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Article ; Online: A Novel Strain of Fusarium oxysporum Virus 1 Isolated from

Hua, Huihui / Zhang, Xinyi / Xia, Jie / Wu, Xuehong

2024 Volume 10, Issue 4

Abstract: A novel strain of Fusarium oxysporum virus 1 (FoV1) was identified from ... ...

Abstract	A novel strain of Fusarium oxysporum virus 1 (FoV1) was identified from the
Language	English
Publishing date	2024-03-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof10040252
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Integrated Metabolomic and Transcriptomic Analysis of Puerarin Biosynthesis in

Hu, Xinyi / Zhu, Ting / Min, Xinyi / He, Jianing / Hou, Cong / Liu, Xia

Genes

2023 Volume 14, Issue 12

Abstract: Puerarin, a class of isoflavonoid compounds concentrated in the roots ... ...

Abstract	Puerarin, a class of isoflavonoid compounds concentrated in the roots of
MeSH term(s)	Pueraria/genetics ; Pueraria/metabolism ; Gene Expression Profiling ; Transcriptome ; Metabolomics
Chemical Substances	puerarin (Z9W8997416)
Language	English
Publishing date	2023-12-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14122230
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Article ; Online: Transcriptome and Metabolome Analysis of Isoquinoline Alkaloid Biosynthesis of

Min, Xinyi / Zhu, Ting / Hu, Xinyi / Hou, Cong / He, Jianing / Liu, Xia

Genes

2023 Volume 14, Issue 12

Abstract: ... Coptis ... ...

Abstract	Coptis chinensis
MeSH term(s)	Coptis chinensis ; Transcriptome ; Coptis/genetics ; Coptis/chemistry ; Coptis/metabolism ; Alkaloids/genetics ; Alkaloids/metabolism ; Metabolome ; Isoquinolines/metabolism
Chemical Substances	Alkaloids ; Isoquinolines
Language	English
Publishing date	2023-12-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14122232
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Article ; Online: Saccadic targeting in the Landolt-C task: Implications for Chinese reading.

Xia, Xinyi / Liu, Qin / Reichle, Erik D / Liu, Yanping

Journal of experimental psychology. Learning, memory, and cognition

2024

Abstract: Participants in an eye-movement experiment performed a modified version of the Landolt-C paradigm (Williams & Pollatsek, 2007) to determine if there are preferred viewing locations when they searched for target squares embedded in linear arrays of ... ...

Abstract	Participants in an eye-movement experiment performed a modified version of the Landolt-C paradigm (Williams & Pollatsek, 2007) to determine if there are preferred viewing locations when they searched for target squares embedded in linear arrays of spatially contiguous clusters of squares (i.e., sequences of one to four squares having missing segments of variable size and orientation). The results of this experiment indicate that, although the peaks of the single- and first-of-multiple-fixation landing-site distributions were respectively located near the centers and beginnings of the clusters, thereby replicating previous patterns that have been interpreted as evidence for the default saccadic-targeting hypothesis, the same dissociation was evident on nonclusters (i.e., arbitrarily defined regions of analysis). Furthermore, properties of the clusters (e.g., character number and gap size) influenced fixation durations and forward saccade length, suggesting that ongoing stimulus processing affects decisions about when and where (i.e., how far) to move the eyes. Finally, results of simulations using simple oculomotor-based, default-targeting, and dynamic-adjustment models indicated that the latter performed better than the other two, suggesting that the dynamic-adjustment strategy likely reflects the basic perceptual and motor constraints shared by a variety of visual tasks, rather than being specific to Chinese reading. The theoretical implications of these results for existing and future accounts of eye-movement control are discussed. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	627313-0
ISSN	1939-1285 ; 0278-7393
ISSN (online)	1939-1285
ISSN	0278-7393
DOI	10.1037/xlm0001343
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Article: Tissue expression of porcine transient receptor potential mucolipin protein channels and their differential responses to porcine reproductive and respiratory syndrome virus infection

Xia, Zhiqiang / Long, Denggao / Hong, Xinyi / Lan, Ying / Xie, Lixia

Journal of veterinary research

2024 Volume 68, Issue 1, Page(s) 45–53

Abstract: Introduction: Porcine reproductive and respiratory syndrome virus (PRRSV) infection results in a serious disease, posing a huge economic threat to the global swine industry. The transient receptor potential mucolipin proteins (TRPMLs) have been shown to ...

Abstract	Introduction: Porcine reproductive and respiratory syndrome virus (PRRSV) infection results in a serious disease, posing a huge economic threat to the global swine industry. The transient receptor potential mucolipin proteins (TRPMLs) have been shown to be strongly associated with virus infection and other physiological processes in humans, but their tissue distribution and responses to PRRSV in pigs remain unknown. Material and methods: Quantitative reverse-transcription PCR analysis was undertaken to determine the optimal primer for TRPML expression detection and for quantifying that expression individually in different pig tissue samples. Meat Animal Research Center 145 (MARC-145) monkey kidney cells and the TRPML-specific activator mucolipin synthetic agonist 1 (ML-SA1) were used to reveal the relationship between TRPML and PRRSV-2 infection. Results: The best primers for each TRPML gene used in a fluorescence-based quantitative method were identified and TRPML1 was found to be highly expressed in the kidneys and liver of pigs, while TRPML2 and TRPML3 were observed to be primarily expressed in the kidney and spleen tissues. The expression of TRPML2 was upregulated with the rise in PRRSV-2 infection titre but not the expression of TRPML1 or TRPML3, and ML-SA1 inhibited PRRSV-2 in a dose-dependent manner. Conclusion: Our research revealed the gene expression of TRPMLs in pigs and identified that TRPML channels may act as key host factors against PRRSV infection, which could lead to new targets for the prevention and treatment of pig infectious diseases.
Language	English
Publishing date	2024-03-23
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2855010-9
ISSN	2450-8608 ; 2450-7393
ISSN (online)	2450-8608
ISSN	2450-7393
DOI	10.2478/jvetres-2024-0014
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Article ; Online: Honokiol induces ferroptosis in ovarian cancer cells through the regulation of YAP by OTUB2.

Liu, Fang / Zhang, Yufang / Xia, Xinyi / Han, Jing / Cao, Linyan

The journal of obstetrics and gynaecology research

2024 Volume 50, Issue 5, Page(s) 864–872

Abstract: Background: Ovarian cancer (OVCA) is prevalent in female reproductive organs. Despite recent advances, clinical outcomes remain poor, warranting fresh treatment avenues. Honokiol has an inhibitory effect on proliferation, invasion, and survival of ... ...

Abstract	Background: Ovarian cancer (OVCA) is prevalent in female reproductive organs. Despite recent advances, clinical outcomes remain poor, warranting fresh treatment avenues. Honokiol has an inhibitory effect on proliferation, invasion, and survival of cancer cells in vitro and in vivo. Therefore, this study intended to explore specific molecular mechanism by which honokiol affected OVCA progression. Methods: Bioinformatics analyzed the drug honokiol that bound to OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2). Cellular thermal shift assay (CETSA) verified the binding relationship between honokiol and OTUB2. Cell counting kit 8 (CCK-8) tested the IC Results: Honokiol was capable of inducing ferroptosis in OVCA cells. CETSA confirmed that honokiol could bind to OTUB2. Further cell functional and molecular experiments revealed that honokiol induced ferroptosis in OVCA cells via repression of YAP signaling pathway through binding to OTUB2. In addition, in vivo experiments have confirmed that honokiol could inhibit the growth of OVCA. Conclusion: Honokiol induced ferroptosis in OVCA cells via repression of YAP signaling pathway through binding to OTUB2, implicating that OTUB2 may be an effective target for OVCA treatment, and our study results may provide new directions for development of more effective OVCA treatment strategies.
MeSH term(s)	Humans ; Female ; Lignans/pharmacology ; Ferroptosis/drug effects ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/metabolism ; Biphenyl Compounds/pharmacology ; Cell Line, Tumor ; Transcription Factors/metabolism ; YAP-Signaling Proteins/metabolism ; Deubiquitinating Enzymes/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Allyl Compounds ; Phenols
Chemical Substances	honokiol (11513CCO0N) ; Lignans ; Biphenyl Compounds ; YAP1 protein, human ; Transcription Factors ; YAP-Signaling Proteins ; Deubiquitinating Enzymes (EC 3.4.19.12) ; Adaptor Proteins, Signal Transducing ; Allyl Compounds ; Phenols
Language	English
Publishing date	2024-03-13
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.15922
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1810: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Honokiol regulates ovarian cancer cell malignant behavior through YAP/TAZ pathway modulation.

Liu, Fang / Zhang, Yufang / Xia, Xinyi / Han, Jing / Cao, Linyan

The journal of obstetrics and gynaecology research

2024

Abstract: Background: Ovarian cancer (OVCA) stands as one of the most fatal gynecological malignancies. Honokiol (HNK) has been substantiated by numerous studies for its anti-tumor activity against malignancies including OVCA. Consequently, this work was designed ...

Abstract	Background: Ovarian cancer (OVCA) stands as one of the most fatal gynecological malignancies. Honokiol (HNK) has been substantiated by numerous studies for its anti-tumor activity against malignancies including OVCA. Consequently, this work was designed to elucidate the impact of HNK-mediated modulation of the YAP/TAZ pathway on the biological functions of OVCA cells. Methods: OVCA cells were subjected to treatment with varying concentrations (0, 25, 50, 75, and 100 μM) of HNK, concomitant with the administration of YAP agonist (XMU). Assessment of cellular viability was executed employing the CCK-8 assay, while quantification of cellular proliferation transpired via colony formation assays. Apoptosis was ascertained using flow cytometry, and expression of apoptosis-related proteins (caspase-3, Bcl-2, Bax), EMT-related proteins (E-cadherin, N-cadherin), migration-associated proteins (MMP-2, MMP-9), and YAP/TAZ pathway-related proteins was evaluated by western blot. Transwell experiments were conducted to assess cellular migratory and invasive propensities. Xenograft tumor models were built to observe tumor growth (volume and weight), apoptosis was assessed by TUNEL staining, and Ki67 expression was evaluated through IHC. Results: HNK exerted inhibitory effects on the viability and proliferative capacity of OVCA cells, elicited apoptotic responses, curtailed the migratory and invasive tendencies of cells, and downregulated the YAP/TAZ pathway. Stimulation with YAP agonist (XMU-MP-1) partially attenuated the impacts of HNK on OVCA cell biology. Experiments in vivo confirmed that HNK inhibited OVCA tumor growth. Conclusion: The outcomes of this investigation conclusively established that HNK orchestrated the modulation of the YAP/TAZ pathway, thereby exerting control over the malignant phenotypic manifestations of OVCA cells. The ascertained function of HNK in restraining cellular proliferation and tumor progression provided novel evidence of its anti-proliferative activity within OVCA cells.
Language	English
Publishing date	2024-04-04
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.15940
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1810: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: A Multi-Modal Deep-Learning Air Quality Prediction Method Based on Multi-Station Time-Series Data and Remote-Sensing Images: Case Study of Beijing and Tianjin.

Xia, Hanzhong / Chen, Xiaoxia / Wang, Zhen / Chen, Xinyi / Dong, Fangyan

Entropy (Basel, Switzerland)

2024 Volume 26, Issue 1

Abstract: The profound impacts of severe air pollution on human health, ecological balance, and economic stability are undeniable. Precise air quality forecasting stands as a crucial necessity, enabling governmental bodies and vulnerable communities to proactively ...

Abstract	The profound impacts of severe air pollution on human health, ecological balance, and economic stability are undeniable. Precise air quality forecasting stands as a crucial necessity, enabling governmental bodies and vulnerable communities to proactively take essential measures to reduce exposure to detrimental pollutants. Previous research has primarily focused on predicting air quality using only time-series data. However, the importance of remote-sensing image data has received limited attention. This paper proposes a new multi-modal deep-learning model, Res-GCN, which integrates high spatial resolution remote-sensing images and time-series air quality data from multiple stations to forecast future air quality. Res-GCN employs two deep-learning networks, one utilizing the residual network to extract hidden visual information from remote-sensing images, and another using a dynamic spatio-temporal graph convolution network to capture spatio-temporal information from time-series data. By extracting features from two different modalities, improved predictive performance can be achieved. To demonstrate the effectiveness of the proposed model, experiments were conducted on two real-world datasets. The results show that the Res-GCN model effectively extracts multi-modal features, significantly enhancing the accuracy of multi-step predictions. Compared to the best-performing baseline model, the multi-step prediction's mean absolute error, root mean square error, and mean absolute percentage error increased by approximately 6%, 7%, and 7%, respectively.
Language	English
Publishing date	2024-01-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e26010091
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Article: Clinical and molecular features of 40 Chinese patients with idiopathic hypogonadotropic hypogonadism.

Wang, Yuanfan / Jiang, Weijun / Xia, Xinyi

Translational andrology and urology

2023 Volume 12, Issue 9, Page(s) 1397–1407

Abstract: Background: Male idiopathic hypogonadotropic hypogonadism (IHH) is a heterogeneous clinical rare genetic disorder that can be divided into two forms: Kallmann syndrome (KS) and olfactory normal IHH (nIHH). Nearly half of unknown pathogenic genes and ... ...

Abstract	Background: Male idiopathic hypogonadotropic hypogonadism (IHH) is a heterogeneous clinical rare genetic disorder that can be divided into two forms: Kallmann syndrome (KS) and olfactory normal IHH (nIHH). Nearly half of unknown pathogenic genes and related pathogenic mechanisms have yet to be explored. Methods: Clinical data of 40 IHH patients (22 KS and 18 nIHH) were retrospectively recorded. All patients were diagnosed at the Department of Endocrinology of Jinling Hospital, Jiangsu Provincial People's Hospital, and the First Affiliated Hospital of the University of Science and Technology of China from 2014 to 2021. The proband genomic DNA (gDNA) was confirmed by whole exome sequencing (WES) and Sanger sequencing. Results: Ten new genetic mutations related to IHH in four families and eight sporadic unrelated IHH patients were identified. The total positive detection rate of 40 patients was 30% (nIHH 8/18 + KS 4/22), and the FGFR1 mutation rate accounted for 7.5% (3/40). Mutation rates of ANOS1, CHD7, and KISS1R were 5% (2/40), respectively. The mutation rates of SEMA3E, PROKR2, and SOX10 were 2.5% (1/40), respectively. After analysis by SIFT and PolyPhen-2 software, all missense mutation sites, such as Conclusions: The study aims to expand the genotype mutation spectrum of IHH and provide evidence for the follow-up clinical treatment and genetic counseling of the disease.
Language	English
Publishing date	2023-08-21
Publishing country	China
Document type	Journal Article
ZDB-ID	2851630-8
ISSN	2223-4691 ; 2223-4691 ; 2223-4683
ISSN (online)	2223-4691
ISSN	2223-4691 ; 2223-4683
DOI	10.21037/tau-23-225
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immune landscape and prognostic immune-related signature in KRAS-mutated lung adenocarcinoma.

Peng, Xinyi / Xia, Zhenqi / Guo, Yong / Li, Yan

Aging

2023 Volume 15, Issue 11, Page(s) 4889–4905

Abstract: The heterogeneity of lung adenocarcinoma (LUAD) indicated that target therapies and immunotherapies may not be effective in all patients. The exploration of the feature of the immune landscape of different gene mutations may provide novel perspectives. ... ...

Abstract	The heterogeneity of lung adenocarcinoma (LUAD) indicated that target therapies and immunotherapies may not be effective in all patients. The exploration of the feature of the immune landscape of different gene mutations may provide novel perspectives. In this study, we obtained LUAD samples from The Cancer Genome Atlas. By applying ESTIMATE and ssGSEA, KRAS-mutated group was discovered to be associated with lower immune infiltration, lower expression of immune checkpoints, especially, a lower abundance of B cell, CD8+ T cell, dendritic cell, natural killer cell, and macrophage, higher abundance of neutrophil and endothelial cell. Through ssGSEA, we found that the process of antigen-presenting cell co-inhibition and co-stimulation were inhibited, cytolytic activity and human leukocyte antigen molecules were downregulated in the KRAS-mutated group. And KRAS mutation is negatively related to antigen presentation and procession, cytotoxic lymphocyte activity, cytolytic activities, and cytokine interaction signaling pathway via gene function enrichment analysis. Finally, 24 immune-related genes were identified to establish an immune-related gene signature with excellent prognostic prediction capacity, whose 1-, 3- and 5-year AUCs were 0.893, 0.986, and 0.999. Our findings elucidate the features of the immune landscape of KRAS-mutated groups and successfully established a prognostic signature on the basis of immune-related genes in LUAD.
MeSH term(s)	Humans ; Prognosis ; Proto-Oncogene Proteins p21(ras)/genetics ; Adenocarcinoma of Lung/genetics ; Antigen Presentation ; Lung Neoplasms/genetics
Chemical Substances	Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; KRAS protein, human
Language	English
Publishing date	2023-06-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204770
Database	MEDical Literature Analysis and Retrieval System OnLINE

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