisms in cancer development, identify therapeutic targets, and test drug candidates. In this study, we developed a strategy for mimicking the ... ...

    Abstract Three-dimensional (3D) cancer cell culture systems have been developed to aid the study of molecular mechanisms in cancer development, identify therapeutic targets, and test drug candidates. In this study, we developed a strategy for mimicking the hypoxic tumor microenvironment in a 3D cancer cell culture system using multi-layer, nanofibrous poly(ε-caprolactone) (PCL) scaffold (pNFS)-based cancer cell cultures. We found that human colon cancer cells infiltrated pNFS within 3 days and could be cultured three-dimensionally within the NFS. When incubated in four stacks of 30 µm-thick pNFS for 3 days, colon cancer cells in layer three showed partially reduced entry into the S phase, whereas those in layer four, located farthest from the media, showed a marked reduction in S-phase entry. As a consequence, cells in layer four exhibited hypoxia-induced disorganization of F-actin on day 3, and those in layers three and four showed an increase in the expression of the hypoxia-induced transcription factor HIF-1α and its target genes,
    Language English
    Publishing date 2021-07-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13143550
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  7. Article ; Online: Fast and sensitive fluorescent detection of inorganic mercury species and methylmercury using a fluorescent probe based on the displacement reaction of arylboronic acid with the mercury species.

    Neupane, Lok Nath / Park, Joohee / Mehta, Pramod Kumar / Oh, Eun-Taex / Park, Heon Joo / Lee, Keun-Hyeung

    Chemical communications (Cambridge, England)

    2020  Volume 56, Issue 19, Page(s) 2941–2944

    Abstract: We present a reaction-based fluorescent probe (1) for ... ...

    Abstract We present a reaction-based fluorescent probe (1) for Hg
    MeSH term(s) Boronic Acids/analysis ; Limit of Detection ; Mercury/analysis ; Methylmercury Compounds/analysis ; Spectrometry, Fluorescence/methods
    Chemical Substances Boronic Acids ; Methylmercury Compounds ; Mercury (FXS1BY2PGL)
    Language English
    Publishing date 2020-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c9cc09240d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Fluorescent Detection of Methyl Mercury in Aqueous Solution and Live Cells Using Fluorescent Probe and Micelle Systems.

    Oh, Semin / Jeon, Jongyong / Jeong, Jaewook / Park, Joohee / Oh, Eun-Taex / Park, Heon Joo / Lee, Keun-Hyeung

    Analytical chemistry

    2020  Volume 92, Issue 7, Page(s) 4917–4925

    Abstract: It is highly challenging to develop fast and sensitive fluorescent methods for monitoring organic mercury in purely aqueous solutions as well as live cells. Especially, selective fluorescent detection of methylmercury over inorganic mercury ions has not ... ...

    Abstract It is highly challenging to develop fast and sensitive fluorescent methods for monitoring organic mercury in purely aqueous solutions as well as live cells. Especially, selective fluorescent detection of methylmercury over inorganic mercury ions has not been reported. We developed a fast and sensitive fluorescent detection method for Hg
    MeSH term(s) A549 Cells ; Fluorescent Dyes/chemistry ; Humans ; Methylmercury Compounds/analysis ; Micelles ; Molecular Conformation ; Optical Imaging ; Solutions ; Spectrometry, Fluorescence ; Water Pollutants, Chemical/chemistry
    Chemical Substances Fluorescent Dyes ; Methylmercury Compounds ; Micelles ; Solutions ; Water Pollutants, Chemical
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.9b05025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Fast and sensitive fluorescent detection of inorganic mercury species and methylmercury using a fluorescent probe based on the displacement reaction of arylboronic acid with the mercury species

    Neupane, Lok Nath / Park, Joohee / Mehta, Pramod Kumar / Oh, Eun-Taex / Park, Heon Joo / Lee, Keun-Hyeung

    Chemical communications. 2020 Mar. 5, v. 56, no. 19

    2020  

    Abstract: We present a reaction-based fluorescent probe (1) for Hg²⁺ and CH₃Hg⁺, based on the displacement reaction of the arylboronic acid with the mercury species. 1 showed promising sensing properties for Hg²⁺ and CH₃Hg⁺, such as high selectivity and ... ...

    Abstract We present a reaction-based fluorescent probe (1) for Hg²⁺ and CH₃Hg⁺, based on the displacement reaction of the arylboronic acid with the mercury species. 1 showed promising sensing properties for Hg²⁺ and CH₃Hg⁺, such as high selectivity and sensitivity, turn-on response, fast response to Hg²⁺ (<2 min) and CH₃Hg⁺ (<5 min), low detection limits and operation in purely aqueous solutions.
    Keywords aqueous solutions ; boronic acids ; chemical reactions ; detection limit ; fluorescence ; fluorescent dyes ; mercury ; methylmercury compounds
    Language English
    Dates of publication 2020-0305
    Size p. 2941-2944.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c9cc09240d
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Stimulus-Induced Conformational Transformation of a Cyclic Peptide for Selective Cell-Targeting On-Off Gatekeeper for Mesoporous Nanocarriers.

    Lee, Jeonghun / Oh, Eun-Taex / Song, Jaehun / Kim, Ha Gyeong / Park, Heon Joo / Kim, Chulhee

    Chemistry, an Asian journal

    2017  Volume 12, Issue 21, Page(s) 2813–2818

    Abstract: ... ...

    Abstract α
    Language English
    Publishing date 2017-11-02
    Publishing country Germany
    Document type Journal Article
    ISSN 1861-471X
    ISSN (online) 1861-471X
    DOI 10.1002/asia.201701050
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