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  1. Article ; Online: More evidence for low-dose IL-2 for chronic GVHD in children.

    Levine, John E

    Blood advances

    2023  Volume 7, Issue 16, Page(s) 4658–4659

    MeSH term(s) Humans ; Child ; Young Adult ; Bronchiolitis Obliterans Syndrome ; Interleukin-2 ; Graft vs Host Disease/drug therapy ; Graft vs Host Disease/etiology
    Chemical Substances Interleukin-2
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023010756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7153: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Book ; Conference proceedings: Hematopoietic stem cell transplantation 2012 education supplement

    Davies, Stella M. / Levine, John E.

    reviews of recent advances in hematopoietic stem cell therapy prepared by clinicians and investigators presenting plenary and concurrent scientific session papers at the 2012 BMT Tandem Meetings [February 1 - 5, 2012 San Diego, California]

    (Biology of blood and marrow transplantation ; 18,1, Suppl. 1)

    2012  

    Event/congress BMT Tandem Meetings (2012, SanDiegoCalif.)
    Author's details ed. Stella M. Davies ; John E. Levine
    Series title Biology of blood and marrow transplantation ; 18,1, Suppl. 1
    Collection
    Language English
    Size S200 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Orlando, FL
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT017177364
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 5082 -18,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: Planning GvHD preemptive therapy: risk factors, biomarkers, and prognostic scores.

    Rozmus, Jacob / Levine, John E / Schultz, Kirk R

    Hematology. American Society of Hematology. Education Program

    2023  Volume 2023, Issue 1, Page(s) 149–154

    Abstract: Prevention of acute and chronic graft-versus-host disease (aGvHD and cGvHD) is an important objective of allogeneic hematopoietic cell transplantation (HCT). While there is has been significant progress in preventative approaches in the peritransplant ... ...

    Abstract Prevention of acute and chronic graft-versus-host disease (aGvHD and cGvHD) is an important objective of allogeneic hematopoietic cell transplantation (HCT). While there is has been significant progress in preventative approaches in the peritransplant period to minimize development of GvHD, no preventative approach has completely eliminated development of either aGvHD or cGvHD. Recently, posttransplant immune biomarker profiling early post-HCT by the Mount Sinai Acute GvHD International Consortium group has resulted in a validated risk assignment algorithm and development of preemptive approaches to decrease aGvHD and mortality in high-risk patients. cGvHD risk assignment algorithms have been developed based on measurements at day 100 and may be used for future preemptive intervention trials to minimize cGvHD. This article discusses the current state of the art in aGvHD and cGvHD preemptive algorithms and therapeutic interventions and what is needed to move these into validated approaches.
    MeSH term(s) Humans ; Prognosis ; Acute Disease ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Biomarkers ; Risk Factors
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/hematology.2023000425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Age-Invariant Genes: Multi-Tissue Identification and Characterization of Murine Reference Genes.

    González, John T / Thrush, Kyra / Meer, Margarita / Levine, Morgan E / Higgins-Chen, Albert T

    bioRxiv : the preprint server for biology

    2024  

    Abstract: ... reference gene normalization (i.e., RT-qPCR) that can be applied to animals across the lifespan. ...

    Abstract Studies of the aging transcriptome focus on genes that change with age. But what can we learn from age-invariant genes-those that remain unchanged throughout the aging process? These genes also have a practical application: they serve as reference genes (often called housekeeping genes) in expression studies. Reference genes have mostly been identified and validated in young organisms, and no systematic investigation has been done across the lifespan. Here, we build upon a common pipeline for identifying reference genes in RNA-seq datasets to identify age-invariant genes across seventeen C57BL/6 mouse tissues (brain, lung, bone marrow, muscle, white blood cells, heart, small intestine, kidney, liver, pancreas, skin, brown, gonadal, marrow, and subcutaneous adipose tissue) spanning 1 to 21+ months of age. We identify 9 pan-tissue age-invariant genes and many tissue-specific age-invariant genes. These genes are stable across the lifespan and are validated in independent bulk RNA-seq datasets and RT-qPCR. We find age-invariant genes have shorter transcripts on average and are enriched for CpG islands. Interestingly, pathway enrichment analysis for age-invariant genes identifies an overrepresentation of molecular functions associated with some, but not all, hallmarks of aging. Thus, though hallmarks of aging typically involve changes in cell maintenance mechanisms, select genes associated with these hallmarks resist fluctuations in expression with age. Finally, our analysis concludes no classical reference gene is appropriate for aging studies in all tissues. Instead, we provide tissue-specific and pan-tissue genes for assays utilizing reference gene normalization (i.e., RT-qPCR) that can be applied to animals across the lifespan.
    Language English
    Publishing date 2024-04-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.09.588721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Acute GVHD: New approaches to clinical trial monitoring.

    Spyrou, Nikolaos / Levine, John E / Ferrara, James L M

    Best practice & research. Clinical haematology

    2022  Volume 35, Issue 4, Page(s) 101400

    Abstract: Acute GVHD occurs in nearly 50% of patients receiving hematopoietic cell transplantation (HCT), and is the major driver of mortality. However, progress in the development of new acute GVHD therapeutics has been slow, in part due to heterogeneity in acute ...

    Abstract Acute GVHD occurs in nearly 50% of patients receiving hematopoietic cell transplantation (HCT), and is the major driver of mortality. However, progress in the development of new acute GVHD therapeutics has been slow, in part due to heterogeneity in acute GVHD data collection and interpretation among centers. Herein, we first describe the methods used by the Mount Sinai Acute GVHD International Consortium (MAGIC) to standardize acute GVHD data collection and curation. We then review the utility of serum biomarkers, specifically the MAGIC Algorithm Probability (MAP) that combines two GI biomarkers (ST2 and REG3α) that has been shown to be more accurate than changes in clinical symptom severity after GVHD treatment. We then present preliminary data on the feasibility of a surrogate clinical trial endpoint that combines clinical response and MAP two weeks after treatment. This novel endpoint is an earlier and potentially better predictor of non-relapse mortality than the current gold standard of clinical response four weeks after treatment.
    MeSH term(s) Humans ; Algorithms ; Biomarkers ; Graft vs Host Disease/drug therapy ; Hematopoietic Stem Cell Transplantation ; Clinical Trials as Topic
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-10-08
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2022.101400
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    Se 1029: Show issues Location:
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  6. Article ; Online: Inefficiency of two-stage designs in phase II oncology clinical trials with high proportion of inevaluable patients.

    Ji, Lingyun / Whangbo, Jennifer / Levine, John E / Alonzo, Todd A

    Contemporary clinical trials

    2022  Volume 120, Page(s) 106849

    Abstract: Background: Two-stage designs are commonly used for oncology Phase II clinical trials with a binary response endpoint. An issue that has not gained sufficient attention is the potential inefficiency in the usage of two-stage designs due to multiple ... ...

    Abstract Background: Two-stage designs are commonly used for oncology Phase II clinical trials with a binary response endpoint. An issue that has not gained sufficient attention is the potential inefficiency in the usage of two-stage designs due to multiple enrollment suspensions when the proportion of patients inevaluable for response is high.
    Methods: Simulation studies were used to assess the performance of Simon's two-stage designs, two-stage designs with a proposed modification, and a single-stage design in the context of Phase II clinical trials with a high proportion of patients inevaluable for response.
    Results: Two-stage designs can require multiple enrollment disruptions when the inevaluable proportion is high, which can result in unacceptable inefficiency. The proposed modification provides a practical solution to this issue by enrolling an extra number of patients towards the end of the 1st stage, anticipating that a proportion of the patients pending response evaluation could be inevaluable. Single-stage designs with interim monitoring of futility that require no interim accrual suspension can be more efficient than two-stage designs, especially when the accrual and inevaluable rates are high.
    Conclusions: Planning of Phase II trials should consider the issue of inefficiency of the two-stage designs, especially for trials with a high inevaluable proportion. Designs with monitoring rules that do not require accrual suspensions may be given more considerations, especially in trials of agents that have already had some evidence for safety and efficacy in other populations.
    MeSH term(s) Computer Simulation ; Humans ; Medical Oncology ; Neoplasms/drug therapy ; Research Design ; Sample Size
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2022.106849
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1581: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Revisiting mycophenolate mofetil for steroid-refractory acute graft-versus-host disease: Is higher dosing effective in children?

    Levine, John E

    Pediatric transplantation

    2015  Volume 19, Issue 6, Page(s) 582–583

    MeSH term(s) Female ; Graft vs Host Disease/drug therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Mycophenolic Acid/analogs & derivatives
    Chemical Substances Immunosuppressive Agents ; Mycophenolic Acid (HU9DX48N0T)
    Language English
    Publishing date 2015-09
    Publishing country Denmark
    Document type Comment ; Editorial
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.12536
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4947: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Risk factors for loss of follow-up after asynchronous dermatology eConsult concerning for skin cancer.

    Himed, Sonia / Levine, Edward / Trinidad, John C / Kaffenberger, Benjamin H

    Archives of dermatological research

    2022  Volume 315, Issue 3, Page(s) 669–672

    Abstract: Asynchronous electronic consultations (e-consults) can be a useful tool for the screening ... an E-consult order from May 2017 to May 2021 were queried. Information collected included patient ...

    Abstract Asynchronous electronic consultations (e-consults) can be a useful tool for the screening of cutaneous lesions, but may offer a malpractice risk. We characterized factors affecting initial eConsult office follow-up in a cohort of patients with documented neoplasm of uncertain behavior. Patients with an ICD 10 code of neoplasm with uncertain behavior (D48.5) at The Ohio State University that received an E-consult order from May 2017 to May 2021 were queried. Information collected included patient demographics, status of follow-up in-office appointment, referral status, and health care utilization. In-office follow-up appointments were defined as completed, cancelled/no-show or no-contact. 667 patients with a diagnosis of D48.5 were identified as having completed an eConsult. 427 (64%) patients had a documented phone/electronic message notifying the patient of the results of the eConsult. Year of encounter (0.88 [0.79-0.97]) and number of previously completed ambulatory visits (0.86 [0.77-0.96]) were significantly associated with documentation of phone/electronic message in the univariate and multivariate model. 429 (84%) patients had a dermatology office follow-up encounter while 82 (16%) had no appointment scheduled. Language spoken, referral status and race were significant in the univariate model, though race was the only significant variable in the multivariate model (P < 0.003). Asynchronous electronic consults to assess possible cutaneous neoplasms is an important tool for population screening of skin cancer. Dermatologists and health systems implementing an eConsult model for screening purposes should be aware of risk factors for loss of follow-up. Additional systems need to be implemented to ensure minorities and non-native English speakers are obtaining adequate dermatologic care.
    MeSH term(s) Humans ; Dermatology/methods ; Follow-Up Studies ; Skin Neoplasms/diagnosis ; Skin Neoplasms/epidemiology ; Referral and Consultation ; Health Services Accessibility ; Risk Factors
    Language English
    Publishing date 2022-10-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 130131-7
    ISSN 1432-069X ; 0340-3696
    ISSN (online) 1432-069X
    ISSN 0340-3696
    DOI 10.1007/s00403-022-02419-y
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  9. Article ; Online: Less (bacterial diversity) is more (deaths).

    Levine, John E

    Blood

    2014  Volume 124, Issue 7, Page(s) 995–996

    MeSH term(s) Female ; Gastrointestinal Tract/microbiology ; Genetic Variation ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Male ; Microbiota/genetics
    Language English
    Publishing date 2014-06-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2014-07-583906
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  10. Article ; Online: Chemokines: a novel chronic GVHD target.

    Kitko, Carrie / Levine, John E

    Blood

    2018  Volume 131, Issue 15, Page(s) 1636–1638

    MeSH term(s) Animals ; Biomarkers ; Chemokines ; Chemokines, CC ; Graft vs Host Disease ; Humans ; Macrophage Inflammatory Proteins ; Mice ; Proteome
    Chemical Substances Biomarkers ; CCL15 protein, human ; Chemokines ; Chemokines, CC ; Macrophage Inflammatory Proteins ; Proteome
    Language English
    Publishing date 2018-04-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2018-02-829101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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