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  1. Article ; Online: Low-Flow Acute Kidney Injury: The Pathophysiology of Prerenal Azotemia, Abdominal Compartment Syndrome, and Obstructive Uropathy.

    Molitoris, Bruce A

    Clinical journal of the American Society of Nephrology : CJASN

    2022  Volume 17, Issue 7, Page(s) 1039–1049

    Abstract: AKI is a syndrome, not a disease. It results from many different primary and/or secondary etiologies and is often multifactorial, especially in the hospitalized patient. This review discusses the pathophysiology of three etiologies that cause AKI, those ... ...

    Abstract AKI is a syndrome, not a disease. It results from many different primary and/or secondary etiologies and is often multifactorial, especially in the hospitalized patient. This review discusses the pathophysiology of three etiologies that cause AKI, those being kidney hypoperfusion, abdominal compartment syndrome, and urinary tract obstruction. The pathophysiology of these three causes of AKI differs but is overlapping. They all lead to a low urine flow rate and low urine sodium initially. In all three cases, with early recognition and correction of the underlying process, the resulting functional AKI can be rapidly reversed. However, with continued duration and/or increased severity, cell injury occurs within the kidney, resulting in structural AKI and a longer and more severe disease state with increased morbidity and mortality. This is why early recognition and reversal are critical.
    MeSH term(s) Acute Kidney Injury/complications ; Acute Kidney Injury/therapy ; Azotemia/etiology ; Biomarkers ; Humans ; Intra-Abdominal Hypertension/complications ; Kidney
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.15341121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Is Albumin Toxic to the Kidney?: It Depends.

    Molitoris, Bruce A / Wagner, Mark C

    Clinical journal of the American Society of Nephrology : CJASN

    2023  Volume 18, Issue 9, Page(s) 1222–1224

    MeSH term(s) Humans ; Kidney ; Albumins
    Chemical Substances Albumins
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000153
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  3. Article ; Online: Proximal tubule role in albumin homeostasis: controversy, species differences, and the contributions of intravital microscopy.

    Molitoris, Bruce A / Dunn, Kenneth W / Sandoval, Ruben M

    Kidney international

    2023  Volume 104, Issue 6, Page(s) 1065–1069

    MeSH term(s) Species Specificity ; Intravital Microscopy
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.05.028
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  4. Article ; Online: Beyond Biomarkers: Machine Learning in Diagnosing Acute Kidney Injury.

    Molitoris, Bruce A

    Mayo Clinic proceedings

    2019  Volume 94, Issue 5, Page(s) 748–750

    MeSH term(s) Acute Kidney Injury ; Biomarkers ; Humans ; Machine Learning
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-04-08
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2019.03.017
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  5. Book: Critical care nephrology

    Molitoris, Bruce A.

    2005  

    Author's details ed. Bruce A. Molitoris
    Keywords Kidney Diseases / therapy ; Kidney Diseases / compications ; Intensive Care
    Language English
    Size XII, 196 S. : Ill., graph. Darst.
    Publisher Remedica
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014372625
    ISBN 1-901346-66-8 ; 978-1-901346-66-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2005 A 2275 order for loan Magazin

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  6. Article ; Online: DNA damage response protects against progressive kidney disease.

    Molitoris, Bruce A

    The Journal of clinical investigation

    2019  Volume 129, Issue 11, Page(s) 4574–4575

    Abstract: The pathophysiology of cellular injury and repair has been extensively studied in acute kidney injury (AKI) for more than 70 years. Although a great deal of knowledge has been generated, a debate over the importance of repairing damaged cells versus ... ...

    Abstract The pathophysiology of cellular injury and repair has been extensively studied in acute kidney injury (AKI) for more than 70 years. Although a great deal of knowledge has been generated, a debate over the importance of repairing damaged cells versus replacing them by proliferation remains. In this issue of the JCI, Kishi et al. demonstrate that following kidney epithelial cell injury, DNA repair, rather than cell proliferation, plays the central role in recovery and longevity by minimizing apoptosis, G2/M cell-cycle arrest, and subsequent fibrosis. This has important therapeutic implications and highlights the need for more sensitive techniques to evaluate functional, structural, and molecular recovery following injury.
    MeSH term(s) Acute Kidney Injury ; Ataxia Telangiectasia Mutated Proteins ; DNA Damage ; DNA Repair ; Humans ; Kidney ; Kidney Tubules, Proximal
    Chemical Substances ATR protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1)
    Language English
    Publishing date 2019-10-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI131171
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  7. Article: Editorial: Proceedings of the 2021 Indiana O'Brien Center Microscopy Workshop.

    Dunn, Kenneth W / Hall, Andrew M / Molitoris, Bruce A

    Frontiers in physiology

    2022  Volume 13, Page(s) 891526

    Language English
    Publishing date 2022-05-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.891526
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  8. Article: Intravital Multiphoton Microscopy as a Tool for Studying Renal Physiology, Pathophysiology and Therapeutics.

    Molitoris, Bruce A / Sandoval, Ruben M / Wagner, Mark C

    Frontiers in physiology

    2022  Volume 13, Page(s) 827280

    Abstract: Intravital multiphoton microscopy has empowered investigators to study dynamic cell and subcellular ... ...

    Abstract Intravital multiphoton microscopy has empowered investigators to study dynamic cell and subcellular processes
    Language English
    Publishing date 2022-03-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.827280
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  9. Article ; Online: Response to Letter to the editor regarding 'Discordance between estimated and measured changes in plasma volume among patients with acute heart failure'.

    Swolinsky, Jutta S / Molitoris, Bruce A / Schmidt-Ott, Kai M

    ESC heart failure

    2022  Volume 9, Issue 4, Page(s) 2762–2763

    MeSH term(s) Heart Failure ; Humans ; Plasma Volume
    Language English
    Publishing date 2022-05-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.13950
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  10. Article ; Online: Rethinking CKD Evaluation: Should We Be Quantifying Basal or Stimulated GFR to Maximize Precision and Sensitivity?

    Molitoris, Bruce A

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2017  Volume 69, Issue 5, Page(s) 675–683

    Abstract: Chronic kidney disease (CKD) is an increasing clinical problem. Although clinical risk factors and biomarkers for the development and progression of CKD have been identified, there is no commercial surveillance technology to definitively diagnose and ... ...

    Abstract Chronic kidney disease (CKD) is an increasing clinical problem. Although clinical risk factors and biomarkers for the development and progression of CKD have been identified, there is no commercial surveillance technology to definitively diagnose and quantify the severity and progressive loss of glomerular filtration rate (GFR) in CKD. This has limited the study of potential therapies to late stages of CKD when FDA-registerable events are more likely. Because patient outcomes, including the rate of CKD progression, correlate with disease severity and effective therapy may require early intervention, being able to diagnose and stratify patients by their level of decreased kidney function early on is key for translational progress. In addition, renal reserve, defined as the increase in GFR following stimulation, may improve the quantification of GFR based solely on basal levels. Various groups are developing and characterizing optical measurement techniques using new minimally invasive or noninvasive approaches for quantifying basal and stimulated kidney function. This development has the potential to allow widespread individualization of therapy at an earlier disease stage. Therefore, the purposes of this review are to suggest why quantifying stimulated GFR, by activating renal reserve, may be advantageous in patients and to review fluorescent technologies to deliver patient-specific GFR.
    MeSH term(s) Animals ; Biomarkers/metabolism ; Creatinine/metabolism ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/physiopathology ; Dietary Proteins/metabolism ; Disease Progression ; Early Medical Intervention ; Fluorescein-5-isothiocyanate/analogs & derivatives ; Fluoresceins ; Glomerular Filtration Rate ; Humans ; Inulin/analogs & derivatives ; Kidney/diagnostic imaging ; Oligosaccharides ; Optical Imaging ; Plasma Volume ; Radiopharmaceuticals ; Renal Insufficiency, Chronic/diagnostic imaging ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/physiopathology ; Severity of Illness Index ; Technetium Tc 99m Pentetate
    Chemical Substances Biomarkers ; Dietary Proteins ; FITC-inulin ; Fluoresceins ; Oligosaccharides ; Radiopharmaceuticals ; fluorescein-isothiocyanate sinistrin ; Inulin (9005-80-5) ; Creatinine (AYI8EX34EU) ; Fluorescein-5-isothiocyanate (I223NX31W9) ; Technetium Tc 99m Pentetate (VW78417PU1)
    Language English
    Publishing date 2017-02-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2016.11.028
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