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  1. Article: Improving the efficacy of Chloroquine and Hydroxychloroquine against SARS-CoV-2 may require Zinc additives - A better synergy for future COVID-19 clinical trials.

    Shittu, Mujeeb Olushola / Afolami, Olufemi Ifeoluwa

    Le infezioni in medicina

    2020  Volume 28, Issue 2, Page(s) 192–197

    Abstract: The recent outbreak of coronavirus disease 2019 (COVID-19), is now officially declared as a pandemic by the World Health Organization. As of now, there is no known effective pharmaceutical agent against the SARS-CoV-2 virus. However, several ... ...

    Abstract The recent outbreak of coronavirus disease 2019 (COVID-19), is now officially declared as a pandemic by the World Health Organization. As of now, there is no known effective pharmaceutical agent against the SARS-CoV-2 virus. However, several precautionary measures have been prescribed to prevent further spread of the virus, which include avoidance of social gatherings, proper handwashing, frequently disinfecting of used items and surfaces and so on. More recent studies have highlighted the possibility of treating patients infected with the novel SARS-CoV-2 virus with chloroquine and hydroxychloroquine, of which mechanism of action is not completely understood. We seek to draw the attention of the scientific community to the possibility of drastically reducing the effects of the virus on the affected patients and improving clinical trials outcome through the synergistic action of zinc and chloroquine in patients suffering from the coronavirus disease.
    MeSH term(s) Betacoronavirus ; Chloroquine/therapeutic use ; Clinical Trials as Topic ; Coronavirus Infections/drug therapy ; Drug Synergism ; Humans ; Hydroxychloroquine/therapeutic use ; Pandemics ; Pneumonia, Viral/drug therapy ; Zinc/therapeutic use
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF) ; Zinc (J41CSQ7QDS)
    Keywords covid19
    Language English
    Publishing date 2020-04-25
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2041081-5
    ISSN 1124-9390
    ISSN 1124-9390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Improving the efficacy of Chloroquine and Hydroxychloroquine against SARS-CoV-2 may require Zinc additives - A better synergy for future COVID-19 clinical trials

    Shittu, Mujeeb Olushola / Afolami, Olufemi Ifeoluwa

    Infez Med

    Abstract: The recent outbreak of coronavirus disease 2019 (COVID-19), is now officially declared as a pandemic by the World Health Organization. As of now, there is no known effective pharmaceutical agent against the SARS-CoV-2 virus. However, several ... ...

    Abstract The recent outbreak of coronavirus disease 2019 (COVID-19), is now officially declared as a pandemic by the World Health Organization. As of now, there is no known effective pharmaceutical agent against the SARS-CoV-2 virus. However, several precautionary measures have been prescribed to prevent further spread of the virus, which include avoidance of social gatherings, proper handwashing, frequently disinfecting of used items and surfaces and so on. More recent studies have highlighted the possibility of treating patients infected with the novel SARS-CoV-2 virus with chloroquine and hydroxychloroquine, of which mechanism of action is not completely understood. We seek to draw the attention of the scientific community to the possibility of drastically reducing the effects of the virus on the affected patients and improving clinical trials outcome through the synergistic action of zinc and chloroquine in patients suffering from the coronavirus disease.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32335560
    Database COVID19

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  3. Book ; Online: Improving the efficacy of Chloroquine and Hydroxychloroquine against SARS-CoV-2 may require Zinc additives - A better synergy for future COVID-19 clinical trials

    Shittu, Mujeeb Olushola / Afolami, Olufemi Ifeoluwa

    Michigan Tech Publications

    2020  

    Abstract: The recent outbreak of coronavirus disease 2019 (COVID-19), is now officially declared as a pandemic by the World Health Organization. As of now, there is no known effective pharmaceutical agent against the SARS-CoV-2 virus. However, several ... ...

    Abstract The recent outbreak of coronavirus disease 2019 (COVID-19), is now officially declared as a pandemic by the World Health Organization. As of now, there is no known effective pharmaceutical agent against the SARS-CoV-2 virus. However, several precautionary measures have been prescribed to prevent further spread of the virus, which include avoidance of social gatherings, proper handwashing, frequently disinfecting of used items and surfaces and so on. More recent studies have highlighted the possibility of treating patients infected with the novel SARS-CoV-2 virus with chloroquine and hydroxychloroquine, of which mechanism of action is not completely understood. We seek to draw the attention of the scientific community to the possibility of drastically reducing the effects of the virus on the affected patients and improving clinical trials outcome through the synergistic action of zinc and chloroquine in patients suffering from the coronavirus disease.
    Keywords Betacoronavirus ; Chloroquine ; Clinical Trials as Topic ; Coronavirus Infections ; Drug Synergism ; Humans ; Hydroxychloroquine ; Pandemics ; Pneumonia ; Viral ; Zinc ; Department of Biological Sciences ; Biology ; covid19
    Subject code 610
    Publishing date 2020-05-12T07:00:00Z
    Publisher Digital Commons @ Michigan Tech
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Molecular and phenotypic identification of Candida isolates from pregnant women in Ogbomoso, Southwestern Nigeria

    Akinbami Abidemi Nurat / Babalola Gbolahan Ola / Shittu Mujeeb Olushola / Tijani Aramide Mikhail / Adekola Saheed Ayodeji

    International Journal of Reproduction, Contraception, Obstetrics and Gynecology, Vol 5, Iss 2, Pp 317-

    2016  Volume 322

    Abstract: Background: Vulvovaginal candidiasis (VVC), often referred to as a yeast infection is a common gynaecologic disease, affecting 3 out of 4 women in their lifetimes. More than 40% of affected women will have 2 or more VVC episodes, and infection occurs ... ...

    Abstract Background: Vulvovaginal candidiasis (VVC), often referred to as a yeast infection is a common gynaecologic disease, affecting 3 out of 4 women in their lifetimes. More than 40% of affected women will have 2 or more VVC episodes, and infection occurs more frequently in pregnant women. This study was carried out to provide information on the appropriate diagnostic method required to differentiate the causative agents of VVC among pregnant women. Methods: In this study, vaginal specimens were collected from one hundred (100) pregnant women aged between 17-44 years and of gestation age of 14-36 weeks who were attending antenatal clinic at LAUTECH Teaching Hospital, Ogbomoso. The species identification was performed using chromogenic medium, induction of fungal germ tube formation, and PCR using universal primers of internal transcriber spacer (ITS1 and ITS4); (ITS1 [5 and #8242;-TCCGTAGGTGAACCTGCGG-3'] and ITS4 [5 and #8242;-TCCTCCGCTTATTGATATGC-3']) and Candida albicans-specific primers [5'-GGTTTGCTTGAAAGACGGTAG-3'] and [5'-AGTTTGAAGATATACGTGGTAG-3'] that target sequences site of the intergenic spacer region (ITS) of the fungal rRNA genes (18S and 28S) were used for this assay. Results: Forty (40) Candida species from 100 specimens were isolated in Saboraud dextrose agar (SDA) medium. Of 19 strains of C. albicans that were identified by chromogenic agar (CHROMagar), 17 were confirmed as true positive by PCR while 2 were false positive. The CHROMagar had 89.4% sensitivity and 90.4% specificity. In comparison, GTT was better in correctly identifying those strains that were confirmed as C. albicans by PCR (Sensitivity=94%) while CHROMagar was better in identifying the strains that were not confirmed as C. albicans by PCR (Specificity=90.4%). Conclusions: The combine uses of chromogenic agar and PCR have the advantage of efficient differentiation and identification of Candida species. [Int J Reprod Contracept Obstet Gynecol 2016; 5(2.000): 317-322]
    Keywords Candida isolates ; Pregnant women ; Molecular identification ; Gynecology and obstetrics ; RG1-991 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2016-02-01T00:00:00Z
    Publisher Medip Academy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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