LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 72

Search options

  1. Article ; Online: Induction of Bcl11b during T cell commitment through a tripartite mechanism.

    Georgopoulos, Katia

    Nature immunology

    2016  Volume 17, Issue 8, Page(s) 903–904

    Language English
    Publishing date 2016-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/ni.3520
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: In search of the mechanism that shapes the neutrophil's nucleus.

    Georgopoulos, Katia

    Genes & development

    2017  Volume 31, Issue 2, Page(s) 85–87

    Abstract: The organization of the genome within the confines of the nuclear compartment is considered a key contributor to transcription and DNA replication, repair, and recombination. A typical higher eukaryotic cell has a spherical nucleus that is ∼10 µm in ... ...

    Abstract The organization of the genome within the confines of the nuclear compartment is considered a key contributor to transcription and DNA replication, repair, and recombination. A typical higher eukaryotic cell has a spherical nucleus that is ∼10 µm in diameter. This is not the case for a neutrophil, a short-lived innate immune cell with an unusual multilobular nuclear structure that may serve purposes outside nuclear functions. In this issue of
    MeSH term(s) Cell Nucleus ; DNA Replication ; Genome ; Humans ; Neutrophils/cytology
    Language English
    Publishing date 2017--15
    Publishing country United States
    Document type Journal Article ; Review ; Comment
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.296228.117
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2292: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 54: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma.

    Georgopoulos, Katia

    Genes & development

    2017  Volume 31, Issue 5, Page(s) 439–450

    Abstract: Lymphocyte differentiation is set to produce myriad immune effector cells with the ability to respond to multitudinous foreign substances. The uniqueness of this developmental system lies in not only the great diversity of cellular functions that it can ... ...

    Abstract Lymphocyte differentiation is set to produce myriad immune effector cells with the ability to respond to multitudinous foreign substances. The uniqueness of this developmental system lies in not only the great diversity of cellular functions that it can generate but also the ability of its differentiation intermediates and mature effector cells to expand upon demand, thereby providing lifelong immunity. Surprisingly, the goals of this developmental system are met by a relatively small group of DNA-binding transcription factors that work in concert to control the timing and magnitude of gene expression and fulfill the demands for cellular specialization, expansion, and maintenance. The cellular and molecular mechanisms through which these lineage-promoting transcription factors operate have been a focus of basic research in immunology. The mechanisms of development discerned in this effort are guiding clinical research on disorders with an immune cell base. Here, I focus on IKAROS, one of the earliest regulators of lymphoid lineage identity and a guardian of lymphocyte homeostasis.
    MeSH term(s) Animals ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Cell Lineage/genetics ; Cell Lineage/immunology ; Gene Expression Regulation, Developmental ; Homeostasis/genetics ; Homeostasis/immunology ; Humans ; Ikaros Transcription Factor/genetics ; Ikaros Transcription Factor/immunology ; Lymphocytes/cytology ; Lymphocytes/immunology ; Transcription Factors/genetics ; Transcription Factors/immunology
    Chemical Substances Transcription Factors ; Ikaros Transcription Factor (148971-36-2)
    Language English
    Publishing date 2017-03-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.297002.117
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2292: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 54: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Ebf1 in DNA repair and leukemogenesis.

    Georgopoulos, Katia

    Blood

    2015  Volume 125, Issue 26, Page(s) 3969–3971

    Abstract: In this issue of Blood, Prasad et al provide evidence for a new role for the B-lineage transcriptional regulator early B-cell factor 1 (Ebf1) during early B-cell development and B-cell acute lymphoblastic leukemia (B-ALL). ...

    Abstract In this issue of Blood, Prasad et al provide evidence for a new role for the B-lineage transcriptional regulator early B-cell factor 1 (Ebf1) during early B-cell development and B-cell acute lymphoblastic leukemia (B-ALL).
    MeSH term(s) Animals ; Cell Transformation, Neoplastic/genetics ; DNA Damage/genetics ; PAX5 Transcription Factor/genetics ; Precursor Cells, B-Lymphoid/metabolism ; Trans-Activators/genetics
    Chemical Substances PAX5 Transcription Factor ; Trans-Activators
    Language English
    Publishing date 2015-06-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2015-05-639427
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Bcl6

    O'Connor, Kevin W / Liu, Tiantian / Kim, Sunkyung / Briseño, Carlos G / Georgopoulos, Katia / Murphy, Theresa L / Murphy, Kenneth M

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 35, Page(s) e2220853120

    Abstract: ... ...

    Abstract Ly6C
    MeSH term(s) Monocytes ; Endothelium, Vascular ; Hematopoiesis ; Signal Transduction
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2220853120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: A double-negative thymocyte-specific enhancer augments Notch1 signaling to direct early T cell progenitor expansion, lineage restriction and β-selection.

    Kashiwagi, Mariko / Figueroa, Daniela Salgado / Ay, Ferhat / Morgan, Bruce A / Georgopoulos, Katia

    Nature immunology

    2022  Volume 23, Issue 11, Page(s) 1628–1643

    Abstract: T cell differentiation requires Notch1 signaling. In the present study, we show that an enhancer upstream of Notch1 active in double-negative (DN) mouse thymocytes is responsible for raising Notch1 signaling intrathymically. This enhancer is required to ... ...

    Abstract T cell differentiation requires Notch1 signaling. In the present study, we show that an enhancer upstream of Notch1 active in double-negative (DN) mouse thymocytes is responsible for raising Notch1 signaling intrathymically. This enhancer is required to expand multipotent progenitors intrathymically while delaying early differentiation until lineage restrictions have been established. Early thymic progenitors lacking the enhancer show accelerated differentiation through the DN stages and increased frequency of B, innate lymphoid (IL) and natural killer (NK) cell differentiation. Transcription regulators for T cell lineage restriction and commitment are expressed normally, but IL and NK cell gene expression persists after T cell lineage commitment and T cell receptor β VDJ recombination, Cd3 expression and β-selection have been impaired. This Notch1 enhancer is inactive in double-positive (DP) thymocytes. Its aberrant reactivation at this stage in Ikaros mutants is required for leukemogenesis. Thus, the DN-specific Notch1 enhancer harnesses the regulatory architecture of DN and DP thymocytes to achieve carefully orchestrated changes in Notch1 signaling required for early lineage restrictions and normal T cell differentiation.
    MeSH term(s) Mice ; Animals ; Thymocytes/metabolism ; Immunity, Innate ; Receptor, Notch1/genetics ; Receptor, Notch1/metabolism ; Lymphocytes/metabolism ; Thymus Gland ; Cell Differentiation/genetics ; Cell Lineage/genetics
    Chemical Substances Receptor, Notch1
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-022-01322-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Actin' Up to Stop SNFin Out TEAD.

    McClatchey, Andrea I / Georgopoulos, Katia

    Developmental cell

    2019  Volume 47, Issue 6, Page(s) 693–695

    Abstract: The transcriptional activators YAP and TAZ integrate mechanical and biochemical signals to support growth and regeneration. A recent study in Nature (Chang et al., 2018) showed that SWI/SNF sequesters YAP from its DNA-binding partner TEAD. Mechanical ... ...

    Abstract The transcriptional activators YAP and TAZ integrate mechanical and biochemical signals to support growth and regeneration. A recent study in Nature (Chang et al., 2018) showed that SWI/SNF sequesters YAP from its DNA-binding partner TEAD. Mechanical coupling between cytoskeleton and nucleus reverses this antagonism by nuclear F-actin sequestering of SWI/SNF.
    MeSH term(s) Actin Cytoskeleton ; Actins ; Cell Nucleus ; Cytoskeleton ; Transcription Factors
    Chemical Substances Actins ; Transcription Factors
    Language English
    Publishing date 2019-01-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2018.11.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5742: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 76: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Acute lymphoblastic leukemia--on the wings of IKAROS.

    Georgopoulos, Katia

    The New England journal of medicine

    2009  Volume 360, Issue 5, Page(s) 524–526

    MeSH term(s) Animals ; B-Lymphocytes/physiology ; Drug Resistance, Neoplasm/genetics ; Hematopoietic Stem Cells/physiology ; Humans ; Ikaros Transcription Factor/genetics ; Mice ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Prognosis
    Chemical Substances IKZF1 protein, human ; Ikaros Transcription Factor (148971-36-2)
    Language English
    Publishing date 2009-01-29
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe0809819
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: The Developmental Transcription Factor p63 Is Redeployed to Drive Allergic Skin Inflammation through Phosphorylation by p38α.

    Jiménez-Andrade, Yanek / Hillette, Kathryn R / Yoshida, Toshimi / Kashiwagi, Mariko / Choo, Min-Kyung / Liang, Yinming / Georgopoulos, Katia / Park, Jin Mo

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 208, Issue 12, Page(s) 2613–2621

    Abstract: Keratinocytes, the epithelial cells of the skin, reprogram their gene expression and produce immune effector molecules when exposed to environmental and endogenous triggers of inflammation. It remains unclear how keratinocytes process physiological ... ...

    Abstract Keratinocytes, the epithelial cells of the skin, reprogram their gene expression and produce immune effector molecules when exposed to environmental and endogenous triggers of inflammation. It remains unclear how keratinocytes process physiological signals generated during skin irritation and switch from a homeostatic to an inflammatory state. In this article, we show that the stress-activated protein kinase p38α is crucial for keratinocytes to prompt changes in their transcriptome upon cytokine stimulation and drive inflammation in allergen-exposed skin. p38α serves this function by phosphorylating p63, a transcription factor essential for the lineage identity and stemness of the skin epithelium. Phosphorylation by p38α alters the activity of p63 and redeploys this developmental transcription factor to a gene expression program linked to inflammation. Genetic ablation and pharmacological inhibition of p38α or the p38α-p63 target gene product MMP13 attenuate atopic dermatitis-like disease in mice. Our study reveals an epithelial molecular pathway promoting skin inflammation and actionable through treatment with topical small-molecule therapeutics.
    MeSH term(s) Animals ; Dermatitis, Atopic/metabolism ; Inflammation/metabolism ; Keratinocytes/metabolism ; Mice ; Mitogen-Activated Protein Kinase 14/metabolism ; Phosphorylation ; Transcription Factors/metabolism
    Chemical Substances Transcription Factors ; Mitogen-Activated Protein Kinase 14 (EC 2.7.11.24)
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2101160
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: From immunity to tolerance through HDAC.

    Georgopoulos, Katia

    Nature immunology

    2008  Volume 10, Issue 1, Page(s) 13–14

    Abstract: Regulation of expression of the gene encoding interleukin 10 by the histone deacetylase HDAC11 emphasizes the ability of an antigen-presenting cell to induce immunity or tolerance in CD4+ T cells. ...

    Abstract Regulation of expression of the gene encoding interleukin 10 by the histone deacetylase HDAC11 emphasizes the ability of an antigen-presenting cell to induce immunity or tolerance in CD4+ T cells.
    MeSH term(s) Animals ; Antigen-Presenting Cells/enzymology ; Antigen-Presenting Cells/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cytokines/biosynthesis ; Gene Expression Regulation ; Histone Deacetylases/metabolism ; Humans ; Immune Tolerance ; Interleukin-10/genetics ; Promoter Regions, Genetic/physiology ; Transcription, Genetic
    Chemical Substances Cytokines ; Interleukin-10 (130068-27-8) ; HDAC11 protein, human (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2008-12-16
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/ni0109-13
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top