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Article: Sindrome plaquetario de Sebastian: descripción de dos casos y revisión de la literatura.

Aguilar Franco, C / Lucía Cuesta, J F / Gómez Ara, A / Navarro, M D

1998 Volume 43, Issue 3, Page(s) 262–264

Title translation	The Sebastian platelet syndrome: description of 2 cases and review of the literature.
MeSH term(s)	Bronchial Neoplasms/complications ; Carcinoma, Squamous Cell/complications ; Genes, Dominant ; Humans ; Inclusion Bodies/ultrastructure ; Leukocytes/ultrastructure ; Male ; Middle Aged ; Myocardial Infarction/complications ; Neutrophils/ultrastructure ; Syndrome ; Thrombocytopenia/classification ; Thrombocytopenia/complications ; Thrombocytopenia/genetics ; Thrombocytopenia/pathology
Language	Spanish
Publishing date	1998-06
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	128404-6
ISSN	0036-4355
ISSN	0036-4355
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Zs.B 204: Show issues

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Article ; Online: The Role of Organic Small Molecules in Pain Management.

Cuesta, Sebastián A / Meneses, Lorena

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 13

Abstract: In this review, a timeline starting at the willow bark and ending in the latest discoveries of analgesic and anti-inflammatory drugs will be discussed. Furthermore, the chemical features of the different small organic molecules that have been used in ... ...

Abstract	In this review, a timeline starting at the willow bark and ending in the latest discoveries of analgesic and anti-inflammatory drugs will be discussed. Furthermore, the chemical features of the different small organic molecules that have been used in pain management will be studied. Then, the mechanism of different types of pain will be assessed, including neuropathic pain, inflammatory pain, and the relationship found between oxidative stress and pain. This will include obtaining insights into the cyclooxygenase action mechanism of nonsteroidal anti-inflammatory drugs (NSAID) such as ibuprofen and etoricoxib and the structural difference between the two cyclooxygenase isoforms leading to a selective inhibition, the action mechanism of pregabalin and its use in chronic neuropathic pain, new theories and studies on the analgesic action mechanism of paracetamol and how changes in its structure can lead to better characteristics of this drug, and cannabinoid action mechanism in managing pain through a cannabinoid receptor mechanism. Finally, an overview of the different approaches science is taking to develop more efficient molecules for pain treatment will be presented.
MeSH term(s)	Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Calcium Channel Blockers/chemistry ; Calcium Channel Blockers/pharmacology ; Cannabinoids/chemistry ; Cannabinoids/therapeutic use ; Drug Discovery/methods ; Humans ; Neuralgia/drug therapy ; Pain Management/methods
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Calcium Channel Blockers ; Cannabinoids
Language	English
Publishing date	2021-07-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26134029
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Article ; Online: The Role of Organic Small Molecules in Pain Management

Sebastián A. Cuesta / Lorena Meneses

Molecules, Vol 26, Iss 4029, p

2021 Volume 4029

Abstract	In this review, a timeline starting at the willow bark and ending in the latest discoveries of analgesic and anti-inflammatory drugs will be discussed. Furthermore, the chemical features of the different small organic molecules that have been used in pain management will be studied. Then, the mechanism of different types of pain will be assessed, including neuropathic pain, inflammatory pain, and the relationship found between oxidative stress and pain. This will include obtaining insights into the cyclooxygenase action mechanism of nonsteroidal anti-inflammatory drugs (NSAID) such as ibuprofen and etoricoxib and the structural difference between the two cyclooxygenase isoforms leading to a selective inhibition, the action mechanism of pregabalin and its use in chronic neuropathic pain, new theories and studies on the analgesic action mechanism of paracetamol and how changes in its structure can lead to better characteristics of this drug, and cannabinoid action mechanism in managing pain through a cannabinoid receptor mechanism. Finally, an overview of the different approaches science is taking to develop more efficient molecules for pain treatment will be presented.
Keywords	anti-inflammatory drugs ; QSAR ; pain management ; cyclooxygenase ; multitarget drug ; cannabinoid ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In Silico Screening of the DrugBank Database to Search for Possible Drugs against SARS-CoV-2.

Cuesta, Sebastián A / Mora, José R / Márquez, Edgar A

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 4

Abstract: Coronavirus desease 2019 (COVID-19) is responsible for more than 1.80 M deaths worldwide. A Quantitative Structure-Activity Relationships (QSAR) model is developed based on experimental ... ...

Abstract	Coronavirus desease 2019 (COVID-19) is responsible for more than 1.80 M deaths worldwide. A Quantitative Structure-Activity Relationships (QSAR) model is developed based on experimental pIC
MeSH term(s)	Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; COVID-19/enzymology ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/chemistry ; Cysteine Proteinase Inhibitors/chemistry ; Cysteine Proteinase Inhibitors/therapeutic use ; Databases, Chemical ; Drug Evaluation, Preclinical ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Quantitative Structure-Activity Relationship ; RNA-Dependent RNA Polymerase/antagonists & inhibitors ; RNA-Dependent RNA Polymerase/chemistry ; SARS-CoV-2/enzymology ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; Cysteine Proteinase Inhibitors ; RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Coronavirus 3C Proteases (EC 3.4.22.28)
Language	English
Publishing date	2021-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26041100
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Article ; Online: Application of 3D-reconstruction and artificial intelligence for complete mesocolic excision and D3 lymphadenectomy in colon cancer.

Garcia-Granero, Alvaro / Jerí Mc-Farlane, Sebastían / Gamundí Cuesta, Margarita / González-Argente, Francesc Xavier

Cirugia espanola

2023 Volume 101, Issue 5, Page(s) 359–368

Abstract: Mathematical algorithms 3D-reconstruction techniques and artificial intelligence are a current line of innovation in colorectal surgical oncology. The objective of this study is to show the initial experience of a 3D image processing and reconstruction ... ...

Abstract	Mathematical algorithms 3D-reconstruction techniques and artificial intelligence are a current line of innovation in colorectal surgical oncology. The objective of this study is to show the initial experience of a 3D image processing and reconstruction system to perform complete mesocolic excision and D3-lymphadenectomy in colon cancer. It is applied to a splenic flexure neoplasm and in a right colon cancer with suspected retroperitoneal infiltration. 3D image processing and reconstruction was employed to delimit 10 cm proximal and distal intestinal margins to the tumor and define its corresponding vascularization. In right colon cancer it showed position and exact dimensions of D3-lymphadenectomy area and possible retroperitoneal fascia infiltration. 3D image processing and reconstruction allows to obtain valuable information from computerized tomography scan. It could be employed during surgical strategy planification to improve oncological results and reduce intraoperative complications.
MeSH term(s)	Humans ; Artificial Intelligence ; Laparoscopy/methods ; Colectomy/methods ; Lymph Node Excision/methods ; Colonic Neoplasms/diagnostic imaging ; Colonic Neoplasms/surgery ; Colonic Neoplasms/pathology
Language	English
Publishing date	2023-01-26
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.cireng.2023.01.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Incidencia de lesiones por presión asociadas a dispositivos de oxigenoterapia en la unidad de cuidados intensivos neonatales.

Garzón Montero, Alicia / López Muguerza, Lucía / Puertas Esteban, Laura / Tundidor Sebastián, Sandra / Albert Also, Montserrat / González de la Cuesta, Delia / Casanovas-Marsal, Josep-Oriol

Revista espanola de salud publica

2024 Volume 98

Abstract: Objective: The administration of oxygen therapy (O: Methods: A retrospective, observational and analytical study of hospitalized neonates who developed PPL secondary to O2 devices in the NICU of the Miguel Servet University Hospital of Zaragoza was ... ...

Title translation	Incidence of pressure injuries associated with oxygen therapy devices in the neonatal intensive care unit.
Abstract	Objective: The administration of oxygen therapy (O Methods: A retrospective, observational and analytical study of hospitalized neonates who developed PPL secondary to O2 devices in the NICU of the Miguel Servet University Hospital of Zaragoza was carried out. Socio-demographical, clinical, type of cot, humidity, temperature, type of oxygen therapy, ventilation mode, device and presence of ulcer (number, degree, location), and preventive measures were recorded. The study was approved by the Research Ethics Committee of the Autonomous Community of Aragon. Statistical analysis was performed using Jamovi 2.3.13®. Results: A total of 191 neonates were included, of whom 158 (82.7%) received O Conclusions: The incidence of pressure injuries associated with different oxygen therapy devices increases with decreasing gestational age. The risk increases with hospital stay, with the presence of medical devices, in particular non-invasive mechanical ventilation, being the main causal relationship.
MeSH term(s)	Humans ; Pressure Ulcer/epidemiology ; Pressure Ulcer/therapy ; Pressure Ulcer/prevention & control ; Pressure Ulcer/etiology ; Infant, Newborn ; Retrospective Studies ; Oxygen Inhalation Therapy/methods ; Oxygen Inhalation Therapy/adverse effects ; Intensive Care Units, Neonatal ; Incidence ; Male ; Female ; Risk Factors
Language	Spanish
Publishing date	2024-04-23
Publishing country	Spain
Document type	Journal Article ; Observational Study ; English Abstract
ZDB-ID	1288657-9
ISSN	2173-9110 ; 0034-8899 ; 1135-5727
ISSN (online)	2173-9110
ISSN	0034-8899 ; 1135-5727
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 483: Show issues

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Article ; Online: ElectroPredictor: An Application to Predict Mayr's Electrophilicity

Cuesta, Sebastián A / Moreno, Martín / López, Romina A / Mora, José R / Paz, José Luis / Márquez, Edgar A

Journal of chemical information and modeling

2023 Volume 63, Issue 2, Page(s) 507–521

Abstract: Electrophilicity ( ...

Abstract	Electrophilicity (
MeSH term(s)	Algorithms ; Machine Learning ; Databases, Factual
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	190019-5
ISSN	1549-960X ; 0095-2338
ISSN (online)	1549-960X
ISSN	0095-2338
DOI	10.1021/acs.jcim.2c01367
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Zs.A 1230: Show issues

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Article ; Online: In Silico Screening of the DrugBank Database to Search for Possible Drugs against SARS-CoV-2

Sebastián A. Cuesta / José R. Mora / Edgar A. Márquez

Molecules, Vol 26, Iss 4, p

2021 Volume 1100

Abstract	Coronavirus desease 2019 (COVID-19) is responsible for more than 1.80 M deaths worldwide. A Quantitative Structure-Activity Relationships (QSAR) model is developed based on experimental pIC 50 values reported for a structurally diverse dataset. A robust model with only five descriptors is found, with values of R 2 = 0.897, Q 2 LOO = 0.854, and Q 2 ext = 0.876 and complying with all the parameters established in the validation Tropsha’s test. The analysis of the applicability domain (AD) reveals coverage of about 90% for the external test set. Docking and molecular dynamic analysis are performed on the three most relevant biological targets for SARS-CoV-2: main protease, papain-like protease, and RNA-dependent RNA polymerase. A screening of the DrugBank database is executed, predicting the pIC 50 value of 6664 drugs, which are IN the AD of the model (coverage = 79%). Fifty-seven possible potent anti-COVID-19 candidates with pIC 50 values > 6.6 are identified, and based on a pharmacophore modelling analysis, four compounds of this set can be suggested as potent candidates to be potential inhibitors of SARS-CoV-2. Finally, the biological activity of the compounds was related to the frontier molecular orbitals shapes.
Keywords	SARS-CoV-2 ; QSAR ; docking analysis ; DrugBank ; molecular dynamics ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical Outcomes of Transcatheter Arterial Embolization for Secondary Stiff Shoulder.

Fernández-Martínez, Ana M / Alonso-Burgos, Alberto / López, Roberto / Cuesta Marcos, M Teresa / Baldi, Sebastián

Journal of vascular and interventional radiology : JVIR

2021 Volume 32, Issue 4, Page(s) 489–496

Abstract: Purpose: To assess the clinical outcomes of transcatheter arterial embolization (TAE) for secondary stiff shoulder (SSS).: Materials and methods: This is a retrospective analysis of prospectively collected data performed between January 2017 and ... ...

Abstract	Purpose: To assess the clinical outcomes of transcatheter arterial embolization (TAE) for secondary stiff shoulder (SSS). Materials and methods: This is a retrospective analysis of prospectively collected data performed between January 2017 and December 2019. This study comprised 25 patients (20 women and 5 men; median age, 49 years; range 27-59) with SSS resistant to conservative management during at least 3 months. The median time of stiffness was 12 months. The etiology of SSS was postoperative in 14 patients (56%) and posttraumatic in the remaining 11 patients (44%). Periods of immobilization in all patients were associated. TAE was performed, and technical aspects, adverse events, changes for pain, and physical examination before and 6 months after TAE were assessed. Results: Abnormal vessels were observed in 20 of 25 (80%) of the procedures. Transitory cutaneous erythema was noted in 4 patients treated after TAE. Significant differences were observed in the median pain visual analog scale reduction between before and 6 months after TAE (8 vs 2, P < .001). Shoulder mobility significantly improved in both flexion and abduction degrees between before and at 6 months after TAE in (70° vs 150°; P < .001). No symptoms of recurrence appeared. Conclusions: TAE can result in pain reduction and mobility improvement in patients with SSS refractory to conservative therapy.
MeSH term(s)	Adult ; Bursitis/diagnostic imaging ; Bursitis/etiology ; Bursitis/physiopathology ; Bursitis/therapy ; Embolization, Therapeutic/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Recovery of Function ; Retrospective Studies ; Shoulder Pain/diagnostic imaging ; Shoulder Pain/etiology ; Shoulder Pain/physiopathology ; Shoulder Pain/therapy ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2021-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2020.11.006
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Zs.A 3720: Show issues

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Article: In Silico Searching for Alternative Lead Compounds to Treat Type 2 Diabetes through a QSAR and Molecular Dynamics Study.

Cabrera, Nicolás / Cuesta, Sebastián A / Mora, José R / Calle, Luis / Márquez, Edgar A / Kaunas, Roland / Paz, José Luis

Pharmaceutics

2022 Volume 14, Issue 2

Abstract: Free fatty acid receptor 1 (FFA1) stimulates insulin secretion in pancreatic β-cells. An advantage of therapies that target FFA1 is their reduced risk of hypoglycemia relative to common type 2 diabetes treatments. In this work, quantitative structure- ... ...

Abstract	Free fatty acid receptor 1 (FFA1) stimulates insulin secretion in pancreatic β-cells. An advantage of therapies that target FFA1 is their reduced risk of hypoglycemia relative to common type 2 diabetes treatments. In this work, quantitative structure-activity relationship (QSAR) approach was used to construct models to identify possible FFA1 agonists by applying four different machine-learning algorithms. The best model (M2) meets the Tropsha's test requirements and has the statistics parameters R
Language	English
Publishing date	2022-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14020232
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