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Article ; Online: Spatial Analysis of Drug-Susceptible and Multidrug-Resistant Cases of Tuberculosis, Ho Chi Minh City, Vietnam, 2020-2023.

Spies, Ruan / Hong, Hanh N / Trieu, Phu P / Lan, Luong K / Lan, Kim / Hue, N N / Huong, Nguyen T L / Thao, Tran T L N / Quang, Nguyen L / Anh, Thu D D / Vinh, Truong V / Ha, Dang T M / Dat, Phan T / Hai, Nguyen P / Van, Le H / Thwaites, Guy E / Thuong, Nguyen T T / Watson, James A / Walker, Timothy M

Emerging infectious diseases

2024 Volume 30, Issue 3, Page(s) 499–509

Abstract: We characterized the spatial distribution of drug-susceptible (DS) and multidrug-resistant (MDR) tuberculosis (TB) cases in Ho Chi Minh City, Vietnam, a major metropolis in southeastern Asia, and explored demographic and socioeconomic factors associated ... ...

Abstract	We characterized the spatial distribution of drug-susceptible (DS) and multidrug-resistant (MDR) tuberculosis (TB) cases in Ho Chi Minh City, Vietnam, a major metropolis in southeastern Asia, and explored demographic and socioeconomic factors associated with local TB burden. Hot spots of DS and MDR TB incidence were observed in the central parts of Ho Chi Minh City, and substantial heterogeneity was observed across wards. Positive spatial autocorrelation was observed for both DS TB and MDR TB. Ward-level TB incidence was associated with HIV prevalence and the male proportion of the population. No ward-level demographic and socioeconomic indicators were associated with MDR TB case count relative to total TB case count. Our findings might inform spatially targeted TB control strategies and provide insights for generating hypotheses about the nature of the relationship between DS and MDR TB in Ho Chi Minh City and the wider southeastern region of Asia.
MeSH term(s)	Male ; Humans ; Vietnam/epidemiology ; Tuberculosis ; Tuberculosis, Multidrug-Resistant/epidemiology ; Asia ; Spatial Analysis
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid3003.231309
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of tissue factor expression and administration routes on thrombosis development induced by mesenchymal stem/stromal cell infusions: re-evaluating the dogma.

Hoang, Van T / Le, Duc Son / Hoang, Duc M / Phan, Trang Thi Kieu / Ngo, Lan Anh Thi / Nguyen, Trung Kien / Bui, Viet Anh / Nguyen Thanh, Liem

Stem cell research & therapy

2024 Volume 15, Issue 1, Page(s) 56

Abstract: Background: Hyperactive coagulation might cause dangerous complications such as portal vein thrombosis and pulmonary embolism after mesenchymal stem/stromal cell (MSC) therapy. Tissue factor (TF), an initiator of the extrinsic coagulation pathway, has ... ...

Abstract	Background: Hyperactive coagulation might cause dangerous complications such as portal vein thrombosis and pulmonary embolism after mesenchymal stem/stromal cell (MSC) therapy. Tissue factor (TF), an initiator of the extrinsic coagulation pathway, has been suggested as a predictor of this process. Methods: The expression of TF and other pro- and anticoagulant genes was analyzed in xeno- and serum-free manufactured MSCs. Furthermore, culture factors affecting its expression in MSCs were investigated. Finally, coagulation tests of fibrinogen, D-dimer, aPPTs, PTs, and TTs were measured in patient serum after umbilical cord (UC)-MSC infusions to challenge a potential connection between TF expression and MSC-induced coagulant activity. RESULTS: Xeno- and serum-free cultured adipose tissue and UC-derived MSCs expressed the highest level of TF, followed by those from dental pulp, and the lowest expression was observed in MSCs of bone marrow origin. Environmental factors such as cell density, hypoxia, and inflammation impact TF expression, so in vitro analysis might fail to reflect their in vivo behaviors. MSCs also expressed heterogeneous levels of the coagulant factor COL1A1 and surface phosphatidylserine and anticoagulant factors TFPI and PTGIR. MSCs of diverse origins induced fibrin clots in healthy plasma that were partially suppressed by an anti-TF inhibitory monoclonal antibody. Furthermore, human umbilical vein endothelial cells exhibited coagulant activity in vitro despite their negative expression of TF and COL1A1. Patients receiving intravenous UC-MSC infusion exhibited a transient increase in D-dimer serum concentration, while this remained stable in the group with intrathecal infusion. There was no correlation between TF expression and D-dimer or other coagulation indicators. Conclusions: The study suggests that TF cannot be used as a solid biomarker to predict MSC-induced hypercoagulation. Local administration, prophylactic intervention with anticoagulation drugs, and monitoring of coagulation indicators are useful to prevent thrombogenic events in patients receiving MSCs. Trial registration NCT05292625. Registered March 23, 2022, retrospectively registered, https://www. Clinicaltrials: gov/ct2/show/NCT05292625?term=NCT05292625&draw=2&rank=1 . NCT04919135. Registered June 9, 2021, https://www. Clinicaltrials: gov/ct2/show/NCT04919135?term=NCT04919135&draw=2&rank=1 .
MeSH term(s)	Humans ; Thromboplastin/genetics ; Thromboplastin/metabolism ; Cells, Cultured ; Thrombosis/genetics ; Mesenchymal Stem Cells/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Anticoagulants ; Umbilical Cord ; Mesenchymal Stem Cell Transplantation
Chemical Substances	Thromboplastin (9035-58-9) ; Anticoagulants
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-023-03582-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Silver nanoparticles loaded on lactose/alginate: in situ synthesis, catalytic degradation, and pH-dependent antibacterial activity.

Tu, Nguyen Thi Thanh / Vo, T Lan-Anh / Ho, T Thu-Trang / Dang, Kim-Phuong T / Le, Van-Dung / Minh, Phan Nhat / Dang, Chi-Hien / Tran, Vinh-Thien / Dang, Van-Su / Chi, Tran Thi Kim / Vu-Quang, Hieu / Fajgar, Radek / Nguyen, Thi-Lan-Huong / Doan, Van-Dat / Nguyen, Thanh-Danh

Beilstein journal of nanotechnology

2023 Volume 14, Page(s) 781–792

Abstract: We present the in situ synthesis of silver nanoparticles (AgNPs) through ionotropic gelation utilizing the biodegradable saccharides lactose (Lac) and alginate (Alg). The lactose reduced silver ions to form AgNPs. The crystallite structure of the ... ...

Abstract	We present the in situ synthesis of silver nanoparticles (AgNPs) through ionotropic gelation utilizing the biodegradable saccharides lactose (Lac) and alginate (Alg). The lactose reduced silver ions to form AgNPs. The crystallite structure of the nanocomposite AgNPs@Lac/Alg, with a mean size of 4-6 nm, was confirmed by analytical techniques. The nanocomposite exhibited high catalytic performance in degrading the pollutants methyl orange and rhodamine B. The antibacterial activity of the nanocomposite is pH-dependent, related to the alterations in surface properties of the nanocomposite at different pH values. At pH 6, the nanocomposite demonstrated the highest antibacterial activity. These findings suggest that this nanocomposite has the potential to be tailored for specific applications in environmental and medicinal treatments, making it a highly promising material.
Language	English
Publishing date	2023-07-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2583584-1
ISSN	2190-4286
ISSN	2190-4286
DOI	10.3762/bjnano.14.64
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Article: Genetic structure of the endemic

Minh Nguyen, Duc / Lan Phan Nguyen, Hong / Minh Nguyen, Tam

AoB PLANTS

2022 Volume 14, Issue 2, Page(s) plac007

Abstract: Anthropogenic disturbances in tropical forests often affect the genetic diversity of a species. ...

Abstract	Anthropogenic disturbances in tropical forests often affect the genetic diversity of a species.
Language	English
Publishing date	2022-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2555823-7
ISSN	2041-2851
ISSN	2041-2851
DOI	10.1093/aobpla/plac007
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Article ; Online: Comparing Catastrophic Costs: Active vs. Passive Tuberculosis Case Finding in Urban Vietnam.

Tropical medicine and infectious disease

2023 Volume 8, Issue 9

Abstract: Active case finding (ACF) is a strategy that aims to identify people with tuberculosis (TB) earlier in their disease. This outreach approach may lead to a reduction in catastrophic cost incurrence (costs exceeding 20% of annual household income), a main ... ...

Abstract	Active case finding (ACF) is a strategy that aims to identify people with tuberculosis (TB) earlier in their disease. This outreach approach may lead to a reduction in catastrophic cost incurrence (costs exceeding 20% of annual household income), a main target of WHO's End TB Strategy. Our study assessed the socio-economic impact of ACF by comparing patient costs in actively and passively detected people with TB. Longitudinal patient cost surveys were prospectively fielded for people with drug-sensitive pulmonary TB, with 105 detected through ACF and 107 passively detected. Data were collected in four Vietnamese cities between October 2020 and March 2022. ACF reduced pre-treatment (USD 10 vs. 101,
Language	English
Publishing date	2023-08-23
Publishing country	Switzerland
Document type	Journal Article
ISSN	2414-6366
ISSN (online)	2414-6366
DOI	10.3390/tropicalmed8090423
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Article ; Online: Correlations between Excessive Body Mass Index, Body Perception, Physical Activity, and Respiratory Functions among Youths in an Urban Setting of Vietnam.

Nguyen, Lan P T / Nguyen, Bach X / Ngo, Tam T / Nguyen, Yen H N / Phan, Hang T

BioMed research international

2020 Volume 2020, Page(s) 9627605

Abstract: Young adults are susceptible to overweight and obesity and their adverse outcomes. However, limited studies have been conducted to understand this health problem in Vietnamese youths. This study was conducted to examine the rate of overweight and obesity, ...

Abstract	Young adults are susceptible to overweight and obesity and their adverse outcomes. However, limited studies have been conducted to understand this health problem in Vietnamese youths. This study was conducted to examine the rate of overweight and obesity, as well as the relationship between this condition on body perception, physical activity, and respiratory function among young adults in Hanoi, Vietnam. We performed a cross-sectional survey with 367 students aged 18-25 years at the Hanoi University of Pharmacy from June 2017 to June 2018. The result showed that the rate of overweight and obesity in our sample was 16.6%. There were 55.7% of overweight/obese students having the misperception of their body image. Results of multivariate regression analysis showed that overweight/obesity increased nearly three times (OR = 2.8, 95% CI: 1.5-5.0) the ability to be active. Overweight/obese students with physical activity had a better respiratory function. To conclude, this study underlined the associations between overweight and obesity with physical activity, body image, and respiratory function in our young sample. Further longitudinal studies should be warranted to examine their causal relationships.
MeSH term(s)	Adolescent ; Adult ; Body Image ; Body Mass Index ; Cross-Sectional Studies ; Exercise ; Female ; Humans ; Male ; Obesity/epidemiology ; Obesity/physiopathology ; Obesity/psychology ; Overweight/epidemiology ; Overweight/physiopathology ; Overweight/psychology ; Prevalence ; Respiratory Function Tests ; Students ; Urban Population ; Vietnam/epidemiology ; Young Adult
Language	English
Publishing date	2020-08-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2020/9627605
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Article ; Online: Digital Healthy Diet Literacy and Fear of COVID-19 as Associated with Treatment Adherence and Its Subscales among Hemodialysis Patients: A Multi-Hospital Study.

Nutrients

2023 Volume 15, Issue 10

Abstract: Treatment adherence (TA) is a critical issue and is under-investigated in hemodialysis patients. A multi-center study was conducted from July 2020 to March 2021 on 972 hemodialysis patients in eight hospitals in Vietnam to explore the factors associated ... ...

Abstract	Treatment adherence (TA) is a critical issue and is under-investigated in hemodialysis patients. A multi-center study was conducted from July 2020 to March 2021 on 972 hemodialysis patients in eight hospitals in Vietnam to explore the factors associated with TA during the COVID-19 pandemic. Data were collected, including socio-demographics, an End-Stage Renal Disease Adherence Questionnaire (ESRD-AQ), 12-item short-form health literacy questionnaire (HLS-SF12), 4-item digital healthy diet literacy scale (DDL), 10-item hemodialysis dietary knowledge scale (HDK), 7-item fear of COVID-19 scale (FCoV-19S), and suspected COVID-19 symptoms (S-COVID19-S). Bivariate and multivariate linear regression models were used to explore the associations. Higher DDL scores were associated with higher TA scores (regression coefficient, B, 1.35; 95% confidence interval, 95%CI, 0.59, 2.12;
MeSH term(s)	Humans ; COVID-19/therapy ; Diet, Healthy ; Pandemics ; Renal Dialysis ; Health Literacy ; Treatment Adherence and Compliance ; Fear
Language	English
Publishing date	2023-05-12
Publishing country	Switzerland
Document type	Multicenter Study ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15102292
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Article ; Online: Determinants of Risk Factors for Renal Impairment among HIV-Infected Patients Treated with Tenofovir Disoproxil Fumarate-Based Antiretroviral Regimen in Southern Vietnam.

Hoang, Cuong Q / Nguyen, Hai D / Vu, Huy Q / Nguyen, Khai T / Hoang, Linh T / Ly, Hong / Tat, Thang D / Phan, Lan T

BioMed research international

2020 Volume 2020, Page(s) 7650104

Abstract: Background: The situation of renal impairment among HIV-infected patients treated with TDF-based antiretroviral (ARV) regimen greater than 3 years is little known when TDF use has been promptly increasing in Vietnam.: Methods: We analyse demographic ... ...

Abstract	Background: The situation of renal impairment among HIV-infected patients treated with TDF-based antiretroviral (ARV) regimen greater than 3 years is little known when TDF use has been promptly increasing in Vietnam. Methods: We analyse demographic and clinical data from a cross-sectional survey of 400 HIV-infected patients aged ≥18 years, who were treatment-naive or switched TDF regimen within over 3 years between November 2018 and March 2019. Serological tests for serum creatinine, ALT, and AST were performed. Renal impairment was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m Results: At the baseline, 7.8% of respondents had estimated glomerular filtration rate (eGFR) of 30-59 mL/min/1.73 m Conclusion: Our findings underscore the need for longitudinal studies to assess the influence of TDF on maintaining the low prevalence of renal impairment among HIV-infected patients in Vietnam.
MeSH term(s)	Adult ; Anti-Retroviral Agents/administration & dosage ; Anti-Retroviral Agents/adverse effects ; Cross-Sectional Studies ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV-1 ; Humans ; Kidney Diseases/chemically induced ; Kidney Diseases/epidemiology ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Tenofovir/administration & dosage ; Tenofovir/adverse effects ; Vietnam/epidemiology
Chemical Substances	Anti-Retroviral Agents ; Tenofovir (99YXE507IL)
Language	English
Publishing date	2020-01-10
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2020/7650104
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Article ; Online: Correlations between Excessive Body Mass Index, Body Perception, Physical Activity, and Respiratory Functions among Youths in an Urban Setting of Vietnam

Lan. P. T. Nguyen / Bach X. Nguyen / Tam T. Ngo / Yen H. N. Nguyen / Hang T. Phan

BioMed Research International, Vol

2020 Volume 2020

Abstract	Young adults are susceptible to overweight and obesity and their adverse outcomes. However, limited studies have been conducted to understand this health problem in Vietnamese youths. This study was conducted to examine the rate of overweight and obesity, as well as the relationship between this condition on body perception, physical activity, and respiratory function among young adults in Hanoi, Vietnam. We performed a cross-sectional survey with 367 students aged 18-25 years at the Hanoi University of Pharmacy from June 2017 to June 2018. The result showed that the rate of overweight and obesity in our sample was 16.6%. There were 55.7% of overweight/obese students having the misperception of their body image. Results of multivariate regression analysis showed that overweight/obesity increased nearly three times (OR=2.8, 95% CI: 1.5-5.0) the ability to be active. Overweight/obese students with physical activity had a better respiratory function. To conclude, this study underlined the associations between overweight and obesity with physical activity, body image, and respiratory function in our young sample. Further longitudinal studies should be warranted to examine their causal relationships.
Keywords	Medicine ; R
Subject code	796
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam.

Phan, Lan T / Nguyen, Thuong V / Luong, Quang C / Nguyen, Thinh V / Nguyen, Hieu T / Le, Hung Q / Nguyen, Thuc T / Cao, Thang M / Pham, Quang D

The New England journal of medicine

2020 Volume 382, Issue 9, Page(s) 872–874

MeSH term(s)	Adult ; Aged ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/transmission ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Male ; Pneumonia, Viral/transmission ; Radiography, Thoracic ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-01-28
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2001272
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