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  1. Book: Atomic force microscopy

    Santos, Nuno C. / Carvalho, Filomena A.

    methods and protocols

    (Methods in molecular biology ; 1886 ; Springer protocols)

    2019  

    Author's details edited by Nuno C. Santos and Filomena A. Carvalho
    Series title Methods in molecular biology ; 1886
    Springer protocols
    Collection
    Language English
    Size xiv, 372 Seiten, Illustrationen
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019928496
    ISBN 978-1-4939-8893-8 ; 9781493988945 ; 1-4939-8893-X ; 1493988948
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1886- verfügbar in Königswinter Königswinter

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  2. Book ; Online: Membrane-Peptide Interactions : From Basics to Current Applications

    Santos, Nuno C. / Gonçalves, Sónia

    2020  

    Keywords Research & information: general ; Biology, life sciences ; tachyplesin ; host defense peptide ; anticancer ; antimicrobial ; antibiofilm ; peptide-membrane interaction ; structure-activity ; model membranes ; nuclear magnetic resonance solution structure ; accelerated molecular dynamics ; alamethicin ; membrane ; peptaibol ; cell-penetrating peptide ; peptide-lipid interaction ; lipid model systems ; molecular dynamics ; NMR ; membrane biophysics ; antimicrobial peptides ; non-lytic peptides ; bacterial membranes ; calcium hydroxide ; chemokine ; human beta defensin-3-C15 ; human dental pulp cell ; Streptococcus gordonii lipoprotein ; luffa sponge ; phosphopeptide ; mass spectrometry ; Matrix-assisted laser desorption ionization ; solid-phase extraction ; surface plasmon resonance ; melittin ; liposomes ; peptide-lipid interactions ; anti-microbial peptides ; pore-forming peptides ; ESKAPE pathogens ; Staphylococcus aureus ; KR12 ; LL-37 ; lipopeptide ; critical aggregation concentration ; CD spectroscopy ; biofilm ; cytotoxicity ; organisms ; sequence analysis ; machine learning ; feature selection ; sesame protein ; ACE inhibitory peptides ; simulated gastrointestinal digestion ; amino acid sequence ; molecular docking ; chionodracines ; circular dichroism ; membrane affinity ; cell-penetrating peptides ; circular dichroism spectroscopy ; atomic force microscopy ; mycolic acid ; Langmuir monolayer ; drug-peptide conjugates ; metastasis model of B16F10 melanoma ; Pisum sativum defensin 1 (Psd1) ; anti-metastatic activity ; glucosylceramide (GlcCer) ; cyclin F ; anti-inflammatory peptide ; cell permeable peptide ; heparin-binding peptide ; collagen-induced arthritis ; inducible nitric oxide ; interferon gamma ; interleukin-6 ; Enbrel
    Size 1 electronic resource (302 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046439
    ISBN 9783039430239 ; 3039430238
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Membrane-Peptide Interactions: From Basics to Current Applications 2.0.

    Gonçalves, Sónia / Santos, Nuno C

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: The interaction between peptides and biological membranes is of fundamental importance in the mechanism of numerous membrane-mediated cellular processes, including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across ... ...

    Abstract The interaction between peptides and biological membranes is of fundamental importance in the mechanism of numerous membrane-mediated cellular processes, including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier, and viral fusion processes [...].
    MeSH term(s) Peptides ; Membranes ; Cell Membrane ; Lipid Bilayers
    Chemical Substances Peptides ; Lipid Bilayers
    Language English
    Publishing date 2023-04-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: State-of-the-Art Macromolecules in Portugal.

    Valente, Artur J M / Santos, Nuno C / Moreno, Maria João

    International journal of molecular sciences

    2024  Volume 25, Issue 1

    Abstract: This Special Issue presents five contributions covering various topics, as it would be expected for an area as comprehensive and multidisciplinary as Macromolecules [ ... ]. ...

    Abstract This Special Issue presents five contributions covering various topics, as it would be expected for an area as comprehensive and multidisciplinary as Macromolecules [...].
    MeSH term(s) Portugal ; Interdisciplinary Studies ; Macromolecular Substances
    Chemical Substances Macromolecular Substances
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25010620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: State-of-the-Art Macromolecules in Portugal

    Artur J. M. Valente / Nuno C. Santos / Maria João Moreno

    International Journal of Molecular Sciences, Vol 25, Iss 1, p

    2024  Volume 620

    Abstract: This Special Issue presents five contributions covering various topics, as it would be expected for an area as comprehensive and multidisciplinary as Macromolecules [.] ...

    Abstract This Special Issue presents five contributions covering various topics, as it would be expected for an area as comprehensive and multidisciplinary as Macromolecules [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Promising strategies employing nucleic acids as antimicrobial drugs.

    Moreira, Luís / Guimarães, Nuno M / Santos, Rita S / Loureiro, Joana A / Pereira, Maria C / Azevedo, Nuno F

    Molecular therapy. Nucleic acids

    2024  Volume 35, Issue 1, Page(s) 102122

    Abstract: Antimicrobial resistance (AMR) is a growing concern because it causes microorganisms to develop resistance to drugs commonly used to treat infections. This results in increased difficulty in treating infections, leading to higher mortality rates and ... ...

    Abstract Antimicrobial resistance (AMR) is a growing concern because it causes microorganisms to develop resistance to drugs commonly used to treat infections. This results in increased difficulty in treating infections, leading to higher mortality rates and significant economic effects. Investing in new antimicrobial agents is, therefore, necessary to prevent and control AMR. Antimicrobial nucleic acids have arisen as potential key players in novel therapies for AMR infections. They have been designed to serve as antimicrobials and to act as adjuvants to conventional antibiotics or to inhibit virulent mechanisms. This new category of antimicrobial drugs consists of antisense oligonucleotides and oligomers, DNAzymes, and transcription factor decoys, differing in terms of structure, target molecules, and mechanisms of action. They are synthesized using nucleic acid analogs to enhance their resistance to nucleases. Because bacterial envelopes are generally impermeable to oligonucleotides, delivery into the cytoplasm typically requires the assistance of nanocarriers, which can affect their therapeutic potency. Given that numerous factors contribute to the success of these antimicrobial drugs, this review aims to provide a summary of the key advancements in the use of oligonucleotides for treating bacterial infections. Their mechanisms of action and the impact of factors such as nucleic acid design, target sequence, and nanocarriers on the antimicrobial potency are discussed.
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2024.102122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Editorial: Improving antimicrobial peptides translational potential through peptidomimetics.

    Angeles-Boza, Alfredo M / Santos, Nuno C / Cardoso, Marlon H

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1304997

    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1304997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Fighting Methicillin-Resistant

    Andrade, Stéphanie / Ramalho, Maria J / Santos, Sílvio B / Melo, Luís D R / Santos, Rita S / Guimarães, Nuno / Azevedo, Nuno F / Loureiro, Joana A / Pereira, Maria C

    International journal of molecular sciences

    2023  Volume 24, Issue 10

    Abstract: Antimicrobial resistance (AMR) is considered one of the greatest threats to global health. Methicillin- ... ...

    Abstract Antimicrobial resistance (AMR) is considered one of the greatest threats to global health. Methicillin-resistant
    MeSH term(s) Humans ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcus aureus ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Nanoparticles ; Drug Delivery Systems ; Microbial Sensitivity Tests ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-05-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24109030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Liposome Delivery of Nucleic Acids in Bacteria: Toward

    Moreira, Luís / Guimarães, Nuno M / Pereira, Sara / Santos, Rita S / Loureiro, Joana A / Pereira, Maria C / Azevedo, Nuno F

    ACS infectious diseases

    2022  Volume 8, Issue 7, Page(s) 1218–1230

    Abstract: Development of specific probes to study ... ...

    Abstract Development of specific probes to study the
    MeSH term(s) Bacteria ; Gram-Positive Bacteria ; Humans ; Lipids ; Liposomes ; Microbiota ; Nucleic Acids
    Chemical Substances Lipids ; Liposomes ; Nucleic Acids
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.1c00601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sex and Age-Specific Hematology and Biochemistry Reference Intervals of Live Iberian Hares (Lepus granatensis) and Comparison with Postmortem Sampling.

    Alves, Paulo C / Santos, Nuno

    Journal of wildlife diseases

    2021  Volume 57, Issue 1, Page(s) 178–183

    Abstract: Hematology and serum biochemistry reference intervals were estimated for the Iberian hare (Lepus granatensis). Most parameters differed significantly between hunted and livetrapped Iberian hares. Significant differences were found for sex (red blood cell ...

    Abstract Hematology and serum biochemistry reference intervals were estimated for the Iberian hare (Lepus granatensis). Most parameters differed significantly between hunted and livetrapped Iberian hares. Significant differences were found for sex (red blood cell count, mean corpuscular volume, total protein, albumin, uric acid, triglycerides, cholesterol, chloride) and age classes (red blood cell count, hematocrit, mean corpuscular hemoglobin, glucose, calcium, and sodium). Sex- and age-specific reference intervals were estimated for these parameters. Red blood cell count, hemoglobin concentration, mean corpuscular hemoglobin, urea, and potassium show seasonal variations, with the lowest values in summer and the highest in winter. Creatinine, calcium, sodium, and phosphorus achieve their highest values in summer and stable baseline values throughout the rest of the year. These reference intervals can be used as baseline to monitor health, physiology, ecology, and nutrition of Iberian hare populations.
    MeSH term(s) Aging/blood ; Animals ; Blood Glucose ; Blood Proteins ; Calcium/blood ; Chlorides/blood ; Cholesterol/blood ; Erythrocyte Count ; Erythrocyte Indices ; Female ; Hares/blood ; Hares/physiology ; Hematocrit/veterinary ; Male ; Potassium/blood ; Reference Values ; Seasons ; Serum Albumin ; Sodium/blood ; Triglycerides/blood ; Urea/blood ; Uric Acid/blood
    Chemical Substances Blood Glucose ; Blood Proteins ; Chlorides ; Serum Albumin ; Triglycerides ; Uric Acid (268B43MJ25) ; Urea (8W8T17847W) ; Cholesterol (97C5T2UQ7J) ; Sodium (9NEZ333N27) ; Potassium (RWP5GA015D) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 410709-3
    ISSN 1943-3700 ; 0090-3558
    ISSN (online) 1943-3700
    ISSN 0090-3558
    DOI 10.7589/JWD-D-19-00010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1441: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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