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  1. Book ; Online ; E-Book: Epigenetics

    Doerfler, Walter / Böhm, Petra

    a different way of looking at genetics

    (Epigenetics and human health)

    2016  

    Author's details Walter Doerfler, Petra Böhm editors
    Series title Epigenetics and human health
    Language English
    Size 1 Online-Ressource (XVI, 254 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019052683
    ISBN 978-3-319-27186-6 ; 9783319271842 ; 3-319-27186-5 ; 3319271849
    DOI 10.1007/978-3-319-27186-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Manipulated landscapes

    Dörfler, Walter

    10.000 years of change ; an exhibition of the Graduate School "Human Development in Landscapes"

    2013  

    Institution Christian-Albrechts-Universität zu Kiel / Graduate School Human Development in Landscapes
    Author's details [ed. Walter Dörfler]
    Keywords Europa ; Siedlungsarchäologie ; Landschaftsentwicklung
    Subject Landschaftsgenese ; Landschaftsveränderung ; Landschaftswandel
    Language English
    Size 56 S. : zahlr. Ill., graph. Darst., Kt.
    Publisher Graduate School ; Habelt
    Publishing place Kiel ; Bonn
    Publishing country Germany
    Document type Book
    HBZ-ID HT017717782
    ISBN 978-3-7749-3847-2 ; 3-7749-3847-4
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    138/683 available for loan (reading room) Freihandmagazin (U1)

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  3. Book ; Conference proceedings: Medicine at the interface between science and ethics

    Doerfler, Walter

    Leopoldina Symposium, May 30 to June 1, 2007, Weißenburg, Bayern ; with 4 tables

    (Nova acta Leopoldina ; N.F., 361 : Bd. 98)

    2010  

    Institution Deutsche Akademie der Naturforscher Leopoldina
    Author's details Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften, Halle (Saale). Ed.: Walter Doerfler
    Series title Nova acta Leopoldina ; N.F., 361 : Bd. 98
    Collection
    Language English
    Size 258 S. : Ill., graph. Darst.
    Publisher Dt. Akad. der Naturforscher Leopoldina, Nationale Akad. der Wiss. u.a.
    Publishing place Halle
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT016355051
    ISBN 978-3-8047-2605-5 ; 3-8047-2605-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 4954 order for loan Magazin

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  4. Article ; Online: Adenoviral Vector DNA- and SARS-CoV-2 mRNA-Based Covid-19 Vaccines: Possible Integration into the Human Genome - Are Adenoviral Genes Expressed in Vector-based Vaccines?

    Doerfler, Walter

    Virus research

    2021  Volume 302, Page(s) 198466

    Abstract: Vigorous vaccination programs against SARS-CoV-2-causing Covid-19 are the major chance to fight this dreadful pandemic. The currently administered vaccines depend on adenovirus DNA vectors or on SARS-CoV-2 mRNA that might become reverse transcribed into ... ...

    Abstract Vigorous vaccination programs against SARS-CoV-2-causing Covid-19 are the major chance to fight this dreadful pandemic. The currently administered vaccines depend on adenovirus DNA vectors or on SARS-CoV-2 mRNA that might become reverse transcribed into DNA, however infrequently. In some societies, people have become sensitized against the potential short- or long-term side effects of foreign DNA being injected into humans. In my laboratory, the fate of foreign DNA in mammalian (human) cells and organisms has been investigated for many years. In this review, a summary of the results obtained will be presented. This synopsis has been put in the evolutionary context of retrotransposon insertions into pre-human genomes millions of years ago. In addition, studies on adenovirus vector-based DNA, on the fate of food-ingested DNA as well as the long-term persistence of SARS-CoV-2 RNA/DNA will be described. Actual integration of viral DNA molecules and of adenovirus vector DNA will likely be chance events whose frequency and epigenetic consequences cannot with certainty be assessed. The review also addresses problems of remaining adenoviral gene expression in adenoviral-based vectors and their role in side effects of vaccines. Eventually, it will come down to weighing the possible risks of genomic insertions of vaccine-associated foreign DNA and unknown levels of vector-carried adenoviral gene expression versus protection against the dangers of Covid-19. A decision in favor of vaccination against life-threatening disease appears prudent. Informing the public about the complexities of biology will be a reliable guide when having to reach personal decisions about vaccinations.
    MeSH term(s) Adenoviridae/genetics ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/genetics ; DNA, Viral/genetics ; Gene Expression ; Genetic Vectors/genetics ; Genome, Human/genetics ; Humans ; Pandemics ; RNA, Messenger/genetics ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Vaccination
    Chemical Substances COVID-19 Vaccines ; DNA, Viral ; RNA, Messenger ; RNA, Viral
    Language English
    Publishing date 2021-06-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2021.198466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1965: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Essential concepts are missing: Foreign DNA in food invades the organisms' cells and can lead to stochastic epigenetic alterations with a wide range of possible pathogenetic consequences.

    Doerfler, Walter

    Clinical epigenetics

    2020  Volume 12, Issue 1, Page(s) 21

    Abstract: In this article, a new concept for general pathogenesis has been proposed. Advances in molecular genetics have led to the realization that essential concepts in the framework of molecular biology are still missing. Clinical medicine is plagued by similar ...

    Abstract In this article, a new concept for general pathogenesis has been proposed. Advances in molecular genetics have led to the realization that essential concepts in the framework of molecular biology are still missing. Clinical medicine is plagued by similar shortcomings: The questioning of current paradigms could open new vistas and invite challenging approaches. This article presents an unconventional idea. Foreign DNA which is regularly ingested with the essential food supply is not completely degraded. Small quantities of fragmented DNA rather persist transiently in the gastro-intestinal tract of mice and can be traced to various organ systems, except for cells in the germ line. Foreign DNA entering and persisting in mammalian cells can stochastically lead to genome-wide alterations of transcriptional and CpG DNA methylation profiles. In the course of food-ingested DNA invading somatic cells, completely new cell types can be generated which might be involved in the causation of common ailments. Projects emanating from this perception merit critical analysis and rigorous pursuit.
    Language English
    Publishing date 2020-02-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553921-8
    ISSN 1868-7083 ; 1868-7075
    ISSN (online) 1868-7083
    ISSN 1868-7075
    DOI 10.1186/s13148-020-0813-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: DNA methylation: development, genetic disease and cancer

    Doerfler, Walter

    with 10 tables

    (Current topics in microbiology and immunology ; 310)

    2006  

    Author's details W. Doerfler ... (eds.)
    Series title Current topics in microbiology and immunology ; 310
    Collection
    Keywords DNS ; Methylierung
    Subject Desoxyribonucleinsäure ; DNA ; DNA-Molekül ; Desoxyribonukleinsäure
    Language English
    Size VIII, 282 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014777518
    ISBN 978-3-540-31180-5 ; 3-540-31180-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 24 -310- verfügbar in Königswinter Königswinter

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  7. Book: DNA methylation: basic mechanisms

    Doerfler, Walter

    with 3 tables

    (Current topics in microbiology and immunology ; 301)

    2006  

    Author's details W. Doerfler ... (ed.)
    Series title Current topics in microbiology and immunology ; 301
    Collection
    Keywords DNS ; Methylierung ; DNS-Methyltransferase
    Subject Desoxyribonucleinsäure ; DNA ; DNA-Molekül ; Desoxyribonukleinsäure ; EC 2.1.1.37 ; DNA-Methyltransferase ; DNA-Methylase ; DNA-cytosin-Methylransfrase ; DNA-cytosin-Methylase ; Cytosin-DNA-Methyltransferase
    Language English
    Size VI, 321 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014595085
    ISBN 3-540-29114-8 ; 978-3-540-29114-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 24 -301- verfügbar in Königswinter Königswinter

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  8. Article ; Online: Epigenetic consequences of genome manipulations: caveats for human germline therapy and genetically modified organisms.

    Doerfler, Walter

    Epigenomics

    2019  Volume 11, Issue 3, Page(s) 247–250

    MeSH term(s) Animals ; DNA Methylation ; Epigenesis, Genetic ; Epigenomics/methods ; Genetic Engineering/methods ; Genetic Therapy/methods ; Genome ; Germ Cells ; Humans ; Organisms, Genetically Modified
    Language English
    Publishing date 2019-05-20
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ISSN 1750-192X
    ISSN (online) 1750-192X
    DOI 10.2217/epi-2018-0201
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Book: Immune system, oncogenesis, gene therapy

    Doerfler, Walter

    (Adenoviruses: model and vectors in virus host interactions ; 2 ; Current topics in microbiology and immunology ; 273)

    2004  

    Author's details W. Doerfler ... (eds.)
    Series title Adenoviruses: model and vectors in virus host interactions ; 2
    Current topics in microbiology and immunology ; 273
    Adenoviruses ; model and vectors in virus host interactions
    Adenoviruses ; model and vectors in virus host interactions
    Collection Adenoviruses ; model and vectors in virus host interactions
    Adenoviruses ; model and vectors in virus host interactions
    Keywords Adenoviren ; Immunsystem ; Carcinogenese ; Gentherapie ; Vektor
    Subject Vektor-DNS ; Genetischer Vektor ; Klonierungsvektor ; Vektor-DNA ; ARD-Viren ; APC-Viren ; Somatische Gentherapie ; Krebs ; Krebsentstehung ; Karzinogenese ; Kanzerogenese ; Onkogenese ; Körpereigene Abwehr ; Körpereigene Abwehrkräfte ; Körpereigenes Abwehrsystem ; Abwehrkräfte
    Language German
    Size VIII, 365 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT013819718
    ISBN 3-540-06851-1 ; 35400068511 ; 978-3-540-06851-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 24 -273- verfügbar in Königswinter Königswinter

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  10. Book: Adenoviruses: model and vectors in virus host interactions

    Doerfler, Walter

    (Current topics in microbiology and immunology ; ...)

    2003  

    Title variant virus-host
    Author's details W. Doerfler ... (eds.)
    Series title Current topics in microbiology and immunology
    ...
    Keywords Adenoviren ; Molekularbiologie
    Subject Molekulare Biologie ; ARD-Viren ; APC-Viren
    Language English
    Dates of publication 2003-9999
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT013819705
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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