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  1. Book ; Online ; E-Book: Heart failure

    Bauersachs, Johann / Butler, Javed / Sandner, Peter

    (Handbook of experimental pharmacology ; 243)

    2017  

    Author's details Johann Bauersachs, Javed Butler, Peter Sandner editors
    Series title Handbook of experimental pharmacology ; 243
    Collection
    Keywords Heart Failure / therapy
    Language English
    Size 1 Online-Ressource (ix, 581 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019415511
    ISBN 978-3-319-59659-4 ; 9783319596587 ; 3-319-59659-4 ; 3319596586
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Mechanobiology of dynamic enzyme systems.

    Butler, Peter J

    APL bioengineering

    2020  Volume 4, Issue 1, Page(s) 10907

    Abstract: This Perspective paper advances a hypothesis of mechanosensation by endothelial cells in which the cell is a dynamic crowded system, driven by continuous enzyme activity, that can be shifted from one non-equilibrium state to another by external force. ... ...

    Abstract This Perspective paper advances a hypothesis of mechanosensation by endothelial cells in which the cell is a dynamic crowded system, driven by continuous enzyme activity, that can be shifted from one non-equilibrium state to another by external force. The nature of the shift will depend on the direction, rate of change, and magnitude of the force. Whether force induces a pathophysiological or physiological change in cell biology will be determined by whether the dynamics of a cellular system can accommodate the dynamics and magnitude of the force application. The complex interplay of non-static cytoskeletal structures governs internal cellular rheology, dynamic spatial reorganization, and chemical kinetics of proteins such as integrins, and a flaccid membrane that is dynamically supported; each may constitute the necessary dynamic properties able to sense external fluid shear stress and reorganize in two and three dimensions. The resulting reorganization of enzyme systems in the cell membrane and cytoplasm may drive the cell to a new physiological state. This review focuses on endothelial cell mechanotransduction of shear stress, but may lead to new avenues of investigation of mechanobiology in general requiring new tools for interrogation of mechanobiological systems, tools that will enable the synthesis of large amounts of spatial and temporal data at the molecular, cellular, and system levels.
    Language English
    Publishing date 2020-03-03
    Publishing country United States
    Document type Journal Article
    ISSN 2473-2877
    ISSN (online) 2473-2877
    DOI 10.1063/1.5133645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploring the mechanisms behind autologous lipotransfer for radiation-induced fibrosis: A systematic review.

    Pattani, Nikhil / Sanghera, Jaspinder / Langridge, Benjamin J / Frommer, Marvin L / Abu-Hanna, Jeries / Butler, Peter

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0292013

    Abstract: Aim: Radiation-induced fibrosis is a recognised consequence of radiotherapy, especially after multiple and prolonged dosing regimens. There is no definitive treatment for late-stage radiation-induced fibrosis, although the use of autologous fat transfer ...

    Abstract Aim: Radiation-induced fibrosis is a recognised consequence of radiotherapy, especially after multiple and prolonged dosing regimens. There is no definitive treatment for late-stage radiation-induced fibrosis, although the use of autologous fat transfer has shown promise. However, the exact mechanisms by which this improves radiation-induced fibrosis remain poorly understood. We aim to explore existing literature on the effects of autologous fat transfer on both in-vitro and in-vivo radiation-induced fibrosis models, and to collate potential mechanisms of action.
    Method: PubMed, Cochrane reviews and Scopus electronic databases from inception to May 2023 were searched. Our search strategy combined both free-text terms with Boolean operators, derived from synonyms of adipose tissue and radiation-induced fibrosis.
    Results: The search strategy produced 2909 articles. Of these, 90 underwent full-text review for eligibility, yielding 31 for final analysis. Nine conducted in-vitro experiments utilising a co-culture model, whilst 25 conducted in-vivo experiments. Interventions under autologous fat transfer included adipose-derived stem cells, stromal vascular function, whole fat and microfat. Notable findings include downregulation of fibroblast proliferation, collagen deposition, epithelial cell apoptosis, and proinflammatory processes. Autologous fat transfer suppressed hypoxia and pro-inflammatory interferon-γ signalling pathways, and tissue treated with adipose-derived stem cells stained strongly for anti-inflammatory M2 macrophages. Although largely proangiogenic initially, studies show varying effects on vascularisation. There is early evidence that adipose-derived stem cell subgroups may have different functional properties.
    Conclusion: Autologous fat transfer functions through pro-angiogenic, anti-fibrotic, immunomodulatory, and extracellular matrix remodelling properties. By characterising these mechanisms, relevant drug targets can be identified and used to further improve clinical outcomes in radiation-induced fibrosis. Further research should focus on adipose-derived stem cell sub-populations and augmentation techniques such as cell-assisted lipotransfer.
    MeSH term(s) Humans ; Radiation Fibrosis Syndrome ; Adipose Tissue ; Adipocytes/physiology ; Transplantation, Autologous ; Fibrosis
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0292013
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  4. Article ; Online: Adropin and insulin resistance: Integration of endocrine, circadian, and stress signals regulating glucose metabolism.

    Butler, Andrew A / Havel, Peter J

    Obesity (Silver Spring, Md.)

    2021  Volume 29, Issue 11, Page(s) 1799–1801

    Abstract: Dysregulation of hepatic glucose production (HGP) and glucose disposal leads to hyperglycemia and type 2 diabetes. Hyperglycemia results from the declining ability of insulin to reduce HGP and increase glucose disposal, as well as inadequate ß-cell ... ...

    Abstract Dysregulation of hepatic glucose production (HGP) and glucose disposal leads to hyperglycemia and type 2 diabetes. Hyperglycemia results from the declining ability of insulin to reduce HGP and increase glucose disposal, as well as inadequate ß-cell compensation for insulin resistance. Hyperglucagonemia resulting from reduced suppression of glucagon secretion by insulin contributes to hyperglycemia by stimulating HGP. The actions of pancreatic hormones are normally complemented by peptides secreted by cells distributed throughout the body. This regulatory network has provided new therapeutics for obesity and type 2 diabetes (e.g., glucagon-like peptide 1). Other peptide hormones under investigation show promise in preclinical studies. Recent experiments using mice and nonhuman primates indicate the small secreted peptide hormone adropin regulates glucose metabolism. Here, recent expression profiling data indicating hepatic adropin expression increases with oxidative stress and declines with fasting or in the presence of hepatic insulin resistance and how adropin interacts with the pancreatic hormones, insulin, and glucagon to modulate glycemic control are discussed.
    MeSH term(s) Animals ; Blood Glucose ; Diabetes Mellitus, Type 2 ; Fasting ; Glucose ; Insulin ; Insulin Resistance ; Liver ; Mice
    Chemical Substances Blood Glucose ; Insulin ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-09-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.23249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4061: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 87: Show issues

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  5. Article ; Online: Facial Selectivity in Mechanical Bond Formation: Axially Chiral Enantiomers and Geometric Isomers from a Simple Prochiral Macrocycle.

    Gallagher, Peter R / Savoini, Andrea / Saady, Abed / Maynard, John R J / Butler, Patrick W V / Tizzard, Graham J / Goldup, Stephen M

    Journal of the American Chemical Society

    2024  Volume 146, Issue 13, Page(s) 9134–9141

    Abstract: In 1971, Schill recognized that a prochiral macrocycle encircling an oriented axle led to geometric isomerism in rotaxanes. More recently, we identified an overlooked chiral stereogenic unit in rotaxanes that arises when a prochiral macrocycle encircles ... ...

    Abstract In 1971, Schill recognized that a prochiral macrocycle encircling an oriented axle led to geometric isomerism in rotaxanes. More recently, we identified an overlooked chiral stereogenic unit in rotaxanes that arises when a prochiral macrocycle encircles a prochiral axle. Here, we show that both stereogenic units can be accessed using equivalent strategies, with a single weak stereodifferentiating interaction sufficient for moderate to excellent stereoselectivity. Using this understanding, we demonstrated the first direct enantioselective (70%
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c14329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

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  6. Article ; Online: Correlation between oral and oropharyngeal resection subsites and impact of reconstruction on speech and swallowing function in head and neck cancer patients: A systematic review.

    Awad, Laura / Langridge, Benjamin J / Noy, Dani / Govender, Roganie / Sinha, Deepti / Butler, Peter Em / Kalavrezos, Nicholas

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

    2024  

    Abstract: This review aims to provide a correlation between oral and oropharyngeal subsites and type of reconstruction used in the management of head and neck cancer patients. A literature search of PubMed, Embase and Web of Science was conducted. All study types ... ...

    Abstract This review aims to provide a correlation between oral and oropharyngeal subsites and type of reconstruction used in the management of head and neck cancer patients. A literature search of PubMed, Embase and Web of Science was conducted. All study types describing long-term speech and swallow outcomes of adults following head and neck oncological reconstruction, which used a subsite classification, were included. Risk of bias was assessed using the Robbins-1 tool. A total of 2270 patients were found in 26 studies. The number of subsites/studies ranged from 2 to 18. Subsites were predominantly divided on an anatomical basis. Other classifications included functionally grouped subsites. Seven articles considered combinations, unilateral and bilateral defects. Base of tongue, FOM, and defects crossing the midline are negatively correlated with post-operative speech and swallow. Lateral distributions were associated with superior outcomes. The University of Washington Quality of Life Questionnaire (UW-QOL) was the most prevalent tool for speech and swallow assessment. Other factors that significantly affect speech and swallow outcomes include adjuvant therapy, size, type of reconstruction (free flap compared to pedicled or local). The role of neoadjuvant therapy remains unknown. A consistent and formalised approach including risk stratification for multiple contributing factors would be useful in clinical pre- and post-operative management.
    Language English
    Publishing date 2024-01-18
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 91267-0
    ISSN 1878-4119 ; 1010-5182 ; 0301-0503
    ISSN (online) 1878-4119
    ISSN 1010-5182 ; 0301-0503
    DOI 10.1016/j.jcms.2024.01.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 882: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: A comparison of commercially available synthetic skin substitutes for surgical simulation training.

    Awad, Laura / Langridge, Benjamin J / Jeon, Faith H K / Bollen, Edward / Butler, Peter E M

    GMS journal for medical education

    2023  Volume 40, Issue 5, Page(s) Doc62

    Abstract: Objective: Simulation training provides an important opportunity to accelerate surgical skills acquisition whilst safeguarding patients. This study compares the suitability of different synthetic skin substitutes for use in surgical simulation training.! ...

    Abstract Objective: Simulation training provides an important opportunity to accelerate surgical skills acquisition whilst safeguarding patients. This study compares the suitability of different synthetic skin substitutes for use in surgical simulation training.
    Design: Data was collected for eight commercially available synthetic skin substitutes and included cost, delivery time, subjective assessment of fidelity by surgeons and trainees, and objective comparison with the biomechanics of human skin was made through cutometry and durometry measurements. Cutometry and durometry data was collected from three healthy adults from the forearm, forehead and back, with measurements being repeated in triplicate. Subjective assessment of skin pad quality was collected using an 8-criteria questionnaire, graded using a 5-point Likert scale for fidelity to normal skin.
    Results: The questionnaire assessment was completed by 30 trainees and practitioners. Overall, felt pads received the poorest outcomes in all criteria; cutometry and durometry results demonstrate poor similarity to skin, and felt received the lowest scores in the questionnaire, although the cheapest. Foam dressings were similar in both cutometric and durometric properties to skin of the face, back and arm. Clinical outcomes of foam dressings were similar to the most expensive commercial skin pad.
    Conclusions: Bilaminar foam-based dressings provide a low cost, high fidelity non-biological simulation of skin for surgical training, which is non-inferior to more expensive specifically designed products. Many products designed to act as skin substitutes for surgical simulation fail to adequately replicate the anatomical and mechanical properties of skin.
    MeSH term(s) Adult ; Humans ; Skin, Artificial ; Simulation Training/methods ; Computer Simulation ; Clinical Competence
    Language English
    Publishing date 2023-09-15
    Publishing country Germany
    Document type Journal Article
    ISSN 2366-5017
    ISSN (online) 2366-5017
    DOI 10.3205/zma001644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Mechanobiology of the abluminal glycocalyx.

    Butler, Peter J / Bhatnagar, Amit

    Biorheology

    2019  Volume 56, Issue 2-3, Page(s) 101–112

    Abstract: Background: Endothelial cells (ECs) sense the forces from blood flow through the glycocalyx, a carbohydrate rich luminal surface layer decorating most cells, and through forces transmitted through focal adhesions (FAs) on the abluminal side of the cell.! ...

    Abstract Background: Endothelial cells (ECs) sense the forces from blood flow through the glycocalyx, a carbohydrate rich luminal surface layer decorating most cells, and through forces transmitted through focal adhesions (FAs) on the abluminal side of the cell.
    Objectives: This perspective paper explores a complementary hypothesis, that glycocalyx molecules on the abluminal side of the EC between the basement membrane and the EC membrane, occupying the space outside of FAs, work in concert with FAs to sense blood flow-induced shear stress applied to the luminal surface.
    Results: First, we summarize recent studies suggesting that the glycocalyx repels the plasma membrane away from the basement membrane, while integrin molecules attach to extracellular matrix (ECM) ligands. This coordinated attraction and repulsion results in the focal nature of integrin-mediated adhesion making the abluminal glycocalyx a participant in mechanotransduction. Further, the glycocalyx mechanically links the plasma membrane to the basement membrane providing a mechanism of force transduction when the cell deforms in the peri-FA space. To determine if the membrane might deform against a restoring force of an elastic abluminal glycocalyx in the peri-FA space we present some analysis from a multicomponent elastic finite element model of a sheared and focally adhered endothelial cell whose abluminal topography was assessed using quantitative total internal reflection fluorescence microscopy with an assumption that glycocalyx fills the space between the membrane and extracellular matrix.
    Conclusions: While requiring experimental verification, this analysis supports the hypothesis that shear on the luminal surface can be transmitted to the abluminal surface and deform the cell in the vicinity of the focal adhesions, with the magnitude of deformation depending on the abluminal glycocalyx modulus.
    MeSH term(s) Animals ; Aorta/physiology ; Basement Membrane/physiology ; Cattle ; Computer Simulation ; Endothelial Cells/physiology ; Endothelium, Vascular/physiology ; Finite Element Analysis ; Focal Adhesions/physiology ; Glycocalyx/physiology ; Mechanotransduction, Cellular/physiology ; Models, Molecular
    Language English
    Publishing date 2019-11-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 82015-5
    ISSN 1878-5034 ; 0006-355X
    ISSN (online) 1878-5034
    ISSN 0006-355X
    DOI 10.3233/BIR-190212
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 394: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Prostate Cancer in Transgender Women in the Veterans Affairs Health System, 2000-2022.

    Nik-Ahd, Farnoosh / De Hoedt, Amanda / Butler, Christi / Anger, Jennifer T / Carroll, Peter R / Cooperberg, Matthew R / Freedland, Stephen J

    JAMA

    2023  Volume 329, Issue 21, Page(s) 1877–1879

    MeSH term(s) Humans ; Male ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/therapy ; Transgender Persons/statistics & numerical data ; United States/epidemiology ; United States Department of Veterans Affairs/statistics & numerical data ; Veterans/statistics & numerical data ; Veterans Health/statistics & numerical data ; Female ; Veterans Health Services/statistics & numerical data
    Language English
    Publishing date 2023-04-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.6028
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Single-Cell Analysis of ADSC Interactions with Fibroblasts and Endothelial Cells in Scleroderma Skin.

    Frommer, Marvin L / Langridge, Benjamin J / Awad, Laura / Jasionowska, Sara / Denton, Christopher P / Abraham, David J / Abu-Hanna, Jeries / Butler, Peter E M

    Cells

    2023  Volume 12, Issue 13

    Abstract: Adipose-derived stem cells (ADSCs) as part of autologous fat grafting have anti-fibrotic and anti-inflammatory effects, but the exact mechanisms of action remain unknown. By simulating the interaction of ADSCs with fibroblasts and endothelial cells (EC) ... ...

    Abstract Adipose-derived stem cells (ADSCs) as part of autologous fat grafting have anti-fibrotic and anti-inflammatory effects, but the exact mechanisms of action remain unknown. By simulating the interaction of ADSCs with fibroblasts and endothelial cells (EC) from scleroderma (SSc) skin in silico, we aim to unravel these mechanisms. Publicly available single-cell RNA sequencing data from the stromal vascular fraction of 3 lean patients and biopsies from the skin of 10 control and 12 patients with SSc were obtained from the GEO and analysed using R and Seurat. Differentially expressed genes were used to compare the fibroblast and EC transcriptome between controls and SSc. GO and KEGG functional enrichment was performed. Ligand-receptor interactions of ADSCs with fibroblasts and ECs were explored with LIANA. Pro-inflammatory and extracellular matrix (ECM) interacting fibroblasts were identified in SSc. Arterial, capillary, venous and lymphatic ECs showed a pro-fibrotic and pro-inflammatory transcriptome. Most interactions with both cell types were based on ECM proteins. Differential interactions identified included
    MeSH term(s) Humans ; Endothelial Cells/metabolism ; Skin/pathology ; Adipocytes/pathology ; Fibroblasts/metabolism ; Fibrosis ; Single-Cell Analysis ; Fibronectins/metabolism
    Chemical Substances FNDC5 protein, human ; Fibronectins
    Language English
    Publishing date 2023-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12131784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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