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  1. Article ; Online: Pluripotent stem cell-based therapies and their path to the clinic.

    Takayama, Kazuo / Yamanaka, Shinya

    Stem cell reports

    2023  Volume 18, Issue 8, Page(s) 1547–1548

    MeSH term(s) Pluripotent Stem Cells ; Induced Pluripotent Stem Cells ; Cell Differentiation ; Cell- and Tissue-Based Therapy ; Stem Cell Transplantation
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2023.06.010
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  2. Article ; Online: In Vitro and Animal Models for SARS-CoV-2 research.

    Takayama, Kazuo

    Trends in pharmacological sciences

    2020  Volume 41, Issue 8, Page(s) 513–517

    Abstract: Basic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and identify best drug targets. Models that can faithfully reproduce the viral life cycle and reproduce the pathology of COVID-19 are required. Here, we briefly review ... ...

    Abstract Basic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and identify best drug targets. Models that can faithfully reproduce the viral life cycle and reproduce the pathology of COVID-19 are required. Here, we briefly review the cell lines, organoids, and animal models that are currently being used in COVID-19 research.
    MeSH term(s) Animals ; Betacoronavirus/isolation & purification ; Biomedical Research/methods ; COVID-19 ; Cell Line ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Disease Models, Animal ; Humans ; In Vitro Techniques ; Organoids/virology ; Pandemics ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2020.05.005
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  3. Article ; Online: [Pharmaceutical Research on Liver Diseases Using iPS Cell and Genome Editing Technologies].

    Takayama, Kazuo

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2019  Volume 139, Issue 10, Page(s) 1219–1225

    Abstract: The liver is a major organ responsible for maintaining the body's homeostasis and xenobiotic metabolism. Liver transplantation is essential for the alleviation of many severe liver diseases. However, there are many patients who cannot receive liver ... ...

    Abstract The liver is a major organ responsible for maintaining the body's homeostasis and xenobiotic metabolism. Liver transplantation is essential for the alleviation of many severe liver diseases. However, there are many patients who cannot receive liver transplants because of donor shortage. Therefore development of effective therapeutic drugs that can replace the need for liver transplantation is desired. To this end, model cells that faithfully reproduce hepatic functions are essential. It is expected that human induced pluripotent stem cell (iPS)-derived hepatocyte-like cells, which faithfully reproduce hepatic functions, would be a valuable tool for drug discovery. Hepatic differentiation from human iPS cells has been performed using growth factors, but the hepatic differentiation efficiency was quite low and liver functions of human iPS cell-derived hepatocyte-like cells were lower than those of primary human hepatocytes. Therefore we tried to improve the hepatic differentiation technology using gene transfer, genome editing, three-dimensional culture, and extracellular matrix technologies. As a result, the purity of human iPS cell-derived hepatocyte-like cells was improved into 90% or more, and the liver functions of human iPS cell-derived hepatocyte-like cells were improved to a level comparable to primary human hepatocytes. In this article, we introduce the research results we have acquired over the last decade.
    MeSH term(s) Adenoviridae ; Cell Culture Techniques ; Cell Differentiation ; Drug Discovery ; Drug Evaluation, Preclinical ; Gene Editing/methods ; Gene Transfer Techniques ; Genetic Vectors ; Hepatocytes ; Humans ; Induced Pluripotent Stem Cells/physiology ; Liver Diseases/therapy ; Pharmaceutical Research
    Language Japanese
    Publishing date 2019-10-03
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.19-00138
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  4. Article ; Online: Corrigendum to "Organ-on-a-chip models for elucidating the cellular biology of infectious diseases" [Biochimica et Biophysica Acta - Molecular cell research 1870 (2023) 119504].

    Yokoi, Fuki / Deguchi, Sayaka / Takayama, Kazuo

    Biochimica et biophysica acta. Molecular cell research

    2023  Volume 1870, Issue 7, Page(s) 119552

    Language English
    Publishing date 2023-08-01
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamcr.2023.119552
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  5. Article ; Online: In Vitro and Animal Models for SARS-CoV-2 research

    Takayama, Kazuo

    Trends in Pharmacological Sciences

    2020  Volume 41, Issue 8, Page(s) 513–517

    Keywords Toxicology ; Pharmacology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2020.05.005
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  6. Article: State-of-the-art liver disease research using liver-on-a-chip.

    Deguchi, Sayaka / Takayama, Kazuo

    Inflammation and regeneration

    2022  Volume 42, Issue 1, Page(s) 62

    Abstract: To understand disease pathophysiologies, models that recapitulate human functions are necessary. In vitro models that consist of human cells are preferred to ones using animal cells, because organ functions can vary from species to species. However, ... ...

    Abstract To understand disease pathophysiologies, models that recapitulate human functions are necessary. In vitro models that consist of human cells are preferred to ones using animal cells, because organ functions can vary from species to species. However, conventional in vitro models do not recapitulate human organ functions well. Organ-on-a-chip technology provides a reliable in vitro model of the functional units of human organs. Organ-on-a-chip technology uses microfluidic devices and their accessories to impart organ functions to human cells. Using microfluidic devices, we can co-culture multiple cell types that compose human organs. Moreover, we can culture human cells under physiologically relevant stresses, such as mechanical and shear stresses. Current organ-on-a-chip technology can reproduce the functions of several organs including the liver. Because it is difficult to maintain the function of human hepatocytes, which are the gold standard of in vitro liver models, under conventional culture conditions, the application of liver-on-a-chips to liver disease research is expected. This review introduces the current status and future prospects of liver-on-a-chips in liver disease research.
    Language English
    Publishing date 2022-12-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2051471-2
    ISSN 1880-9693 ; 0389-4290
    ISSN 1880-9693 ; 0389-4290
    DOI 10.1186/s41232-022-00248-0
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  7. Article: In Vitro and Animal Models for SARS-CoV-2 research

    Takayama, Kazuo

    Trends Pharmacol Sci

    Abstract: Basic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and identify best drug targets. Models that can faithfully reproduce the viral life cycle and reproduce the pathology of COVID-19 are required. Here, we briefly review ... ...

    Abstract Basic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and identify best drug targets. Models that can faithfully reproduce the viral life cycle and reproduce the pathology of COVID-19 are required. Here, we briefly review the cell lines, organoids, and animal models that are currently being used in COVID-19 research.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #457060
    Database COVID19

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  8. Article ; Online: Organ-on-a-chip models for elucidating the cellular biology of infectious diseases.

    Yokoi, Fuki / Deguchi, Sayaka / Takayama, Kazuo

    Biochimica et biophysica acta. Molecular cell research

    2023  Volume 1870, Issue 6, Page(s) 119504

    Abstract: Infectious diseases are caused by the invasion of pathogens into a host. To explore the mechanisms of pathogen infections and cellular responses, human models that can accurately recapitulate human pathophysiology are needed. Organ-on-a-chip is a type of ...

    Abstract Infectious diseases are caused by the invasion of pathogens into a host. To explore the mechanisms of pathogen infections and cellular responses, human models that can accurately recapitulate human pathophysiology are needed. Organ-on-a-chip is a type of advanced in vitro model system that cultures cells in microfluidic devices to replicate physiologically relevant microenvironments such as 3D structures, shear stress, and mechanical stimulation. Recently, organ-on-a-chips have been widely adopted to examine the pathophysiology of infectious diseases in detail. Here, we will summarize recent advances in infectious disease research of visceral organs such as the lung, intestine, liver, and kidneys, using organ-on-a-chips.
    MeSH term(s) Humans ; Microphysiological Systems ; Communicable Diseases ; Lung ; Liver
    Language English
    Publishing date 2023-05-26
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamcr.2023.119504
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  9. Article ; Online: In Vitro and Animal Models for SARS-CoV-2 research

    Takayama, Kazuo

    2020  

    Abstract: Basic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and identify best drug targets. Models that can faithfully reproduce the viral life cycle and reproduce the pathology of COVID-19 are required. Here, we briefly review ... ...

    Abstract Basic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and identify best drug targets. Models that can faithfully reproduce the viral life cycle and reproduce the pathology of COVID-19 are required. Here, we briefly review the cell lines, organoids, and animal models that are currently being used in COVID-19 research.
    Keywords SARS-CoV-2 ; COVID-19 ; cell models ; animal models ; organoids ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country jp
    Document type Article ; Online
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  10. Article ; Online: [Establishment of a Method of Hepatocyte Differentiation from Human Pluripotent Stem Cells for Innovative Drug Development].

    Takayama, Kazuo

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2015  Volume 135, Issue 10, Page(s) 1141–1146

    Abstract: Hepatocyte-like cells differentiated from human pluripotent stem cells (such as human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells) are expected to be utilized in drug screening. However, the hepatocyte differentiation efficiency ... ...

    Abstract Hepatocyte-like cells differentiated from human pluripotent stem cells (such as human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells) are expected to be utilized in drug screening. However, the hepatocyte differentiation efficiency and hepatic functions of hepatocyte-like cells were not sufficient to perform ES/iPS cell-based drug discovery. Therefore, we decided to improve the method of hepatocyte differentiation from human ES/iPS cells. To enhance this hepatocyte differentiation efficiency, hepatocyte-related transcription factors, such as forkhead box protein A2 (FOXA2) and hepatocyte nuclear factor 1 alpha (HNF1α), were overexpressed during the hepatocyte differentiation process. In addition, to enhance the functions of hepatocyte-like cells, these cells were cultured in three dimensional (3D) conditions using a Nanopillar plate. By FOXA2 and HNF1α overexpression, human ES/iPS cells could efficiently (more than 80%) differentiate into albumin-positive hepatocyte-like cells. Various hepatic functions, including albumin secretion and drug metabolism capacities, of the hepatocyte-like cells were significantly enhanced by performing 3D cell culture. These results suggest that the method of hepatocyte differentiation could be improved by using gene transfer and 3D cell culture technologies. We believe that these new hepatocyte-like cells would be useful tools in drug development.
    MeSH term(s) Cell Differentiation/genetics ; Cells, Cultured ; Cytological Techniques/methods ; Drug Discovery/methods ; Drug Evaluation, Preclinical ; Embryonic Stem Cells/cytology ; Gene Expression ; Gene Expression Regulation, Developmental ; Gene Transfer Techniques ; Hepatocyte Nuclear Factor 1-alpha ; Hepatocyte Nuclear Factor 3-beta ; Hepatocytes/cytology ; Humans ; Pluripotent Stem Cells/cytology
    Chemical Substances FOXA2 protein, human ; Hepatocyte Nuclear Factor 1-alpha ; Hepatocyte Nuclear Factor 3-beta (135845-92-0)
    Language Japanese
    Publishing date 2015
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.15-00194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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