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  1. Article: Improving Non-specific Immunity to Coronavirus Disease (COVID-19) by the Novelty, Diversity, and Quantity of Antigen.

    Boucher, Patrice / Boucher, Roger

    Frontiers in public health

    2020  Volume 8, Page(s) 393

    MeSH term(s) Antigens, Viral/immunology ; COVID-19/immunology ; Humans ; Immunity, Innate
    Chemical Substances Antigens, Viral
    Keywords covid19
    Language English
    Publishing date 2020-07-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.00393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Improving Non-specific Immunity to Coronavirus Disease (COVID-19) by the Novelty, Diversity, and Quantity of Antigen

    Patrice Boucher / Roger Boucher

    Frontiers in Public Health, Vol

    2020  Volume 8

    Keywords coronavirus ; COVID-19 ; natural killer cells ; vaccination ; non-specific immunity ; pandemic crisis ; Public aspects of medicine ; RA1-1270 ; covid19
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Improving Non-specific Immunity to Coronavirus Disease (COVID-19) by the Novelty, Diversity, and Quantity of Antigen

    Boucher, Patrice / Boucher, Roger

    Frontiers in Public Health

    2020  Volume 8

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.00393
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Acute Stress Assessment From Excess Cortisol Secretion: Fundamentals and Perspectives.

    Boucher, Patrice / Plusquellec, Pierrich

    Frontiers in endocrinology

    2019  Volume 10, Page(s) 749

    Abstract: Our paper aims to redefine the concept of stress in the context of maintaining allostasis; the term has been reserved for situations that concomitantly involve established physiological and psychological stress components. In particular, we analyze how ... ...

    Abstract Our paper aims to redefine the concept of stress in the context of maintaining allostasis; the term has been reserved for situations that concomitantly involve established physiological and psychological stress components. In particular, we analyze how novelty, unpredictability, threat to the ego, and low sense of control challenge allostasis. The concept of stress is then related to
    Language English
    Publishing date 2019-11-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2019.00749
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  6. Article: Ex vivo

    Arribarat, Germain / Cartiaux, Benjamin / Boucher, Samuel / Montel, Charles / Gros-Dagnac, Hélène / Fave, Yoann / Péran, Patrice / Mogicato, Giovanni / Deviers, Alexandra

    Frontiers in neuroanatomy

    2022  Volume 16, Page(s) 948159

    Abstract: Now that access of large domestic mammals to high-field MRI becomes more common, techniques initially implemented for human patients can be used for the structural and functional study of the brain of these animals. Among them, susceptibility-weighted ... ...

    Abstract Now that access of large domestic mammals to high-field MRI becomes more common, techniques initially implemented for human patients can be used for the structural and functional study of the brain of these animals. Among them, susceptibility-weighted imaging (SWI) is a recent technique obtained from gradient echo (GE) imaging that allow for an excellent anatomical tissue contrast and a non-invasive assessment of brain iron content. The goal of this study was to design an optimal GE SWI imaging protocol to be used in dogs undergoing an MRI examination of the brain in a 3-Tesla scanner. This imaging protocol was applied to
    Language English
    Publishing date 2022-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452969-2
    ISSN 1662-5129
    ISSN 1662-5129
    DOI 10.3389/fnana.2022.948159
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  7. Article ; Online: Pharmacological Characterization of [

    Beaurain, Marie / Talmont, Franck / Pierre, Damien / Péran, Patrice / Boucher, Samuel / Hitzel, Anne / Rols, Marie-Pierre / Cuvillier, Olivier / Payoux, Pierre / Salabert, Anne-Sophie

    Molecular imaging and biology

    2023  Volume 25, Issue 4, Page(s) 692–703

    Abstract: Purpose: NMDA receptors (NMDARs) dysfunction plays a central role in the physiopathology of psychiatric and neurodegenerative disorders whose mechanisms are still poorly understood. The development of a PET (positron emission tomography) tracer able to ... ...

    Abstract Purpose: NMDA receptors (NMDARs) dysfunction plays a central role in the physiopathology of psychiatric and neurodegenerative disorders whose mechanisms are still poorly understood. The development of a PET (positron emission tomography) tracer able to selectively bind to the NMDARs intra-channel PCP site may make it possible to visualize NMDARs in an open and active state. We describe the in vitro pharmacological characterization of [
    Procedures: The affinity of the non-radioactive analog for the intra-channel PCP site was determined in a radioligand competition assay using [
    Results: FNM displayed IC
    Conclusions: In spite of FNM's poor affinity for NMDAR PCP site, this study supports the ability of this tracer to track massive activation of NMDARs in neurological diseases.
    MeSH term(s) Rats ; Animals ; Receptors, N-Methyl-D-Aspartate/metabolism ; Rats, Sprague-Dawley ; Phencyclidine/metabolism ; Brain Injuries/metabolism ; Positron-Emission Tomography/methods ; Brain/diagnostic imaging ; Brain/metabolism
    Chemical Substances Receptors, N-Methyl-D-Aspartate ; Phencyclidine (J1DOI7UV76)
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-023-01811-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6468: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Diffusion Tensor Imaging Tractography of White Matter Tracts in the Equine Brain.

    Boucher, Samuel / Arribarat, Germain / Cartiaux, Benjamin / Lallemand, Elodie Anne / Péran, Patrice / Deviers, Alexandra / Mogicato, Giovanni

    Frontiers in veterinary science

    2020  Volume 7, Page(s) 382

    Abstract: Tractography, a noninvasive technique tracing brain pathways from diffusion tensor magnetic resonance imaging (DTI) data, is increasingly being used for brain investigation of domestic mammals. In the equine species, such a technique could be useful to ... ...

    Abstract Tractography, a noninvasive technique tracing brain pathways from diffusion tensor magnetic resonance imaging (DTI) data, is increasingly being used for brain investigation of domestic mammals. In the equine species, such a technique could be useful to improve our knowledge about structural connectivity or to assess structural changes of white matter tracts potentially associated with neurodegenerative diseases. The goals of the present study were to establish the feasibility of DTI tractography in the equine brain and to provide a morphologic description of the most representative tracts in this species.
    Language English
    Publishing date 2020-07-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2020.00382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Diffusion Tensor Imaging Tractography of White Matter Tracts in the Equine Brain

    Samuel Boucher / Germain Arribarat / Benjamin Cartiaux / Elodie Anne Lallemand / Patrice Péran / Alexandra Deviers / Giovanni Mogicato

    Frontiers in Veterinary Science, Vol

    2020  Volume 7

    Abstract: Tractography, a noninvasive technique tracing brain pathways from diffusion tensor magnetic resonance imaging (DTI) data, is increasingly being used for brain investigation of domestic mammals. In the equine species, such a technique could be useful to ... ...

    Abstract Tractography, a noninvasive technique tracing brain pathways from diffusion tensor magnetic resonance imaging (DTI) data, is increasingly being used for brain investigation of domestic mammals. In the equine species, such a technique could be useful to improve our knowledge about structural connectivity or to assess structural changes of white matter tracts potentially associated with neurodegenerative diseases. The goals of the present study were to establish the feasibility of DTI tractography in the equine brain and to provide a morphologic description of the most representative tracts in this species. Postmortem DTI and susceptibility-weighted imaging (SWI) of an equine brain were acquired with a 3-T system using a head coil. Association, commissural, and projection fibers, the three fiber groups typically investigated in tractography studies, were successfully reconstructed and overlaid on SWI or fractional anisotropy maps. The fibers derived from DTI correlate well with their description in anatomical textbooks. Our results demonstrate the feasibility of using postmortem DTI data to reconstruct the main white matter tracts of the equine brain. Further DTI acquisitions and corresponding dissections of equine brains will be necessary to validate these findings and create an equine stereotaxic white matter atlas that could be used in future neuroimaging research.
    Keywords MRI ; DTI ; tractography ; equine ; white matter tracts ; Veterinary medicine ; SF600-1100
    Subject code 630
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Costs of occupational injuries and diseases in Québec.

    Lebeau, Martin / Duguay, Patrice / Boucher, Alexandre

    Journal of safety research

    2014  Volume 50, Page(s) 89–98

    Abstract: Problem: Occupational injuries and diseases are costly for companies and for society as a whole. This study estimates the overall costs of occupational injuries and diseases in Québec, both human and financial, during the period from 2005 to 2007.: ... ...

    Abstract Problem: Occupational injuries and diseases are costly for companies and for society as a whole. This study estimates the overall costs of occupational injuries and diseases in Québec, both human and financial, during the period from 2005 to 2007.
    Method: The human capital method is used to estimate lost productivity. A health indicator (DALY) is used in combination with a value of statistical life (VSL) to estimate, in monetary terms, the pain and suffering costs resulting from occupational injuries.
    Results: The costs of occupational injuries and diseases occurring in a single year in Québec are estimated at $4.62 billion, on average, for the 2005-2007 period. Of this amount, approximately $1.78 billion is allocated to financial costs and $2.84 billion to human costs. The average cost per case is $38,355. In view of the limitations identified in the study, it can be argued that this is an underestimation of the costs. Result analysis allows the injury/disease descriptors and industries for which the costs are highest to be identified.
    Practical applications: The results of these estimates are a relevant source of information for helping to determine research directions in OHS and prevention. The methodology used can be replicated for the purposes of estimating the costs of injuries and diseases in other populations.
    MeSH term(s) Cause of Death ; Cost of Illness ; Costs and Cost Analysis ; Efficiency, Organizational/economics ; Humans ; Industry/classification ; Industry/economics ; Industry/statistics & numerical data ; Occupational Diseases/classification ; Occupational Diseases/economics ; Occupational Diseases/epidemiology ; Occupational Diseases/mortality ; Occupational Injuries/classification ; Occupational Injuries/economics ; Occupational Injuries/epidemiology ; Quebec/epidemiology ; Workers' Compensation/statistics & numerical data
    Language English
    Publishing date 2014-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2015321-1
    ISSN 1879-1247 ; 0022-4375
    ISSN (online) 1879-1247
    ISSN 0022-4375
    DOI 10.1016/j.jsr.2014.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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