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Article ; Online: Response to the Comments of H.B. Ferraz et al. about the paper "High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson's disease patients. C.G. Coimbraand V.B.C. Junqueira. Brazilian Journal of Medical and Biological Research, 36

C.G. Coimbra / V.B.C. Junqueira

Brazilian Journal of Medical and Biological Research, Vol 37, Iss 9, Pp 1297-

1409-1417, 2003"

2004 Volume 1302

Keywords	Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2004-09-01T00:00:00Z
Publisher	Associação Brasileira de Divulgação Científica
Document type	Article ; Online
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Article ; Online: Binary Coalescences as Sources of Ultrahigh-Energy Cosmic Rays.

Pereira, Jonas P / Coimbra-Araújo, Carlos H / Dos Anjos, Rita C / Coelho, Jaziel G

Physical review letters

2024 Volume 132, Issue 9, Page(s) 91401

Abstract: ... B's) larger than approximately 10^{10} G, charged particles colliding around their event horizons ... for particle collisions arise for basically any rotation parameter of the BH when B≳10^{10} G, meaning ...

Abstract	Binary coalescences are known sources of gravitational waves (GWs) and they encompass combinations of black holes (BHs) and neutron stars (NSs). Here we show that when BHs are embedded in magnetic fields (B's) larger than approximately 10^{10} G, charged particles colliding around their event horizons can easily have center-of-mass energies in the range of ultrahigh energies (≳10^{18} eV) and become more likely to escape. Such B-embedding and high-energy particles can take place in BH-NS binaries, or even in BH-BH binaries with one of the BHs being charged (with charge-to-mass ratios as small as 10^{-5}, which do not change GW waveforms) and having a residual accretion disk. Ultrahigh center-of-mass energies for particle collisions arise for basically any rotation parameter of the BH when B≳10^{10} G, meaning that it should be a common aspect in binaries, especially in BH-NS ones given the natural presence of a B onto the BH and charged particles due to the magnetosphere of the NS. We estimate that the number of ultrahigh center-of-mass collisions ranges from a few up to millions before the merger of binary compact systems. Thus, binary coalescences may also be efficient sources of ultrahigh energy cosmic rays (UHECRs) and constraints to NS/BH parameters would be possible if UHECRs are detected along with GWs.
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.132.091401
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Article ; Online: Evaluating the Probiotic Potential of Lactic Acid Bacteria Implicated in Natural Fermentation of Table Olives, cv.

Coimbra-Gomes, Joana / Reis, Patrícia J M / Tavares, Tânia G / Faria, Miguel A / Malcata, F Xavier / Macedo, Angela C

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 8

Abstract: The probiotic features ... ...

Abstract	The probiotic features of
MeSH term(s)	Humans ; Lactobacillales ; Olea/microbiology ; Caco-2 Cells ; Fermentation ; Escherichia coli ; Probiotics
Language	English
Publishing date	2023-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28083285
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Article: Study of Lactic Acid Bacteria Biodiversity in Fermented

Coimbra-Gomes, Joana / Reis, Patrícia J M / Tavares, Tânia G / Malcata, Francisco Xavier / Macedo, Angela C

Foods (Basel, Switzerland)

2022 Volume 11, Issue 19

Abstract: Current market trends point at increasing demand for functional foods, namely those carrying probiotics. In the case of table olives, presence of probiotics would convey a competitive advantage to Mediterranean-based diets, already established for their ... ...

Abstract	Current market trends point at increasing demand for functional foods, namely those carrying probiotics. In the case of table olives, presence of probiotics would convey a competitive advantage to Mediterranean-based diets, already established for their cultural heritage and gastronomic character. This work assessed the safety and resistance to gastrointestinal digestion of 19 native LAB strains from Cobrançosa table olives. Strains were identified via molecular sequencing (4 fingerprints/10 strains for Lactiplantibacillus pentosus, and 2 fingerprints/9 strains for L. paraplantarum), and exposed to simulated gastrointestinal fluids, as per the INFOGEST in vitro protocol with modifications. None of those strains proved dangerous for human consumption. Survivability to the gastrointestinal resistance test ranged from 29% to 70%, with strain-dependent variability. L. paraplantarum i18, i27, and i102, and L. pentosus i10 and i11 exhibited statistically lower survival rates (29−35%) than probiotic the Greek table olive reference strain L. pentosus B281 (53%). Among the other strains, L. paraplantarum i101 and L. pentosus i53 and i106 showed the highest survival rates but were not significantly different from the strain of Lacticaseibacillus casei isolated from commercial probiotic yoghurt (65−70%). In vitro results proved that strains retrieved from fermenting cultivar Cobrançosa possess the potential to be claimed as probiotics—thus deserving further attention toward the development of a specific starter culture.
Language	English
Publishing date	2022-10-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11193050
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Article ; Online: Neuroinflammation regulates the balance between hippocampal neuron death and neurogenesis in an ex vivo model of thiamine deficiency.

Cassiano, Larissa M G / Oliveira, Marina S / Pioline, Jeanne / Salim, Anna C M / Coimbra, Roney S

Journal of neuroinflammation

2022 Volume 19, Issue 1, Page(s) 272

Abstract: Background: Thiamine (vitamin B1) is a cofactor for enzymes of central energy metabolism and its deficiency (TD) impairs oxidative phosphorylation, increases oxidative stress, and activates inflammatory processes that can lead to neurodegeneration. ... ...

Abstract	Background: Thiamine (vitamin B1) is a cofactor for enzymes of central energy metabolism and its deficiency (TD) impairs oxidative phosphorylation, increases oxidative stress, and activates inflammatory processes that can lead to neurodegeneration. Wernicke-Korsakoff syndrome (WKS) is a consequence of chronic TD, which leads to extensive neuronal death, and is associated with neuropathological disorders, including cognitive deficits and amnesia. The hippocampus is one of the brain areas most affected by WKS. B1 replacement may not be enough to prevent the irreversible cognitive deficit associated with WKS. Materials and methods: An organotypic hippocampal slice culture (OHC) model was developed to investigate, using immunofluorescence and confocal microscopy and transcriptome analysis, the molecular mechanisms underlying the neurodegeneration associated with TD. The effect of anti-inflammatory pharmacological intervention with resveratrol (RSV) was also assessed in B1-deprived OHCs. Results: In OHCs cultured without B1, neuronal density decayed after 5 days and, on the 7th day, the epigenetic markings H3K4me3 and H3K9me3 were altered in mature neurons likely favoring gene transcription. Between the 7th and the 14th day, a pulse of neurogenesis was observed followed by a further massive neuron loss. Transcriptome analysis at day nine disclosed 89 differentially expressed genes in response to B1 deprivation. Genes involved in tryptophan metabolism and lysine degradation KEGG pathways, and those with Gene Ontology (GO) annotations related to the organization of the extracellular matrix, cell adhesion, and positive regulation of synaptic transmission were upregulated. Several genes of the TNF and FoxO signaling pathways and with GO terms related to inflammation were inhibited in response to B1 deprivation. Nsd1, whose product methylates histone H3 lysine 36, was upregulated and the epigenetic marking H3K36me3, associated with negative regulation of neurogenesis, was increased in neurons. Treating B1-deprived OHCs with RSV promoted an earlier neurogenesis pulse. Conclusion: Neuroregeneration occurs in B1-deficient hippocampal tissue during a time window. This phenomenon depends on reducing neuroinflammation and, likely, on metabolic changes, allowing acetyl-CoA synthesis from amino acids to ensure energy supply via oxidative phosphorylation. Thus, neuroinflammation is implicated as a major regulator of hippocampal neurogenesis in TD opening a new search space for treating WKS.
MeSH term(s)	Humans ; Neuroinflammatory Diseases ; Lysine/metabolism ; Thiamine Deficiency/complications ; Thiamine Deficiency/metabolism ; Thiamine Deficiency/pathology ; Neurogenesis/physiology ; Hippocampus/metabolism ; Thiamine/metabolism ; Neurons/metabolism
Chemical Substances	Lysine (K3Z4F929H6) ; Thiamine (X66NSO3N35)
Language	English
Publishing date	2022-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2156455-3
ISSN	1742-2094 ; 1742-2094
ISSN (online)	1742-2094
ISSN	1742-2094
DOI	10.1186/s12974-022-02624-6
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Article ; Online: Partial Labyrinth Removal Restricted to the Superior Semicircular Canal in Focal Combined Transpetrosal Approach: Description and Illustrative Cases.

Vidal, Claudio H F / Figueiredo, Eberval G / Hazin, Gabriela F / Hahn, Yoav / Leal, Mariana C / Coimbra, Caetano J

Operative neurosurgery (Hagerstown, Md.)

2023 Volume 26, Issue 4, Page(s) 442–451

Abstract: Background and objectives: The labyrinthine structures obstruct the surgical view of the deep petroclival region in the transpetrosal approach. Historically, labyrinthectomy and removal of all 3 semicircular canals, with resultant deafness, was used in ... ...

Abstract	Background and objectives: The labyrinthine structures obstruct the surgical view of the deep petroclival region in the transpetrosal approach. Historically, labyrinthectomy and removal of all 3 semicircular canals, with resultant deafness, was used in patients with ipsilateral functional hearing deficits to improve access. The advent and systematization of superior and posterior semicircular canal removal (transcrusal approach) with good rates of hearing preservation has allowed a redefinition of the possibility of partial labyrinthectomy in patients without previous hearing deficits. The present manuscript is intended to describe a technical refinement of partial labyrinthectomy during focal combined petrosectomy, offering a customization of the approach through the selective removal of the superior semicircular canal for specific types of tumors. Methods: The use of the technique is demonstrated through surgical drawings, pictures, and videos. The rationale to indicate this new approach is discussed based on clinical cases. Results: Three illustrative clinical cases (petroclival meningiomas) are demonstrated. Functional hearing on the approach side has been preserved in all of them. Conclusion: The focal combined transpetrosal approach associated with the superior semicircular canal resection has been a promising surgical technique in the treatment of selected petroclival tumors. It has the potential to further decrease the risks of postoperative auditory and vestibular dysfunctions associated with labyrinthectomies.
MeSH term(s)	Humans ; Semicircular Canals/surgery ; Meningioma/surgery ; Craniotomy/methods ; Meningeal Neoplasms/diagnostic imaging ; Meningeal Neoplasms/surgery
Language	English
Publishing date	2023-10-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2767575-0
ISSN	2332-4260 ; 2332-4252
ISSN (online)	2332-4260
ISSN	2332-4252
DOI	10.1227/ons.0000000000000967
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Article ; Online: Vitamin B12 attenuates leukocyte inflammatory signature in COVID-19

Cassiano, Larissa M G / Cavalcante-Silva, Vanessa / Oliveira, Marina S / Prado, Bárbara V O / Cardoso, Cristianne G / Salim, Anna C M / Franco, Gloria R / D'Almeida, Vânia / Francisco, Saionara C / Coimbra, Roney S

Frontiers in immunology

2023 Volume 14, Page(s) 1048790

Abstract: COVID-19 induces chromatin remodeling in host immune cells, and it had previously been shown that vitamin B12 downregulates some inflammatory ... ...

Abstract	COVID-19 induces chromatin remodeling in host immune cells, and it had previously been shown that vitamin B12 downregulates some inflammatory genes
MeSH term(s)	Vitamin B 12/pharmacology ; Vitamin B 12/therapeutic use ; COVID-19/genetics ; COVID-19/immunology ; Epigenesis, Genetic ; DNA Methylation/drug effects ; Inflammation/drug therapy ; Inflammation/genetics ; Inflammation/immunology ; Humans ; Male ; Female ; Middle Aged ; Aged ; Inflammation Mediators/metabolism ; Leukocytes/drug effects ; Leukocytes/metabolism ; Chemokine CCL3/genetics ; Transcriptome ; Down-Regulation
Chemical Substances	Vitamin B 12 (P6YC3EG204) ; Inflammation Mediators ; Chemokine CCL3
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1048790
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Article ; Online: Elderly patients over 70 years benefit from enhanced recovery programme after colorectal surgery as much as younger patients.

Joris, J / Hans, G / Coimbra, C / Decker, E / Kaba, A

Journal of visceral surgery

2019 Volume 157, Issue 1, Page(s) 23–31

Abstract: Aim of the study: Enhanced recovery programme (ERP) reduces length of hospital stay (LOS) and postoperative complications after colorectal surgery. ERP is feasible and effective in elderly patients. We tested the hypothesis of non-inferiority for ... ...

Abstract	Aim of the study: Enhanced recovery programme (ERP) reduces length of hospital stay (LOS) and postoperative complications after colorectal surgery. ERP is feasible and effective in elderly patients. We tested the hypothesis of non-inferiority for elderly patients as compared to younger patients with regard to LOS. Patients and methods: The first 302 consecutive patients scheduled for colorectal surgery and prospectively introduced in our audit database were retrospectively analysed. LOS (primary endpoint), postoperative complications, and adherence to the ERP of elderly (≥70 years, n=100) were compared with those of younger patients (n=202). The same ERP was used in all patients. Non-inferiority hypothesis for LOS was tested using the confidence interval method. Secondary endpoints were compared using the Mann-Whitney U and the Chi Results: Except for age patients' demographic data were not different in both groups: 53.8 (17-69) vs. 76.8 (70-90) years. The actual LOS were 3.5 [2-7] and 4.0 [3-7] days in the young and elderly group, respectively. The difference in median LOS between the two groups was 0 (95% CI, -0.97-0.97), demonstrating non-inferiority. Although with more risk factors (anaemia, COPD, cardiac disease, and cancer, P<0.05), elderly patients experienced neither more postoperative medical (17.0 vs. 16.3 %) nor surgical (19.0 vs. 22.3 %) complications than young patients. The adherence to protocol was slightly less in elderly (16 [15-18] vs. 17 [16-18], P=0.05). Conclusion: Not only ERP is feasible in seniors, but elderly patients benefit from this perioperative care as much as younger patients. Clinical trials registration: NCT03620851.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Colonic Diseases/surgery ; Comorbidity ; Elective Surgical Procedures ; Enhanced Recovery After Surgery ; Female ; Humans ; Male ; Middle Aged ; Rectal Diseases/surgery ; Retrospective Studies
Language	English
Publishing date	2019-07-31
Publishing country	France
Document type	Comparative Study ; Journal Article
ISSN	1878-7886
ISSN (online)	1878-7886
DOI	10.1016/j.jviscsurg.2019.07.011
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Article ; Online: Nucleus accumbens neurons dynamically respond to appetitive and aversive associative learning.

Deseyve, Catarina / Domingues, Ana Verónica / Carvalho, Tawan T A / Armada, Gisela / Correia, Raquel / Vieitas-Gaspar, Natacha / Wezik, Marcelina / Pinto, Luísa / Sousa, Nuno / Coimbra, Bárbara / Rodrigues, Ana João / Soares-Cunha, Carina

Journal of neurochemistry

2024 Volume 168, Issue 3, Page(s) 312–327

Abstract: To survive, individuals must learn to associate cues in the environment with emotionally relevant outcomes. This association is partially mediated by the nucleus accumbens (NAc), a key brain region of the reward circuit that is mainly composed by ... ...

Abstract	To survive, individuals must learn to associate cues in the environment with emotionally relevant outcomes. This association is partially mediated by the nucleus accumbens (NAc), a key brain region of the reward circuit that is mainly composed by GABAergic medium spiny neurons (MSNs), that express either dopamine receptor D1 or D2. Recent studies showed that both populations can drive reward and aversion, however, the activity of these neurons during appetitive and aversive Pavlovian conditioning remains to be determined. Here, we investigated the relevance of D1- and D2-neurons in associative learning, by measuring calcium transients with fiber photometry during appetitive and aversive Pavlovian tasks in mice. Sucrose was used as a positive valence unconditioned stimulus (US) and foot shock was used as a negative valence US. We show that during appetitive Pavlovian conditioning, D1- and D2-neurons exhibit a general increase in activity in response to the conditioned stimuli (CS). Interestingly, D1- and D2-neurons present distinct changes in activity after sucrose consumption that dynamically evolve throughout learning. During the aversive Pavlovian conditioning, D1- and D2-neurons present an increase in the activity in response to the CS and to the US (shock). Our data support a model in which D1- and D2-neurons are concurrently activated during appetitive and aversive conditioning.
MeSH term(s)	Animals ; Mice ; Nucleus Accumbens/metabolism ; Receptors, Dopamine D1/metabolism ; Conditioning, Classical ; Neurons/metabolism ; Avoidance Learning/physiology ; Sucrose/pharmacology
Chemical Substances	Receptors, Dopamine D1 ; Sucrose (57-50-1)
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1111/jnc.16063
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Article ; Online: Contribution of non-ionic interactions on bile salt sequestration by chitooligosaccharides: Potential hypocholesterolemic activity.

Coreta-Gomes, Filipe / Silva, Inês M V / Nunes, Cláudia / Marin-Montesinos, Ildefonso / Evtuguin, Dmitry / Geraldes, Carlos F G C / João Moreno, Maria / Coimbra, Manuel A

Journal of colloid and interface science

2023 Volume 646, Page(s) 775–783

Abstract: Chitooligosaccharides have been suggested as cholesterol reducing ingredients mostly due to their ability to sequestrate bile salts. The nature of the chitooligosaccharides-bile salts binding is usually linked with the ionic interaction. However, at ... ...

Abstract	Chitooligosaccharides have been suggested as cholesterol reducing ingredients mostly due to their ability to sequestrate bile salts. The nature of the chitooligosaccharides-bile salts binding is usually linked with the ionic interaction. However, at physiological intestinal pH range (6.4 to 7.4) and considering chitooligosaccharides pKa, they should be mostly uncharged. This highlights that other type of interaction might be of relevance. In this work, aqueous solutions of chitooligosaccharides with an average degree of polymerization of 10 and 90 % deacetylated, were characterized regarding their effect on bile salt sequestration and cholesterol accessibility. Chitooligosaccharides were shown to bind bile salts to a similar extent as the cationic resin colestipol, both decreasing cholesterol accessibility as measured by NMR at pH 7.4. A decrease in the ionic strength leads to an increase in the binding capacity of chitooligosaccharides, in agreement with the involvement of ionic interactions. However, when the pH is decreased to 6.4, the increase in charge of chitooligosaccharides is not followed by a significant increase in bile salt sequestration. This corroborates the involvement of non-ionic interactions, which was further supported by NMR chemical shift analysis and by the negative electrophoretic mobility attained for the bile salt-chitooligosaccharide aggregates at high bile salt concentrations. These results highlight that chitooligosaccharides non-ionic character is a relevant structural feature to aid in the development of hypocholesterolemic ingredients.
MeSH term(s)	Bile Acids and Salts ; Cholesterol/chemistry ; Micelles ; Cations
Chemical Substances	Bile Acids and Salts ; oligochitosan ; Cholesterol (97C5T2UQ7J) ; Micelles ; Cations
Language	English
Publishing date	2023-05-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.05.056
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