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Article ; Online: The Seventeenth International Conference on Endothelin (ET-17).

Gumz, Michelle L / Hyndman, Kelly A

Canadian journal of physiology and pharmacology

2022

Abstract: The Seventeenth International Conference on Endothelin (ET-17) was held during 4-7 October 2021 and because of the SARS-CoV-2 pandemic it was held virtually. Sponsored by the American Physiological Society, ET-17 was held over 4 half-days, with exciting ... ...

Abstract	The Seventeenth International Conference on Endothelin (ET-17) was held during 4-7 October 2021 and because of the SARS-CoV-2 pandemic it was held virtually. Sponsored by the American Physiological Society, ET-17 was held over 4 half-days, with exciting studies related to all organ systems presented. Since the
Language	English
Publishing date	2022-09-28
Publishing country	Canada
Document type	Journal Article
ZDB-ID	127527-6
ISSN	1205-7541 ; 0008-4212
ISSN (online)	1205-7541
ISSN	0008-4212
DOI	10.1139/cjpp-2022-0091
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Zs.A 589: Show issues

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Article: Towards Development of a Non-Toxigenic

Hughes, Jaime / Aston, Carl / Kelly, Michelle L / Griffin, Ruth

Pharmaceutics

2022 Volume 14, Issue 5

Abstract: Clostridioides ... ...

Abstract	Clostridioides difficile
Language	English
Publishing date	2022-05-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14051086
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Article: Nursing Faculty Experiences During the COVID-19 Pandemic Response.

Sacco, Tara L / Kelly, Michelle M

Nursing education perspectives

2021 Volume 42, Issue 5, Page(s) 285–290

Abstract: Aim: The specific aim of the study was to describe nursing faculty experiences during the COVID-19 pandemic.: Background: Academic nursing experiences were disrupted due to the COVID-19 pandemic. There is concern that the resulting stress threatens ... ...

Abstract	Aim: The specific aim of the study was to describe nursing faculty experiences during the COVID-19 pandemic. Background: Academic nursing experiences were disrupted due to the COVID-19 pandemic. There is concern that the resulting stress threatens nursing faculty emotional well-being. Method: A descriptive, quantitative study was conducted, exploring faculty academic and clinical roles during the COVID-19 pandemic, including perception of institutional support provided; faculty burnout, satisfaction, and well-being; and student support needs and well-being. Results: Analyses were performed on 117 quantitative and 49 qualitative responses. Participants perceived support from academic institutions and increased need to provide emotional support to students. Most reported negative effects on well-being but did not report high levels of burnout. Conclusion: Nursing faculty are essential to the profession. Stress responses from the COVID-19 pandemic may not be fully realized. Nursing faculty require proactive and sustained institutional and personal support to provide exceptional ongoing education, build resilience, and support students.
MeSH term(s)	Burnout, Professional ; COVID-19 ; Faculty, Nursing ; Humans ; Pandemics ; SARS-CoV-2 ; Students, Nursing
Language	English
Publishing date	2021-06-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2075410-3
ISSN	1943-4685 ; 1536-5026
ISSN (online)	1943-4685
ISSN	1536-5026
DOI	10.1097/01.NEP.0000000000000843
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Zs.A 3023: Show issues

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Article ; Online: An Environmental Scan of Suicide Prevention Resources for Older Veterans in Primary Care.

Sullivan, Jennifer L / Burns, Benjamin / O'Malley, Kelly / Mlinac, Michelle

Clinical gerontologist

2023 , Page(s) 1–9

Abstract: Objectives: Previous research has identified the critical role of primary care for suicide prevention. Although several suicide prevention resources for primary care already exist, it is unclear how many have been created specifically for older veterans. ...

Abstract	Objectives: Previous research has identified the critical role of primary care for suicide prevention. Although several suicide prevention resources for primary care already exist, it is unclear how many have been created specifically for older veterans. This environmental scan sought to assemble a compendium of suicide prevention resources to be utilized in primary care. Methods: We searched four academic databases, Google Scholar, and Google to identify available suicide prevention resources. Data from 64 resources was extracted and summarized; 15 were general resources and did not meet inclusion criteria. Results: Our scan identified 49 resources with three resources specifically developed for older veterans in primary care. Identified resources shared overlapping content, including implementing a safety plan and lethal means reduction. Conclusion: Although only 10 of the identified resources were exclusively primary care focused, many of the resources had content applicable to suicide prevention in primary care. Clinical implications: Primary care providers can use this compendium of resources to strengthen suicide prevention work within their clinics including: safety planning, lethal means reduction, assessing for risk factors that place older veteran at increased risk of suicide, and mitigating risk factors through referral to programs designed to support older adult health and well-being.
Language	English
Publishing date	2023-07-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	226146-7
ISSN	1545-2301 ; 0731-7115
ISSN (online)	1545-2301
ISSN	0731-7115
DOI	10.1080/07317115.2023.2234901
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Zs.B 2772: Show issues

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Article ; Online: Composite CYP3A (CYP3A4 and CYP3A5) phenotypes and influence on tacrolimus dose adjusted concentrations in adult heart transplant recipients.

Liu, Michelle / Hernandez, Savine / Aquilante, Christina L / Deininger, Kimberly M / Lindenfeld, Joann / Schlendorf, Kelly H / Van Driest, Sara L

The pharmacogenomics journal

2024 Volume 24, Issue 2, Page(s) 4

Abstract: CYP3A5 genetic variants are associated with tacrolimus metabolism. Controversy remains on whether CYP3A4 increased [*1B (rs2740574), *1 G (rs2242480)] and decreased function [*22 (rs35599367)] genetic variants provide additional information. This ... ...

Abstract	CYP3A5 genetic variants are associated with tacrolimus metabolism. Controversy remains on whether CYP3A4 increased [1B (rs2740574), 1 G (rs2242480)] and decreased function [22 (rs35599367)] genetic variants provide additional information. This retrospective cohort study aims to address whether tacrolimus dose-adjusted trough concentrations differ between combined CYP3A (CYP3A5 and CYP3A4) phenotype groups. Heart transplanted patients (n = 177, between 2008 and 2020) were included and median age was 54 years old. Significant differences between CYP3A phenotype groups in tacrolimus dose-adjusted trough concentrations were found in the early postoperative period and continued to 6 months post-transplant. In CYP3A5 nonexpressers, carriers of CYP3A41B or 1 G variants (Group 3) compared to CYP3A41/*1 (Group 2) patients were found to have lower tacrolimus dose-adjusted trough concentrations at 2 months. In addition, significant differences were found among CYP3A phenotype groups in the dose at discharge and time to therapeutic range while time in therapeutic range was not significantly different. A combined CYP3A phenotype interpretation may provide more nuanced genotype-guided TAC dosing in heart transplant recipients.
MeSH term(s)	Adult ; Humans ; Middle Aged ; Tacrolimus ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Immunosuppressive Agents/therapeutic use ; Retrospective Studies ; Polymorphism, Single Nucleotide ; Phenotype ; Genotype ; Heart Transplantation/adverse effects ; Transplant Recipients
Chemical Substances	Tacrolimus (WM0HAQ4WNM) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Immunosuppressive Agents ; CYP3A5 protein, human (EC 1.14.14.1) ; CYP3A4 protein, human (EC 1.14.14.55)
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2106831-8
ISSN	1473-1150 ; 1470-269X
ISSN (online)	1473-1150
ISSN	1470-269X
DOI	10.1038/s41397-024-00325-2
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Zs.A 5806: Show issues

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Article ; Online: Suicides among American Indian/Alaska Native firefighters: Data from the National Violent Death Reporting System, 2003 - 2017.

Pennington, Michelle L / Ylitalo, Kelly R / Thomas, Katharine L / Coe, Elizabeth / Humphries, Mariah / Gulliver, Suzy B

Psychiatry research

2023 Volume 330, Page(s) 115593

Abstract: Suicide is a significant public health problem in the United States and disproportionally affects male American Indian/Alaska Natives (AI/AN). Suicide is particularly problematic among AI/AN firefighters who are more likely to report suicide ideation, ... ...

Abstract	Suicide is a significant public health problem in the United States and disproportionally affects male American Indian/Alaska Natives (AI/AN). Suicide is particularly problematic among AI/AN firefighters who are more likely to report suicide ideation, planning, attempts, and risk compared to non-Hispanic white (NHW) firefighters. The aim of the current study was to compare non-Hispanic AI/AN firefighter and NHW firefighter suicide decedents by demographics and risk/precipitating factors using National Violent Death Reporting System data for 45 male non-Hispanic AI/AN firefighter and 588 male NHW firefighter decedents who died by suicide. Compared to NHW firefighter decedents, AI/AN firefighter decedents were significantly younger and had significantly higher odds of experiencing alcohol use problems and a recent death/suicide of a family member/friend. AI/AN firefighter decedents had significantly lower odds of documented mental health problems, documented diagnosis of depression/dysthymia, receipt of mental health treatment, or leaving a suicide note compared to NHW firefighter decedents. Results from this study may inform tailored suicide prevention and screening efforts among first responders with the goal of lowering suicide mortality among AI/AN firefighters and fire service as a whole.
MeSH term(s)	Humans ; Male ; American Indian or Alaska Native/statistics & numerical data ; Cause of Death ; Firefighters/statistics & numerical data ; United States/epidemiology ; Violence/ethnology ; Violence/statistics & numerical data ; Suicide/ethnology ; Suicide/statistics & numerical data ; White/statistics & numerical data
Language	English
Publishing date	2023-11-05
Publishing country	Ireland
Document type	Comparative Study ; Journal Article
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2023.115593
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Zs.A 1541: Show issues

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Article ; Online: Adolescents' and Parents' Perspectives on a Novel Decision-Making Process for Return of Results in Genomic Research.

Matula, Kelly A / Blumling, Amy A / Myers, Melanie F / McGowan, Michelle L / Lipstein, Ellen A

Journal of empirical research on human research ethics : JERHRE

2023 Volume 18, Issue 4, Page(s) 278–283

Abstract: To understand whether they found a two-step decision process helpful and why, adolescent-parent dyads participating in a study investigating return of genomic testing results were asked about their decision-making experience. Responses were qualitatively ...

Abstract	To understand whether they found a two-step decision process helpful and why, adolescent-parent dyads participating in a study investigating return of genomic testing results were asked about their decision-making experience. Responses were qualitatively coded and analyzed using thematic analysis. Adolescents and parents found both joint and independent decision-making stages helpful. Regarding independent decision-making, adolescents appreciated exercising independence, while parents valued both adolescent and parental independence. Joint decision-making allowed each to hear the other's viewpoints. Some found joint decision-making irrelevant but recognized it might help others. Overall, adolescents and parents had similar reasons for finding the two-step decision-making process helpful. Our findings support using such a process for engaging parents and adolescents in challenging research and clinical decisions.
MeSH term(s)	Humans ; Adolescent ; Decision Making ; Parents ; Genomics
Language	English
Publishing date	2023-07-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2263068-5
ISSN	1556-2654 ; 1556-2646
ISSN (online)	1556-2654
ISSN	1556-2646
DOI	10.1177/15562646231190826
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Article ; Online: Palliative Intent Treatment and Palliative Care Delivery for Individuals With Advanced Nonsmall Cell Lung Cancer and Melanoma: A Patterns of Care Study.

Mollica, Michelle A / Gallicchio, Lisa / Stevens, Jennifer L / Tonorezos, Emily / Jacobsen, Paul B / Filipski, Kelly K / Halpern, Michael T

Journal of palliative medicine

2023 Volume 27, Issue 3, Page(s) 316–323

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/therapy ; Palliative Care ; Lung Neoplasms/therapy ; Melanoma/therapy ; Hospice and Palliative Care Nursing
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1427361-5
ISSN	1557-7740 ; 1096-6218
ISSN (online)	1557-7740
ISSN	1096-6218
DOI	10.1089/jpm.2023.0054
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Zs.A 5440: Show issues

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Article ; Online: STING-Dependent Signaling in Microglia or Peripheral Immune Cells Orchestrates the Early Inflammatory Response and Influences Brain Injury Outcome.

Fritsch, Lauren E / Kelly, Colin / Leonard, John / de Jager, Caroline / Wei, Xiaoran / Brindley, Samantha / Harris, Elizabeth A / Kaloss, Alexandra M / DeFoor, Nicole / Paul, Swagatika / O'Malley, Hannah / Ju, Jing / Olsen, Michelle L / Theus, Michelle H / Pickrell, Alicia M

The Journal of neuroscience : the official journal of the Society for Neuroscience

2024 Volume 44, Issue 12

Abstract: While originally identified as an antiviral pathway, recent work has implicated that cyclic GMP-AMP-synthase-Stimulator of Interferon Genes (cGAS-STING) signaling is playing a critical role in the neuroinflammatory response to traumatic brain injury (TBI) ...

Abstract	While originally identified as an antiviral pathway, recent work has implicated that cyclic GMP-AMP-synthase-Stimulator of Interferon Genes (cGAS-STING) signaling is playing a critical role in the neuroinflammatory response to traumatic brain injury (TBI). STING activation results in a robust inflammatory response characterized by the production of inflammatory cytokines called interferons, as well as hundreds of interferon stimulated genes (ISGs). Global knock-out (KO) mice inhibiting this pathway display neuroprotection with evidence that this pathway is active days after injury; yet, the early neuroinflammatory events stimulated by STING signaling remain understudied. Furthermore, the source of STING signaling during brain injury is unknown. Using a murine controlled cortical impact (CCI) model of TBI, we investigated the peripheral immune and microglial response to injury utilizing male chimeric and conditional STING KO animals, respectively. We demonstrate that peripheral and microglial STING signaling contribute to negative outcomes in cortical lesion volume, cell death, and functional outcomes postinjury. A reduction in overall peripheral immune cell and neutrophil infiltration at the injury site is STING dependent in these models at 24 h. Transcriptomic analysis at 2 h, when STING is active, reveals that microglia drive an early, distinct transcriptional program to elicit proinflammatory genes including interleukin 1-β (IL-1β), which is lost in conditional knock-out mice. The upregulation of alternative innate immune pathways also occurs after injury in these animals, which supports a complex relationship between brain-resident and peripheral immune cells to coordinate the proinflammatory response and immune cell influx to damaged tissue after injury.
MeSH term(s)	Animals ; Male ; Mice ; Brain Injuries, Traumatic/pathology ; Cytokines/metabolism ; Interferons/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/metabolism ; Signal Transduction
Chemical Substances	Cytokines ; Interferons (9008-11-1) ; Sting1 protein, mouse
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.0191-23.2024
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Zs.A 1668: Show issues

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Article ; Online: Health Experiences of African American Mothers, Wellness in the Postpartum Period and Beyond (HEAL): A Qualitative Study Applying a Critical Race Feminist Theoretical Framework.

Ogunwole, S Michelle / Oguntade, Habibat A / Bower, Kelly M / Cooper, Lisa A / Bennett, Wendy L

International journal of environmental research and public health

2023 Volume 20, Issue 13

Abstract: The objective of this study is to explore the cultural, social, and historical factors that affect postpartum primary care utilization among Black women with cardiometabolic risk factors and to identify the needs, barriers, and facilitators that are ... ...

Abstract	The objective of this study is to explore the cultural, social, and historical factors that affect postpartum primary care utilization among Black women with cardiometabolic risk factors and to identify the needs, barriers, and facilitators that are associated with it. We conducted in-depth interviews of 18 Black women with one or more cardiometabolic complications (pre-pregnancy chronic hypertension, diabetes, obesity, preeclampsia, or gestational diabetes) within one year of delivery. We recruited women from three early home-visiting programs in Baltimore, Maryland, between May 2020 and June 2021. We used Critical Race Feminism theory and a behavioral model for healthcare utilization as an analytical lens to develop a codebook and code interview transcripts. We identified and summarized emergent patterns and themes using textual and thematic analysis. We categorized our findings into six main themes: (1) The enduring influence of structural racism, (2) personally mediated racism in healthcare and beyond, (3) sociocultural beliefs about preventative healthcare, (4) barriers to postpartum care transitions, such as education and multidisciplinary communication, (5) facilitators of postpartum care transitions, such as patient-provider relationships and continuity of care, and (6) postpartum health and healthcare needs, such as mental health and social support. Critical race feminism provides a valuable lens for exploring drivers of postpartum primary care utilization while considering the intersectional experiences of Black women.
MeSH term(s)	Female ; Humans ; Pregnancy ; Black or African American ; Feminism ; Mothers ; Postpartum Period ; Qualitative Research ; Maternal Health
Language	English
Publishing date	2023-07-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20136283
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