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Article ; Online: In COVID-19, therapeutic vs. prophylactic anticoagulation did not improve clinical outcomes and increased bleeding.

Diep, Robert / Garcia, David

2021 Volume 174, Issue 10, Page(s) JC112

Abstract: Source citation: Lopes RD, de Barros E Silva PG, Furtado RH, et al. ...

Abstract	Source citation: Lopes RD, de Barros E Silva PG, Furtado RH, et al.
MeSH term(s)	Anticoagulants ; COVID-19 ; Hemorrhage ; Hospitalization ; Humans ; SARS-CoV-2
Chemical Substances	Anticoagulants
Language	English
Publishing date	2021-10-05
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/ACPJ202110190-112
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Article ; Online: Should we monitor the direct oral anticoagulants?

Diep, Robert / Garcia, David

Journal of thrombosis and thrombolysis

2020 Volume 50, Issue 1, Page(s) 30–32

MeSH term(s)	Atrial Fibrillation/drug therapy ; Drug Monitoring/methods ; Factor Xa Inhibitors/administration & dosage ; Factor Xa Inhibitors/adverse effects ; Factor Xa Inhibitors/pharmacokinetics ; Hemorrhage/chemically induced ; Hemorrhage/prevention & control ; Humans ; Prognosis ; Risk Adjustment/methods ; Risk Assessment ; Stroke/etiology ; Stroke/prevention & control ; Venous Thromboembolism/drug therapy
Chemical Substances	Factor Xa Inhibitors
Language	English
Publishing date	2020-04-22
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-020-02119-2
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Zs.A 4352: Show issues

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Article ; Online: Does aspirin prevent venous thromboembolism?

Diep, Robert / Garcia, David

Hematology. American Society of Hematology. Education Program

2020 Volume 2020, Issue 1, Page(s) 634–641

Abstract: Venous thromboembolism (VTE; deep vein thrombosis and/or pulmonary embolism) is a well-established cause of morbidity and mortality in the medical and surgical patient populations. Clinical research in the prevention and treatment of VTE has been a ... ...

Abstract	Venous thromboembolism (VTE; deep vein thrombosis and/or pulmonary embolism) is a well-established cause of morbidity and mortality in the medical and surgical patient populations. Clinical research in the prevention and treatment of VTE has been a dynamic field of study, with investigations into various treatment modalities ranging from mechanical prophylaxis to the direct oral anticoagulants. Aspirin has long been an inexpensive cornerstone of arterial vascular disease therapy, but its role in the primary or secondary prophylaxis of VTE has been debated. Risk-benefit tradeoffs between aspirin and anticoagulants have changed, in part due to advances in surgical technique and postoperative care, and in part due to the development of safe, easy-to-use oral anticoagulants. We review the proposed mechanisms in which aspirin may act on venous thrombosis, the evidence for aspirin use in the primary and secondary prophylaxis of VTE, and the risk of bleeding with aspirin as compared with anticoagulation.
MeSH term(s)	Administration, Oral ; Aged ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Aspirin/adverse effects ; Aspirin/therapeutic use ; Hemorrhage/chemically induced ; Hemorrhage/prevention & control ; Humans ; Male ; Venous Thromboembolism/prevention & control
Chemical Substances	Anticoagulants ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2020-12-04
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2084287-9
ISSN	1520-4383 ; 1520-4391
ISSN (online)	1520-4383
ISSN	1520-4391
DOI	10.1182/hematology.2020000150
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Article ; Online: A prospective observational cohort study of covid-19 epidemiology and vaccine seroconversion in South Western Sydney, Australia, during the 2021-2022 pandemic period.

Potter, Daniela / Diep, Jason / Munro, Colleen / Lin, Noelle / Xu, Ramon / Wong, Jeffrey / Porritt, Robert / Maley, Michael / Foo, Hong / Makris, Angela

BMC nephrology

2024 Volume 25, Issue 1, Page(s) 131

Abstract: Background: It is known that COVID-19 disproportionally adversely affects the immunocompromised, including kidney transplant recipients (KTR), as compared to the general population. Risk factors for adverse outcomes and vaccine seroconversion patterns ... ...

Abstract	Background: It is known that COVID-19 disproportionally adversely affects the immunocompromised, including kidney transplant recipients (KTR), as compared to the general population. Risk factors for adverse outcomes and vaccine seroconversion patterns are not fully understood. Australia was uniquely positioned to reduce initial case numbers during the 2021-2022 pandemic period due to its relative isolation and several significant public health interventions. South-Western Sydney Local Heath District was one of the predominant regions affected. Methods: A single centre, prospective cohort study of prevalent renal transplant recipients was conducted between 25th July 2021 and 1st May 2022. Baseline characteristics, COVID-19 vaccination status, COVID-19 diagnosis and outcomes were determined from the electronic medical record, Australian vaccination register and Australian and New Zealand Dialysis and Transplant Registry. Assessment of vaccine-induced seroconversion was assessed with ELISA in a subpopulation. Analysis was performed using SPSS v.28. Results: We identified 444 prevalent transplant recipients (60% male, 50% diabetic, median age 58 years (Interquartile range (IQR)21.0) and eGFR 56 ml/min/1.73m Conclusions: COVID-19 was associated with a high mortality rate. Older age, respiratory disease and prior smoking exposure may be risk factors for increased mortality. Vaccination of 3 doses is protective against acquiring COVID-19 and death, however not hospitalisation. Antibody response is protective for acquiring COVID-19, however seroconversion rates are low.
MeSH term(s)	Humans ; Male ; Middle Aged ; Female ; Prospective Studies ; Australia/epidemiology ; COVID-19 Testing ; COVID-19 Vaccines ; Pandemics ; Seroconversion ; COVID-19/epidemiology ; COVID-19/prevention & control ; Renal Dialysis ; Vaccines
Chemical Substances	COVID-19 Vaccines ; Vaccines
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-024-03560-8
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Article ; Online: A rare CALR variant mutation and a review of CALR in essential thrombocythemia.

Diep, Robert / Metjian, Ara

Journal of thrombosis and thrombolysis

2018 Volume 45, Issue 3, Page(s) 457–462

Abstract: Essential thrombocythemia (ET) is an indolent myeloproliferative neoplasm characterized by megakaryocyte hyperplasia, thrombocytosis, thrombotic and hemorrhagic complications, and potential transformation into myelofibrosis and acute myeloid leukemia. ... ...

Abstract	Essential thrombocythemia (ET) is an indolent myeloproliferative neoplasm characterized by megakaryocyte hyperplasia, thrombocytosis, thrombotic and hemorrhagic complications, and potential transformation into myelofibrosis and acute myeloid leukemia. The vast majority of cases are driven by a somatic mutation in JAK2, CALR, or MPL. CALR, a gene that codes for the calcium-binding chaperone calreticulin, is the predominant mutation in patients with non-mutated JAK2 essential thrombocythemia, accounting for 20-25% of the overall somatic mutation frequency in ET. In this brief review of ET, we introduce a rare CALR mutation through a case presentation of a 58-year-old man with diffuse pulmonary emboli in the setting of thrombocytosis. We subsequently characterize the main types of CALR mutations and their value in diagnosis and prognosis of disease course, and lastly discuss the current clinical approach to ET.
MeSH term(s)	Calreticulin/genetics ; Humans ; Male ; Middle Aged ; Mutation ; Prognosis ; Pulmonary Embolism ; Thrombocythemia, Essential/diagnosis ; Thrombocythemia, Essential/genetics
Chemical Substances	CALR protein, human ; Calreticulin
Language	English
Publishing date	2018-01-13
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-018-1619-0
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Zs.A 4352: Show issues

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Article: Stevens-Johnson Syndrome in a Patient of Color: A Case Report and an Assessment of Diversity in Medical Education Resources.

Diep, Darlene / Aluri, Bineetha / Crane, Alison / Miao, Kathleen / Kannan, Kamilah S / Goldsteen, Robert

Cureus

2022 Volume 14, Issue 2, Page(s) e22245

Abstract: This is a review of a patient encounter that underscores the common trend of insufficient inclusivity and lack of diversity regarding skin of color representation in teaching materials including textbooks in the medical education setup. A Black woman who ...

Abstract	This is a review of a patient encounter that underscores the common trend of insufficient inclusivity and lack of diversity regarding skin of color representation in teaching materials including textbooks in the medical education setup. A Black woman who was treated with carbamazepine for trigeminal neuralgia after a dental procedure presented with upper airway breathing difficulties and facial pain and swelling. After doubling her dose of carbamazepine as advised by her primary care physician, her symptoms continued to worsen, and she was treated in the emergency department for a presumed allergic reaction of unknown etiology. Two days later, her symptoms progressively worsened. She self-admitted to the emergency department, where she required cardiopulmonary resuscitation. Eventually, the formal diagnosis of carbamazepine-induced Stevens-Johnson syndrome (SJS) was made based on history, clinical presentation, and skin biopsy. The nature of the disease progression in this case prompted our investigation into the lack of representation of skin of color in current medical training resources regarding SJS. Our assessment demonstrates that there is a significant underrepresentation of SJS in skin of color in medical educational resources. Increased inclusivity of skin disorders in patients of color is crucial in training healthcare professionals to recognize life-threatening cutaneous disorders quickly and accurately in such patients.
Language	English
Publishing date	2022-02-15
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.22245
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Article ; Online: Pregnancy in patients with thrombocytopenia and absent radii (TAR) syndrome.

Diep, Robert T / Arcasoy, Murat O

Annals of hematology

2017 Volume 96, Issue 9, Page(s) 1589–1590

MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Female ; Fetal Growth Retardation/etiology ; Humans ; Infant, Newborn ; Platelet Transfusion ; Pregnancy ; Pregnancy Complications, Hematologic/blood ; Pregnancy Complications, Hematologic/therapy ; Radius ; Thrombocytopenia/blood ; Upper Extremity Deformities, Congenital/blood ; Young Adult
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2017-07-20
Publishing country	Germany
Document type	Case Reports ; Letter
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-017-3053-3
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Uh III Zs.181: Show issues

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Article ; Online: Real world prognostic utility of platelet lymphocyte ratio and nutritional status in first-line immunotherapy response in stage IV non-small cell lung cancer.

MacDonald, Madeline / Poei, Darin / Leyba, Alexis / Diep, Raymond / Chennapan, Krithika / Leon, Christopher / Xia, Bing / Nieva, Jorge J / Hsu, Robert

Cancer treatment and research communications

2023 Volume 36, Page(s) 100752

Abstract: Background: Elevated platelet lymphocyte ratio (PLR) and low body mass index (BMI) are associated with inferior survival in non-small cell lung cancer (NSCLC) patients receiving immunotherapy (IO). We evaluated real-world prognostic utility of PLR, BMI, ...

Abstract	Background: Elevated platelet lymphocyte ratio (PLR) and low body mass index (BMI) are associated with inferior survival in non-small cell lung cancer (NSCLC) patients receiving immunotherapy (IO). We evaluated real-world prognostic utility of PLR, BMI, and albumin level in stage IV NSCLC patients receiving first line (1L) IO. Methods: We identified 75 stage IV patients who received 1L IO therapy at USC Norris Comprehensive Cancer Center and Los Angeles General Medical Center from 2015 to 2022. The primary outcome was overall survival (OS) from time of IO with attention to pre-treatment BMI < 22, albumin < 3.5 g/dL, and PLR > 180. Results: Median age was 66.5 years with 49 (65.3%) males. 25 (33.3%) had BMI < 22. 45/75 (60%) had PLR > 180. Patients with BMI < 22 had inferior OS (13.1 months (m) vs. 37.4 m in BMI > 28, p-value = 0.042) along with patients with albumin<3.5 g/dL (OS: 2.8 m vs. 14.6 m, p-value = 0.0027), and patients with PLR>180 (OS: 8.7 m vs. 23.0 m, p = 0.028). Composite BMI < 22, PLR > 180 had the worst OS, p-value = 0.0331. Multivariate analysis controlling for age, smoking, gender, PD-L1 tumor proportion score (TPS), and histology (adenocarcinoma, squamous, adenosquamous, and large cell) showed that BMI (HR: 0.8726, 95% CI: 0.7892-0.954) and PLR > 180 (HR: 2.48, 95% CI: 1.076-6.055) were significant in OS mortality risk. Conclusion: Patients with a composite of BMI < 22, albumin < 3.5 g/dL, and PLR > 180 had significantly worse OS. This highlights the importance of screening for poor nutritional status and high PLR to better inform stage IV NSCLC patients receiving IO therapy of their prognosis and supportive care. Microabstract: We evaluated real-world prognostic utility of platelet lymphocyte ratio (PLR), body mass index (BMI), and albumin level in 75 Stage IV NSCLC patients receiving first line IO. Patients with a composite of BMI < 22, albumin < 3.5 g/dL, and PLR > 180 had significantly worse OS. This highlights the importance of screening for poor nutritional status and high PLR to better inform stage IV NSCLC patients of their prognosis and to emphasize supportive care needs.
MeSH term(s)	Male ; Humans ; Aged ; Female ; Nutritional Status ; Carcinoma, Non-Small-Cell Lung/therapy ; Prognosis ; Lung Neoplasms/therapy ; Immunotherapy ; Albumins ; Lymphocytes
Chemical Substances	Albumins
Language	English
Publishing date	2023-08-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2468-2942
ISSN (online)	2468-2942
DOI	10.1016/j.ctarc.2023.100752
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Article ; Online: A novel nucleotide substitution in the 5' untranslated region of ANKRD26 gene is associated with inherited thrombocytopenia: a report of two new families.

Diep, Robert T / Corey, Kristin / Arcasoy, Murat O

Annals of hematology

2019 Volume 98, Issue 7, Page(s) 1789–1791

MeSH term(s)	5' Untranslated Regions ; Adult ; Aged ; Family ; Female ; Genetic Diseases, Inborn/genetics ; Humans ; Mutation, Missense ; Nuclear Proteins/genetics ; Thrombocytopenia/genetics
Chemical Substances	5' Untranslated Regions ; ANKRD26 protein, human ; Nuclear Proteins
Language	English
Publishing date	2019-02-12
Publishing country	Germany
Document type	Letter
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-019-03632-y
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Uh III Zs.181: Show issues

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Article ; Online: The role of SWEET4 proteins in the post-phloem sugar transport pathway of Setaria viridis sink tissues.

Chen, Lily / Ganguly, Diep R / Shafik, Sarah H / Danila, Florence / Grof, Christopher P L / Sharwood, Robert E / Furbank, Robert T

Journal of experimental botany

2023 Volume 74, Issue 10, Page(s) 2968–2986

Abstract: In the developing seeds of all higher plants, filial cells are symplastically isolated from the maternal tissue supplying photosynthate to the reproductive structure. Photoassimilates must be transported apoplastically, crossing several membrane barriers, ...

Abstract	In the developing seeds of all higher plants, filial cells are symplastically isolated from the maternal tissue supplying photosynthate to the reproductive structure. Photoassimilates must be transported apoplastically, crossing several membrane barriers, a process facilitated by sugar transporters. Sugars Will Eventually be Exported Transporters (SWEETs) have been proposed to play a crucial role in apoplastic sugar transport during phloem unloading and the post-phloem pathway in sink tissues. Evidence for this is presented here for developing seeds of the C4 model grass Setaria viridis. Using immunolocalization, SvSWEET4 was detected in various maternal and filial tissues within the seed along the sugar transport pathway, in the vascular parenchyma of the pedicel, and in the xylem parenchyma of the stem. Expression of SvSWEET4a in Xenopus laevis oocytes indicated that it functions as a high-capacity glucose and sucrose transporter. Carbohydrate and transcriptional profiling of Setaria seed heads showed that there were some developmental shifts in hexose and sucrose content and consistent expression of SvSWEET4 homologues. Collectively, these results provide evidence for the involvement of SWEETs in the apoplastic transport pathway of sink tissues and allow a pathway for post-phloem sugar transport into the seed to be proposed.
MeSH term(s)	Sugars/metabolism ; Setaria Plant/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Phloem/metabolism ; Biological Transport ; Membrane Transport Proteins/metabolism ; Sucrose/metabolism
Chemical Substances	Sugars ; Plant Proteins ; Membrane Transport Proteins ; Sucrose (57-50-1)
Language	English
Publishing date	2023-03-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2976-2
ISSN	1460-2431 ; 0022-0957
ISSN (online)	1460-2431
ISSN	0022-0957
DOI	10.1093/jxb/erad076
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