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  1. Article ; Online: Future trajectory of respiratory infections following the COVID-19 pandemic in Hong Kong.

    Cheng, Weibin / Zhou, Hanchu / Ye, Yang / Chen, Yifan / Jing, Fengshi / Cao, Zhidong / Zeng, Daniel Dajun / Zhang, Qingpeng

    Chaos (Woodbury, N.Y.)

    2023  Volume 33, Issue 1, Page(s) 13124

    Abstract: The accumulation of susceptible populations for respiratory infectious diseases (RIDs) when COVID-19-targeted non-pharmaceutical interventions (NPIs) were in place might pose a greater risk of future RID outbreaks. We examined the timing and magnitude of ...

    Abstract The accumulation of susceptible populations for respiratory infectious diseases (RIDs) when COVID-19-targeted non-pharmaceutical interventions (NPIs) were in place might pose a greater risk of future RID outbreaks. We examined the timing and magnitude of RID resurgence after lifting COVID-19-targeted NPIs and assessed the burdens on the health system. We proposed the Threshold-based Control Method (TCM) to identify data-driven solutions to maintain the resilience of the health system by re-introducing NPIs when the number of severe infections reaches a threshold. There will be outbreaks of all RIDs with staggered peak times after lifting COVID-19-targeted NPIs. Such a large-scale resurgence of RID patients will impose a significant risk of overwhelming the health system. With a strict NPI strategy, a TCM-initiated threshold of 600 severe infections can ensure a sufficient supply of hospital beds for all hospitalized severely infected patients. The proposed TCM identifies effective dynamic NPIs, which facilitate future NPI relaxation policymaking.
    MeSH term(s) Humans ; Hong Kong/epidemiology ; COVID-19/epidemiology ; Pandemics ; Respiratory Tract Infections ; Disease Outbreaks
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1472677-4
    ISSN 1089-7682 ; 1054-1500
    ISSN (online) 1089-7682
    ISSN 1054-1500
    DOI 10.1063/5.0123870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Characteristics of SARS-CoV-2 Omicron infection in children imported from Hong Kong].

    Ma, W J / Wang, X S / Tian, H / Zhu, Y F / Wei, Z Q / Xu, J / Zhu, Q R / Zeng, M

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2022  Volume 60, Issue 6, Page(s) 539–544

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) COVID-19/epidemiology ; COVID-19 Vaccines ; Child ; China/epidemiology ; Female ; Hong Kong/epidemiology ; Humans ; Male ; Retrospective Studies ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language Chinese
    Publishing date 2022-05-31
    Publishing country China
    Document type Journal Article
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    DOI 10.3760/cma.j.cn112140-20220423-00367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Accurate genotype diagnosis of Hong Kongαα thalassemia based on third-generation sequencing.

    Li, Jun / Ye, Guimei / Zeng, Dan / Tian, Baodong / Wang, Wenjuan / Feng, Qiao / Zhu, Chunjiang

    Annals of translational medicine

    2022  Volume 10, Issue 20, Page(s) 1113

    Abstract: Background: The Hong Kongαα (HKαα) allele is a complex structural rearrangement of the α-globin ...

    Abstract Background: The Hong Kongαα (HKαα) allele is a complex structural rearrangement of the α-globin gene containing -α
    Methods: Between January 2015 and June 2021, 32 patients suspected of having HKαα thalassemia were included in this study. Genomic DNA was extracted, and gap-polymerase chain reaction (PCR), two-round nested PCR, multiplex ligation-dependent probe amplification (MLPA), and TGS were used for thalassemia gene detection.
    Results: The results of HKαα/αα and HKαα/-α
    Conclusions: Long-read TGS is a reliable and efficient approach for accurate detection of HKαα thalassemia, which can be widely used in clinical practice. Accurate molecular diagnosis of HKαα thalassemia will benefit clinical genetic counseling and prenatal diagnosis.
    Language English
    Publishing date 2022-11-09
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-22-4309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Simulation of mangrove suitable habitat in the Guangdong-Hong Kong-Macao Area under the background of climate change.

    Zeng, Jiali / Ai, Bin / Jian, Zhuokai / Zhao, Jun / Sun, Shaojie

    Journal of environmental management

    2023  Volume 351, Page(s) 119678

    Abstract: ... the mangrove habitat suitability along the western coast of the Guangdong-Hong Kong-Macao Area (GHMA) was ...

    Abstract Climate change has resulted in great influence on the geographical distribution of species. Mangrove forests are one of the most precious ecosystems on the planet, yet they are being threatened by the habitat destruction and degradation under the situation of global warming. Seeking suitable areas for planting mangroves to tackle climate change has been gradually popular in ecological restoration. In this study, we applied the Maximum Entropy algorithm to assess the contribution of environmental factors on mangrove distribution, simulated mangrove suitable habitat for present and future (scenario of SSP245-2070s), and used kernel density analysis for identifying priority of mangrove reserve construction. Results indicate that mean diurnal range and elevation made the highest contribution on mangrove distribution. At present, the mangrove habitat suitability along the western coast of the Guangdong-Hong Kong-Macao Area (GHMA) was the highest while that along the eastern coast was the lowest. By 2070s, mangrove suitable areas would show a decreasing trend under SSP245 scenario. High suitable areas (HSAs) would change fastest and shift to northeast in the same direction as dominant environmental factors. For further mangrove restoration, it is advisable to select sites with high suitability density in the future but low reclamation density at present as prior mangrove reserves, and these sites distribute along the northeastern and northwestern coast of Zhanjiang, Yangjiang and Jiangmen, the Pearl River Estuary and Honghai Bay of Shanwei. Meanwhile, regions with lower suitability density but higher reclamation density could be listed as secondary mangrove reserves.
    MeSH term(s) Hong Kong ; Ecosystem ; Macau ; Climate Change ; Wetlands ; China
    Language English
    Publishing date 2023-12-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2023.119678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Comparison of multi-mode Hong-Ou-Mandel interference and multi-slit interference.

    Guo, Yan / Yang, Zi-Xiang / Zeng, Zi-Qi / Ding, Chunling / Shimizu, Ryosuke / Jin, Rui-Bo

    Optics express

    2023  Volume 31, Issue 20, Page(s) 32849–32864

    Abstract: Hong-Ou-Mandel (HOM) interference of multi-mode frequency entangled states plays a crucial role ...

    Abstract Hong-Ou-Mandel (HOM) interference of multi-mode frequency entangled states plays a crucial role in quantum metrology. However, as the number of modes increases, the HOM interference pattern becomes increasingly complex, making it challenging to comprehend intuitively. To overcome this problem, we present the theory and simulation of multi-mode-HOM interference (MM-HOMI) and compare it to multi-slit interference (MSI). We find that these two interferences have a strong mapping relationship and are determined by two factors: the envelope factor and the details factor. The envelope factor is contributed by the single-mode HOM interference (single-slit diffraction) for MM-HOMI (MSI). The details factor is given by sin (Nx)/sin (x) ([sin (Nv)/sin (v)]
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.501645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Factors associated with willingness and preferences to attend family services in Hong Kong: A population-based survey.

    Zeng, Yingpei / Gong, Weijie / Lai, Agnes Yuen Kwan / Sit, Shirley Man Man / Wang, Man Ping / Ho, Sai Yin / Lam, Tai Hing

    Frontiers in public health

    2023  Volume 11, Page(s) 1057164

    Abstract: ... characteristics, family wellbeing, and family communication quality) in Hong Kong.: Methods: A population-based survey ...

    Abstract Objective: Family services are open to the community at large as well as vulnerable groups; however, little is known about the willingness of communities to attend such services. We investigated the willingness and preferences to attend family services and their associated factors (including sociodemographic characteristics, family wellbeing, and family communication quality) in Hong Kong.
    Methods: A population-based survey was conducted on residents aged over 18 years from February to March 2021. Data included sociodemographic characteristics (sex, age, education, housing type, monthly household income, and the number of cohabitants), willingness to attend family services to promote family relationships (yes/no), family service preferences (healthy living, emotion management, family communication promotion, stress management, parent-child activities, family relationship fostering, family life education, and social network building; each yes/no), family wellbeing, and family communication quality (both scores 0-10). Family wellbeing was assessed using the average scores of perceived family harmony, happiness and health (each score 0-10). Higher scores indicate better family wellbeing or family communication quality. Prevalence estimates were weighted by sex, age and educational level of the general population. Adjusted prevalence ratios (aPR) for the willingness and preferences to attend family services were calculated in relation to sociodemographic characteristics, family wellbeing, and family communication quality.
    Results: Overall, 22.1% (1,355/6,134) and 51.6% (996/1,930) of respondents were willing to attend family services to promote relationships or when facing problems, respectively. Older age (aPR = 1.37-2.30,
    Conclusions: Lower levels of family wellbeing and communication quality were associated with unwillingness to attend family services and preferences for emotion and stress management, family communication promotion, and social network building.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Hong Kong/epidemiology ; Family Relations ; Communication ; Happiness ; Emotions
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1057164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Relationship between temperature variability and daily hospitalisations in Hong Kong over two decades.

    Li, Kehang / Wang, Yawen / Jiang, Xiaoting / Li, Conglu / Chen, Jinjian / Zeng, Yiqian / Zhao, Shi / Ho, Janice Ying-En / Ran, Jinjun / Han, Lefei / Wei, Yuchen / Yeoh, Eng Kiong / Chong, Ka Chun

    Journal of global health

    2023  Volume 13, Page(s) 4122

    Abstract: ... in Hong Kong from 1999 to 2019, we examined the TV-hospitalisation associations by causes, ages, and seasons ...

    Abstract Background: Studies have highlighted the impacts of temperature variability (TV) on mortality from respiratory diseases and cardiovascular diseases, with inconsistent results specifically in subtropical urban areas than temperate ones. We aimed to fully determine TV-associated health risks over a spectrum of diseases and various subgroups in a subtropical setting.
    Methods: Using inpatient data from all public hospitals in Hong Kong from 1999 to 2019, we examined the TV-hospitalisation associations by causes, ages, and seasons by fitting a quasi-Poisson regression. We presented the results as estimated percentage changes of hospitalisations per interquartile range (IQR) of TV.
    Results: TVs in exposure days from 0-5 days (TV
    Conclusions: Our population-based study highlighted that TV-related health burden, usually regarded as minimal compared to other environmental factors, should receive more attention and be addressed in future relevant health policies, especially for vulnerable populations during the cold seasons.
    MeSH term(s) Humans ; Aged ; Hong Kong/epidemiology ; Temperature ; Hospitalization ; Respiration Disorders ; Respiratory Tract Diseases/epidemiology ; Seasons ; Cardiovascular Diseases
    Language English
    Publishing date 2023-10-13
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2986
    ISSN (online) 2047-2986
    ISSN 2047-2986
    DOI 10.7189/jogh.13.04122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: COVID-19 Vaccination Preferences Among Non-Chinese Migrants in Hong Kong: Discrete Choice Experiment.

    Asim, Saba / Wang, Kailu / Nichini, Elena / Yip, Faustina Fu / Zhu, Liling / Fung, Hin Chung Eddy / Zeng, Yan / Fang, Zhilan / Cheung, Annie Wai-Ling / Wong, Eliza Lai-Yi / Dong, Dong / Yeoh, Eng-Kiong

    JMIR public health and surveillance

    2023  Volume 9, Page(s) e40587

    Abstract: ... in certain settings compared to the general population. Hong Kong has a growing migrant population ... among the migrant population in Hong Kong.: Methods: An online discrete choice experiment (DCE) was conducted ... non-Asian migrants (Europeans, Americans, and Africans) in Hong Kong from February 26 to April 26 ...

    Abstract Background: Studies have shown increasing COVID-19 vaccination hesitancy among migrant populations in certain settings compared to the general population. Hong Kong has a growing migrant population with diverse ethnic backgrounds. Apart from individual-level factors, little is known about the migrants' preference related to COVID-19 vaccines.
    Objective: This study aims to investigate which COVID-19 vaccine-related attributes combined with individual factors may lead to vaccine acceptance or refusal among the migrant population in Hong Kong.
    Methods: An online discrete choice experiment (DCE) was conducted among adults, including Chinese people, non-Chinese Asian migrants (South, Southeast and Northeast Asians), and non-Asian migrants (Europeans, Americans, and Africans) in Hong Kong from February 26 to April 26, 2021. The participants were recruited using quota sampling and sent a link to a web survey. The vaccination attributes included in 8 choice sets in each of the 4 blocks were vaccine brand, safety and efficacy, vaccine uptake by people around, professionals' recommendation, vaccination venue, and quarantine exemption for vaccinated travelers. A nested logistic model (NLM) and a latent-class logit (LCL) model were used for statistical analysis.
    Results: A total of 208 (response rate 62.1%) migrant participants were included. Among the migrants, those with longer local residential years (n=31, 27.7%, for ≥10 years, n=7, 20.6%, for 7-9 years, n=2, 6.7%, for 4-6 years, and n=3, 9.7%, for ≤3 years; P=.03), lower education level (n=28, 28.3%, vs n=15, 13.9%, P=.01), and lower income (n=33, 25.2%, vs n=10, 13.2%, P=.04) were more likely to refuse COVID-19 vaccination irrespective of vaccination attributes. The BioNTech vaccine compared with Sinovac (adjusted odds ratio [AOR]=1.75, 95% CI 1.14-2.68), vaccine with 90% (AOR=1.44, 95% CI 1.09-1.91) and 70% efficacy (AOR=1.21, 95% CI 1.03-1.44) compared with 50% efficacy, vaccine with fewer serious adverse events (1/100,000 compared with 1/10,000; AOR=1.12, 95% CI 1.00-1.24), and quarantine exemption for cross-border travelers (AOR=1.14, 95% CI 1.01-1.30) were the vaccine attributes that could increase the likelihood of vaccination among migrants. For individual-level factors, full-time homemakers (AOR=0.44, 95% CI 0.29-0.66), those with chronic conditions (AOR=0.61, 95% CI 0.41-0.91) and more children, and those who frequently received vaccine-related information from the workplace (AOR=0.42, 95% CI 0.31-0.57) were found to be reluctant to accept the vaccine. Those with a higher income (AOR=1.79, 95% CI 1.26-2.52), those knowing anyone infected with COVID-19 (AOR=1.73, 95% CI 1.25-2.38), those having greater perceived susceptibility of COVID-19 infection (AOR=3.42, 95% CI 2.52-4.64), those who received the influenza vaccine (AOR=2.15, 95% CI 1.45-3.19), and those who frequently received information from social media (AOR=1.52, 95% CI 1.12-2.05) were more likely to accept the vaccine.
    Conclusions: This study implies that migrants have COVID-19 vaccination preference heterogeneity and that more targeted and tailored approaches are needed to promote vaccine acceptance for different subgroups of the migrant population in Hong Kong. Vaccination promotion strategies are needed for low-education and low-income migrant groups, migrants with chronic diseases, the working migrant population, homemakers, and parents.
    MeSH term(s) Adult ; Child ; Humans ; COVID-19 Vaccines ; Hong Kong/epidemiology ; Transients and Migrants ; COVID-19/epidemiology ; COVID-19/prevention & control ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-03-27
    Publishing country Canada
    Document type Journal Article
    ISSN 2369-2960
    ISSN (online) 2369-2960
    DOI 10.2196/40587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Factors associated with willingness and preferences to attend family services in Hong Kong

    Yingpei Zeng / Weijie Gong / Agnes Yuen Kwan Lai / Shirley Man Man Sit / Man Ping Wang / Sai Yin Ho / Tai Hing Lam

    Frontiers in Public Health, Vol

    A population-based survey

    2023  Volume 11

    Abstract: ... characteristics, family wellbeing, and family communication quality) in Hong Kong.MethodsA population-based survey was ...

    Abstract ObjectiveFamily services are open to the community at large as well as vulnerable groups; however, little is known about the willingness of communities to attend such services. We investigated the willingness and preferences to attend family services and their associated factors (including sociodemographic characteristics, family wellbeing, and family communication quality) in Hong Kong.MethodsA population-based survey was conducted on residents aged over 18 years from February to March 2021. Data included sociodemographic characteristics (sex, age, education, housing type, monthly household income, and the number of cohabitants), willingness to attend family services to promote family relationships (yes/no), family service preferences (healthy living, emotion management, family communication promotion, stress management, parent-child activities, family relationship fostering, family life education, and social network building; each yes/no), family wellbeing, and family communication quality (both scores 0–10). Family wellbeing was assessed using the average scores of perceived family harmony, happiness and health (each score 0–10). Higher scores indicate better family wellbeing or family communication quality. Prevalence estimates were weighted by sex, age and educational level of the general population. Adjusted prevalence ratios (aPR) for the willingness and preferences to attend family services were calculated in relation to sociodemographic characteristics, family wellbeing, and family communication quality.ResultsOverall, 22.1% (1,355/6,134) and 51.6% (996/1,930) of respondents were willing to attend family services to promote relationships or when facing problems, respectively. Older age (aPR = 1.37–2.30, P < 0.001–0.034) and having four or more cohabitants (aPR = 1.44–1.53, P = 0.002–0.003) were associated with increased aPR of willingness for both situations. Lower family wellbeing and communication quality were associated with lower aPR for such willingness (aPR = 0.43–0.86, P = 0.018–<0.001). ...
    Keywords family wellbeing ; family communication ; family support ; social service ; family service ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The pedigree analysis and prenatal diagnosis of Hong Kongαα Thalassemia and the sequence analysis of Hong Kongαα Allele.

    Wang, Wenjuan / Zheng, Haiqing / Zeng, Dan / Jiang, Linbin / Yu, Donglan / Yang, Yuzhong / Feng, Qiao / Xia, Yang / Zhu, Chunjiang

    Molecular genetics & genomic medicine

    2020  Volume 8, Issue 7, Page(s) e1285

    Abstract: Background: Thalassemia is one of the most common monogenic hemolytic disorders in the world. Hong ...

    Abstract Background: Thalassemia is one of the most common monogenic hemolytic disorders in the world. Hong Kongαα (HKαα) thalassemia was initially found among the people of southern China. Because of the complexity of genetic changes in HKαα thalassemia, we lack a precise sequence analysis of the HKαα allele. Here we aim to detect the specific genotype and trace the law of inheritance of this rare genotype.
    Methods: We recruited an unprecedented huge pedigree containing 11 individuals carrying the HKαα thalassemia gene and 4 nongenetic-related patients suffering from HKαα from south China. Regular hematological analysis and routine genetic screening were performed on the pedigree and two-round nested PCR (polymerase chain reaction) for HKαα thalassemia were performed on each individual. The first-generation gene sequencing was performed on six individuals, including four nongenetic-related patients.
    Result: We found that five family members were positive for the HKαα allele. Patients Ⅱ-2, Ⅲ-1, and Ⅱ-3 with only HKαα/--
    Conclusion: The two-round nested PCR is an effective method to detect HKαα allele. Besides, our study for the first time revealed the sequence of the HKαα allele, the evidence of the same ancestor with HKαα thalassemia and enriched the composition as well as the formation mechanism of HKαα allele, and immediately opened up novel potential diagnosis and prenatal counseling for HKαα thalassemia.
    MeSH term(s) Adult ; Alleles ; Child ; Child, Preschool ; Female ; Hemoglobins/genetics ; Humans ; Male ; Middle Aged ; Pedigree ; Pregnancy ; Prenatal Diagnosis ; alpha-Thalassemia/diagnosis ; alpha-Thalassemia/genetics
    Chemical Substances Hemoglobins
    Language English
    Publishing date 2020-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2734884-2
    ISSN 2324-9269 ; 2324-9269
    ISSN (online) 2324-9269
    ISSN 2324-9269
    DOI 10.1002/mgg3.1285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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