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Article ; Online: Diagnostic Testing for Crimean-Congo Hemorrhagic Fever.

Raabe, Vanessa N

2020 Volume 58, Issue 4

Abstract: Crimean-Congo hemorrhagic fever is the most geographically widespread tick-borne virus, with infection resulting in mortality in up to 30% of cases. Clinical diagnosis alone is difficult due to the nonspecific nature of symptoms; therefore, laboratory ... ...

Abstract	Crimean-Congo hemorrhagic fever is the most geographically widespread tick-borne virus, with infection resulting in mortality in up to 30% of cases. Clinical diagnosis alone is difficult due to the nonspecific nature of symptoms; therefore, laboratory diagnostics should be utilized for patients with residence in or travel to regions of endemicity in whom the disease is suspected. This minireview provides an overview of laboratory tests available for Crimean-Congo hemorrhagic fever (CCHF) and their utility in diagnosis with a focus on diagnosing CCHF in humans.
MeSH term(s)	Diagnostic Techniques and Procedures ; Diagnostic Tests, Routine ; Hemorrhagic Fever Virus, Crimean-Congo ; Hemorrhagic Fever, Crimean/diagnosis ; Humans ; Travel
Language	English
Publishing date	2020-03-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.01580-19
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Article: A Pregnant Adolescent with COVID-19 and Multisystem Inflammatory Syndrome in Children.

Trostle, Megan E / Grossman, Tracy B / Penfield, Christina A / Phoon, Colin K L / Raabe, Vanessa N / Sloane, Mark F / Roman, Ashley S

AJP reports

2024 Volume 14, Issue 1, Page(s) e66–e68

Abstract: Multisystem inflammatory syndrome in children (MIS-C), a new condition related to coronavirus disease 2019 (COVID-19) in the pediatric population, was recognized by physicians in the United Kingdom in April 2020. Given those up to the age of 21 years can ...

Abstract	Multisystem inflammatory syndrome in children (MIS-C), a new condition related to coronavirus disease 2019 (COVID-19) in the pediatric population, was recognized by physicians in the United Kingdom in April 2020. Given those up to the age of 21 years can be affected, pregnant adolescents and young adults are susceptible. However, there is scant information on how MIS-C may affect pregnancy and whether the presentation differs in the pregnant population. We report a case of a pregnant adolescent with COVID-19 and MIS-C with a favorable outcome. This case highlights the considerations in managing a critically ill pregnant patient with a novel illness and the importance of a multidisciplinary team in coordinating care.
Language	English
Publishing date	2024-02-18
Publishing country	United States
Document type	Case Reports
ZDB-ID	2628074-7
ISSN	2157-7005 ; 2157-6998
ISSN (online)	2157-7005
ISSN	2157-6998
DOI	10.1055/s-0044-1779032
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Article ; Online: Group B

Raabe, Vanessa N / Shane, Andi L

Microbiology spectrum

2019 Volume 7, Issue 2

Abstract: Invasive disease due to group ... ...

Abstract	Invasive disease due to group B
MeSH term(s)	Adult ; Aged ; Anti-Bacterial Agents/therapeutic use ; Antibiotic Prophylaxis ; Female ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/microbiology ; Infant, Newborn, Diseases/prevention & control ; Pregnancy ; Pregnancy Complications, Infectious/microbiology ; Streptococcal Infections/drug therapy ; Streptococcal Infections/epidemiology ; Streptococcal Infections/microbiology ; Streptococcus agalactiae/classification ; Streptococcus agalactiae/pathogenicity
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2019-04-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/microbiolspec.GPP3-0007-2018
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Pregnant Adolescent with COVID-19 and Multisystem Inflammatory Syndrome in Children

Trostle, Megan E. / Grossman, Tracy B. / Penfield, Christina A. / Phoon, Colin K. L. / Raabe, Vanessa N. / Sloane, Mark F. / Roman, Ashley S.

American Journal of Perinatology Reports

2024 Volume 14, Issue 01, Page(s) e66–e68

Abstract	Multisystem inflammatory syndrome in children (MIS-C), a new condition related to coronavirus disease 2019 (COVID-19) in the pediatric population, was recognized by physicians in the United Kingdom in April 2020. Given those up to the age of 21 years can be affected, pregnant adolescents and young adults are susceptible. However, there is scant information on how MIS-C may affect pregnancy and whether the presentation differs in the pregnant population. We report a case of a pregnant adolescent with COVID-19 and MIS-C with a favorable outcome. This case highlights the considerations in managing a critically ill pregnant patient with a novel illness and the importance of a multidisciplinary team in coordinating care.
Keywords	multisystem inflammatory syndrome in children ; COVID-19 ; pregnancy ; critical illness
Language	English
Publishing date	2024-01-01
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2628074-7
ISSN	2157-7005 ; 2157-6998
ISSN (online)	2157-7005
ISSN	2157-6998
DOI	10.1055/s-0044-1779032
Database	Thieme publisher's database

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Article ; Online: Importance of Pediatric Inclusion in COVID-19 Therapeutic Trials.

Raabe, Vanessa N / Lighter, Jennifer / Caplan, Arthur L / Ratner, Adam J

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 71, Issue 12, Page(s) 3248–3249

Abstract: Pediatric patients are excluded from most coronavirus disease 2019 (COVID-19) therapeutic trials. We outline a rationale for the inclusion of children in COVID-19 therapeutic trials, which enabled us to include children of all ages in a therapeutic COVID- ...

Abstract	Pediatric patients are excluded from most coronavirus disease 2019 (COVID-19) therapeutic trials. We outline a rationale for the inclusion of children in COVID-19 therapeutic trials, which enabled us to include children of all ages in a therapeutic COVID-19 trial at our institution.
MeSH term(s)	Adolescent ; COVID-19/drug therapy ; COVID-19/therapy ; Child ; Clinical Trials as Topic ; Coronavirus Infections ; Humans ; Immunization, Passive ; SARS-CoV-2 ; United States
Keywords	covid19
Language	English
Publishing date	2020-05-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciaa656
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Importance of Pediatric Inclusion in COVID-19 Therapeutic Trials

Raabe, Vanessa N / Lighter, Jennifer / Caplan, Arthur L / Ratner, Adam J

Clin. infect. dis

Abstract: Pediatric patients are excluded from most COVID-19 therapeutic trials. We outline a rationale for the inclusion of children in COVID-19 therapeutic trials with enabled us to include children of all ages in a therapeutic COVID-19 trial at our institution. ...

Abstract	Pediatric patients are excluded from most COVID-19 therapeutic trials. We outline a rationale for the inclusion of children in COVID-19 therapeutic trials with enabled us to include children of all ages in a therapeutic COVID-19 trial at our institution.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #381729
Database	COVID19

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Article ; Online: Importance of Pediatric Inclusion in COVID-19 Therapeutic Trials

Raabe, Vanessa N / Lighter, Jennifer / Caplan, Arthur L / Ratner, Adam J

Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

2020

Abstract: Abstract Pediatric patients are excluded from most coronavirus disease 2019 (COVID-19) therapeutic trials. We outline a rationale for the inclusion of children in COVID-19 therapeutic trials, which enabled us to include children of all ages in a ... ...

Abstract	Abstract Pediatric patients are excluded from most coronavirus disease 2019 (COVID-19) therapeutic trials. We outline a rationale for the inclusion of children in COVID-19 therapeutic trials, which enabled us to include children of all ages in a therapeutic COVID-19 trial at our institution.
Keywords	Microbiology (medical) ; Infectious Diseases ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
DOI	10.1093/cid/ciaa656
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Febrile Infants Without Respiratory Distress.

Paret, Michal / Lighter, Jennifer / Pellett Madan, Rebecca / Raabe, Vanessa N / Shust, Gail F / Ratner, Adam J

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 71, Issue 16, Page(s) 2243–2245

Abstract: We report 2 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19) in infants presenting with fever in the absence of respiratory distress who required hospitalization for evaluation of possible invasive bacterial ... ...

Abstract	We report 2 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19) in infants presenting with fever in the absence of respiratory distress who required hospitalization for evaluation of possible invasive bacterial infections. The diagnoses resulted from routine isolation and real-time reverse-transcription polymerase chain reaction-based testing for SARS-CoV-2 for febrile infants in an outbreak setting.
MeSH term(s)	COVID-19/diagnosis ; Dyspnea/virology ; Fever/virology ; Hospitalization/statistics & numerical data ; Humans ; Infant ; Infant, Newborn ; Male ; Nasopharynx/virology ; Respiratory Distress Syndrome, Newborn ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-17
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciaa452
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cellular and humoral immunity to Ebola Zaire glycoprotein and viral vector proteins following immunization with recombinant vesicular stomatitis virus-based Ebola vaccine (rVSVΔG-ZEBOV-GP).

Raabe, Vanessa / Lai, Lilin / Morales, Juliet / Xu, Yongxian / Rouphael, Nadine / Davey, Richard T / Mulligan, Mark J

Vaccine

2023 Volume 41, Issue 8, Page(s) 1513–1523

Abstract: While effective at preventing Zaire ebolavirus (ZEBOV) disease, cellular immunity to ZEBOV and vector-directed immunity elicited by the recombinant vesicular stomatitis virus expressing ZEBOV glycoprotein (rVSVΔG-ZEBOV-GP) vaccine remain poorly ... ...

Abstract	While effective at preventing Zaire ebolavirus (ZEBOV) disease, cellular immunity to ZEBOV and vector-directed immunity elicited by the recombinant vesicular stomatitis virus expressing ZEBOV glycoprotein (rVSVΔG-ZEBOV-GP) vaccine remain poorly understood. Sera and peripheral blood mononuclear cells were collected from 32 participants enrolled in a prospective multicenter study [ClinicalTrials.gov NCT02788227] before vaccination and up to six months post-vaccination. IgM and IgG antibodies, IgG-producing memory B cells (MBCs), and T cell reactivity to ZEBOV glycoprotein (ZEBOV-GP), vesicular stomatitis virus-Indiana strain (VSV-I) matrix (M) protein, and VSV-I nucleoprotein (NP) were measured using ELISA, ELISpot, and flow cytometry, respectively. 11/32 (34.4%) participants previously received a different investigational ZEBOV vaccine prior to enrollment and 21/32 (65.6%) participants were ZEBOV vaccine naïve. Both ZEBOV vaccine naïve and experienced participants had increased ZEBOV-GP IgG optical densities (ODs) post-rVSVΔG-ZEBOV-GP vaccination while only ZEBOV vaccine naïve participants had increased ZEBOV-GP IgM ODs. Transient IgM and IgG antibody responses to VSV-I M protein and NP were observed in a minority of participants. All participants had detectable ZEBOV-GP specific IgG-producing MBCs by 6 months post-vaccination while no changes were observed in the median IgG-producing MBCs to VSV-I proteins. T cell responses to ZEBOV-GP differed between ZEBOV vaccine experienced and ZEBOV vaccine naïve participants. T cell responses to both VSV-I M protein and VSV-I NP were observed, but were of a low magnitude. The rVSVΔG-ZEBOV-GP vaccine elicits robust humoral and memory B cell responses to ZEBOV glycoprotein in both ZEBOV vaccine naïve and experienced individuals and can generate vector-directed T cell immunity. Further research is needed to understand the significance of pre-existing vector and target antigen immunity on responses to booster doses of rVSVΔG-ZEBOV-GP and other rVSV-vectored vaccines.
MeSH term(s)	Animals ; Humans ; Hemorrhagic Fever, Ebola ; Ebolavirus ; Ebola Vaccines ; Viral Proteins ; Immunity, Humoral ; Democratic Republic of the Congo ; Leukocytes, Mononuclear ; Vesicular Stomatitis ; Prospective Studies ; Antibodies, Viral ; Vaccination ; Immunization ; Glycoproteins ; Immunoglobulin G ; Immunoglobulin M
Chemical Substances	Ebola Vaccines ; Viral Proteins ; Antibodies, Viral ; Glycoproteins ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2023-01-31
Publishing country	Netherlands
Document type	Multicenter Study ; Journal Article ; Research Support, N.I.H., Intramural ; Research Support, N.I.H., Extramural
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.01.059
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Zs.MO 458: Show issues

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Article ; Online: Hydroxychloroquine pre-exposure prophylaxis to prevent SARS-CoV-2 among health care workers at risk for SARS-CoV-2 exposure: A nonrandomized controlled trial

Raabe, Vanessa N / Fleming, Andrew / Samanovic, Marie I / Lai, Lilin / Belli, Hayley M / Mulligan, Mark J / Belmont, H. Michael

medRxiv

Abstract: Background: Aerosol-generating procedures increase the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among health care workers (HCWs). An effective pre-exposure prophylaxis would mitigate this risk. Objective: To ... ...

Abstract	Background: Aerosol-generating procedures increase the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among health care workers (HCWs). An effective pre-exposure prophylaxis would mitigate this risk. Objective: To determine the efficacy of pre-exposure prophylactic hydroxychloroquine for the prevention of SARS-CoV-2 infection and symptomatic coronavirus 19 disease (COVID-19) among HCWs at high occupational risk of SARS-CoV-2 exposure. Methods: 130 HCWs in the New York University Langone Health System (NYULHS) who performed aerosol-generating procedures on patients with COVID-19 or provided bedside care for inpatients with COVID-19 or persons with suspected COVID-19 in an emergency department, for at least three shifts in a 7-day period, during the first 2020 COVID-19 wave in New York City were enrolled. Participants elected to take oral hydroxychloroquine, 600 mg on day 1 followed by 200 mg daily, or not take hydroxychloroquine for up to 90 days. Participants self-collected dried blood spots and completed digital questionnaires regarding COVID-19 symptoms, adverse events, and other COVID-19 medication use. Results: Six participants (7.5%) seroconverted during the trial: four who took hydroxychloroquine (6.8%) and two who declined hydroxychloroquine (9.5%). All participants not taking hydroxychloroquine reported COVID-19 symptoms at seroconversion compared to one of four participants (25%) who took hydroxychloroquine. Adverse events occurred in eight participants (9.6%) on hydroxychloroquine and were mostly mild. Conclusions: This study (ClinicalTrials.gov NCT04354870) did not demonstrate a statistically significant difference in SARS-CoV-2 seroconversion associated with hydroxychloroquine pre-exposure prophylaxis among HCWs at high risk of occupational SARS-CoV-2 exposure, although was underpowered and a high rate of hydroxychloroquine discontinuation was observed.
Keywords	covid19
Language	English
Publishing date	2022-07-03
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2022.07.01.22277058
Database	COVID19

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