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Article ; Online: Latent profile analysis of post-traumatic stress and post-traumatic growth among firefighters.

Shin, Yongchan / Nam, JeeEun Karin / Lee, Aeyoung / Kim, Youngkeun

2023 Volume 14, Issue 1, Page(s) 2159048

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Posttraumatic Growth, Psychological ; Stress Disorders, Post-Traumatic/epidemiology ; Firefighters ; Cross-Sectional Studies
Language	English
Publishing date	2023-04-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2586642-4
ISSN	2000-8066 ; 2000-8066
ISSN (online)	2000-8066
ISSN	2000-8066
DOI	10.1080/20008066.2022.2159048
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Extracellular CIRP Induces Calpain Activation in Neurons via PLC-IP

Sharma, Archna / Sari, Ezgi / Lee, Yongchan / Patel, Shivani / Brenner, Max / Marambaud, Philippe / Wang, Ping

Molecular neurobiology

2023 Volume 60, Issue 6, Page(s) 3311–3328

Abstract: Abnormal calcium homeostasis, activation of protease calpain, generation of p25 and hyperactivation of cyclin-dependent kinase 5 (Cdk5) have all been implicated in the pathogenesis of neurogenerative diseases including Alzheimer's disease. We have ... ...

Abstract	Abnormal calcium homeostasis, activation of protease calpain, generation of p25 and hyperactivation of cyclin-dependent kinase 5 (Cdk5) have all been implicated in the pathogenesis of neurogenerative diseases including Alzheimer's disease. We have recently shown that extracellular cold-inducible RNA-binding protein (eCIRP) induces Cdk5 activation via p25. However, the precise molecular mechanism by which eCIRP regulates calcium signaling and calpain remains to be addressed. We hypothesized that eCIRP regulates p25 via Ca
MeSH term(s)	Calcium/metabolism ; Calpain/metabolism ; Neurons/metabolism ; Phosphorylation ; Proteolysis ; RNA-Binding Proteins/metabolism
Chemical Substances	Calcium (SY7Q814VUP) ; Calpain (EC 3.4.22.-) ; RNA-Binding Proteins
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-023-03273-3
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Article ; Online: Self-recovering passive cooling utilizing endothermic reaction of NH

Kim, Seonggon / Park, Jong Ha / Lee, Jae Won / Kim, Yongchan / Kang, Yong Tae

Nature communications

2023 Volume 14, Issue 1, Page(s) 2374

Abstract: Power efficiency of photovoltaic cell is significantly affected by the cell temperature. Here, a self-recovering passive cooling unit is developed. The water-saturated zeolite 13X is coated on the back side of photovoltaic cell, and ammonium nitrate is ... ...

Abstract	Power efficiency of photovoltaic cell is significantly affected by the cell temperature. Here, a self-recovering passive cooling unit is developed. The water-saturated zeolite 13X is coated on the back side of photovoltaic cell, and ammonium nitrate is dispersed as a layer to form a thin film. When heat is supplied, water is desorbed from zeolite 13X (latent cooling), and dissolves ammonium nitrate to induce endothermic reaction cooling. It is a reversible process that recovers itself at night. The unit works on the basis that the water sorption performance of porous materials is inversely proportional to temperature, and the solubility of endothermic reaction pairs increases proportionally with temperature. The average temperature of photovoltaic cell can be reduced by 15.1 °C, and the cooling energy density reaches 2,876 kJ/kg with average cooling power of 403 W/m
Language	English
Publishing date	2023-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-38081-9
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Article: Heating performance of a coolant-source heat pump using waste heat from stack and electric devices in fuel cell electric vehicles under cold conditions

Lee, Hoseong / Lee, Dongchan / Kim, Yongchan

Energy conversion and management. 2022 Jan. 15, v. 252

2022

Abstract: An efficient heating system for the cabin of fuel cell electric vehicles (FCEVs) is required to minimize the reduction in the driving range. However, studies regarding heat pumps that use waste heat from fuel cell stack and electric devices in FCEVs are ... ...

Abstract	An efficient heating system for the cabin of fuel cell electric vehicles (FCEVs) is required to minimize the reduction in the driving range. However, studies regarding heat pumps that use waste heat from fuel cell stack and electric devices in FCEVs are limited. In this study, the heating performance of a coolant-source heat pump using waste heat in FCEVs is investigated by varying the inlet air temperature, compressor speed, coolant temperature, and coolant volumetric flow rate. A novel triple-fluid heat exchanger is introduced to recover waste heat from the fuel cell stack and electric devices at different temperatures. The heating performance of the coolant-source heat pump depends significantly on the compressor speed, and the heating capacity is inversely proportional to the COP. The effects of the coolant temperature are also investigated in the stack, electric device, and hybrid coolant modes. The stack coolant mode exhibits a relatively higher heating capacity than the electric device coolant mode owing to the higher refrigerant flow rate resulting from the increased evaporating pressure. The heating performance of the coolant-source heat pumps using the electric device coolant and the stack coolant shows different characteristics owing to the different temperature levels of the coolants. In conclusion, using the coolant-source heat pump improves the driving range of FCEVs by 10.8% compared with using the conventional electric heater under cold ambient conditions.
Keywords	administrative management ; air temperature ; cold ; energy conversion ; fuel cells ; heat exchangers ; heat pumps
Language	English
Dates of publication	2022-0115
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2000891-0
ISSN	0196-8904
ISSN	0196-8904
DOI	10.1016/j.enconman.2021.115092
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Unveiling the Role of Side Chain for Improving Nonvolatile Characteristics of Conjugated Polymers-Based Artificial Synapse.

Sung, Junho / Chung, Sein / Jang, Yongchan / Jang, Hyoik / Kim, Jiyeon / Lee, Chan / Lee, Donghwa / Jeong, Dongyeong / Cho, Kilwon / Kim, Youn Sang / Kang, Joonhee / Lee, Wonho / Lee, Eunho

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 Volume 11, Issue 16, Page(s) e2400304

Abstract: Interest has grown in services that consume a significant amount of energy, such as large language models (LLMs), and research is being conducted worldwide on synaptic devices for neuromorphic hardware. However, various complex processes are problematic ... ...

Abstract	Interest has grown in services that consume a significant amount of energy, such as large language models (LLMs), and research is being conducted worldwide on synaptic devices for neuromorphic hardware. However, various complex processes are problematic for the implementation of synaptic properties. Here, synaptic characteristics are implemented through a novel method, namely side chain control of conjugated polymers. The developed devices exhibit the characteristics of the biological brain, especially spike-timing-dependent plasticity (STDP), high-pass filtering, and long-term potentiation/depression (LTP/D). Moreover, the fabricated synaptic devices show enhanced nonvolatile characteristics, such as long retention time (≈10
MeSH term(s)	Polymers/chemistry ; Synapses/physiology ; Neuronal Plasticity/physiology ; Neural Networks, Computer
Chemical Substances	Polymers
Language	English
Publishing date	2024-02-26
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202400304
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Performance characteristics of novel magnetic-field applied polymer electrolyte membrane fuel cells under various operating conditions

Lee, Wooyeol / Yang, Wonseok / Kim, Yongchan

Energy conversion and management. 2022 Sept. 15, v. 268

2022

Abstract: In this study, the oxygen reduction reaction (ORR) performance improvement of polymer electrolyte membrane fuel cells (PEMFCs) is investigated using a low magnetic field density. The transient performance of a PEMFC using a magnetic field (MF-PEMFC) was ... ...

Abstract	In this study, the oxygen reduction reaction (ORR) performance improvement of polymer electrolyte membrane fuel cells (PEMFCs) is investigated using a low magnetic field density. The transient performance of a PEMFC using a magnetic field (MF-PEMFC) was measured and analyzed by varying the cell temperature, voltage, relative humidity, and pre-humidification time. Based on the results, the mechanism of the performance improvement of MF-PEMFC was revealed, and a strategy to maximize its performance was proposed. Enhanced oxygen mobility by a magnetic field led to a higher ORR performance and membrane humidification was accelerated by the vigorous ORR. The performance improvement of MF-PEMFC was more substantial under unfavorable membrane humidification conditions such as high temperature and low operating voltage. The maximum performance improvement of MF-PEMFC compared to that of normal PEMFC was 8.6% at 40% relative humidity, 0.30 V voltage, and 80 ℃ cell temperature due to an enhanced self-humidification effect. In addition, the maximum performance improvement and stability of MF-PEMFC were obtained with the proper pre-humidification time. In conclusion, using a magnetic field can improve the performance and stability of PEMFCs under unfavorable operating conditions.
Keywords	administrative management ; electric potential difference ; electrochemistry ; electrolytes ; energy conversion ; humidification ; magnetic fields ; oxygen ; polymers ; relative humidity ; temperature
Language	English
Dates of publication	2022-0915
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2000891-0
ISSN	0196-8904
ISSN	0196-8904
DOI	10.1016/j.enconman.2022.116013
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Multi-objective optimization of solar-assisted ground-source heat pumps for minimizing life-cycle cost and climate performance in heating-dominated regions

Lee, Minwoo / Ham, Se Hyeon / Lee, Sewon / Kim, Jinyoung / Kim, Yongchan

Energy. 2023 May, v. 270 p.126868-

2023

Abstract: The use of solar-assisted ground-source heat pumps (SGSHPs) with serial and parallel configurations can reduce the energy consumption compared with conventional ground-source heat pumps (GSHPs). However, the environmental and economic issues associated ... ...

Abstract	The use of solar-assisted ground-source heat pumps (SGSHPs) with serial and parallel configurations can reduce the energy consumption compared with conventional ground-source heat pumps (GSHPs). However, the environmental and economic issues associated with SGSHPs, which involve high initial costs and CO₂ emissions, remain major barriers to their application. Therefore, SGSHPs should be carefully designed considering both the economic and environmental circumstances to guarantee their competitiveness over GSHPs. In this study, multi-objective optimization of SGSHPs with serial and parallel configurations was conducted to minimize the life-cycle cost (LCC) and climate performance (LCCP). Based on the estimated energy consumption using Transient System Simulation Tool (TRNSYS), the design parameters and refrigerants of the SGSHPs were optimized using an artificial neural network and multi-objective genetic algorithm in the four heating-dominated regions. The optimized SGSHP with a parallel configuration exhibited lower LCC and LCCP by up to 7% and 10%, respectively, compared to that with a serial configuration. Furthermore, as building insulation technology improves, the optimal system size decreases. In addition, R134a is the best option for minimizing LCC owing to its high performance, whereas R1234yf is the best option for minimizing LCCP in Helsinki and Stockholm, showing up to a 37% reduction in LCCP.
Keywords	algorithms ; carbon dioxide ; climate ; energy ; heat ; insulating materials ; neural networks ; Heating-dominated regions ; Life-cycle climate performance ; Life-cycle cost ; Refrigerant ; Solar-assisted ground-source heat pump
Language	English
Dates of publication	2023-05
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2023.126868
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: After-Death Functions of Cell Death.

Lee, Yongchan / Overholtzer, Michael

The Yale journal of biology and medicine

2019 Volume 92, Issue 4, Page(s) 687–694

Abstract: Cell death can occur through numerous regulated mechanisms, from apoptosis to necrosis, entosis, and others. Each has a distinct mode of regulation and effect on tissue homeostasis. While the elimination of individual cells is typically considered the ... ...

Abstract	Cell death can occur through numerous regulated mechanisms, from apoptosis to necrosis, entosis, and others. Each has a distinct mode of regulation and effect on tissue homeostasis. While the elimination of individual cells is typically considered the relevant physiologic endpoint of cell death, in some cases the remnants left behind by death can also function to support tissue homeostasis. Here we discuss specific functions of the end products of cell death, and how "after-death" functions may contribute to the roles of programmed cell death in physiology.
MeSH term(s)	Animals ; Apoptosis ; Entosis ; Humans ; Models, Biological ; Phagocytosis
Language	English
Publishing date	2019-12-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	200515-3
ISSN	1551-4056 ; 0044-0086
ISSN (online)	1551-4056
ISSN	0044-0086
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Ua VI Zs.197: Show issues

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Article ; Online: Energy, economic, and environmental evaluation of a solar-assisted heat pump integrated with photovoltaic thermal modules using low-GWP refrigerants

Kim, Jinyoung / Lee, Minwoo / Lee, Dongchan / Han, Changho / Kim, Yongchan

Energy Conversion and Management. 2023, p.117512-

2023 , Page(s) 117512–

Abstract: Solar-assisted heat pumps integrated with photovoltaic thermal modules (PVT-HPs) have been extensively studied owing to their superior heating performance. However, the investigation of PVT-HPs using low global warming potential (GWP) refrigerants to ... ...

Abstract	Solar-assisted heat pumps integrated with photovoltaic thermal modules (PVT-HPs) have been extensively studied owing to their superior heating performance. However, the investigation of PVT-HPs using low global warming potential (GWP) refrigerants to replace R134a is required to comply with environmental regulations. This study aimed to investigate the substitutability of R1234yf, R1234ze(E), and R152a in PVT-HPs based on energy, economic, and environmental analyses. The heating performance of heat pumps using these low-GWP refrigerants was measured. Furthermore, transient simulations were performed using transient system simulation software to determine the annual performance of the PVT-HPs using low-GWP refrigerants. Based on the simulation results, the levelized cost of energy (LCOE) and Specific Life Cycle Climate Performance (SLCCP) were evaluated. R152a was the most economical refrigerant, showing a 50% reduction in LCOE compared to R134a because of its lower electricity purchase cost and higher sale cost. Furthermore, the SLCCPs of PVT-HPs using R1234yf, R1234ze(E), and R152a decreased by 16.8%, 17.5%, and 20.8%, respectively, compared to those using R134a. Accordingly, the refrigerant substitutability index of R152a was the highest at 1.431, owing to its superior economic and environmental performance. In conclusion, only R152a was deemed appropriate for replacing R134a in PVT-HPs.
Keywords	administrative management ; climate ; computer simulation ; electricity ; energy conversion ; environmental assessment ; environmental performance ; heat ; heat pumps ; Solar-assisted heat pump ; Photovoltaic thermal module ; Global warming potential ; Alternative refrigerant ; Life cycle climate performance
Language	English
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2000891-0
ISSN	0196-8904
ISSN	0196-8904
DOI	10.1016/j.enconman.2023.117512
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Neutrophil trogocytosis during their trans-endothelial migration: role of extracellular CIRP.

Takizawa, Satoshi / Lee, Yongchan / Jacob, Asha / Aziz, Monowar / Wang, Ping

Molecular medicine (Cambridge, Mass.)

2022 Volume 28, Issue 1, Page(s) 91

Abstract: Background: Neutrophils are the most abundant innate immune cells in the circulating blood, and they act as the first responder against bacterial and fungal infection. However, accumulation of activated neutrophils can cause severe inflammation and ... ...

Abstract	Background: Neutrophils are the most abundant innate immune cells in the circulating blood, and they act as the first responder against bacterial and fungal infection. However, accumulation of activated neutrophils can cause severe inflammation and tissue damage. Recently, neutrophil trogocytosis or membrane transfer with neighboring cells was reported to modulate immune responses. Extracellular cold-inducible RNA binding protein (eCIRP) is a newly identified damage-associated molecular pattern (DAMP). eCIRP can activate neutrophils to be more pro-inflammatory. This study aimed to identify the role of eCIRP in neutrophil trogocytosis during their trans-endothelial migration. Methods: A trans-endothelial migration (TEM) assay using bone marrow neutrophils and mouse primary lung vascular endothelial cells was conducted using transwell chambers and neutrophil trogocytosis was assessed in vitro. In an in vivo mouse model of acute lung injury, neutrophil trogocytosis was assessed from bronchoalveolar lavage fluid. Results: In TEM assay, the trogocytosis of neutrophils occurred during trans-endothelial migration and eCIRP significantly increased the percentage of these neutrophils. The trogocytosed neutrophils acquired the endothelial membrane containing junctional adhesion molecule-C (JAM-C) and VE-cadherin, and these membrane patches were polarized by Mac-1 binding. Furthermore, eCIRP-induced JAM-C positive trogocytosed neutrophils are more pro-inflammatory than the JAM-C negative counterpart. JAM-C positive trogocytosed neutrophils were also observed in the bronchoalveolar lavage fluid of a mouse model of acute lung injury. Conclusion: These data suggest that during the paracellular trans-endothelial migration of neutrophils in response to inflammation, eCIRP induces trogocytosis of neutrophils, and the trogocytosed neutrophils exhibit an exaggerated pro-inflammatory phenotype promoting acute lung injury.
MeSH term(s)	Acute Lung Injury ; Animals ; Endothelial Cells/metabolism ; Inflammation/metabolism ; Mice ; Neutrophils ; Trogocytosis
Language	English
Publishing date	2022-08-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-022-00515-3
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