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  1. Article: Taste and Smell Disorders: A Critical Look at Olfactory and Gustatory Dysfunction.

    Maniaci, Antonino / Lechien, Jérome R / Vaira, Luigi Angelo / La Via, Luigi

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 3

    Abstract: In an era where modern medicine has made remarkable advances in managing diseases in the head and neck region, we present this Special Issue to provide a spotlight on the new research advances on olfactory and gustatory disorders [ ... ]. ...

    Abstract In an era where modern medicine has made remarkable advances in managing diseases in the head and neck region, we present this Special Issue to provide a spotlight on the new research advances on olfactory and gustatory disorders [...].
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14030301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Accuracy of ChatGPT-3.5 and -4 in providing scientific references in otolaryngology-head and neck surgery.

    Lechien, Jerome R / Briganti, Giovanni / Vaira, Luigi A

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2024  Volume 281, Issue 4, Page(s) 2159–2165

    Abstract: Introduction: Chatbot generative pre-trained transformer (ChatGPT) is a new artificial intelligence-powered language model of chatbot able to help otolaryngologists in practice and research. We investigated the accuracy of ChatGPT-3.5 and -4 in the ... ...

    Abstract Introduction: Chatbot generative pre-trained transformer (ChatGPT) is a new artificial intelligence-powered language model of chatbot able to help otolaryngologists in practice and research. We investigated the accuracy of ChatGPT-3.5 and -4 in the referencing of manuscripts published in otolaryngology.
    Methods: ChatGPT-3.5 and ChatGPT-4 were interrogated for providing references of the top-30 most cited papers in otolaryngology in the past 40 years including clinical guidelines and key studies that changed the practice. The responses were regenerated three times to assess the accuracy and stability of ChatGPT. ChatGPT-3.5 and ChatGPT-4 were compared for accuracy of reference and potential mistakes.
    Results: The accuracy of ChatGPT-3.5 and ChatGPT-4.0 ranged from 47% to 60%, and 73% to 87%, respectively (p < 0.005). ChatGPT-3.5 provided 19 inaccurate references and invented 2 references throughout the regenerated questions. ChatGPT-4.0 provided 13 inaccurate references, while it proposed only one invented reference. The stability of responses throughout regenerated answers was mild (k = 0.238) and moderate (k = 0.408) for ChatGPT-3.5 and 4.0, respectively.
    Conclusions: ChatGPT-4.0 reported higher accuracy than the free-access version (3.5). False references were detected in both 3.5 and 4.0 versions. Practitioners need to be careful regarding the use of ChatGPT in the reach of some key reference when writing a report.
    MeSH term(s) Humans ; Artificial Intelligence ; Otolaryngology ; Software ; Otolaryngologists ; Language
    Language English
    Publishing date 2024-01-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-08441-8
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  3. Article ; Online: Helicobacter pylori eradication and aspirin: a puzzle yet to be solved.

    Gatta, Luigi / Zullo, Angelo / Vaira, Dino

    Lancet (London, England)

    2023  Volume 401, Issue 10384, Page(s) 1265–1266

    MeSH term(s) Humans ; Aspirin/therapeutic use ; Helicobacter pylori ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Helicobacter Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Aspirin (R16CO5Y76E) ; Anti-Inflammatory Agents, Non-Steroidal ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)00279-9
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  4. Article ; Online: Gastroesophageal reflux disease, laryngopharyngeal reflux, and nasopharyngeal reflux in chronic rhinosinusitis patients.

    Maniaci, Antonino / Vaira, Luigi A / Cammaroto, Giovanni / Favier, Valentin / Lechien, Jerome R

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2024  

    Language English
    Publishing date 2024-02-15
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-024-08510-6
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  5. Article ; Online: Personalized medicine in olfactory testing: perspectives to improve patient compliance to psychophysical tests.

    Lechien, Jerome R / Vaira, Luigi A / Carsuzaa, Florent / Lisan, Quentin / Saussez, Sven

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2024  Volume 281, Issue 4, Page(s) 2175–2177

    MeSH term(s) Humans ; Precision Medicine ; Smell ; Olfaction Disorders/diagnosis ; Physical Examination ; Patient Compliance
    Language English
    Publishing date 2024-01-25
    Publishing country Germany
    Document type Letter
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-024-08454-x
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  6. Article ; Online: Usefulness of pepsin saliva measurement for the detection of primary burning mouth syndrome related to reflux.

    Lechien, Jérôme R / Bobin, Francois / Vaira, Luigi A

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2023  Volume 281, Issue 2, Page(s) 827–833

    Abstract: Objectives: To study the diagnostic value of salivary pepsin tests for detecting laryngopharyngeal reflux (LPR) in patients with primary burning mouth syndrome (BMS).: Methods: Patients with BMS and asymptomatic individuals were consecutively ... ...

    Abstract Objectives: To study the diagnostic value of salivary pepsin tests for detecting laryngopharyngeal reflux (LPR) in patients with primary burning mouth syndrome (BMS).
    Methods: Patients with BMS and asymptomatic individuals were consecutively recruited from September 2018 to June 2023. Patients underwent hypopharyngeal-esophageal impedance pH-monitoring (HEMII-pH) and saliva collections to measure pepsin. Stomatology evaluation was carried out to exclude other causes of BMS. Oral, pharyngeal and laryngeal signs and symptoms were evaluated with Reflux Sign Assessment (RSA) and Reflux Symptom Score (RSS). Sensitivity, specificity, positive (PPV) and negative (NPV) predictive values of pepsin test were calculated considering the highest values of pepsin tests at ≥ 16, ≥ 36, and ≥ 100 ng/mL cutoffs. Receiver operating characteristic curve (ROC) was evaluated.
    Results: Forty-nine patients with both BMS and LPR at the HEMII-pH and 21 asymptomatic individuals were recruited. Pepsin test was 83.7%, 79.6%, and 71.4% sensitive at cutoffs ≥ 16, ≥ 36, and ≥ 100 ng/mL, respectively. The ROC analysis reported that a threshold of ≥ 21.5 ng/mL was associated with sensitivity, specificity, PPV and NPV of 81.6%, 81.0%, 90.1% and 65.4%, respectively. The severity score of burning mouth symptom was significantly associated with the saliva pepsin concentration (r
    Conclusion: Pepsin test is a valuable diagnostic approach for detecting LPR in patients with BMS. Patients with high level of saliva pepsin reported more severe burning mouth symptoms. Future studies are needed to confirm the role of LPR in the primary BMS.
    MeSH term(s) Humans ; Saliva/chemistry ; Pepsin A/analysis ; Burning Mouth Syndrome/etiology ; Burning Mouth Syndrome/complications ; Prospective Studies ; Esophageal pH Monitoring ; Laryngopharyngeal Reflux/complications ; Laryngopharyngeal Reflux/diagnosis ; Electric Impedance
    Chemical Substances Pepsin A (EC 3.4.23.1)
    Language English
    Publishing date 2023-10-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-08317-x
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  7. Article ; Online: Smell and taste dysfunction after covid-19.

    Boscolo-Rizzo, Paolo / Polesel, Jerry / Vaira, Luigi A

    BMJ (Clinical research ed.)

    2022  Volume 378, Page(s) o1653

    MeSH term(s) COVID-19 ; Humans ; Prognosis ; SARS-CoV-2 ; Smell ; Taste Disorders/etiology
    Language English
    Publishing date 2022-07-27
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.o1653
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  8. Article ; Online: Otolaryngologic manifestations of the ongoing outbreak of human monkeypox: ENT specialists should be on the alert.

    Boscolo-Rizzo, Paolo / Hopkins, Claire / Vaira, Luigi A

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2022  Volume 279, Issue 12, Page(s) 5975–5976

    MeSH term(s) Humans ; Mpox (monkeypox)/epidemiology ; Otolaryngology ; Otolaryngologists ; Disease Outbreaks ; Pharynx
    Language English
    Publishing date 2022-08-28
    Publishing country Germany
    Document type Letter
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-022-07601-6
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  9. Article ; Online: Is ChatGPT-4 Accurate in Proofread a Manuscript in Otolaryngology-Head and Neck Surgery?

    Lechien, Jerome R / Gorton, Amy / Robertson, Jean / Vaira, Luigi A

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2023  

    Abstract: ChatGPT is a new artificial intelligence-powered language model of chatbot able to help otolaryngologists in clinical practice and research. We investigated the ability of ChatGPT-4 in the editing of a manuscript in otolaryngology. Four papers were ... ...

    Abstract ChatGPT is a new artificial intelligence-powered language model of chatbot able to help otolaryngologists in clinical practice and research. We investigated the ability of ChatGPT-4 in the editing of a manuscript in otolaryngology. Four papers were written by a nonnative English otolaryngologist and edited by a professional editing service. ChatGPT-4 was used to detect and correct errors in manuscripts. From the 171 errors in the manuscripts, ChatGPT-4 detected 86 errors (50.3%) including vocabulary (N = 36), determiner (N = 27), preposition (N = 24), capitalization (N = 20), and number (N = 11). ChatGPT-4 proposed appropriate corrections for 72 (83.7%) errors, while some errors were poorly detected (eg, capitalization [5%] and vocabulary [44.4%] errors. ChatGPT-4 claimed to change something that was already there in 82 cases. ChatGPT demonstrated usefulness in identifying some types of errors but not all. Nonnative English researchers should be aware of the current limits of ChatGPT-4 in the proofreading of manuscripts.
    Language English
    Publishing date 2023-09-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1002/ohn.526
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  10. Article ; Online: Acute or persistent mechanisms of dysphonia in COVID-19 patients.

    Lechien, Jerome R / Maniaci, Antonino / Gengler, Isabelle M / Barillari, Maria Rosaria / Vaira, Luigi A / Mayo-Yanez, Miguel

    American journal of otolaryngology

    2024  Volume 45, Issue 3, Page(s) 104223

    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Letter
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2024.104223
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