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Article ; Online: Which are the best murine models to study Eosinophilic Chronic Rhinosinusitis? A contemporary review.

Leite-Santos, Francisco / Tamashiro, Edwin / de Andrade Batista Murashima, Adriana / Anselmo-Lima, Wilma T / Valera, Fabiana C P

Brazilian journal of otorhinolaryngology

2023 Volume 89, Issue 6, Page(s) 101328

Abstract: Objective: Mechanisms that lead to Eosinophilic Chronic Rhinosinusitis (ECRS) are not fully established in the literature. It is desirable to assess ECRS in a model that embraces most of the related events. This article reviewed the murine models for ... ...

Abstract	Objective: Mechanisms that lead to Eosinophilic Chronic Rhinosinusitis (ECRS) are not fully established in the literature. It is desirable to assess ECRS in a model that embraces most of the related events. This article reviewed the murine models for ECRS and compared them regarding eosinophilic polypoid formation. Methods: The authors reviewed the articles that included the terms "chronic rhinosinusitis" OR "chronic sinusitis" AND "animal model". We analyzed articles in English that evaluated both the number of polyps and the number of eosinophils in the sinus mucosa of mouse models. Results: We identified a total of 15 articles describing different models of ECRS that used BALB/c or C57BL/6 mice, and different triggers/stimulants such as Staphylococcus aureus Enterotoxin B (SEB) + Ovalbumin (OVA); House Dust Mite (HDM) ± Ovalbumin (OVA); and Aspergillus oryzae Protease (AP) + Ovalbumin (OVA). OVA associated with SEB was the commonest protocol to induce ECRS in both BALB/c and C57BL/6 mice, and it produced a robust response of eosinophilic nasal polyps in both. AP + OVA protocol also led to a good ECRS response. The other models were not considered adequate to produce eosinophilic polyps in mice. Conclusion: In conclusion, OVA associated with SEB seems to produce the most robust eosinophilic sinonasal inflammation.
Language	English
Publishing date	2023-09-15
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2428110-4
ISSN	1808-8686 ; 1808-8694
ISSN (online)	1808-8686
ISSN	1808-8694
DOI	10.1016/j.bjorl.2023.101328
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Article ; Online: Revisiting the orbital complications of acute rhinosinusitis.

Anselmo-Lima, Wilma T / Soares, Mateus R / Fonseca, Jefferson P / Garcia, Denny M / Velasco E Cruz, Antonio A / Tamashiro, Edwin / Valera, Fabiana C P

Brazilian journal of otorhinolaryngology

2023 Volume 89, Issue 5, Page(s) 101316

MeSH term(s)	Humans ; Retrospective Studies ; Abscess/diagnostic imaging ; Abscess/etiology ; Rhinitis/complications ; Rhinitis/diagnostic imaging ; Rhinitis/surgery ; Orbital Cellulitis/diagnostic imaging ; Orbital Cellulitis/etiology ; Sinusitis/complications ; Sinusitis/diagnostic imaging ; Sinusitis/surgery ; Acute Disease ; Orbital Diseases/etiology ; Orbital Diseases/complications
Language	English
Publishing date	2023-08-30
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2428110-4
ISSN	1808-8686 ; 1808-8694
ISSN (online)	1808-8686
ISSN	1808-8694
DOI	10.1016/j.bjorl.2023.101316
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Article ; Online: Brazilian guideline for the use of immunobiologicals in chronic rhinosinusitis with nasal polyps ‒ 2024 update.

Anselmo-Lima, Wilma T / Romano, Fabrizio R / Tamashiro, Edwin / Roithmann, Renato / Dinarte, Vanessa R P / Piltcher, Otavio B / Miyake, Marcel M / Fornazieri, Marco A / Nakanishi, Marcio / Bezerra, Thiago F P / Dolci, Ricardo L L / Mello, João F / Lessa, Marcus M / Voegels, Richard L / Kosugi, Eduardo M / Sakano, Eulalia / Valera, Fabiana C P

Brazilian journal of otorhinolaryngology

2024 Volume 90, Issue 3, Page(s) 101394

Abstract: Introduction: Biologics targeting type 2 inflammation have revolutionized the way we treat patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Particularly in severe and difficult-to-control cases, these drugs have provided a new reality ... ...

Abstract	Introduction: Biologics targeting type 2 inflammation have revolutionized the way we treat patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Particularly in severe and difficult-to-control cases, these drugs have provided a new reality for these patients, allowing for the effective and safe treatment of extensive diseases that were not completely managed with the typical strategy of surgery and topical medications. Objectives: The experience achieved with the approval of these medications by ANVISA for use in CRSwNP and the knowledge obtained regarding outcomes, adverse effects, and the ideal patient profile prompted the update of the previously published guideline, with a detailed review of the most recent scientific literature, the personal experiences of experts, and the adaptation to the reality of the Brazilian healthcare system, both public and private. Results: We proposed a new eligibility criterion for biologics in patients with CRSwNP based on four pillars of indication: the impact of the disease on the patient's life, whether in the presence of specific symptoms or in overall quality of life; the extent of sinonasal disease; the presence of type 2 comorbidities, considering other associated diseases that may also benefit from anti-T2 biologics, and the presence of biomarkers to define type 2 inflammation, especially those associated with worse disease prognoses. Conclusions: This innovative and pioneering method has two major advantages. First, it ensures a comprehensive evaluation of patients; second, it is flexible, as advancements in our understanding of the disease and changes in cost-effectiveness can be addressed by simply adjusting the required score for indication, without the need to modify the entire evaluation scheme.
Language	English
Publishing date	2024-01-30
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2428110-4
ISSN	1808-8686 ; 1808-8694
ISSN (online)	1808-8686
ISSN	1808-8694
DOI	10.1016/j.bjorl.2024.101394
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Article ; Online: Biofilm and Planktonic Antibiotic Resistance in Patients With Acute Exacerbation of Chronic Rhinosinusitis.

Sabino, Henrique Augusto Cantareira / Valera, Fabiana Cardoso Pereira / Santos, Denise Vieira / Fantucci, Marina Zilio / Titoneli, Carolina Carneiro / Martinez, Roberto / Anselmo-Lima, Wilma T / Tamashiro, Edwin

Frontiers in cellular and infection microbiology

2022 Volume 11, Page(s) 813076

Abstract: Introduction: The recalcitrant nature of patients with acute exacerbation of chronic rhinosinusitis (AECRS) potentially involves persisting colonization of the sinonasal mucosa by bacterial biofilms. Biofilms are known to be highly resistant to ... ...

Abstract	Introduction: The recalcitrant nature of patients with acute exacerbation of chronic rhinosinusitis (AECRS) potentially involves persisting colonization of the sinonasal mucosa by bacterial biofilms. Biofilms are known to be highly resistant to antibiotics, which may trigger or maintain chronic inflammation in the sinonasal mucosa. However, little is known about the relationship between the minimum inhibitory concentration (MIC) and antibiofilm concentrations of bacteria obtained from AECRS patients. Material and methods: Thirty bacterial strains from 25 patients with AECRS were identified and underwent MIC determination (VITEK Results: The main bacteria retrieved was Conclusions: Biofilm-forming bacteria from AECRS patients are prevalent, and biofilm forms are highly resistant to antibiotics compared to their planktonic counterparts. Antibiotic resistance observed in planktonic forms is a good indicator of biofilm resistance, although near 20% of susceptible planktonic bacteria can produce antibiotic tolerant biofilms.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Biofilms ; Drug Resistance, Microbial ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Humans ; Microbial Sensitivity Tests ; Plankton ; Staphylococcus aureus
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-01-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2021.813076
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Article ; Online: Chronic rhinosinusitis with nasal polyps does not harbor KRAS, BRAF, and EGFR mutations.

da Silva Vieira, Tamara / Guimarães, Letícia Martins / Diniz, Marina Gonçalves / Gomes-Fernandes, Bianca / Anselmo-Lima, Wilma Terezinha / Tamashiro, Edwin / Bastos-Rodrigues, Luciana / De Marco, Luiz / Gomez, Ricardo Santiago / Valera, Fabiana Cardoso Pereira / Gomes, Carolina Cavalieri

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

2022 Volume 52, Issue 5, Page(s) 426–430

Abstract: Background: Chronic rhinosinusitis is a chronic inflammation of the nasal mucosa and nasal polyps are present in ~25%-30% of cases (chronic rhinosinusitis with nasal polyps [CRSwNP]). CRSwNP is associated with significant morbidity and decreased quality ...

Abstract	Background: Chronic rhinosinusitis is a chronic inflammation of the nasal mucosa and nasal polyps are present in ~25%-30% of cases (chronic rhinosinusitis with nasal polyps [CRSwNP]). CRSwNP is associated with significant morbidity and decreased quality of life, making it clinically important. Inflammation leads to DNA damage and DNA mutations occur in some inflammatory diseases. Notably, mutations in KRAS, BRAF, and EGFR have been reported in different human benign and malignant neoplastic lesions. In addition, KRAS mutations have also been reported in non-neoplastic tissues under chronic inflammatory conditions. Importantly, KRAS mutations have been reported in oncocytic sinonasal papillomas and sinonasal squamous cell carcinoma associated with oncocytic sinonasal papilloma and EGFR mutations have been reported in sinonasal adenocarcinoma, inverted sinonasal papilloma, and sinonasal squamous cell carcinoma associated with inverted sinonasal papilloma. The molecular pathogenesis of nasal polyps remains unclear. Therefore, the present study aimed to investigate the presence of KRAS, BRAF, and EGFR pathogenic mutations in CRSwNP. Methods: Fourteen chronic rhinosinusitis-associated nasal polyp samples were direct sequenced, targeting KRAS exons 2, 3, and 4 (encompassing important hotspot mutations, including codons 12, 13, 61 and 146), BRAF exons 11 and 15, and EGFR exons 19 and 20. Results: No pathogenic mutations were detected in the sequenced regions of KRAS, BRAF, and EGFR genes. Conclusion: This finding suggests that mutations in these genes are not a frequent event in CRSwNP, and, if they occur, they might represent marginal events at best.
MeSH term(s)	Humans ; Nasal Polyps/complications ; Nasal Polyps/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins p21(ras)/genetics ; Quality of Life ; Mutation ; Sinusitis/complications ; Sinusitis/genetics ; Head and Neck Neoplasms ; Squamous Cell Carcinoma of Head and Neck ; Papilloma/genetics ; Inflammation ; ErbB Receptors/genetics ; Chronic Disease
Chemical Substances	Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; ErbB Receptors (EC 2.7.10.1) ; KRAS protein, human ; BRAF protein, human (EC 2.7.11.1) ; EGFR protein, human (EC 2.7.10.1)
Language	English
Publishing date	2022-10-03
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1021270-x
ISSN	1600-0714 ; 0904-2512
ISSN (online)	1600-0714
ISSN	0904-2512
DOI	10.1111/jop.13356
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Article ; Online: Clearance of Pneumococcal Colonization in Infants Is Delayed through Altered Macrophage Trafficking.

Siegel, Steven J / Tamashiro, Edwin / Weiser, Jeffrey N

PLoS pathogens

2015 Volume 11, Issue 6, Page(s) e1005004

Abstract: Infections are a common cause of infant mortality worldwide, especially due to Streptococcus pneumoniae. Colonization is the prerequisite to invasive pneumococcal disease, and is particularly frequent and prolonged in children, though the mechanisms ... ...

Abstract	Infections are a common cause of infant mortality worldwide, especially due to Streptococcus pneumoniae. Colonization is the prerequisite to invasive pneumococcal disease, and is particularly frequent and prolonged in children, though the mechanisms underlying this susceptibility are unknown. We find that infant mice exhibit prolonged pneumococcal carriage, and are delayed in recruiting macrophages, the effector cells of clearance, into the nasopharyngeal lumen. This lack of macrophage recruitment is paralleled by a failure to upregulate chemokine (C-C) motif ligand 2 (Ccl2 or Mcp-1), a macrophage chemoattractant that is required in adult mice to promote clearance. Baseline expression of Ccl2 and the related chemokine Ccl7 is higher in the infant compared to the adult upper respiratory tract, and this effect requires the infant microbiota. These results demonstrate that signals governing macrophage recruitment are altered at baseline in infant mice, which prevents the development of appropriate innate cell infiltration in response to pneumococcal colonization, delaying clearance of pneumococcal carriage.
MeSH term(s)	Animals ; Animals, Newborn ; Cell Movement/physiology ; Chemokine CCL2/immunology ; Macrophages/immunology ; Mice, Inbred C57BL ; Nasopharynx/immunology ; Pneumococcal Infections/immunology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines/immunology ; Streptococcus pneumoniae/growth & development ; Streptococcus pneumoniae/immunology
Chemical Substances	Ccl2 protein, mouse ; Chemokine CCL2 ; Pneumococcal Vaccines
Language	English
Publishing date	2015-06-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1005004
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Article ; Online: Biodegradable Electrospun Nanofibers: A New Approach For Rhinosinusitis Treatment.

Rivelli, Graziella Gomes / Perez, André Coura / Silva, Pedro Henrique Reis / Gomes, Elionai Cassiana de Lima / Moreira, Carolina Paula de Souza / Tamashiro, Edwin / Valera, Fabiana Cardoso Pereira / Anselmo-Lima, Wilma Terezinha / Pianetti, Gérson Antônio / Silva-Cunha, Armando

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2021 Volume 163, Page(s) 105852

Abstract: Biodegradable polymeric nanofibers containing mometasone furoate can be a new approach to drug delivery to treat chronic rhinosinusitis, providing controlled steroid delivery to the sinonasal mucosa. This study aimed to develop biodegradable polymeric ... ...

Abstract	Biodegradable polymeric nanofibers containing mometasone furoate can be a new approach to drug delivery to treat chronic rhinosinusitis, providing controlled steroid delivery to the sinonasal mucosa. This study aimed to develop biodegradable polymeric nanofibers and explore the safety of these fibers in an in vivo rabbit model. The nanofibers' development has been optimized using the Response Surface Methodology (RSM) obtained with Design of Experiments (DoE) with the best conditions related to the polymer concentration and proportion of solvents used in the electrospinning process. The nanofibers were prepared, operating as a determinant factor, the nanofiber formation and its diameter evaluated by Scanning Electron Microscopy (SEM). The ideal system obtained was assessed by SEM, thermogravimetric analysis (TGA), X-ray diffraction (XRD), differential scanning calorimetry (DSC), assay, and drug delivery by UHLPC validated method. The results showed that the drug is dispersed in the polymeric matrix, is stable, and showed sustained release kinetics in a bio-relevant nasal environment (Higuchi model kinetics). In vivo tests, the level of inflammation at the animals' mucosa which received the nanofiber with the mometasone furoate was lower than those that received the nanofibers without the drug (α = 0.05). Histopathology analysis showed that the polymeric nanofibers containing mometasone are safe when topically applied on the sinonasal mucosa, opening a new horizon in chronic rhinosinusitis treatment.
MeSH term(s)	Animals ; Calorimetry, Differential Scanning ; Microscopy, Electron, Scanning ; Nanofibers ; Polymers ; Rabbits ; X-Ray Diffraction
Chemical Substances	Polymers
Language	English
Publishing date	2021-04-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2021.105852
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Article ; Online: Clearance of Pneumococcal Colonization in Infants Is Delayed through Altered Macrophage Trafficking.

Steven J Siegel / Edwin Tamashiro / Jeffrey N Weiser

PLoS Pathogens, Vol 11, Iss 6, p e

2015 Volume 1005004

Abstract	Infections are a common cause of infant mortality worldwide, especially due to Streptococcus pneumoniae. Colonization is the prerequisite to invasive pneumococcal disease, and is particularly frequent and prolonged in children, though the mechanisms underlying this susceptibility are unknown. We find that infant mice exhibit prolonged pneumococcal carriage, and are delayed in recruiting macrophages, the effector cells of clearance, into the nasopharyngeal lumen. This lack of macrophage recruitment is paralleled by a failure to upregulate chemokine (C-C) motif ligand 2 (Ccl2 or Mcp-1), a macrophage chemoattractant that is required in adult mice to promote clearance. Baseline expression of Ccl2 and the related chemokine Ccl7 is higher in the infant compared to the adult upper respiratory tract, and this effect requires the infant microbiota. These results demonstrate that signals governing macrophage recruitment are altered at baseline in infant mice, which prevents the development of appropriate innate cell infiltration in response to pneumococcal colonization, delaying clearance of pneumococcal carriage.
Keywords	Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2015-06-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Perillyl alcohol for pediatric TP53- and RAS-mutated SHH-medulloblastoma: an in vitro and in vivo translational pre-clinical study.

Silva, Marcela de Oliveira / de Sousa, Graziella Ribeiro / Simões, Sarah Capelupe / Nicolucci, Patrícia / Tamashiro, Edwin / Saggioro, Fabiano / de Oliveira, Ricardo Santos / Brassesco, María Sol

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2021 Volume 37, Issue 7, Page(s) 2163–2175

Abstract: Purpose: Inhalation of perillyl alcohol (POH) recently emerged as an investigational promising antiglioma strategy. However, little attention has been paid to its therapeutic potential for other brain tumors, especially in the pediatric setting.: ... ...

Abstract	Purpose: Inhalation of perillyl alcohol (POH) recently emerged as an investigational promising antiglioma strategy. However, little attention has been paid to its therapeutic potential for other brain tumors, especially in the pediatric setting. Methods: The effects of POH were explored in medulloblastoma cell models belonging to the SHH variant with activation of RAS (ONS-76) or with TP53 mutations (DAOY and UW402), by means of proliferation and invasion assays. Interactions with methotrexate, thiotepa, or ionizing radiation were also assessed. Mice bearing subcutaneous tumors were treated with intraperitoneal injections. Alternatively, animals with intracranial tumors were exposed to intranasal POH alone or combined with radiation. Tumor growth was measured by bioluminescence. Analyses of cytotoxicity to the nasal cavity were also performed, and the presence of POH in the brain, lungs, and plasma was surveyed through chromatography/mass spectrometry. Results: POH decreased cell proliferation and colony formation, with conspicuous death, though the invasive capacity was only affected in the NRAS-mutated cell line. Median-drug effect analysis displayed synergistic combinations with methotrexate. Otherwise, POH showed to be a reasonable radiosensitizer. In vivo, intraperitoneal injection significantly decreased tumor volume. However, its inhalation did not affect orthotopic tumors, neither alone or followed by cranial irradiation. Nasal cavity epithelium showed unimportant alterations, though, no traces of POH or its metabolites were detected in tissue samples. Conclusion: POH presents robust in vitro antimedulloblastoma effects and sensitizes cell lines to other conventional therapeutics, reducing tumor volume when administered intraperitoneally. Nevertheless, further improvement of delivery devices and/or drug formulations are needed to better characterize its effectiveness through inhalation.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Cerebellar Neoplasms/drug therapy ; Child ; Hedgehog Proteins ; Humans ; Medulloblastoma/drug therapy ; Medulloblastoma/genetics ; Mice ; Monoterpenes ; Tumor Suppressor Protein p53 ; ras Proteins
Chemical Substances	Antineoplastic Agents ; Hedgehog Proteins ; Monoterpenes ; SHH protein, human ; TP53 protein, human ; Tumor Suppressor Protein p53 ; perillyl alcohol (319R5C7293) ; ras Proteins (EC 3.6.5.2)
Language	English
Publishing date	2021-04-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-021-05115-w
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Article ; Online: Does ibuprofen, prednisolone, or amoxicillin reduce post-tonsillectomy pain in children? A prospective randomized controlled trial.

de Azevedo, Carolina B / Valera, Fabiana C P / Carenzi, Lucas R / Küpper, Daniel S / Caetano, João Vitor B / Queiroz, Danielle L C / Anselmo-Lima, Wilma T / Tamashiro, Edwin

International journal of pediatric otorhinolaryngology

2021 Volume 148, Page(s) 110824

Abstract: Objective: To evaluate whether the use of anti-inflammatory or antibiotic in the postoperative period modifies pain in children undergoing tonsillectomy.: Methods: 225 children who underwent cold knife tonsillectomy ± adenoidectomy were randomized ... ...

Abstract	Objective: To evaluate whether the use of anti-inflammatory or antibiotic in the postoperative period modifies pain in children undergoing tonsillectomy. Methods: 225 children who underwent cold knife tonsillectomy ± adenoidectomy were randomized into five groups, receiving #1 metamizole/acetaminophen, #2 amoxicillin, #3 ibuprofen, #4 prednisolone, or #5 amoxicillin plus prednisolone. All groups received oral analgesics (metamizole/acetaminophen) to use as needed. Pain was monitored during the 7 days following surgery using the Parents' Postoperative Pain Measurement (PPPM) and the Faces Pain Scale - Revised (FPS-R). Pain was also indirectly evaluated by the dose of analgesics administered on each day and by the time needed to return to a solid diet. Results: After losses (24%), 170 individuals were submitted for analysis. Multiple comparisons demonstrated that the evolution of pain between the different groups, as matched day-per-day, was not significantly different by either PPPM or FPS-R (p > 0.05). The instances of analgesic intake were also similar in all the groups (p > 0.05), as was the return to solid food ingestion (p = 0.41). All groups presented a similar standard of clinical improvement at intervals of 2 days (p < 0.01). Independent of postoperative pain management, patients developed significant pain up to the day 4 following surgery. Conclusion: The addition of amoxicillin, ibuprofen, prednisolone, or amoxicillin and prednisolone does not modify postoperative pain in children undergoing cold-knife tonsillectomy. Special pain control should be performed on the first 4 days following tonsillectomy in children.
MeSH term(s)	Amoxicillin ; Analgesics, Non-Narcotic/therapeutic use ; Child ; Humans ; Ibuprofen/therapeutic use ; Pain, Postoperative/diagnosis ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Prednisolone ; Prospective Studies ; Tonsillectomy/adverse effects
Chemical Substances	Analgesics, Non-Narcotic ; Amoxicillin (804826J2HU) ; Prednisolone (9PHQ9Y1OLM) ; Ibuprofen (WK2XYI10QM)
Language	English
Publishing date	2021-06-30
Publishing country	Ireland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	754501-0
ISSN	1872-8464 ; 0165-5876
ISSN (online)	1872-8464
ISSN	0165-5876
DOI	10.1016/j.ijporl.2021.110824
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