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Article ; Online: Essential updates 2021/2022: Perioperative and surgical treatments for gastric and esophagogastric junction cancer.

Yanagimoto, Yoshitomo / Kurokawa, Yukinori / Doki, Yuichiro

Annals of gastroenterological surgery

2023 Volume 7, Issue 5, Page(s) 698–708

Abstract: In recent years, important clinical trials for gastric cancer (GC) and esophagogastric junction cancer (EGJC) have been reported, changing the strategies of surgical and perioperative treatment. Although laparoscopic gastrectomy has already been shown to ...

Abstract	In recent years, important clinical trials for gastric cancer (GC) and esophagogastric junction cancer (EGJC) have been reported, changing the strategies of surgical and perioperative treatment. Although laparoscopic gastrectomy has already been shown to be effective for early-stage cancer, recent evidence from both Asia (JLSSG0901, CLASS-01 and KLASS-02) and Europe (LOGICA and STOMACH trials) has demonstrated that it is useful for advanced GC. Robotic surgery has been rapidly gaining popularity in recent years, and randomized controlled trials are ongoing to evaluate its efficacy. A prospective nationwide multicenter study mapped sites with frequent metastasis and revealed lymphatic flow specific to EGJC, thus establishing the optimal lymph node dissection area and surgical approach based on esophageal involvement. Perioperative chemotherapy, the mainstay of treatment in Europe, also has been established in Asia by the PRODIGY and RESOLVE studies. New clinical trials have been conducted to evaluate the efficacy of combining immunotherapy or molecular-targeted therapy with perioperative chemotherapy or chemoradiotherapy. In this review, we present important recent clinical trials regarding the treatment of GC and EGJC published in 2021 or 2022.
Language	English
Publishing date	2023-06-29
Publishing country	Japan
Document type	Journal Article ; Review
ISSN	2475-0328
ISSN (online)	2475-0328
DOI	10.1002/ags3.12711
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Article ; Online: A Novel Surgical Technique for Double Flap Reconstruction Using a Circular Stapler After Laparoscopic Proximal Gastrectomy.

Yanagimoto, Yoshitomo / Omori, Takeshi / Odagiri, Kazuki / Kawase, Tomono / Takeyama, Hiroshi / Suzuki, Yozo / Imamura, Hiroshi

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2023 Volume 27, Issue 10, Page(s) 2209–2212

MeSH term(s)	Humans ; Surgical Flaps/surgery ; Gastrectomy/methods ; Laparoscopy/methods ; Stomach Neoplasms/surgery ; Anastomosis, Surgical/methods ; Esophagogastric Junction/surgery ; Retrospective Studies
Language	English
Publishing date	2023-09-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1007/s11605-023-05822-6
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Zs.A 5207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: [Our Experience with Atezolizumab plus Bevacizumab for Unresectable Hepatocellular Carcinoma].

Shimizu, Junzo / Yamashita, Masafumi / Odagiri, Kazuki / Takeyama, Hiroshi / Yanagimoto, Yoshitomo / Suzuki, Yozo / Ikenaga, Masakazu / Kawase, Tomono / Imamura, Hiroshi / Dono, Keizo

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1513–1515

Abstract: We report our experience with atezolizumab plus bevacizumab for unresectable hepatocellular carcinoma.: Methods: Fourteen patients with unresectable hepatocellular carcinoma treated with atezolizumab plus bevacizumab at our department were ... ...

Abstract	We report our experience with atezolizumab plus bevacizumab for unresectable hepatocellular carcinoma. Methods: Fourteen patients with unresectable hepatocellular carcinoma treated with atezolizumab plus bevacizumab at our department were retrospectively evaluated for antitumor efficacy and adverse events. Results: Age ranged from 66-91 years(median 77.5 years), 11 males and 3 females, number of doses ranged from 2-26(median 13), and observation period ranged from 31-790 days (median 427 days). Antitumor efficacy was CR in 3 patients, PR in 3, SD in 6, and PD in 2. One patient with PD died 650 days after the start of treatment, but the others are still alive. Adverse events included proteinuria in 9 patients who discontinued bevacizumab, hypothyroidism requiring levothyroxine sodium hydrate in 7 patients, dermatitis in 2 patients, and colitis requiring hospitalization in 2 patients. Discussion: Despite the small number of cases, a high antitumor effect was observed with a CR rate of 21%. Although proteinuria and hypothyroidism were observed relatively frequently as adverse events, they were easily controlled and did not pose a major clinical problem.
MeSH term(s)	Female ; Male ; Humans ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular/drug therapy ; Bevacizumab/adverse effects ; Retrospective Studies ; Liver Neoplasms/drug therapy ; Hypothyroidism/chemically induced ; Proteinuria ; Antibodies, Monoclonal, Humanized
Chemical Substances	Bevacizumab (2S9ZZM9Q9V) ; atezolizumab (52CMI0WC3Y) ; Antibodies, Monoclonal, Humanized
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Zs.B 2573: Show issues

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Article: [Clinical Outcome of Five Patients with Perforated Colorectal Cancer].

Jinushi, Koichi / Ikenaga, Masakazu / Odagiri, Kazuki / Yanagimoto, Yoshitomo / Yamashita, Masafumi / Takeyama, Hiroshi / Suzuki, Yozo / Kawase, Tomono / Shimizu, Junzo / Imamura, Hiroshi / Dono, Keizo

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1566–1568

Abstract: We studied the clinicopathological findings of 5 patients with perforated colorectal cancer. Three patients were male, and the primary cancer site was left side colon in 4 patents. Two patients had endoscopy-related perforation. The chief complaint was ... ...

Abstract	We studied the clinicopathological findings of 5 patients with perforated colorectal cancer. Three patients were male, and the primary cancer site was left side colon in 4 patents. Two patients had endoscopy-related perforation. The chief complaint was abdominal pain in all cases. All patients underwent emergency surgery. Two patients had Stage Ⅱ cancer, 3 had Stage Ⅳ. The mean ICU stay was 2.8 days. The average postoperative hospital stay was 71.8 days. Three patients were discharged home and 2 were transferred to other hospitals. The 3 patients who were discharged home received chemotherapy. Perforation of the cancer site is a risk factor for recurrence, and early recovery and additional treatment should be considered.
MeSH term(s)	Humans ; Male ; Female ; Colorectal Neoplasms/complications ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/surgery ; Endoscopy ; Treatment Outcome ; Retrospective Studies
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: [A Case Report of the Ascending Colon Cancer with Bullous Pemphigoid].

Iijima, Ken / Ikenaga, Masakazu / Takeyama, Hiroshi / Suzuki, Yozo / Tomita, Naohiro / Odagiri, Kazuki / Yanagimoto, Yoshitomo / Yamashita, Masafumi / Shimizu, Junzo / Kawase, Tomono / Imamura, Hiroshi / Dono, Keizo

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1589–1591

Abstract: The patient was a 70-year-old man. The patient had progressive anemia while taking 10 mg/day of prednisolone and 100 mg/day of mizoribine orally for bullous pemphigoid, a colonoscopy diagnosed ascending colon cancer. Adenocarcinoma, Group 5 was detected ... ...

Abstract	The patient was a 70-year-old man. The patient had progressive anemia while taking 10 mg/day of prednisolone and 100 mg/day of mizoribine orally for bullous pemphigoid, a colonoscopy diagnosed ascending colon cancer. Adenocarcinoma, Group 5 was detected on biopsy. Abdominal computed tomography showed no metastases. The tumor was diagnosed as ascending colon cancer, cT4aN0M0, cStage Ⅱb. We performed laparoscopic right hemicolectomy and D3 dissection. Histopathological examination revealed pT3N0M0, pStage Ⅱa. In the present report, we describe a case of the ascending colon cancer with bullous pemphigoid, and discuss the case with a review of the literature.
MeSH term(s)	Male ; Humans ; Aged ; Colon, Ascending/surgery ; Pemphigoid, Bullous/complications ; Pemphigoid, Bullous/drug therapy ; Pemphigoid, Bullous/surgery ; Colonic Neoplasms/complications ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/surgery ; Colectomy ; Adenocarcinoma/surgery
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	Review ; Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Surgical and perioperative treatment strategy for resectable esophagogastric junction cancer.

Yanagimoto, Yoshitomo / Kurokawa, Yukinori / Doki, Yuichiro / Yoshikawa, Takaki / Boku, Narikazu / Terashima, Masanori

Japanese journal of clinical oncology

2022 Volume 52, Issue 5, Page(s) 417–424

Abstract: Esophagogastric junction cancer is defined as adenocarcinoma with the epicenter within 5 cm of the esophagogastric junction in the West according to the Siewert classification. In contrast, it is defined as cancer of any histological type with the ... ...

Abstract	Esophagogastric junction cancer is defined as adenocarcinoma with the epicenter within 5 cm of the esophagogastric junction in the West according to the Siewert classification. In contrast, it is defined as cancer of any histological type with the epicenter located within 2 cm proximal or distal to the esophagogastric junction in Japan according to the Nishi classification. Recently, the incidence of esophagogastric junction cancer has been rapidly rising all over the world, leading to much attention. Esophagogastric junction cancer was previously treated like gastric cancer or esophageal cancer because it is a less frequently occurring tumor. Esophagogastric junction cancer is considered to have worse prognosis than gastric cancer. Therefore, in recent years, esophagogastric junction cancer has been recognized as an independent malignant disease with poor prognosis, and thus development of treatment strategies focused on esophagogastric junction cancer is needed. The mapping of frequent metastasis in the mediastinal and abdominal lymph nodes has revealed the lymphatic flow from esophagogastric junction cancer specifically, establishing the optimal lymph node dissection area and surgical approach. The development of multimodal treatment that includes chemotherapy, radiotherapy and immunotherapy has been applied to improve the survival of esophagogastric junction cancer. In this review, we summarize clinical trials with important evidence on surgical and multimodal perioperative treatments for esophagogastric junction cancer.
MeSH term(s)	Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophagogastric Junction/pathology ; Esophagogastric Junction/surgery ; Gastrectomy ; Humans ; Lymph Node Excision ; Retrospective Studies ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery
Language	English
Publishing date	2022-03-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyac019
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Zs.A 1298: Show issues

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Article ; Online: Association between methicillin-resistant Staphylococcus aureus nasal carriage and infection after pancreatic surgery.

Jinushi, Koichi / Shimizu, Junzo / Yamashita, Masafumi / Odagiri, Kazuki / Yanagimoto, Yoshitomo / Takeyama, Hiroshi / Suzuki, Yozo / Ikenaga, Masakazu / Imamura, Hiroshi / Dono, Keizo

Journal of hepato-biliary-pancreatic sciences

2023 Volume 31, Issue 1, Page(s) 42–49

Abstract: Background: Methicillin-resistant Staphylococcus aureus (MRSA) infections after pancreatectomy are relatively rare; however, they can be fatal when associated with pseudoaneurysms. For the past 12 years, we have been investigating nasal MRSA carriage by ...

Abstract	Background: Methicillin-resistant Staphylococcus aureus (MRSA) infections after pancreatectomy are relatively rare; however, they can be fatal when associated with pseudoaneurysms. For the past 12 years, we have been investigating nasal MRSA carriage by polymerase chain reaction testing, postoperatively in patients admitted to the intensive care units, to prevent nosocomial infections. Here, we investigated the relationship between MRSA nasal carriage and postoperative MRSA infection at the surgical site, following pancreatectomy. Methods: This single-center retrospective study analyzed 313 pancreatectomies (220 pancreaticoduodenectomies and 93 distal pancreatectomies), performed at our hospital between January 2011 and June 2022. The incidence of surgical site infection (SSI) and postoperative MRSA infection were compared between the nasal MRSA-positive and nasal MRSA-negative groups. Results: MRSA nasal carriage was identified in 24 cases (7.6%), and the frequency of SSIs in the nasal MRSA-positive and MRSA-negative groups were 50% and 36.7%, respectively, with no significant difference (p = .273). However, the frequency of MRSA infection among the SSI cases was significantly higher in the nasal MRSA-positive group (16.7%) than in the nasal MRSA-negative group (1.7%) (p = .003). Conclusion: It should be noted that MRSA carriers have a significantly higher frequency of MRSA-positive SSIs.
MeSH term(s)	Humans ; Methicillin-Resistant Staphylococcus aureus ; Retrospective Studies ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/prevention & control ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/prevention & control ; Incidence
Language	English
Publishing date	2023-10-04
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2536236-7
ISSN	1868-6982 ; 1868-6974
ISSN (online)	1868-6982
ISSN	1868-6974
DOI	10.1002/jhbp.1371
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Zs.A 4024: Show issues

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Article: [Conversion Surgery Performed after SOX plus Nivolumab Therapy for Advanced Gastric Cancer with Para-Aortic Lymph Node Metastasis].

Okuda, Tadahiro / Odagiri, Kazuki / Yanagimoto, Yoshitomo / Yamashita, Masafumi / Takeyama, Hiroshi / Suzuki, Yozo / Ikenaga, Masakazu / Kawase, Tomono / Shimizu, Junzo / Imamura, Hiroshi / Dono, Keizo

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1671–1673

Abstract: The patient was a 78-year-old woman. She presented with anemia and a positive fecal occult blood test. Endoscopic findings revealed type 3 advanced gastric cancer. As it had metastasized to the para-aortic lymph node(PALN: No. 16a2 lat), it was diagnosed ...

Abstract	The patient was a 78-year-old woman. She presented with anemia and a positive fecal occult blood test. Endoscopic findings revealed type 3 advanced gastric cancer. As it had metastasized to the para-aortic lymph node(PALN: No. 16a2 lat), it was diagnosed as gastric cancer at cardia cT4aN1(No.1)M1(No.16a2 lat), cStage Ⅳ. She was administered S-1, oxaliplatin, and nivolumab(SOX plus Nivo)therapy as a first-line treatment. SOX plus Nivo resulted in a remarkable reduction of the lymph nodes, which were PR. After 3 courses of chemotherapy, a laparoscopic proximal gastrectomy was performed, with D2 plus No. 16a2 int/lat lymph nodes dissection as conversion surgery. Histopathological examination was pT3N0M0, and R0 resection was pStage ⅡA. She was discharged at POD21 and started S-1 from POD69. The patient is alive with no signs of recurrence 10 months postoperatively.
MeSH term(s)	Female ; Humans ; Aged ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/surgery ; Stomach Neoplasms/pathology ; Nivolumab/therapeutic use ; Lymphatic Metastasis ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Neoplasm Recurrence, Local/surgery ; Lymph Nodes/pathology ; Lymph Node Excision ; Gastrectomy
Chemical Substances	Nivolumab (31YO63LBSN)
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: [A Case of Preoperative Chemotherapy for Advanced Gastric Cancer, Laparoscopic Total Gastrectomy, Pancreaticoduodenectomy, and Para-Aortic Lymph Node Dissection].

Fukuda, Kenta / Odagiri, Kazuki / Yanagimoto, Yoshitomo / Yamashita, Masafumi / Takeyama, Hiroshi / Suzuki, Yozo / Ikenaga, Masakazu / Kawase, Tomono / Shimizu, Junzo / Imamura, Hiroshi / Dono, Keizo

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1438–1440

Abstract: Bulky N+ gastric cancer has a poor prognosis. The results of JCOG0405 showed the efficacy of neoadjuvant chemotherapy with S-1 plus cisplatin combination therapy for Bulky N+ gastric cancer. JLSSG0901 demonstrated the safety and efficacy of laparoscopic ... ...

Abstract	Bulky N+ gastric cancer has a poor prognosis. The results of JCOG0405 showed the efficacy of neoadjuvant chemotherapy with S-1 plus cisplatin combination therapy for Bulky N+ gastric cancer. JLSSG0901 demonstrated the safety and efficacy of laparoscopic surgery for advanced gastric cancer. But the safety of laparoscopic surgery for locally advanced and extensive nodal metastasis cancer(T4b, para-aortic lymph node metastasis)is not apparent. After DOS therapy, we performed total laparoscopic gastrectomy, DP(distal pancreatectomy), D2+ #16a2/b1 lat, and Roux-en-Y reconstruction, and histopathological results showed that the aortic lymph node metastasis disappeared. We controlled extensive lymph node metastasis using preoperative triplet chemotherapy. Laparoscopic surgery after preoperative chemotherapy for Bulky N+ gastric cancer can be a treatment option because we performed laparoscopic resection and para-aortic lymph node dissection with no complications, including pancreatic complications.
MeSH term(s)	Humans ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/surgery ; Stomach Neoplasms/pathology ; Lymphatic Metastasis/pathology ; Pancreaticoduodenectomy ; Lymph Node Excision/methods ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Lymph Nodes/pathology ; Laparoscopy/methods ; Gastrectomy/methods
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: [A Case of 30s Female with Advanced Anal Canal Adenocarcinoma Managed with Adolescent-And-Young-Adult Team].

Suzuki, Yozo / Ikenaga, Masakazu / Sato, Yasufumi / Odagiri, Kazuki / Yanagimoto, Yoshitomo / Yamashita, Masafumi / Takeyama, Hiroshi / Kobayashi, Aki / Noura, Shingo / Shimizu, Junzo / Kawase, Tomono / Akagi, Kenzo / Iwazawa, Takashi / Tomita, Naohiro / Imamura, Hiroshi

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 51, Issue 1, Page(s) 69–71

Abstract: A 30s female complaining of anal pain and melena was referred to our hospital. The support by adolescent-and-young- adult(AYA)team was initiated after the first encounter. Colonoscopic examination revealed an ulcerated tumor on the anterior wall of anal ... ...

Abstract	A 30s female complaining of anal pain and melena was referred to our hospital. The support by adolescent-and-young- adult(AYA)team was initiated after the first encounter. Colonoscopic examination revealed an ulcerated tumor on the anterior wall of anal canal with its anal margin on anal verge and the tumor was diagnosed as an adenocarcinoma. Contrast- enhanced CT and MRI revealed adjacency of tumor and vagina, enlarged lymph nodes and multiple pulmonary nodules. 18F-fluorodeoxyglucose(FDG)-positron emission tomography(PET)additionally revealed tracer accumulation in left sciatica, which led us to the diagnosis of advanced anal cancer. We planned and safely performed concomitant partial vaginal resection in robot-assisted laparoscopic abdominoperineal resection for the palliative purpose after discussion on physical and psychosocial issues including stoma and fertility with the patient, her family and AYA members. The pathological diagnosis was pT4b(vagina)N1aM1b, pStage ⅣB, and the local margin was pathologically negative. The postoperative course was smooth and she was discharged on postoperative day 16. Fifty one days after operation, she started systemic chemotherapy after decision on not to take ovarian samples and continues systemic chemotherapy as of writing. Support by AYA team was effective to facilitate the patient's decision-making and the communication between the patient and the medical team.
MeSH term(s)	Female ; Humans ; Adolescent ; Adult ; Anal Canal ; Adenocarcinoma/surgery ; Anus Neoplasms/surgery ; Pelvis ; Fluorodeoxyglucose F18
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	Japanese
Publishing date	2024-01-22
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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