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  1. Article ; Online: Cellular interactions in resident memory T cell establishment and function.

    Hasan, Mohammad H / Beura, Lalit K

    Current opinion in immunology

    2021  Volume 74, Page(s) 68–75

    Abstract: Tissue resident memory T cells ( ... ...

    Abstract Tissue resident memory T cells (T
    MeSH term(s) Autoimmunity ; CD8-Positive T-Lymphocytes ; Cell Communication ; Humans ; Immunologic Memory ; Memory T Cells ; Neoplasms/pathology
    Language English
    Publishing date 2021-11-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2021.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2773: Show issues Location:
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  2. Article ; Online: Tissue-resident memory T cells trigger rapid exudation and local antibody accumulation.

    Rosato, Pamela C / Lotfi-Emran, Sahar / Joag, Vineet / Wijeyesinghe, Sathi / Quarnstrom, Clare F / Degefu, Hanna N / Nedellec, Rebecca / Schenkel, Jason M / Beura, Lalit K / Hangartner, Lars / Burton, Dennis R / Masopust, David

    Mucosal immunology

    2023  Volume 16, Issue 1, Page(s) 17–26

    Abstract: Adaptive immunity is didactically partitioned into humoral and cell-mediated effector mechanisms, which may imply that each arm is separate and does not function together. Here, we report that the activation of CD8+ resident memory T cells ( ... ...

    Abstract Adaptive immunity is didactically partitioned into humoral and cell-mediated effector mechanisms, which may imply that each arm is separate and does not function together. Here, we report that the activation of CD8+ resident memory T cells (T
    MeSH term(s) Mice ; Animals ; Female ; CD8-Positive T-Lymphocytes ; Memory T Cells ; Immunoglobulins ; Stomatitis ; Immunologic Memory
    Chemical Substances Immunoglobulins
    Language English
    Publishing date 2023-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1016/j.mucimm.2022.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6796: Show issues Location:
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  3. Article: Epithelial organoid supports resident memory CD8 T cell differentiation.

    Ulibarri, Max R / Lin, Ying / Ramprashad, Julian R / Han, Geongoo / Hasan, Mohammad H / Mithila, Farha J / Ma, Chaoyu / Gopinath, Smita / Zhang, Nu / Milner, J Justin / Beura, Lalit K

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Resident Memory T cells (TRM) play a vital role in regional immune defense in barrier organs. Although laboratory rodents have been extensively used to study fundamental TRM biology, poor isolation efficiency, sampling bias and low cell survival rates ... ...

    Abstract Resident Memory T cells (TRM) play a vital role in regional immune defense in barrier organs. Although laboratory rodents have been extensively used to study fundamental TRM biology, poor isolation efficiency, sampling bias and low cell survival rates have limited our ability to conduct TRM-focused high-throughput assays. Here, we engineered a murine vaginal epithelial organoid (VEO)-CD8 T cell co-culture system that supports CD8 TRM differentiation
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.01.569395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take? CD8 T-Cell Vaccines: To B or Not to B?

    Beura, Lalit K / Jameson, Stephen C / Masopust, David

    Cold Spring Harbor perspectives in biology

    2018  Volume 10, Issue 9

    Abstract: Although CD8 T-cell vaccines do not have the record of success of humoral-mediated vaccines, they do not receive the same degree of effort. Many diseases, including malaria, tuberculosis, and acquired immune deficiency syndrome (AIDS) have not yielded to ...

    Abstract Although CD8 T-cell vaccines do not have the record of success of humoral-mediated vaccines, they do not receive the same degree of effort. Many diseases, including malaria, tuberculosis, and acquired immune deficiency syndrome (AIDS) have not yielded to vaccines, and intrinsic barriers may impede approaches limited solely to generating antibodies. Moreover, population growth and modernization are driving an increased pace of new emerging global health threats (human immunodeficiency virus [HIV] is a recent example), which will create unpredictable challenges for vaccinologists. Vaccine-elicited CD8 T cells may contribute to protective modalities, although their development will require a more thorough understanding of CD8 T-cell biology, practices for manufacturing and delivering CD8 T-cell-eliciting vectors that have acceptable safety profiles, and, ultimately, the political will and faith of those that make vaccine research funding decisions.
    MeSH term(s) CD8-Positive T-Lymphocytes/immunology ; Communicable Disease Control ; Humans ; Immunity, Humoral ; Immunologic Memory ; Vaccines/immunology
    Chemical Substances Vaccines
    Language English
    Publishing date 2018-09-04
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a028910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Infected cells call their killers to the scene of the crime.

    Beura, Lalit K / Masopust, David

    Immunity

    2015  Volume 42, Issue 3, Page(s) 399–401

    Abstract: Effector CD8(+) T cells scan tissues to locate and kill infected host cells. In this issue of Immunity, Hickman et al. (2015) show that the exploration is not random: infected monocytes attract their assassins by secreting chemokines, which accelerates ... ...

    Abstract Effector CD8(+) T cells scan tissues to locate and kill infected host cells. In this issue of Immunity, Hickman et al. (2015) show that the exploration is not random: infected monocytes attract their assassins by secreting chemokines, which accelerates clearance of epicutaneous vaccinia virus infection.
    MeSH term(s) Animals ; Female ; Humans ; Keratinocytes/immunology ; Poxviridae Infections/immunology ; Receptors, CXCR3/immunology ; Skin/immunology ; T-Lymphocytes, Cytotoxic/immunology ; Vaccinia virus/immunology
    Chemical Substances Cxcr3 protein, mouse ; Receptors, CXCR3
    Language English
    Publishing date 2015-03-17
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2015.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4227: Show issues Location:
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    Zs.MG 69: Show issues

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  6. Article ; Online: Tissue resident memory T cells and viral immunity.

    Rosato, Pamela C / Beura, Lalit K / Masopust, David

    Current opinion in virology

    2017  Volume 22, Page(s) 44–50

    Abstract: Tissue resident memory T cells ( ... ...

    Abstract Tissue resident memory T cells (T
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; Humans ; Immunologic Memory ; T-Lymphocyte Subsets/immunology ; Virus Diseases/immunology
    Language English
    Publishing date 2017-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2016.11.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Industrialized human gut microbiota increases CD8+ T cells and mucus thickness in humanized mouse gut.

    Vangay, Pajau / Ward, Tonya / Lucas, Sarah / Beura, Lalit K / Sabas, Dominique / Abramson, Max / Till, Lisa / Hoops, Susan L / Kashyap, Purna / Hunter, Ryan C / Masopust, David / Knights, Dan

    Gut microbes

    2023  Volume 15, Issue 2, Page(s) 2266627

    Abstract: Immigration to a highly industrialized nation has been associated with metabolic disease and simultaneous shifts in microbiota composition, but the underlying mechanisms are challenging to test in human studies. Here, we conducted a pilot study to assess ...

    Abstract Immigration to a highly industrialized nation has been associated with metabolic disease and simultaneous shifts in microbiota composition, but the underlying mechanisms are challenging to test in human studies. Here, we conducted a pilot study to assess the differential effects of human gut microbiota collected from the United States (US) and rural Thailand on the murine gut mucosa and immune system. Colonization of germ-free mice with microbiota from US individuals resulted in an increased accumulation of innate-like CD8 T cells in the small intestine lamina propria and intra-epithelial compartments when compared to colonization with microbiota from Thai individuals. Both TCRγδ and CD8αα T cells showed a marked increase in mice receiving Western microbiota and, interestingly, this phenotype was also associated with an increase in intestinal mucus thickness. Serendipitously, an accidentally infected group of mice corroborated this association between elevated inflammatory response and increased mucus thickness. These results suggest that Western-associated human gut microbes contribute to a pro-inflammatory immune response.
    MeSH term(s) Humans ; Mice ; Animals ; Gastrointestinal Microbiome ; Inflammation ; Pilot Projects ; Intestinal Mucosa/metabolism ; Mucus ; CD8-Positive T-Lymphocytes
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2023.2266627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: SnapShot: resident memory T cells.

    Beura, Lalit K / Masopust, David

    Cell

    2014  Volume 157, Issue 6, Page(s) 1488–1488.e1

    Abstract: Resident memory T cells (TRM) comprise a subset of nonrecirculating memory T cells that remain positioned at common portals of reinfection. These include barrier tissues such as the mucosae and skin. TRM orchestrate the initial response to pathogens re- ... ...

    Abstract Resident memory T cells (TRM) comprise a subset of nonrecirculating memory T cells that remain positioned at common portals of reinfection. These include barrier tissues such as the mucosae and skin. TRM orchestrate the initial response to pathogens re-encountered at these locales, thereby accelerating protective immune responses.
    MeSH term(s) Animals ; Humans ; Immunologic Memory ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology
    Language English
    Publishing date 2014-05-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2014.05.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1167: Show issues Location:
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  9. Article ; Online: New Insights into the Immune System Using Dirty Mice.

    Hamilton, Sara E / Badovinac, Vladimir P / Beura, Lalit K / Pierson, Mark / Jameson, Stephen C / Masopust, David / Griffith, Thomas S

    Journal of immunology (Baltimore, Md. : 1950)

    2020  Volume 205, Issue 1, Page(s) 3–11

    Abstract: The mouse ( ...

    Abstract The mouse (
    MeSH term(s) Animals ; Immunity/physiology ; Mice/immunology ; Mice/microbiology ; Microbiota/immunology ; Models, Animal ; Specific Pathogen-Free Organisms/immunology ; Translational Medical Research/methods
    Language English
    Publishing date 2020-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2000171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: SnapShot: Resident Memory T Cells

    Beura, Lalit K / David Masopust

    Cell. 2014 June 05, v. 157

    2014  

    Abstract: Resident memory T cells (TRM) comprise a subset of nonrecirculating memory T cells that remain positioned at common portals of reinfection. These include barrier tissues such as the mucosae and skin. TRM orchestrate the initial response to pathogens re- ... ...

    Abstract Resident memory T cells (TRM) comprise a subset of nonrecirculating memory T cells that remain positioned at common portals of reinfection. These include barrier tissues such as the mucosae and skin. TRM orchestrate the initial response to pathogens re-encountered at these locales, thereby accelerating protective immune responses.
    Keywords T-lymphocytes ; immune response ; mucosa ; pathogens
    Language English
    Dates of publication 2014-0605
    Size p. 1488-1488.e1.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2014.05.026
    Database NAL-Catalogue (AGRICOLA)

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