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Article ; Online: Nitric oxide signalling in kidney regulation and cardiometabolic health.

Carlström, Mattias

2021 Volume 17, Issue 9, Page(s) 575–590

Abstract: The prevalence of cardiovascular and metabolic disease coupled with kidney dysfunction is increasing worldwide. This triad of disorders is associated with considerable morbidity and mortality as well as a substantial economic burden. Further ... ...

Abstract	The prevalence of cardiovascular and metabolic disease coupled with kidney dysfunction is increasing worldwide. This triad of disorders is associated with considerable morbidity and mortality as well as a substantial economic burden. Further understanding of the underlying pathophysiological mechanisms is important to develop novel preventive or therapeutic approaches. Among the proposed mechanisms, compromised nitric oxide (NO) bioactivity associated with oxidative stress is considered to be important. NO is a short-lived diatomic signalling molecule that exerts numerous effects on the kidneys, heart and vasculature as well as on peripheral metabolically active organs. The enzymatic L-arginine-dependent NO synthase (NOS) pathway is classically viewed as the main source of endogenous NO formation. However, the function of the NOS system is often compromised in various pathologies including kidney, cardiovascular and metabolic diseases. An alternative pathway, the nitrate-nitrite-NO pathway, enables endogenous or dietary-derived inorganic nitrate and nitrite to be recycled via serial reduction to form bioactive nitrogen species, including NO, independent of the NOS system. Signalling via these nitrogen species is linked with cGMP-dependent and independent mechanisms. Novel approaches to restoring NO homeostasis during NOS deficiency and oxidative stress have potential therapeutic applications in kidney, cardiovascular and metabolic disorders.
MeSH term(s)	Animals ; Humans ; Kidney/metabolism ; Kidney/physiology ; Kidney Diseases/complications ; Kidney Diseases/metabolism ; Metabolic Syndrome/etiology ; Metabolic Syndrome/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide/physiology ; Signal Transduction/physiology
Chemical Substances	Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2021-06-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2490366-8
ISSN	1759-507X ; 1759-5061
ISSN (online)	1759-507X
ISSN	1759-5061
DOI	10.1038/s41581-021-00429-z
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Article ; Online: The Other Glucose Transporter, SGLT1 - Also a Potential Trouble Maker in Diabetes?

Carlström, Mattias

Journal of the American Society of Nephrology : JASN

2019 Volume 30, Issue 4, Page(s) 519–521

MeSH term(s)	Diabetes Mellitus ; Feedback ; Glucose Transport Proteins, Facilitative ; Humans ; Hyperglycemia ; Kidney Glomerulus ; Nitric Oxide Synthase Type I ; Sodium-Glucose Transporter 1
Chemical Substances	Glucose Transport Proteins, Facilitative ; Sodium-Glucose Transporter 1 ; NOS1 protein, human (EC 1.14.13.39) ; Nitric Oxide Synthase Type I (EC 1.14.13.39)
Language	English
Publishing date	2019-03-13
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2019020171
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Article ; Online: Hydronephrosis and risk of later development of hypertension.

Carlström, Mattias

Acta paediatrica (Oslo, Norway : 1992)

2018 Volume 108, Issue 1, Page(s) 50–57

Abstract: Aim: Congenital ureteral obstruction is a fairly common condition in infants, and its clinical management has been long debated during the last decade. The long-term physiological consequences of today's conservative non-surgical management in many ... ...

Abstract	Aim: Congenital ureteral obstruction is a fairly common condition in infants, and its clinical management has been long debated during the last decade. The long-term physiological consequences of today's conservative non-surgical management in many asymptomatic hydronephrotic children are unclear. Methods: Experimental studies in rats and mice, retrospective studies in children and adults, as well as prospective studies in children are included in this mini review. Results: Experimental models of hydronephrosis in rats and mice have demonstrated that partial ureteropelvic junction obstruction (UPJO) is casually linked with development of hypertension and renal injuries in later life. The mechanisms are multifactorial and involve increased activity of the renin-angiotensin-aldosterone system and renal sympathetic nerve activity. Furthermore, oxidative stress and nitric oxide deficiency in the affected kidney appear to play important roles in the development and maintenance of hypertension. Clinical case reports in adults and recent prospective studies in children have associated hydronephrosis with elevated blood pressure, which could be reduced by surgical management of the obstruction. Conclusion: Based on current experimental and clinical knowledge regarding the link between partial UPJO and changes in blood pressure, it is proposed that today's non-operative management of hydronephrosis should be reconsidered to reduce the risk of developing elevated blood pressure or hypertension in later life.
MeSH term(s)	Adolescent ; Adult ; Age Distribution ; Animals ; Blood Pressure Determination/methods ; Child ; Cohort Studies ; Disease Models, Animal ; Humans ; Hydronephrosis/complications ; Hydronephrosis/diagnosis ; Hypertension/epidemiology ; Hypertension/etiology ; Hypertension/physiopathology ; Incidence ; Infant ; Mice ; Prognosis ; Rats ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Sex Distribution ; Ureteral Obstruction/complications ; Ureteral Obstruction/congenital ; Ureteral Obstruction/diagnosis
Language	English
Publishing date	2018-07-24
Publishing country	Norway
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.14482
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Article: Specific NOX4 Inhibition Preserves Mitochondrial Function and Dampens Kidney Dysfunction Following Ischemia-Reperfusion-Induced Kidney Injury.

Schiffer, Tomas A / Carvalho, Lucas Rannier Ribeiro Antonino / Guimaraes, Drielle / Boeder, Ariela / Wikström, Per / Carlström, Mattias

Antioxidants (Basel, Switzerland)

2024 Volume 13, Issue 4

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox13040489
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Article ; Online: Enterococcus faecalis: implications for host health.

Boeder, Ariela Maína / Spiller, Fernando / Carlstrom, Mattias / Izídio, Geison Souza

World journal of microbiology & biotechnology

2024 Volume 40, Issue 6, Page(s) 190

Abstract: The microbiota represents a crucial area of research in maintaining human health due to its potential for uncovering novel biomarkers, therapies, and molecular mechanisms relevant to population identification and experimental model characterization. ... ...

Abstract	The microbiota represents a crucial area of research in maintaining human health due to its potential for uncovering novel biomarkers, therapies, and molecular mechanisms relevant to population identification and experimental model characterization. Among these microorganisms, Enterococcus faecalis, a Gram-positive bacterium found in the gastrointestinal tract of humans and animals, holds particular significance. Strains of this bacterial species have sparked considerable debate in the literature due to their dual nature; they can either be utilized as probiotics in the food industry or demonstrate resistance to antibiotics, potentially leading to severe illness, disability, and death. Given the diverse characteristics of Enterococcus faecalis strains, this review aims to provide a comprehensive understanding of their impact on various systems within the host, including the immunological, cardiovascular, metabolic, and nervous systems. Furthermore, we summarize the bacterium-host interaction characteristics and molecular effects to highlight their targets, features, and overall impact on microbial communities and host health.
MeSH term(s)	Humans ; Enterococcus faecalis ; Animals ; Probiotics ; Gastrointestinal Microbiome ; Gram-Positive Bacterial Infections/microbiology ; Anti-Bacterial Agents/pharmacology ; Host-Pathogen Interactions ; Gastrointestinal Tract/microbiology ; Host Microbial Interactions
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-05-04
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1499109-3
ISSN	1573-0972 ; 0959-3993
ISSN (online)	1573-0972
ISSN	0959-3993
DOI	10.1007/s11274-024-04007-w
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Article ; Online: Dimethyl malonate preserves renal and mitochondrial functions following ischemia-reperfusion via inhibition of succinate dehydrogenase

Mattias Carlström / Lucas Rannier Ribeiro Antonino Carvalho / Drielle Guimaraes / Ariela Boeder / Tomas A Schiffer

Redox Biology, Vol 69, Iss , Pp 102984- (2024)

1481

Abstract: Background: Acute kidney injury (AKI), often experienced at the intensive care units, is associated with high morbidity/mortality where ischemia-reperfusion injury is a main causative factor. Succinate accumulation during ischemia contributes to the ... ...

Abstract	Background: Acute kidney injury (AKI), often experienced at the intensive care units, is associated with high morbidity/mortality where ischemia-reperfusion injury is a main causative factor. Succinate accumulation during ischemia contributes to the excessive generation of reactive oxygen species at reperfusion. Inhibition of succinate dehydrogenase has been associated with protective outcome in cardiac ischemia-reperfusion after 24h, but the effects on kidney and mitochondrial functions are less well studied. Aim: To investigate the therapeutic potential of succinate dehydrogenase inhibition, by using dimethyl malonate (DMM), on kidney and mitochondria functions in a mouse model of AKI. Methods: Male C57BL/6J mice were pre-treated with DMM or placebo, i.p. 30min prior to bilateral renal ischemia (20min). After 3-days of reperfusion, glomerular filtration rate (GFR) was calculated from plasma clearance of FITC-inulin. Kidney mitochondria was isolated and mass specific and intrinsic mitochondrial function were evaluated by high resolution respirometry. Kidney sections were stained (i.e., hematoxylin-eosin and TUNEL) and analyzed for histopathological evaluation of injuries and apotosis, respectively. NADPH oxidase activity in kidney and human proximal tubular cell-line (HK2) were measured luminometrically. Results: DMM treatment improved GFR (p < 0.05) and reduced levels of blood urea nitrogen (p < 0.01) compared to untreated animals, which was associated with lower degree of ischemia-reperfusion-induced tubular injuries (P < 0.001) and apoptosis (P < 0.01). These therapeutic renal effects were linked with improved mitochondrial function, both mass-specific and intrinsic. Finally, DMM treatment prevented ischemia-reperfusion-induced NADPH oxidase activity in the kidney (p < 0.001), which was showed also in HK2 cells exposed to hypoxia and reoxygenation (P < 0.01). Conclusion: Inhibition of succinate dehydrogenase with DMM, in conjunction with the ischemia-reperfusion phase, significantly ...
Keywords	Ischemia-reperfusion ; Reverse electron transfer ; Dimethyl malonate ; Kidney ; Glomerular filtration rate ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2024-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: miR-27a in Extracellular Vesicles: Is It a Novel Modulator of Hypertension?

Carlström, Mattias / Braga, Valdir A

American journal of hypertension

2019 Volume 33, Issue 1, Page(s) 21–22

MeSH term(s)	Extracellular Vesicles ; Humans ; Hypertension ; MicroRNAs ; Monocytes
Chemical Substances	MicroRNAs
Language	English
Publishing date	2019-12-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	639383-4
ISSN	1941-7225 ; 1879-1905 ; 0895-7061
ISSN (online)	1941-7225 ; 1879-1905
ISSN	0895-7061
DOI	10.1093/ajh/hpz165
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Article ; Online: Mechanisms underlying the effects of renal denervation in renovascular hypertension.

Carlström, Mattias / Braga, Valdir A

Hypertension research : official journal of the Japanese Society of Hypertension

2019 Volume 42, Issue 5, Page(s) 754–757

MeSH term(s)	Animals ; Blood Pressure ; Brain ; Denervation ; Hypertension, Renovascular ; Kidney ; Oxidative Stress ; Rats
Language	English
Publishing date	2019-02-22
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1175297-x
ISSN	1348-4214 ; 0916-9636
ISSN (online)	1348-4214
ISSN	0916-9636
DOI	10.1038/s41440-019-0233-7
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Article ; Online: Inorganic nitrate: A potential prebiotic for oral microbiota dysbiosis associated with type 2 diabetes.

Bahadoran, Zahra / Mirmiran, Parvin / Carlström, Mattias / Ghasemi, Asghar

Nitric oxide : biology and chemistry

2021 Volume 116, Page(s) 38–46

Abstract: Oral microbiota dysbiosis, concomitant with decreased abundance of nitrate ( ... ...

Abstract	Oral microbiota dysbiosis, concomitant with decreased abundance of nitrate (NO
MeSH term(s)	Animals ; Bacteria/enzymology ; Bacteria/metabolism ; Bacterial Proteins/metabolism ; Diabetes Mellitus, Type 2/complications ; Dysbiosis/drug therapy ; Dysbiosis/etiology ; Humans ; Microbiota/drug effects ; Mouth/microbiology ; Nitrate Reductase/metabolism ; Nitrates/metabolism ; Nitrates/therapeutic use ; Prebiotics
Chemical Substances	Bacterial Proteins ; Nitrates ; Prebiotics ; Nitrate Reductase (EC 1.7.99.4)
Language	English
Publishing date	2021-09-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1362794-6
ISSN	1089-8611 ; 1089-8603
ISSN (online)	1089-8611
ISSN	1089-8603
DOI	10.1016/j.niox.2021.09.001
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Article ; Online: Dimethyl malonate preserves renal and mitochondrial functions following ischemia-reperfusion via inhibition of succinate dehydrogenase.

Carlström, Mattias / Rannier Ribeiro Antonino Carvalho, Lucas / Guimaraes, Drielle / Boeder, Ariela / Schiffer, Tomas A

Redox biology

2023 Volume 69, Page(s) 102984

Abstract	Background: Acute kidney injury (AKI), often experienced at the intensive care units, is associated with high morbidity/mortality where ischemia-reperfusion injury is a main causative factor. Succinate accumulation during ischemia contributes to the excessive generation of reactive oxygen species at reperfusion. Inhibition of succinate dehydrogenase has been associated with protective outcome in cardiac ischemia-reperfusion after 24h, but the effects on kidney and mitochondrial functions are less well studied. Aim: To investigate the therapeutic potential of succinate dehydrogenase inhibition, by using dimethyl malonate (DMM), on kidney and mitochondria functions in a mouse model of AKI. Methods: Male C57BL/6J mice were pre-treated with DMM or placebo, i.p. 30min prior to bilateral renal ischemia (20min). After 3-days of reperfusion, glomerular filtration rate (GFR) was calculated from plasma clearance of FITC-inulin. Kidney mitochondria was isolated and mass specific and intrinsic mitochondrial function were evaluated by high resolution respirometry. Kidney sections were stained (i.e., hematoxylin-eosin and TUNEL) and analyzed for histopathological evaluation of injuries and apotosis, respectively. NADPH oxidase activity in kidney and human proximal tubular cell-line (HK2) were measured luminometrically. Results: DMM treatment improved GFR (p < 0.05) and reduced levels of blood urea nitrogen (p < 0.01) compared to untreated animals, which was associated with lower degree of ischemia-reperfusion-induced tubular injuries (P < 0.001) and apoptosis (P < 0.01). These therapeutic renal effects were linked with improved mitochondrial function, both mass-specific and intrinsic. Finally, DMM treatment prevented ischemia-reperfusion-induced NADPH oxidase activity in the kidney (p < 0.001), which was showed also in HK2 cells exposed to hypoxia and reoxygenation (P < 0.01). Conclusion: Inhibition of succinate dehydrogenase with DMM, in conjunction with the ischemia-reperfusion phase, significantly improved both renal and mitochondrial functions. These findings may have clinical implications for future therapeutic strategies to prevent development of AKI and associated adverse complications, especially in high risk hospitalized patients.
MeSH term(s)	Mice ; Animals ; Humans ; Male ; Succinate Dehydrogenase ; Mice, Inbred C57BL ; Kidney/pathology ; Ischemia/pathology ; Mitochondria ; Reperfusion Injury/drug therapy ; Reperfusion Injury/pathology ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/etiology ; Acute Kidney Injury/pathology ; Reperfusion ; NADPH Oxidases ; Malonates
Chemical Substances	methyl malonate (EM8Y79998C) ; Succinate Dehydrogenase (EC 1.3.99.1) ; NADPH Oxidases (EC 1.6.3.-) ; Malonates
Language	English
Publishing date	2023-12-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2023.102984
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