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Article: Analysis of mRNA-miRNA-lncRNA differential expression in prediabetes/type 2 diabetes mellitus patients as potential players in insulin resistance.

Ali, Hebatalla Said / Kamel, Marwa Mostafa / Agwa, Sara H A / Hakeem, Mohamed S Abdel / Meteini, Mahmoud Shawky El / Matboli, Marwa

Frontiers in endocrinology

2023 Volume 14, Page(s) 1131171

Abstract: Introduction: Type 2 diabetes mellitus (T2DM) is a major global health concern. It usually develops gradually and is frequently preceded by undetectable pre-diabetes mellitus (pre-DM) stage. The purpose of this study was to identify a novel set of seven ...

Abstract	Introduction: Type 2 diabetes mellitus (T2DM) is a major global health concern. It usually develops gradually and is frequently preceded by undetectable pre-diabetes mellitus (pre-DM) stage. The purpose of this study was to identify a novel set of seven candidate genes associated with the pathogenesis of insulin resistance (IR) and pre-DM, followed by their experimental validation in patients' serum samples. Methods: We used the bioinformatics tools and through a two-step process, we first identified and verified two mRNA candidate genes linked to insulin resistance molecular pathogenesis. Second, we identified a non-coding RNAs related to the selected mRNAs and implicated in the insulin resistance molecular pathways followed by pilot study for the RNA panel differential expression in 66 patients with T2DM, 49 individuals with prediabetes and 45 matched controls using real time PCR. Results: The levels of expression of TMEM173 and CHUK mRNAs, hsa-miR (-611, -5192, and -1976) miRNAs gradually increased from the healthy control group to the prediabetic group, reaching their maximum levels in the T2DM group (p <10-3), whereas the levels of expression of RP4-605O3.4 and AC074117.2 lncRNAs declined gradually from the healthy control group to the prediabetic group, reaching their lowest levels in the T2DM group (p <10-3). TMEM173, CHUK mRNAs, hsa_miR (-611 & -1976) and RP4-605O3.4 lncRNA were useful in distinguishing insulin resistant from insulin sensitive groups. miR_611 together with RP4-605O3.4 exhibited significant difference in good versus poor glycemic control groups. Discussion: The presented study provides an insight about this RNA based STING/NOD/IR associated panel that could be used for PreDM-T2DM diagnosis and also as a therapeutic target based on the differences of its expression level in the pre-DM and T2DM stages.
MeSH term(s)	Humans ; MicroRNAs/genetics ; Prediabetic State/genetics ; Diabetes Mellitus, Type 2/genetics ; RNA, Long Noncoding/genetics ; Insulin Resistance/genetics ; Pilot Projects ; Insulin ; RNA, Messenger/genetics
Chemical Substances	MicroRNAs ; RNA, Long Noncoding ; Insulin ; RNA, Messenger
Language	English
Publishing date	2023-05-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1131171
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Article ; Online: Discriminatory power of a circulating multi-noncoding RNA panel in acute coronary syndrome subtypes: Towards precision detection.

Agwa, Sara H A / Elzahwy, Sherif Samir / Hossam, Nourhan / Yahia, Yahia A / Hamady, Shaimaa / Sherif, Nadine / Elshazly, Ahmed / Darwish, Reham M / Hashim, Jomana Osama / Adly, Mahmoud Ashraf / Abd Elsamee, Aya M / Shamekh, Rania / Roushdy, Marian Maher Salib / Matboli, Marwa

The international journal of biochemistry & cell biology

2024 Volume 169, Page(s) 106531

Abstract: Background: Acute Coronary Syndrome (ACS) stands as a significant contributor to cardiovascular mortality, necessitating improved diagnostic tools for early detection and tailored therapeutic interventions. Current diagnostic modalities, exhibit ... ...

Abstract	Background: Acute Coronary Syndrome (ACS) stands as a significant contributor to cardiovascular mortality, necessitating improved diagnostic tools for early detection and tailored therapeutic interventions. Current diagnostic modalities, exhibit limitations in sensitivity and specificity, urging the quest for novel biomarkers to enhance discrimination of the different stages of ACS including unstable angina, Non-ST-segment Elevation Myocardial Infarction (NSTEMI), and ST-segment Elevation Myocardial Infarction (STEMI). Methods: This study investigated the potential of a plasma-circulating multi-noncoding RNA (ncRNA) panel, comprising four miRNAs (miR-182-5p, miR-23a-3p, miR-146a-5p, and miR-183-5p) and three lncRNAs (SNHG15, SNHG5, and RMRP), selected based on their intricate involvement in ACS pathogenesis and signaling pathways regulating post-myocardial infarction (MI) processes. The differential expression of these ncRNAs was validated in sera of ACS patients and healthy controls via real-time polymerase chain reaction (RT-PCR). Results: Analysis revealed a marked upregulation of the multi-ncRNAs panel in ACS patients. Notably, miRNA-182-5p and lncRNA-RMRP exhibited exceptional discriminatory power, indicated by the high area under the curve (AUC) values (0.990 and 0.980, respectively). Importantly, this panel displayed superior efficacy in discriminating between STEMI and NSTEMI, outperforming conventional biomarkers like creatine kinase-MB and cardiac troponins. Additionally, the four miRNAs and lncRNA RMRP showcased remarkable proficiency in distinguishing between STEMI and unstable angina. Conclusion: The findings underscore the promising potential of the multi-ncRNA panel as a robust tool for early ACS detection, and precise differentiation among ACS subtypes, and as a potential therapeutic target.
MeSH term(s)	Humans ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/genetics ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/therapy ; Non-ST Elevated Myocardial Infarction/diagnosis ; Non-ST Elevated Myocardial Infarction/pathology ; RNA, Long Noncoding/genetics ; MicroRNAs/genetics ; Myocardial Infarction/diagnosis ; Myocardial Infarction/genetics ; Biomarkers ; Angina, Unstable/diagnosis ; Angina, Unstable/genetics
Chemical Substances	RNA, Long Noncoding ; MicroRNAs ; Biomarkers ; Mirn182 microRNA, human
Language	English
Publishing date	2024-01-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1228429-4
ISSN	1878-5875 ; 1357-2725
ISSN (online)	1878-5875
ISSN	1357-2725
DOI	10.1016/j.biocel.2024.106531
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Article ; Online: Identification of a Multi-Messenger RNA Signature as Type 2 Diabetes Mellitus Candidate Genes Involved in Crosstalk between Inflammation and Insulin Resistance.

Ali, Hebatalla Said / Boshra, Mariam Sameh / Agwa, Sara H A / Hakeem, Mohamed S Abdel / Meteini, Mahmoud Shawky El / Matboli, Marwa

Biomolecules

2022 Volume 12, Issue 9

Abstract: Type 2 Diabetes Mellitus (T2DM) is a metabolic disease associated with inflammation widening the scope of immune-metabolism, linking the inflammation to insulin resistance and beta cell dysfunction. New potential and prognostic biomarkers are urgently ... ...

Abstract	Type 2 Diabetes Mellitus (T2DM) is a metabolic disease associated with inflammation widening the scope of immune-metabolism, linking the inflammation to insulin resistance and beta cell dysfunction. New potential and prognostic biomarkers are urgently required to identify individuals at high risk of β-cell dysfunction and pre-DM. The DNA-sensing stimulator of interferon genes (STING) is an important component of innate immune signaling that governs inflammation-mediated T2DM. NOD-like receptor (NLR) reduces STING-dependent innate immune activation in response to cyclic di-GMP and DNA viruses by impeding STING-TBK1 interaction. We proposed exploring novel blood-based mRNA signatures that are selective for components related to inflammatory, immune, and metabolic stress which may reveal the landscape of T2DM progression for diagnosing or treating patients in the pre-DM state. In this study, we used microarray data set to identify a group of differentially expressed mRNAs related to the cGAS/STING, NODlike receptor pathways (NLR) and T2DM. Then, we comparatively analyzed six mRNAs expression levels in healthy individuals, prediabetes (pre-DM) and T2DM patients by real-time PCR. The expressions of ZBP1, DDX58, NFKB1 and CHUK were significantly higher in the pre-DM group compared to either healthy control or T2DM patients. The expression of ZBP1 and NFKB1 mRNA could discriminate between good versus poor glycemic control groups. HSPA1B mRNA showed a significant difference in its expression regarding the insulin resistance. Linear regression analysis revealed that LDLc, HSPA1B and NFKB1 were significant variables for the prediction of pre-DM from the healthy control. Our study shed light on a new finding that addresses the role of ZBP1 and HSPA1B in the early prediction and progression of T2DM.
MeSH term(s)	Biomarkers ; DNA ; Diabetes Mellitus, Type 2/genetics ; Humans ; Inflammation/genetics ; Insulin Resistance/genetics ; Interferons ; NLR Proteins ; Nucleotidyltransferases/metabolism ; RNA, Messenger/genetics
Chemical Substances	Biomarkers ; NLR Proteins ; RNA, Messenger ; DNA (9007-49-2) ; Interferons (9008-11-1) ; Nucleotidyltransferases (EC 2.7.7.-)
Language	English
Publishing date	2022-09-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12091230
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Article ; Online: Predictive urinary RNA biomarkers of kidney injury after extracorporeal shock wave lithotripsy.

Tawfick, Ahmed / Matboli, Marwa / Shamloul, Sara / Agwa, Sara H A / Saad, Maha / Shaker, Hassan / Selim, Mohamed M Yassin / Salim, Mohamed S / Radwan, A / Shorbagy, A A / Mousa, Waleed

World journal of urology

2022 Volume 40, Issue 6, Page(s) 1561–1567

Abstract: ... urine samples were obtained before, 2 h, and 1 day after ESWL. We measured the urinary level of LncRNA (SBF2-AS1 ...

Abstract	Background: Extracorporeal shock wave lithotripsy (ESWL) is considered one of the best choices for the treatment of various kinds of urinary tract calculi, although it might cause acute kidney injury. Objective: To measure the urinary long non-coding RNA-messenger RNA (LncRNA-mRNA) panel before and after ESWL to evaluate post-ESWL renal injury in a reliable and non-invasive method. Patients and methods: The study included 60 patients with renal stones treated with ESWL and 30 healthy volunteers. Voided urine samples were obtained before, 2 h, and 1 day after ESWL. We measured the urinary level of LncRNA (SBF2-AS1, FENDRR-19) and mRNA (GBP1, NLRP3) by real-time qPCR and compared the results with serum creatinine and eGFR. Results: LncRNA (SBF2-AS1, FENDRR-19) and mRNA (GBP1, NLRP3) levels were higher in patients with renal stones when compared with healthy volunteers. They showed a statistically significant increase in the level of LncRNA-mRNA panel in baseline and after ESWL treatment. Conclusion: LncRNA (SBF2-AS1, FENDRR-19) and mRNA (GBP1, NLRP3) levels were significantly elevated following ESWL treatment, highlighting the usefulness of urinary biomarkers in identifying patients at higher risk of developing renal injury after ESWL treatment.
MeSH term(s)	Acute Kidney Injury/etiology ; Acute Kidney Injury/urine ; Biomarkers/urine ; Humans ; Kidney/injuries ; Kidney/surgery ; Kidney Calculi/etiology ; Kidney Calculi/therapy ; Kidney Calculi/urine ; Lithotripsy/adverse effects ; NLR Family, Pyrin Domain-Containing 3 Protein/urine ; RNA, Long Noncoding/urine ; RNA, Messenger/urine
Chemical Substances	Biomarkers ; NLR Family, Pyrin Domain-Containing 3 Protein ; RNA, Long Noncoding ; RNA, Messenger
Language	English
Publishing date	2022-04-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-022-03996-3
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Article ; Online: Prospective insight into the role of benzyl propylene glycoside as a modulator of the cGAS-STING signaling pathway in the management of nonalcoholic fatty pancreas animal model.

Albadawy, Reda / Hasanin, Amany Helmy / Agwa, Sara H A / Hamady, Shaimaa / Mohamed, Reham Hussein / Gomaa, Eman / Othman, Mohamed / Yahia, Yahia A / Ghani, Amani Mohamed Abdel / Matboli, Marwa

Biological research

2023 Volume 56, Issue 1, Page(s) 11

Abstract: Background: Nonalcoholic fatty pancreatitis (NAFP) is one of the metabolic syndrome manifestations that need further studies to determine its molecular determinants and find effective medications. We aimed to investigate the potential effect of benzyl ... ...

Abstract	Background: Nonalcoholic fatty pancreatitis (NAFP) is one of the metabolic syndrome manifestations that need further studies to determine its molecular determinants and find effective medications. We aimed to investigate the potential effect of benzyl propylene glycoside on NAFP management via targeting the pancreatic cGAS-STING pathway-related genes (DDX58, NFκB1 & CHUK) and their upstream regulator miRNA (miR-1976) that were retrieved from bioinformatics analysis. Methods: The rats were fed either normal chow or a high-fat high-sucrose diet (HFHS), as a nutritional model for NAFP. After 8 weeks, the HFHS-fed rats were subdivided randomly into 4 groups; untreated HFHS group (NAFP model group) and three treated groups which received 3 doses of benzyl propylene glycoside (10, 20, and 30 mg/kg) daily for 4 weeks, parallel with HFHS feeding. Results: The molecular analysis revealed that benzyl propylene glycoside could modulate the expression of the pancreatic cGAS-STING pathway-related through the downregulation of the expression of DDX58, NFκB1, and CHUK mRNAs and upregulation of miR-1976 expression. Moreover, the applied treatment reversed insulin resistance, inflammation, and fibrosis observed in the untreated NAFP group, as evidenced by improved lipid panel, decreased body weight and the serum level of lipase and amylase, reduced protein levels of NFκB1 and caspase-3 with a significant reduction in area % of collagen fibers in the pancreatic sections of treated animals. Conclusion: benzyl propylene glycoside showed a potential ability to attenuate NAFP development, inhibit pancreatic inflammation and fibrosis and reduce the pathological and metabolic disturbances monitored in the applied NAFP animal model. The detected effect was correlated with modulation of the expression of pancreatic (DDX58, NFκB1, and CHUK mRNAs and miR-1976) panel.
MeSH term(s)	Animals ; Rats ; Fibrosis ; Glycosides/pharmacology ; Inflammation ; MicroRNAs ; Models, Animal ; Nucleotidyltransferases/metabolism ; Pancreas/pathology ; Signal Transduction ; Pancreatic Diseases
Chemical Substances	Glycosides ; MicroRNAs ; Nucleotidyltransferases (EC 2.7.7.-) ; propylene (AUG1H506LY)
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1138990-4
ISSN	0717-6287 ; 0716-9760
ISSN (online)	0717-6287
ISSN	0716-9760
DOI	10.1186/s40659-023-00423-8
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Article: Harnessing immunoinformatics for developing a multiple-epitope peptide-based vaccination approach against SARS-CoV-2 spike protein.

Moustafa, Rehab I / Faraag, Ahmed H I / El-Shenawy, Reem / Agwa, Mona M / Elsayed, Hassan

Saudi journal of biological sciences

2023 Volume 30, Issue 6, Page(s) 103661

Abstract: ... The candidate epitopes were designed from highly conserved regions of the SARS-CoV-2 spike (S) glycoprotein ... The consensus amino acids sequence of ten SARS-CoV-2 variants including Gamma, Beta, Epsilon, Delta, Alpha ...

Abstract	COVID-19 has spread to over 200 countries with variable severity and mortality rates. Computational analysis is a valuable tool for developing B-cell and T-cell epitope-based vaccines. In this study, by harnessing immunoinformatics tools, we designed a multiple-epitope vaccine to protect against COVID-19. The candidate epitopes were designed from highly conserved regions of the SARS-CoV-2 spike (S) glycoprotein. The consensus amino acids sequence of ten SARS-CoV-2 variants including Gamma, Beta, Epsilon, Delta, Alpha, Kappa, Iota, Lambda, Mu, and Omicron was involved. Applying the multiple sequence alignment plugin and the antigenic prediction tools of Geneious prime 2021, ten predicted variants were identified and consensus S-protein sequences were used to predict the antigenic part. According to ElliPro analysis of S-protein B-cell prediction, we explored 22 continuous linear epitopes with high scores ranging from 0.879 to 0.522. First, we reported five promising epitopes: BE1
Language	English
Publishing date	2023-04-28
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2023.103661
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Article ; Online: Anti-inflammatory effect of trans-anethol in a rat model of myocardial ischemia-reperfusion injury.

Matboli, Marwa / Hasanin, Amany Helmy / Hamady, Shaimaa / Khairy, Eman / Mohamed, Reham Hussein / Aboul-Ela, Yasmin M / Raafat, Mona Hussien / Elsebay, Sara Abdel Gawad / Emam, Hossam Y / Shamekh, Rania Shamekh / Agwa, Sara H A

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 150, Page(s) 113070

Abstract: Myocardial ischemia‑reperfusion injury (MI/R) is considered a main risk factor for global cardiac mortality and morbidity, for which no effective treatment exists. Both inflammation and epigenetic regulation play a pivotal role in the early stage of MI/R. ...

Abstract	Myocardial ischemia‑reperfusion injury (MI/R) is considered a main risk factor for global cardiac mortality and morbidity, for which no effective treatment exists. Both inflammation and epigenetic regulation play a pivotal role in the early stage of MI/R. The present study aimed at investigating the prospective anti-inflammatory role of trans-anethole (TNA) in targeting MI/R and its related mechanism in upregulating the expression of the inflammatory and cardiac-related gene (VAV3), and its epigenetic regulators (lncRNA-JRKL-AS1 and miR-1298) that were retrieved from in-silico data analysis in an ischemia/reperfusion (I/R) rat model. Materials & methods: TNA was administered in 3 doses (50, 100, and 200 mg/kg), 15 min prior to coronary ligation in male Wistar rats. The left ventricular end-diastolic pressure and dP/dtmax were assessed. Histopathological, biochemical, and molecular analyses were performed to assess the effects of TNA pre-treatment on the I/R rats model. Results: TNA alleviated the I/R-induced cardiac injury pathologically and improved the cardiac function tests and enzymes. At the molecular level, TNA upregulated the expression level of the retrieved RNA-based panel (VAV3 mRNA/miR-1298/lncRNA JRKL-AS1). At the protein level, TNA decreased the cardiac content of the pro-inflammatory cytokine TNF-α. Conclusion: TNA has demonstrated a potential ability to alleviate the cardiac injury and attenuate the inflammatory response following ischemia-reperfusion in the rat model through modulation of the expression of RNA panel (VAV3 mRNA/miR-1298/lncRNA JRKL-AS1) and TNF- α protein.
MeSH term(s)	Allylbenzene Derivatives ; Animals ; Anisoles ; Apoptosis ; Disease Models, Animal ; Epigenesis, Genetic ; Male ; MicroRNAs/metabolism ; Myocardial Reperfusion Injury/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Messenger/therapeutic use ; Rats ; Rats, Wistar
Chemical Substances	Allylbenzene Derivatives ; Anisoles ; MicroRNAs ; RNA, Long Noncoding ; RNA, Messenger ; anethole (Q3JEK5DO4K)
Language	English
Publishing date	2022-05-06
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.113070
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Article ; Online: HPLC with fluorescence detection for the bioanalysis and pharmacokinetic study of Doxorubicin and Prodigiosin loaded on eco-friendly casein nanomicelles in rat plasma.

Aboras, Sara I / Korany, Mohamed A / Abdine, Heba H / Ragab, Marwa A A / El Diwany, Ahmed / Agwa, Mona M

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2021 Volume 1187, Page(s) 123043

Abstract: A rapid, efficient, and sensitive liquid chromatographic assay hyphenated to fluorometric detector (HPLC-FLD) was developed and validated for the determination of doxorubicin (DXR) and prodigiosin (PDG) in rat plasma. The sample pre-treatment involves a ... ...

Abstract	A rapid, efficient, and sensitive liquid chromatographic assay hyphenated to fluorometric detector (HPLC-FLD) was developed and validated for the determination of doxorubicin (DXR) and prodigiosin (PDG) in rat plasma. The sample pre-treatment involves a protein precipitation with acetonitrile with satisfying extraction efficiency (98% and 85% for DXR and PDG, respectively). The chromatographic separation was accomplished using stationary phase: Agilent Zorbax Eclipse plus-C18 analytical column (250 × 4.6 mm, 5 μm) and gradient eluting mobile phase of ammonium acetate (pH = 3), acetonitrile and methanol with programmed fluorescence detection. As the proposed method has been validated, it was subsequently implemented to evaluate DXR and PDG loaded on novel eco-friendly Casein nano drug delivery system after intravenous injection in healthy rats. A comparative pharmacokinetics' study was carried out in rats for DXR in free form, DXR alone entrapped in the nanomicelle and DXR with PDG entrapped in the nano micelle. After testing the differences in pharmacokinetic parameters of the different formulations using ANOVA, the results showed insignificant differences among the tested parameters. This indicates that the presented nanomicelle delivery system has succeeded to incorporate PDG and DXR in a hydrophilic, safe, and potent formulation. This novel nanomicelle has negligible effect on the distribution and elimination of DXR.
MeSH term(s)	Animals ; Caseins/blood ; Caseins/chemistry ; Caseins/pharmacokinetics ; Chromatography, High Pressure Liquid/methods ; Doxorubicin/blood ; Doxorubicin/chemistry ; Doxorubicin/pharmacokinetics ; Male ; Micelles ; Nanoparticle Drug Delivery System/analysis ; Nanoparticle Drug Delivery System/chemistry ; Nanoparticle Drug Delivery System/pharmacokinetics ; Prodigiosin/blood ; Prodigiosin/chemistry ; Prodigiosin/pharmacokinetics ; Rats ; Rats, Wistar ; Spectrometry, Fluorescence
Chemical Substances	Caseins ; Micelles ; Nanoparticle Drug Delivery System ; Doxorubicin (80168379AG) ; Prodigiosin (OL369FU7CJ)
Language	English
Publishing date	2021-11-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1180823-8
ISSN	1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
ISSN (online)	1873-376X
ISSN	0378-4347 ; 1570-0232 ; 1387-2273
DOI	10.1016/j.jchromb.2021.123043
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Article: Impact of circ-0000221 in the Pathogenesis of Hepatocellular via Modulation of miR-661-PTPN11 mRNA Axis.

Matboli, Marwa / Hassan, Mohmed Kamal / Ali, Mahmoud A / Mansour, Mohamed Tarek / Elsayed, Waheba / Atteya, Reham / Aly, Hebatallah Said / Meteini, Mahmoud El / Elghazaly, Hesham / El-Khamisy, Sherif / Agwa, Sara H A

Pharmaceutics

2022 Volume 14, Issue 1

Abstract: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in Egypt. A deep understanding of the molecular events occurring in HCC can facilitate the development of novel diagnostic and/or therapeutic approaches. In the present study, we ... ...

Abstract	Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in Egypt. A deep understanding of the molecular events occurring in HCC can facilitate the development of novel diagnostic and/or therapeutic approaches. In the present study, we describe a novel axis of
Language	English
Publishing date	2022-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14010138
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Article: Identifying SARS-CoV-2 Lineage Mutation Hallmarks and Correlating Them With Clinical Outcomes in Egypt: A Pilot Study.

Agwa, Sara H A / Elghazaly, Hesham / El Meteini, Mahmoud Shawky / Yahia, Yahia A / Khaled, Radwa / Abd Elsamee, Aya M / Darwish, Reham M / Elsayed, Shaimaa M / Hafez, Hala / Mahmoud, Basma S / Em, Fouda / Matboli, Marwa

Frontiers in molecular biosciences

2022 Volume 9, Page(s) 817735

Abstract: The SARS-CoV-2 pandemic has led to over 4.9 million deaths as of October 2021. One of the main ... were used as nomenclature for SARS-CoV-2 variants and lineages. One of the most used is the Pangolin ... nomenclature. In our study, we enrolled 35 confirmed SARS-CoV-2 patients and sequenced the viral RNA ...

Abstract	The SARS-CoV-2 pandemic has led to over 4.9 million deaths as of October 2021. One of the main challenges of creating vaccines, treatment, or diagnostic tools for the virus is its mutations and emerging variants. A couple of variants were declared as more virulent and infectious than others. Some approaches were used as nomenclature for SARS-CoV-2 variants and lineages. One of the most used is the Pangolin nomenclature. In our study, we enrolled 35 confirmed SARS-CoV-2 patients and sequenced the viral RNA in their samples. We also aimed to highlight the hallmark mutations in the most frequent lineage. We identified a seven-mutation signature for the SARS-CoV-2
Language	English
Publishing date	2022-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2022.817735
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