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Article: Arterial blood gases made easy.

Burns, Graham P

2014 Volume 14, Issue 1, Page(s) 66–68

MeSH term(s)	Bicarbonates/blood ; Blood Gas Analysis ; Carbon Dioxide/blood ; Humans ; Hydrogen-Ion Concentration ; Metabolism ; Oxygen/blood ; Partial Pressure ; Respiratory Physiological Phenomena
Chemical Substances	Bicarbonates ; Carbon Dioxide (142M471B3J) ; Oxygen (S88TT14065)
Language	English
Publishing date	2014-02-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2048646-7
ISSN	1473-4893 ; 1470-2118
ISSN (online)	1473-4893
ISSN	1470-2118
DOI	10.7861/clinmedicine.14-1-66
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Article ; Online: Ibrutinib as part of risk-stratified treatment for post-transplant lymphoproliferative disorder: The phase 2 TIDaL trial.

Chaganti, Sridhar / Maycock, Shanna / McIlroy, Graham / Jackson, Aimee E / Bishop, Rebecca / Johnson, Sarah / Kanfer, Edward / Kassam, Shireen / Cwynarski, Kate / Wrench, David J / Arumainathan, Arvind / Fox, Christopher P / Johnson, Rod J / McKay, Pamela / Paneesha, Shankara / Rowntree, Clare / Balotis, Constantine / Collins, Graham P / Davies, Andrew J /

Wright, Josh / Burns, Sarah / Laurence, Arian Dominic John / Wheatley, Keith / Menne, Tobias

Blood

2024

Abstract: Post-transplant lymphoproliferative disorder (PTLD) is a rare complication of solid organ transplantation, and cytotoxic chemotherapy is associated with treatment-related morbidity and mortality. Current treatment takes a sequential, risk-stratified ... ...

Abstract	Post-transplant lymphoproliferative disorder (PTLD) is a rare complication of solid organ transplantation, and cytotoxic chemotherapy is associated with treatment-related morbidity and mortality. Current treatment takes a sequential, risk-stratified approach, patients with low-risk disease following initial immunotherapy can avoid escalation to immunochemotherapy. TIDaL is a prospective, single-arm phase 2 trial investigating the activity and tolerability of ibrutinib combined with risk-stratified therapy for first-line treatment of PTLD. Eligible patients were adults with newly-diagnosed CD20-positive B-cell PTLD after solid organ transplant and performance status 0 to 2. Initial treatment comprised 49 days of ibrutinib 560mg once daily, with 4 doses of weekly rituximab. Treatment response on interim scan and baseline international prognostic index were used to allocate patients to either a low-risk arm (who continued ibrutinib, alongside 4 further doses of 3-weekly rituximab) or high-risk (escalation to R-CHOP immunochemotherapy, ibrutinib continuing in patients aged <65 years). The primary outcome was complete response on interim scan, achieved by 11/38 patients (29%, 95% confidence interval (CI) 15% - 46%). This did not reach the pre-specified threshold for clinically significant activity. Secondary outcomes included allocation to the low-risk arm (41% of patients), 2-year progression-free survival (58%, 95% CI 44% - 76%), and 2-year overall survival (76%, 95% CI 63% - 91%). Adverse events were mostly haematological, gastrointestinal and infective. Whilst TIDaL does not support adding ibrutinib into first-line treatment of PTLD, increasing the proportion of patients who can be treated without cytotoxic chemotherapy remains an important aim of future research. This trial was registered as ISRCTN32667607.
Language	English
Publishing date	2024-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2024023847
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Article ; Online: The British HIV Association national clinical audit 2021: Management of HIV and hepatitis C coinfection.

Raya, Reynie P / Curtis, Hilary / Kulasegaram, Ranjababu / Cooke, Graham S / Burns, Fiona / Chadwick, David / Sabin, Caroline A

HIV medicine

2022 Volume 24, Issue 4, Page(s) 471–479

Abstract: Objectives: We aimed to describe clinical policies for the management of people with HIV/hepatitis C virus (HCV) coinfection and to audit routine monitoring and assessment of people with HIV/HCV coinfection attending UK HIV care.: Methods: This was a ...

Abstract	Objectives: We aimed to describe clinical policies for the management of people with HIV/hepatitis C virus (HCV) coinfection and to audit routine monitoring and assessment of people with HIV/HCV coinfection attending UK HIV care. Methods: This was a clinic survey and retrospective case-note review. HIV clinics in the UK participated in the audit from May to July 2021 by completing an online questionnaire regarding their clinic's policies for the management of people with HIV/HCV coinfection, and by contributing to a case-note review of people living with HIV with detectable HCV RNA who were under the care of their service. Results: Ninety-five clinics participated in the clinic survey; of these, 15 (15.8%) were regional specialist centres, 19 (20.0%) were HIV services with their own coinfection clinics, 40 (42.1%) were HIV services that referred coinfected individuals to a local hepatology service and 20 (21.1%) were HIV services that referred to a regional specialist centre. Eighty-one clinics provided full caseload estimates; of the approximately 3951 people with a history of HIV/HCV coinfection accessing their clinics, only 4.9% were believed to have detectable HCV RNA, 3.15% of whom were already receiving or approved for direct-acting antiviral (DAA) treatment. In total, 29 (30.5%) of the clinics reported an impact of COVID-19 on coinfection care, including delays or reductions in the frequency of services, monitoring, treatment initiation and appointments, and changes to the way that treatment was dispensed. Case-note reviews were provided for 283 people with detectable HCV RNA from 74 clinics (median age 42 years, 74.6% male, 56.2% HCV genotype 1, 22.3% HCV genotype 3). Overall, 56% had not received treatment for HCV, primarily due to lack of engagement in care (54.7%) and/or being uncontactable (16.4%). Conclusions: Our findings show that the small number of people with HIV with detectable HCV RNA in the UK should mean that it is possible to achieve HCV micro-elimination. However, more work is needed to improve engagement in care for those who are untreated for HCV.
MeSH term(s)	Humans ; Male ; Adult ; Female ; Hepacivirus/genetics ; Antiviral Agents/therapeutic use ; Retrospective Studies ; Coinfection/drug therapy ; Hepatitis C, Chronic/drug therapy ; HIV Infections/complications ; HIV Infections/drug therapy ; COVID-19 ; Hepatitis C/complications ; Hepatitis C/drug therapy
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2022-09-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2001932-4
ISSN	1468-1293 ; 1464-2662
ISSN (online)	1468-1293
ISSN	1464-2662
DOI	10.1111/hiv.13417
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Article ; Online: Geographically targeted chronic infection screening: lessons from a hepatitis B pilot study in the UK.

O'Ferrall, Angus M / MacElhinney-West, Alison / Bell, Mark S / Haslam, Michael P / Walker, Gemma / Norton, Donna / Burns, Sean A / Ferrier, Graham / Easom, Nicholas J W

Transactions of the Royal Society of Tropical Medicine and Hygiene

2022 Volume 117, Issue 6, Page(s) 403–406

Abstract: Chronic hepatitis B (CHB) most commonly occurs following infection in early childhood. Prevalence varies markedly around the globe. Country of birth is therefore a strong predictor of CHB risk in adults. We used country of birth census data to predict ... ...

Abstract	Chronic hepatitis B (CHB) most commonly occurs following infection in early childhood. Prevalence varies markedly around the globe. Country of birth is therefore a strong predictor of CHB risk in adults. We used country of birth census data to predict CHB risk and carry out geographically targeted screening in East Yorkshire, UK. Despite engaging individuals born in high-prevalence countries with testing, we observed lower than expected prevalence in targeted highest-risk areas, which may indicate barriers to testing for people with undiagnosed CHB. Improved strategies for engagement with high-risk groups will be key for viral hepatitis elimination.
MeSH term(s)	Adult ; Humans ; Child, Preschool ; Hepatitis B, Chronic/diagnosis ; Hepatitis B, Chronic/epidemiology ; Pilot Projects ; Persistent Infection ; Hepatitis B ; Prevalence ; United Kingdom/epidemiology
Language	English
Publishing date	2022-12-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	441375-1
ISSN	1878-3503 ; 0035-9203
ISSN (online)	1878-3503
ISSN	0035-9203
DOI	10.1093/trstmh/trac131
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Article ; Online: Revisiting the Landscape of Potential Small and Drug Substance Related Nitrosamines in Pharmaceuticals.

Burns, Michael J / Ponting, David J / Foster, Robert S / Thornton, Benjamin P / Romero, Naiffer E / Smith, Graham F / Ashworth, Ian W / Teasdale, Andrew / Simon, Stephanie / Schlingemann, Joerg

Journal of pharmaceutical sciences

2023 Volume 112, Issue 12, Page(s) 3005–3011

Abstract: N-Nitrosamines are a class of indirect acting mutagens, as their metabolic degradation leads to the formation of the DNA-alkylating diazonium ion. Following up on the in-silico identification of thousands of nitrosamines that can potentially be derived ... ...

Abstract	N-Nitrosamines are a class of indirect acting mutagens, as their metabolic degradation leads to the formation of the DNA-alkylating diazonium ion. Following up on the in-silico identification of thousands of nitrosamines that can potentially be derived from small molecule drugs and their known impurities described in a previous publication, we have now re-analyzed this dataset to apply EMA's Carcinogenic Potency Categorization Approach (CPCA) introduced with the 16th revision of their Q&A document for Marketing Authorization Holders. We find that the majority of potential nitrosamines from secondary amine precursors belongs to potency categories 4 and 5, corresponding to an acceptable daily intake of 1500 ng, whereas nitrosamines from tertiary amine precursors distribute more evenly among all categories, resulting in a substantial number of structures that are assigned the more challenging acceptable intakes of 18 ng/day and 100 ng/day for potency categories 1 and 2, respectively. However, the nitrosative dealkylation pathway for tertiary amine is generally far slower than the direct nitrosation on secondary amines, with a direct nitrosation mechanism suspected only for structures featuring electron-rich (hetero)aromatic substituents. This allows for greater focus towards those structures that require further review, and we demonstrate that their number is not substantial. In addition, we reflect on the nitrosamine risk posed by secondary amine API impurities and demonstrate that based on the ICH Q3A/B identification threshold unknown impurities may exist that could be transformed to relevant amounts of NA. We also demonstrate that the analytical sensitivity required for the quantification of high potency nitrosamines can be problematic especially for high dose APIs. In summary, the regulatory framework rolled out with the latest Q&A document represents a substantial improvement compared with the previous situation, but further refinement through interaction between manufacturers, regulators, not-for-profit and academic institutions will be required to ensure patient access to vital medicines without compromising safety.
MeSH term(s)	Humans ; Nitrosamines/chemistry ; Amines/chemistry ; Pharmaceutical Preparations
Chemical Substances	Nitrosamines ; Amines ; Pharmaceutical Preparations
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	3151-3
ISSN	1520-6017 ; 0022-3549
ISSN (online)	1520-6017
ISSN	0022-3549
DOI	10.1016/j.xphs.2023.10.001
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Article ; Online: Influence of omega-3 polyunsaturated fatty acids from fish oil or meal on the structure of lipid microdomains in bovine luteal cells.

Plewes, M R / Burns, P D / Graham, P E / Bruemmer, J E / Engle, T E

Animal reproduction science

2018 Volume 193, Page(s) 40–57

Abstract: Biological membranes are composed of a lipid bilayer and proteins that form lipid microdomains. This study examined the effects of fish byproducts on lipid-protein interactions within lipid microdomains of bovine luteal cells. In Exp. 1 and 2, luteal ... ...

Abstract	Biological membranes are composed of a lipid bilayer and proteins that form lipid microdomains. This study examined the effects of fish byproducts on lipid-protein interactions within lipid microdomains of bovine luteal cells. In Exp. 1 and 2, luteal cells were prepared from corpora lutea (CL; n = 4 to 8) collected at an abattoir. Exp. 1 was conducted to optimize ultrasonication in a detergent-free protocol for isolation of lipid microdomains. A power setting of 10 to 20% was effective in isolating lipid microdomains from bulk lipid. In Exp. 2, cells were cultured in control medium or fish oil to determine influence of fish oil on distribution of lipid microdomain markers and prostaglandin F
MeSH term(s)	Animal Feed/analysis ; Animal Nutritional Physiological Phenomena/drug effects ; Animals ; Cattle ; Cells, Cultured ; Dietary Fats, Unsaturated/pharmacology ; Dietary Supplements ; Fatty Acids/metabolism ; Fatty Acids, Omega-3/pharmacology ; Female ; Fish Oils/chemistry ; Fish Oils/pharmacology ; Luteal Cells/drug effects ; Luteal Cells/metabolism ; Membrane Microdomains/drug effects ; Membrane Microdomains/metabolism ; Primary Cell Culture/veterinary
Chemical Substances	Dietary Fats, Unsaturated ; Fatty Acids ; Fatty Acids, Omega-3 ; Fish Oils
Language	English
Publishing date	2018-03-31
Publishing country	Netherlands
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	429674-6
ISSN	1873-2232 ; 0378-4320
ISSN (online)	1873-2232
ISSN	0378-4320
DOI	10.1016/j.anireprosci.2018.03.036
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Article ; Online: Effect of fish oil on lateral mobility of prostaglandin F

Plewes, M R / Burns, P D / Graham, P E / Hyslop, R M / Barisas, B G

Domestic animal endocrinology

2017 Volume 58, Page(s) 39–52

Abstract: Lipid microdomains are ordered regions on the plasma membrane of cells, rich in cholesterol and sphingolipids, ranging in size from 10 to 200 nm in diameter. These lipid-ordered domains may serve as platforms to facilitate colocalization of intracellular ...

Abstract	Lipid microdomains are ordered regions on the plasma membrane of cells, rich in cholesterol and sphingolipids, ranging in size from 10 to 200 nm in diameter. These lipid-ordered domains may serve as platforms to facilitate colocalization of intracellular signaling proteins during agonist-induced signal transduction. It is hypothesized that fish oil will disrupt the lipid microdomains, increasing spatial distribution of these lipid-ordered domains and lateral mobility of the prostaglandin (PG) F
MeSH term(s)	Animals ; Cattle ; Cell Membrane/chemistry ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cells, Cultured ; Diffusion/drug effects ; Dinoprost/pharmacology ; Female ; Fish Oils/pharmacology ; Lipids/analysis ; Luteal Cells/ultrastructure ; Receptors, Prostaglandin/metabolism
Chemical Substances	Fish Oils ; Lipids ; Receptors, Prostaglandin ; prostaglandin F2alpha receptor ; Dinoprost (B7IN85G1HY)
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	594468-5
ISSN	1879-0054 ; 0739-7240
ISSN (online)	1879-0054
ISSN	0739-7240
DOI	10.1016/j.domaniend.2016.08.001
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Book: Lecture notes

Bourke, S. J / Burns, Graham P

2015

Title variant	Respiratory medicine
Author's details	Stephen J. Bourke, Graham P. Burns
MeSH term(s)	Respiratory Tract Diseases
Language	English
Size	247 pages :, illustrations
Edition	Ninth edition.
Document type	Book
ISBN	9781118652329 ; 1118652320
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Effect of fish meal supplementation on spatial distribution of lipid microdomains and on the lateral mobility of membrane-bound prostaglandin F

Plewes, M R / Burns, P D / Graham, P E / Bruemmer, J E / Engle, T E / Barisas, B G

Domestic animal endocrinology

2017 Volume 60, Page(s) 9–18

Abstract: This study examined the effects of fish meal supplementation on spatial distribution of lipid microdomains and lateral mobility of prostaglandin ... ...

Abstract	This study examined the effects of fish meal supplementation on spatial distribution of lipid microdomains and lateral mobility of prostaglandin F
MeSH term(s)	Animal Feed/analysis ; Animal Nutritional Physiological Phenomena ; Animals ; Cattle ; Corpus Luteum/cytology ; Corpus Luteum/drug effects ; Diet/veterinary ; Dietary Supplements ; Female ; Fish Products ; Lipid Metabolism/drug effects ; Receptors, Prostaglandin/genetics ; Receptors, Prostaglandin/metabolism
Chemical Substances	Receptors, Prostaglandin ; prostaglandin F2alpha receptor
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	594468-5
ISSN	1879-0054 ; 0739-7240
ISSN (online)	1879-0054
ISSN	0739-7240
DOI	10.1016/j.domaniend.2017.02.001
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Article ; Online: Original publication: Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity.

Panagiotou, Grigorios / Tee, Su Ann / Ihsan, Yasir / Athar, Waseem / Marchitelli, Gabriella / Kelly, Donna / Boot, Christopher S / Stock, Nadia / Macfarlane, James / Martineau, Adrian R / Burns, Graham P / Quinton, Richard

Clinical endocrinology

2020 Volume 93, Issue 5, Page(s) 629–630

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Vitamin D/analogs & derivatives
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Keywords	covid19
Language	English
Publishing date	2020-09-10
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.14310
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