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  1. Article ; Online: Drug hypersensitivity: Past, present and future.

    Torres, Maria J / Doña, Inmaculada

    Allergy

    2024  Volume 79, Issue 3, Page(s) 549–551

    MeSH term(s) Humans ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/etiology ; Basophils ; Basophil Degranulation Test ; Hypersensitivity, Immediate
    Language English
    Publishing date 2024-02-16
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.16050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A new oral kallikrein inhibitor for long-term prophylaxis of hereditary angioedema.

    Doña, Inmaculada / Torres, María José

    Allergy

    2021  Volume 76, Issue 6, Page(s) 1619–1620

    MeSH term(s) Angioedemas, Hereditary/diagnosis ; Angioedemas, Hereditary/drug therapy ; Angioedemas, Hereditary/prevention & control ; Antibodies, Monoclonal, Humanized ; Complement C1 Inhibitor Protein ; Humans ; Plasma Kallikrein
    Chemical Substances Antibodies, Monoclonal, Humanized ; Complement C1 Inhibitor Protein ; Plasma Kallikrein (EC 3.4.21.34)
    Language English
    Publishing date 2021-02-26
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14798
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  3. Article ; Online: Accurate phenotyping of cross-reactive hypersensitivity is essential to shed light on the underlying mechanisms in NSAID-induced urticaria/angioedema.

    Cornejo-García, José Antonio / Núñez, Rafael / Torres, María J / Doña, Inmaculada

    The Journal of allergy and clinical immunology

    2022  Volume 151, Issue 3, Page(s) 803

    MeSH term(s) Humans ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Angioedema/chemically induced ; Urticaria/chemically induced ; Drug Hypersensitivity
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2022-12-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.10.032
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  4. Article ; Online: Hypersensitivity to gadolinium-based contrast.

    Sáenz de Santa María, Rocío / Labella, Marina / Bogas, Gádor / Doña, Inmaculada / Torres, María José

    Current opinion in allergy and clinical immunology

    2023  Volume 23, Issue 4, Page(s) 300–306

    Abstract: Purpose of review: The use of contrast media is increasing in recent decades. Although gadolinium-based contrast agents (GBCAs) are generally well tolerated, adverse reactions, including hypersensitivity reactions (HSRs), although infrequent, may occur. ...

    Abstract Purpose of review: The use of contrast media is increasing in recent decades. Although gadolinium-based contrast agents (GBCAs) are generally well tolerated, adverse reactions, including hypersensitivity reactions (HSRs), although infrequent, may occur. It is important to perform a thorough allergological evaluation in patients with suspected GBCA-HSRs to avoid potentially serious reactions in subsequent exposures.
    Recent findings: Data on GBCA-HSRs are scarce. Most published articles dealing with skin tests and drug provocation tests (DPTs) with GBCAs are case series and small cohorts. Controversies exist about the role of premedication for preventing HSRs on subsequent exposures. Selection of well tolerated alternatives is based on potential cross-reactivity among GBCAs; however, the extent of cross-reactivity among them remains unclear.
    Summary: As premedication is not useful because breakthrough reactions are frequent in patients with GBCA-HSRs in subsequent exposures, an allergological evaluation is required. Available data suggest a high negative predictive value of skin tests, being crucial for guiding the selection of an alternative GBCA. However, DPTs are still necessary to confirm or exclude the diagnosis or find alternative GBCAs. Cross-reactivity is high among GBCAs belonging from the same group, mainly among macrocyclic compounds, so this must be taken into account for selecting alternatives.
    MeSH term(s) Humans ; Gadolinium/adverse effects ; Drug Hypersensitivity/prevention & control ; Contrast Media/adverse effects ; Hypersensitivity/diagnosis ; Hypersensitivity/complications
    Chemical Substances Gadolinium (AU0V1LM3JT) ; diphenylthiosulfinate (1208-20-4) ; Contrast Media
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0000000000000911
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  5. Article ; Online: Biomarkers of immediate drug hypersensitivity.

    Mayorga, Cristobalina / Ariza, Adriana / Muñoz-Cano, Rosa / Sabato, Vito / Doña, Inmaculada / Torres, Maria J

    Allergy

    2023  Volume 79, Issue 3, Page(s) 601–612

    Abstract: Immediate drug hypersensitivity reactions (IDHRs) are a burden for patients and the health systems. This problem increases when taking into account that only a small proportion of patients initially labelled as allergic are finally confirmed after an ... ...

    Abstract Immediate drug hypersensitivity reactions (IDHRs) are a burden for patients and the health systems. This problem increases when taking into account that only a small proportion of patients initially labelled as allergic are finally confirmed after an allergological workup. The diverse nature of drugs involved will imply different interactions with the immunological system. Therefore, IDHRs can be produced by a wide array of mechanisms mediated by the drug interaction with specific antibodies or directly on effector target cells. These heterogeneous mechanisms imply an enhanced complexity for an accurate diagnosis and the identification of the phenotype and endotype at early stages of the reaction is of vital importance. Currently, several endophenotypic categories (type I IgE/non-IgE, cytokine release, Mast-related G-protein coupled receptor X2 (MRGPRX2) or Cyclooxygenase-1 (COX-1) inhibition and their associated biomarkers have been proposed. A precise knowledge of endotypes will permit to discriminate patients within the same phenotype, which is crucial in order to personalise diagnosis, future treatment and prevention to improve the patient's quality of life.
    MeSH term(s) Humans ; Quality of Life ; Drug Hypersensitivity/diagnosis ; Hypersensitivity, Immediate/diagnosis ; Hypersensitivity ; Biomarkers ; Receptors, G-Protein-Coupled/genetics ; Mast Cells ; Cell Degranulation ; Nerve Tissue Proteins ; Receptors, Neuropeptide
    Chemical Substances Biomarkers ; Receptors, G-Protein-Coupled ; MRGPRX2 protein, human ; Nerve Tissue Proteins ; Receptors, Neuropeptide
    Language English
    Publishing date 2023-11-10
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15933
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  6. Article ; Online: LPS in combination with amoxicillin increases BAT sensitivity to amoxicillin IgE-mediated hypersensitivity.

    Céspedes, Jose A / Fernández-Santamaría, Rubén / Bogas, Gador / Veguillas, Adriana Ariza / Doña, Inmaculada / Salas, María / Labella, Marina / Fernández Duarte, Tahia D / Mayorga, Cristobalina / Torres, María J / Frecha, Cecilia A

    Allergy

    2024  

    Language English
    Publishing date 2024-04-27
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.16133
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  7. Article ; Online: Algorithm for betalactam allergy diagnosis.

    Doña, Inmaculada / Romano, Antonino / Torres, María José

    Allergy

    2019  Volume 74, Issue 9, Page(s) 1817–1819

    MeSH term(s) Algorithms ; Anti-Bacterial Agents/adverse effects ; Disease Management ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/etiology ; Humans ; beta-Lactams/adverse effects
    Chemical Substances Anti-Bacterial Agents ; beta-Lactams
    Language English
    Publishing date 2019-06-02
    Publishing country Denmark
    Document type News ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.13844
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  8. Article ; Online: Basophil Activation Test for Allergy Diagnosis.

    Doña, Inmaculada / Ariza, Adriana / Fernández, Tahia D / Torres, María J

    Journal of visualized experiments : JoVE

    2021  , Issue 171

    Abstract: The basophil activation test (BAT) is a complementary in vitro diagnostic test that can be used in addition to clinical history, skin test (ST), and specific IgE (sIgE) determination in the evaluation of IgE-mediated allergic reactions to food, insect ... ...

    Abstract The basophil activation test (BAT) is a complementary in vitro diagnostic test that can be used in addition to clinical history, skin test (ST), and specific IgE (sIgE) determination in the evaluation of IgE-mediated allergic reactions to food, insect venom, drugs, as well as some forms of chronic urticaria. However, the role of this technique in the diagnostic algorithms is highly variable and not well determined. BAT is based on the determination of basophil response to allergen/drug cross-linking IgE activation through the measurement of activation markers (such as CD63, CD203c) by flow cytometry. This test can be a useful and complementary tool to avoid controlled challenge tests to confirm allergy diagnosis, especially in subjects experiencing severe life-threatening reactions. In general, the performance of BAT should be considered if i) the allergen/drug produces false positive results in ST; ii) there is no allergen/drug source to use for ST or sIgE determination; iii) there is discordance between patient history and ST or sIgE determination; iv) symptoms suggest that ST may result in systemic response; v) before considering a CCT to confirm the culprit allergen/drug. The main limitations of the test are related to non-optimal sensitivity, especially in drug allergy, the need to perform the test no longer than 24 h after sample extraction, and the lack of standardization between laboratories in terms of procedures, concentrations, and cell markers.
    MeSH term(s) Allergens ; Basophils/immunology ; Diagnostic Tests, Routine ; Humans ; Hypersensitivity/diagnosis ; Skin Tests ; Tetraspanin 30
    Chemical Substances Allergens ; Tetraspanin 30
    Language English
    Publishing date 2021-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/62600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Drug hypersensitivity, in vitro tools, biomarkers, and burden with COVID-19 vaccines.

    Palomares, Francisca / Paris, Juan L / Labella, Marina / Doña, Inmaculada / Mayorga, Cristobalina / Torres, María José

    Allergy

    2022  Volume 77, Issue 12, Page(s) 3527–3537

    Abstract: Hypersensitivity reactions to drugs are increasing worldwide. They display a large degree of variability in the immunological mechanisms involved, which impacts both disease severity and the optimal diagnostic procedure. Therefore, drug hypersensitivity ... ...

    Abstract Hypersensitivity reactions to drugs are increasing worldwide. They display a large degree of variability in the immunological mechanisms involved, which impacts both disease severity and the optimal diagnostic procedure. Therefore, drug hypersensitivity diagnosis relies on both in vitro and in vivo assessments, although most of the methods are not well standardized. Moreover, several biomarkers can be used as valuable parameters for precision medicine that provide information on the endotypes, diagnosis, prognosis, and prediction of drug hypersensitivity development, as well on the identification of therapeutic targets and treatment efficacy monitoring. Furthermore, in the last 2 years, the SARS-CoV-2 (severe acute respiratory syndrome-coronavirus) pandemic has had an important impact on health system, leading us to update approaches on how to manage hypersensitivity reactions to drugs used for its treatment and on COVID-19 (Coronavirus disease) vaccines used for its prevention. This article reviews recent advances in these 3 areas regarding drug hypersensitivity: in vitro tools for drug hypersensitivity diagnosis, recently identified biomarkers that could guide clinical decision making and management of hypersensitivity reactions to drugs and vaccines used for COVID-19.
    MeSH term(s) Humans ; Biomarkers ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/therapy ; SARS-CoV-2 ; Vaccines
    Chemical Substances Biomarkers ; COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-08-08
    Publishing country Denmark
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15461
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  10. Article ; Online: Reply to correspondence: Basophil reactivity to BNT162b2 in COVID-19 convalescence.

    Labella, Marina / Céspedes, Jose Antonio / Doña, Inmaculada / Shamji, Mohamed H / Agache, Ioana / Mayorga, Cristobalina / Torres, Maria José

    Allergy

    2022  Volume 77, Issue 7, Page(s) 2266–2267

    MeSH term(s) BNT162 Vaccine ; Basophils ; COVID-19 ; Convalescence ; Humans ; Immunoglobulin E
    Chemical Substances Immunoglobulin E (37341-29-0) ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-06-30
    Publishing country Denmark
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15208
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