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  1. Article: Successful treatment with atezolizumab in a haemodialysis patient with large cell neuroendocrine carcinoma.

    Imai, Ryosuke / Kitamura, Atsushi

    Respirology case reports

    2023  Volume 11, Issue 8, Page(s) e01193

    Abstract: In this report, a modified regimen based on IMpower 133 (carboplatin + etoposide + atezolizumab) was administered to a patient diagnosed with large cell neuroendocrine carcinoma (LCNEC) who was concurrently undergoing haemodialysis. Adverse events led to ...

    Abstract In this report, a modified regimen based on IMpower 133 (carboplatin + etoposide + atezolizumab) was administered to a patient diagnosed with large cell neuroendocrine carcinoma (LCNEC) who was concurrently undergoing haemodialysis. Adverse events led to the discontinuation of carboplatin and etoposide after the first course. Nevertheless, the patient exhibited reduction in pulmonary nodule and adrenal metastasis while receiving atezolizumab, indicating its sustained efficacy for a duration of 7 months. To the best of our knowledge, this is the first documented case demonstrating successful treatment with atezolizumab in LCNEC patients undergoing haemodialysis. Atezolizumab can be administered safely in patients undergoing dialysis and is a promising therapeutic option for dialysis patients with LCNEC.
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2750180-2
    ISSN 2051-3380
    ISSN 2051-3380
    DOI 10.1002/rcr2.1193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Acrokeratosis neoplastica (Bazex syndrome): Report of two cases and literature review.

    Yamada, Atsushi / Umemoto, Naoka / Demitsu, Toshio / Kitamura, Osamu

    Heliyon

    2024  Volume 10, Issue 5, Page(s) e26411

    Abstract: The skin often reflects the presence of internal diseases. Acrokeratosis neoplastica (Bazex syndrome) is a unique skin manifestation characterized by its erythematous hyperkeratosis with yellowish, adherent scales on the palm, sole, or other acral ... ...

    Abstract The skin often reflects the presence of internal diseases. Acrokeratosis neoplastica (Bazex syndrome) is a unique skin manifestation characterized by its erythematous hyperkeratosis with yellowish, adherent scales on the palm, sole, or other acral locations. There is a potentially high association between Bazex syndrome and malignant pathology, especially squamous cell carcinomas (SCC). To date, various skin conditions have been recognized as diagnostic indicators of insidious malignancies. The recognition of paraneoplastic dermatoses has a strong potential for prompt cancer detection and early therapeutic intervention. Here we describe clinical and forensic cases of Bazex syndrome that are associated with SCC of the glottis and lung. Bazex syndrome has been reported to be associated with a variety of cancers in addition to SCC. We review the clinical manifestations of Bazex syndrome and include updated knowledge on disease pathogenesis.
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Case Reports
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e26411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Giant complex pulmonary arteriovenous malformation treated with coil embolisation under general anaesthesia with a history of contrast media allergy.

    Nakamura, Tomoaki / Yabuta, Minoru / Kitamura, Atsushi / Jinta, Torahiko

    BMJ case reports

    2023  Volume 16, Issue 2

    MeSH term(s) Humans ; Contrast Media ; Arteriovenous Malformations/therapy ; Pulmonary Artery/abnormalities ; Pulmonary Veins/abnormalities ; Anesthesia, General ; Hypersensitivity ; Embolization, Therapeutic
    Chemical Substances Contrast Media
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-254148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Corticospinal excitability during observation of basketball free-throw movement

    Masaya Kitamura / Katsuya Yamamoto / Atsushi Oshima / Kiyotaka Kamibayashi

    PLoS ONE, Vol 18, Iss

    Effects of video playback speed and stimulus timing

    2023  Volume 9

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Diel, seasonal and vertical changes in the abundance, biomass and community structure of pelagic polychaetes at the subtropical station S1 in the western North Pacific: comparison with the results from the subarctic station K2.

    Amei, Kanako / Dobashi, Ryo / Kitamura, Minoru / Yamaguchi, Atsushi

    Journal of plankton research

    2023  Volume 45, Issue 4, Page(s) 661–676

    Abstract: Information on pelagic polychaete community structure in the western North Pacific is available for the subarctic region (Station K2) but not for the subtropical region. Hence, we analyzed day-night vertically stratified samples collected in eight layers ...

    Abstract Information on pelagic polychaete community structure in the western North Pacific is available for the subarctic region (Station K2) but not for the subtropical region. Hence, we analyzed day-night vertically stratified samples collected in eight layers within the first 1000 m of the water column during four seasons in 1 year, using the same sampling method as St. K2, at the subtropical region (Station S1). At St. S1, 27 species of pelagic polychaetes belonging to 13 genera and six families were identified. The annual mean abundance was 35.0 ind. 1000 m
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 756271-8
    ISSN 0142-7873
    ISSN 0142-7873
    DOI 10.1093/plankt/fbad023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 81/705: Show issues

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  6. Article ; Online: Erratum to "Development of liquid crystal displays and related improvements to their performances".

    Kobayashi, Shunsuke / Miyama, Tomohiro / Akiyama, Hidenari / Ikemura, Atsushi / Kitamura, Michio

    Proceedings of the Japan Academy. Series B, Physical and biological sciences

    2023  Volume 99, Issue 3, Page(s) 102

    Language English
    Publishing date 2023-03-13
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 161781-3
    ISSN 1349-2896 ; 0386-2208
    ISSN (online) 1349-2896
    ISSN 0386-2208
    DOI 10.2183/pjab.99.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 46/60 b: Show issues
    Z PRO 15: Show issues

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  7. Article ; Online: Corticospinal excitability during observation of basketball free-throw movement: Effects of video playback speed and stimulus timing.

    Kitamura, Masaya / Yamamoto, Katsuya / Oshima, Atsushi / Kamibayashi, Kiyotaka

    PloS one

    2023  Volume 18, Issue 9, Page(s) e0292060

    Abstract: Transcranial magnetic stimulation studies have indicated that action observation (AO) modulates corticospinal excitability. Although a few previous studies have shown that the AO of simple motor movements at a slow playback speed facilitates ... ...

    Abstract Transcranial magnetic stimulation studies have indicated that action observation (AO) modulates corticospinal excitability. Although a few previous studies have shown that the AO of simple motor movements at a slow playback speed facilitates corticospinal excitability more than that at normal playback speed, it is unclear if this effect occurs during the AO of sport-related complex movements. Therefore, we investigated the changes in the motor evoked potential (MEP) amplitudes of the flexor carpi radialis (FCR) and abductor digiti minimi (ADM) muscles during the AO of a basketball free-throw movement at three different playback speeds (100%, 75%, and 50% speeds). Additionally, we evaluated the effects of stimulus timing (holding the ball vs. releasing the ball for shooting) and motor expertise (expert basketball players vs. novices) on the MEP amplitude during the AO. Our results demonstrated that regardless of motor expertise, the MEP amplitude of the FCR muscle was significantly smaller in the 50% speed condition than in the 100% condition. In the ADM muscle, the MEP amplitude was significantly larger when the ball was held after dribbling than when the ball was released. Therefore, it is suggested that corticospinal excitability in specific muscles during the observation of complex whole-body movements is influenced by video playback speed and stimulus timing.
    MeSH term(s) Basketball ; Movement/physiology ; Muscle, Skeletal/physiology ; Evoked Potentials, Motor/physiology ; Transcranial Magnetic Stimulation ; Electromyography ; Pyramidal Tracts/physiology
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0292060
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  8. Article ; Online: Feather buds exert a polarizing activity when transplanted to chick limb buds.

    Uchiyama, Kohji / Yanazawa, Masako / Kuroiwa, Atsushi / Kitamura, Kunio

    Development, growth & differentiation

    2023  Volume 38, Issue 6, Page(s) 635–645

    Abstract: Homeoproteins have been shown to be expressed in a position-specific manner along the anterior-posterior axis in the developing chick feather bud, as seen also in the developing limb bud. These facts raise the possibility that there may be common ... ...

    Abstract Homeoproteins have been shown to be expressed in a position-specific manner along the anterior-posterior axis in the developing chick feather bud, as seen also in the developing limb bud. These facts raise the possibility that there may be common mechanistic features in the establishment of the anterior-posterior polarity between both organs. In order to investigate this possibility, feather bud tissues were transplanted into the anterior region of limb buds to determine whether feather bud tissues possess properties such as the zone of polarizing activity of the limb bud. The manipulated limb bud formed a mirror image duplication of the skeletal elements, mainly (2)2234 digit pattern or sometimes 3(2)234. Both the anterior and posterior halves of feather bud tissue exhibited almost equal activity in inducing ectopic skeletal elements. Hoxd-12 and Hoxa-13 were expressed coordinately around the transplanted site of the operated limb bud. This secondary axis-inducing activity of the feather bud was enhanced when grafts were pretreated with trypsin. In contrast, the presumptive feather bud tissue and inter-feather bud tissue did not induce a secondary axis of the limb bud. These results suggest that the feather bud contains a region that exerts polarizing activity and that this region may play key roles in the formation of the anterior-posterior and, if it exists, proximal-distal axis of the feather bud, possibly via the regulation of region specific expression of Hox genes.
    Language English
    Publishing date 2023-06-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 280433-5
    ISSN 1440-169X ; 0012-1592
    ISSN (online) 1440-169X
    ISSN 0012-1592
    DOI 10.1046/j.1440-169X.1996.t01-5-00007.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 194: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Corticospinal excitability during observation of basketball free-throw movement

    Masaya Kitamura / Katsuya Yamamoto / Atsushi Oshima / Kiyotaka Kamibayashi

    PLoS ONE, Vol 18, Iss 9, p e

    Effects of video playback speed and stimulus timing.

    2023  Volume 0292060

    Abstract: Transcranial magnetic stimulation studies have indicated that action observation (AO) modulates corticospinal excitability. Although a few previous studies have shown that the AO of simple motor movements at a slow playback speed facilitates ... ...

    Abstract Transcranial magnetic stimulation studies have indicated that action observation (AO) modulates corticospinal excitability. Although a few previous studies have shown that the AO of simple motor movements at a slow playback speed facilitates corticospinal excitability more than that at normal playback speed, it is unclear if this effect occurs during the AO of sport-related complex movements. Therefore, we investigated the changes in the motor evoked potential (MEP) amplitudes of the flexor carpi radialis (FCR) and abductor digiti minimi (ADM) muscles during the AO of a basketball free-throw movement at three different playback speeds (100%, 75%, and 50% speeds). Additionally, we evaluated the effects of stimulus timing (holding the ball vs. releasing the ball for shooting) and motor expertise (expert basketball players vs. novices) on the MEP amplitude during the AO. Our results demonstrated that regardless of motor expertise, the MEP amplitude of the FCR muscle was significantly smaller in the 50% speed condition than in the 100% condition. In the ADM muscle, the MEP amplitude was significantly larger when the ball was held after dribbling than when the ball was released. Therefore, it is suggested that corticospinal excitability in specific muscles during the observation of complex whole-body movements is influenced by video playback speed and stimulus timing.
    Keywords Medicine ; R ; Science ; Q
    Subject code 796
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Pharmacokinetics and Safety of Imeglimin in Japanese Patients With Impaired Renal Function.

    Kitamura, Atsushi / Yumizaki, Takuya / Kondo, Tomoe / Sekino, Hisakuni / Kakuyama, Hiroyoshi

    Journal of clinical pharmacology

    2023  Volume 63, Issue 7, Page(s) 807–816

    Abstract: Imeglimin is a diabetic drug excreted mainly in the urine; therefore, the impact of renal impairment on its pharmacokinetics (PK) is of interest. We assessed the PK and safety of imeglimin in Japanese patients with impaired renal function. This was an ... ...

    Abstract Imeglimin is a diabetic drug excreted mainly in the urine; therefore, the impact of renal impairment on its pharmacokinetics (PK) is of interest. We assessed the PK and safety of imeglimin in Japanese patients with impaired renal function. This was an uncontrolled, open-label, single-dose, phase 1 study. Participants were classified into 4 groups by their estimated glomerular filtration rate (mL/min/1.73 m
    MeSH term(s) Humans ; Area Under Curve ; East Asian People ; Kidney/physiology ; Renal Insufficiency
    Chemical Substances imeglimin (UU226QGU97)
    Language English
    Publishing date 2023-04-05
    Publishing country England
    Document type Clinical Trial, Phase I ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188980-1
    ISSN 1552-4604 ; 0091-2700 ; 0021-9754
    ISSN (online) 1552-4604
    ISSN 0091-2700 ; 0021-9754
    DOI 10.1002/jcph.2218
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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.176: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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