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  1. Article: Bilateral Dilation of the Superior Ophthalmic Veins-Consequential or Incidental.

    Ferrara, Joseph M / Thornton, Kathryn

    The Neurohospitalist

    2022  Volume 12, Issue 3, Page(s) 583–584

    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2629083-2
    ISSN 1941-8752 ; 1941-8744
    ISSN (online) 1941-8752
    ISSN 1941-8744
    DOI 10.1177/19418744221089783
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  2. Article: Contactin-Associated Protein-Like 2-Related Peripheral Nerve Hyperexcitability Associated With Charcot-Marie-Tooth Type 4F.

    Ferrara, Joseph M / Wiid, Michael / Burke, Sean

    The Neurohospitalist

    2023  Volume 13, Issue 2, Page(s) 164–168

    Abstract: Contactin-associated protein-like 2 autoimmunity is an uncommon disorder resulting in peripheral nerve hyperexcitability or encephalitis. In a fifth of cases, onset may be provoked by thymoma, but other associations are largely unknown. We report a ... ...

    Abstract Contactin-associated protein-like 2 autoimmunity is an uncommon disorder resulting in peripheral nerve hyperexcitability or encephalitis. In a fifth of cases, onset may be provoked by thymoma, but other associations are largely unknown. We report a patient with anti-contactin-associated protein-like 2-related peripheral nerve hyperexcitability arising in the setting of Charcot-Marie-Tooth type 4F and discuss potential mechanisms underlying the association.
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2629083-2
    ISSN 1941-8752 ; 1941-8744
    ISSN (online) 1941-8752
    ISSN 1941-8744
    DOI 10.1177/19418744221140182
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  3. Article ; Online: Diagnosis of orthostatic tremor using smartphone accelerometry.

    Calvo, Nicholas E / Ferrara, Joseph M

    BMC neurology

    2021  Volume 21, Issue 1, Page(s) 457

    Abstract: Background: Primary orthostatic tremor (OT) is a rare movement disorder characterized by a 13-18 Hz leg tremor, which arises when standing and is relieved by walking/sitting. Those affected generally do not fall, but experience fear of falling, lessened ...

    Abstract Background: Primary orthostatic tremor (OT) is a rare movement disorder characterized by a 13-18 Hz leg tremor, which arises when standing and is relieved by walking/sitting. Those affected generally do not fall, but experience fear of falling, lessened by ambulation. Because of its low amplitude, the tremor is not readily visible, and diagnosis requires confirmation with surface electromyography (sEMG). Recently, applications using the accelerometer feature of smartphones have been used to detect and quantify tremors, including OT, though the accuracy of smartphone accelerometry (SPA) in diagnosing OT is unknown.
    Methods: We completed SPA in consecutive adults (18+ years), who presented to our neurology clinic with either subjective leg shakiness upon standing or unsteadiness when standing that lessened with ambulation, which comprised 59 of 2578 patients. We assessed tremor using the StudyMyTremor application on an iPhone 6 s adhered with tape to the patient's tibialis anterior. Surface electromyography was completed on the same muscle. The primary outcome of this study was to determine SPA's sensitivity and specificity in detecting OT compared with surface electromyography.
    Results: Fifty-nine patients with the following diagnoses were included: OT (6), Parkinson's disease, Hereditary Spastic Paraplegia, orthostatic hypotension, essential tremor, spinal cerebellar ataxia, sensory ataxia and functional movement disorder. Smartphone accelerometry detected a 13-18 Hz tremor in 5 of 6 patients diagnosed with OT by sEMG with no false positives in other conditions, yielding a sensitivity of 83%, specificity of 100% in the cohort we studied.
    Conclusions: Though a larger sample size is desirable, preliminary data suggest that smartphone accelerometry is an alternative to surface electromyography in diagnosing OT.
    MeSH term(s) Accelerometry ; Accidental Falls ; Adult ; Electromyography ; Essential Tremor ; Fear ; Humans ; Smartphone ; Tremor/diagnosis
    Language English
    Publishing date 2021-11-22
    Publishing country England
    Document type Journal Article
    ISSN 1471-2377
    ISSN (online) 1471-2377
    DOI 10.1186/s12883-021-02486-0
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  4. Article ; Online: Signal hyperintensity of the callosum after ventriculoperitoneal shunting.

    Ferrara, Joseph M

    Neurology

    2015  Volume 84, Issue 15, Page(s) 1609–1610

    MeSH term(s) Aged ; Corpus Callosum/pathology ; Humans ; Hydrocephalus/surgery ; Magnetic Resonance Imaging/methods ; Male ; Ventriculoperitoneal Shunt
    Language English
    Publishing date 2015-04-14
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000001464
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  5. Article ; Online: CRPS-related neurogenic edema responsive to dextromethorphan/quinidine.

    Ferrara, Joseph M

    Pain medicine (Malden, Mass.)

    2014  Volume 15, Issue 11, Page(s) 1981–1983

    MeSH term(s) Adult ; Causalgia/complications ; Causalgia/drug therapy ; Dextromethorphan/therapeutic use ; Drug Combinations ; Edema/drug therapy ; Edema/etiology ; Female ; Humans ; Leg/pathology ; Quinidine/therapeutic use
    Chemical Substances Drug Combinations ; dextromethorphan - quinidine combination ; Dextromethorphan (7355X3ROTS) ; Quinidine (ITX08688JL)
    Language English
    Publishing date 2014-11
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1111/pme.12539
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  6. Article ; Online: Incidence and risk of attention-deficit/hyperactivity disorder and learning disability by adulthood after traumatic brain injury in childhood: a population-based birth cohort study.

    Brown, Allen W / Esterov, Dmitry / Zielinski, Martin D / Weaver, Amy L / Mara, Kristin C / Ferrara, Michael J / Immermann, Joseph M / Moir, Christopher

    Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence

    2022  Volume 29, Issue 5, Page(s) 808–824

    Abstract: The aim of this study was to understand the risk of developing attention-deficit/hyperactivity disorder (ADHD) or learning disability (LD) after childhood traumatic brain injury (TBI) in a population-based birth cohort. Cases of TBI for children from ... ...

    Abstract The aim of this study was to understand the risk of developing attention-deficit/hyperactivity disorder (ADHD) or learning disability (LD) after childhood traumatic brain injury (TBI) in a population-based birth cohort. Cases of TBI for children from birth to 10 years were confirmed and stratified by severity of injury. For each TBI case, two age-matched and sex-matched referents without TBI were identified from the same birth cohort. Presence of ADHD and LD before age 19 were confirmed using medical and/or school records. Associations between TBI exposure and subsequent ADHD or LD were assessed in multivariable Cox regression models, adjusting for maternal age, education, and race. The incidence rate of TBI before age 10 was 1,156 per 100,000 person-years. Children who had a TBI before age 10 were more likely to have met the research criteria for ADHD (hazard ratio [HR], 1.68; 95% CI, 1.15-2.45) or LD (HR, 1.29; 95% CI, 1.00-1.68) by age 19. No statistically significant associations were shown between TBI and ADHD or LD when restricted to definite and probable TBI cases (consistent with moderate to severe and mild TBI, respectively) and their referents. Significant associations were shown when the analysis was confined to possible TBI cases (consistent with concussive TBI) and their referents (ADHD: HR, 2.05; 95% CI, 1.31-3.20; and LD: HR, 1.42; 95% CI, 1.05-1.91). Increased risk for developing ADHD and LD by adulthood was shown particularly for children with the least-severe injuries, indicating that factors other than trauma-related altered brain function likely contribute to this risk.
    MeSH term(s) Child ; Humans ; Adult ; Young Adult ; Attention Deficit Disorder with Hyperactivity/complications ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Incidence ; Cohort Studies ; Birth Cohort ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/epidemiology ; Learning Disabilities/epidemiology ; Learning Disabilities/etiology ; Brain Injuries/complications ; Brain Concussion/complications
    Language English
    Publishing date 2022-10-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1262599-1
    ISSN 1744-4136 ; 0929-7049
    ISSN (online) 1744-4136
    ISSN 0929-7049
    DOI 10.1080/09297049.2022.2136645
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  7. Article: Management of levodopa-induced jig-like gait disorder with pallidal stimulation.

    Ferrara, Joseph M / Houghton, David J / Knoop, Colleen / Park, Michael C

    Neurology. Clinical practice

    2017  Volume 4, Issue 6, Page(s) 499–501

    Language English
    Publishing date 2017-06-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000000054
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  8. Article: A laboratory-based, low-energy, multi-modal x-ray microscope with user-defined resolution.

    Esposito, Michela / Massimi, Lorenzo / Buchanan, Ian / Ferrara, Joseph D / Endrizzi, Marco / Olivo, Alessandro

    Applied physics letters

    2022  Volume 120, Issue 23, Page(s) 234101

    Abstract: We report on the development of a low-energy x-ray phase-based microscope using intensity-modulation masks for single-shot retrieval of three contrast channels: transmission, refraction, and ultra-small-angle scattering or dark field. The retrieval ... ...

    Abstract We report on the development of a low-energy x-ray phase-based microscope using intensity-modulation masks for single-shot retrieval of three contrast channels: transmission, refraction, and ultra-small-angle scattering or dark field. The retrieval method is based on beam tracking, an incoherent and phase-based imaging approach. We demonstrate that the spatial resolution of this imaging system does not depend on focal spot size nor detector pixel pitch, as opposed to conventional and propagation-based x-ray imaging, and it is only dependent on the mask aperture size. This result enables the development of a multi-resolution microscope where multi-scale samples can be explored on different length scales by adjusting only the mask aperture size, without other modifications. Additionally, we show an extended capability of the system to resolve periodic structures below the resolution limit imposed by the mask apertures, which potentially extends dark-field imaging beyond its conventional use.
    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1469436-0
    ISSN 1077-3118 ; 0003-6951
    ISSN (online) 1077-3118
    ISSN 0003-6951
    DOI 10.1063/5.0082968
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  9. Article ; Online: Technical note: Cartilage imaging with sub-cellular resolution using a laboratory-based phase-contrast x-ray microscope.

    Esposito, Michela / Astolfo, Alberto / Cipiccia, Silvia / Jones, Charlotte Maughan / Savvidis, Savvas / Ferrara, Joseph D / Endrizzi, Marco / Dudhia, Jayesh / Olivo, Alessandro

    Medical physics

    2023  Volume 50, Issue 10, Page(s) 6130–6136

    Abstract: Background: Microscopic imaging of cartilage is a key tool for the study and development of treatments for osteoarthritis. When cellular and sub-cellular resolution is required, histology remains the gold standard approach, albeit limited by the lack of ...

    Abstract Background: Microscopic imaging of cartilage is a key tool for the study and development of treatments for osteoarthritis. When cellular and sub-cellular resolution is required, histology remains the gold standard approach, albeit limited by the lack of volumetric information as well as by processing artifacts. Cartilage imaging with the sub-cellular resolution has only been demonstrated in the synchrotron environment.
    Purpose: To provide a proof-of-concept demonstration of the capability of a laboratory-based x-ray phase-contrast microscope to resolve sub-cellular features in a cartilage sample.
    Methods: This work is based on a laboratory-based x-ray microscope using intensity-modulation masks. The structured nature of the beam, resulting from the mask apertures, allows the retrieval of three contrast channels, namely, transmission, refraction and dark-field, with resolution depending only on the mask aperture width. An ex vivo equine cartilage sample was imaged with the x-ray microscope and results were validated with synchrotron tomography and histology.
    Results: Individual chondrocytes, that is, cells responsible for cartilage formation, could be detected with the laboratory-based microscope. The complementarity of the three retrieved contrast channels allowed the detection of sub-cellular features in the chondrocytes.
    Conclusions: We provide the first proof-of-concept of imaging cartilage tissue with sub-cellular resolution using a laboratory-based x-ray microscope.
    MeSH term(s) Animals ; Horses ; X-Rays ; Radiography ; Cartilage/diagnostic imaging ; Microscopy ; Laboratories
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1002/mp.16599
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  10. Article ; Online: Comparing No-Show Rates of Neurology Outpatients with and without Parkinson's Disease: A Real-World Assessment of the Parkinsonian Personality Profile.

    Bell, Jeremiah Fuller / Wu, Yingxing / Sollinger, Ann B / Muthukattil, Ronex J / Ferrara, Joseph M

    Journal of Parkinson's disease

    2019  Volume 10, Issue 1, Page(s) 347–350

    Abstract: Background: Parkinson's disease (PD) has been hypothesized to be associated with certain personality traits, including conscientiousness and punctuality. However, research aimed at quantifying these traits is largely derived from questionnaire-based ... ...

    Abstract Background: Parkinson's disease (PD) has been hypothesized to be associated with certain personality traits, including conscientiousness and punctuality. However, research aimed at quantifying these traits is largely derived from questionnaire-based personality inventories rather than real-world observations.
    Objective: To explore the presence of a parkinsonian personality profile by assessing the no-show rate of patients with PD versus other neurological disorders.
    Methods: We extracted data from our electronic health record for all neurology appointments over a 78-month interval. Additionally, we obtained primary care appointment data for the same patients over the same timeframe. For each appointment we collected appointment date/time, check-in time, provider, age, sex, insurance type, days between appointment date and scheduling, diagnosis code, and no-show status.
    Results: 19,433 unique patients (400 with PD) accounting for a total of 252,347 outpatient appointments were included in our analysis. The overall no-show rate for PD patients was 3% versus 7.4% for patients with other neurologic disorders (OND). No show rates for PD patients were lower than those with OND for both neurology appointments (2.7% versus 13.6%) and for primary care visits (3.1% versus 5.9%).
    Conclusions: Patients with PD have lower no-show rates than patients with OND. Additionally, the no-show rate for patients with PD did not differ between their neurology and primary care appointments, confirming that patient's personality rather than provider traits account for this difference, and supporting the presence of a parkinsonian personality.
    MeSH term(s) Aged ; Appointments and Schedules ; Electronic Health Records ; Female ; Humans ; Male ; Middle Aged ; Nervous System Diseases/therapy ; Neurologists/statistics & numerical data ; No-Show Patients/statistics & numerical data ; Parkinson Disease/physiopathology ; Parkinson Disease/therapy ; Personality/physiology ; Primary Health Care/statistics & numerical data
    Language English
    Publishing date 2019-10-08
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 2620609-2
    ISSN 1877-718X ; 1877-7171
    ISSN (online) 1877-718X
    ISSN 1877-7171
    DOI 10.3233/JPD-191651
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