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  1. Article ; Online: In severe COVID-19, adding lopinavir-ritonavir to usual care did not improve mortality at 28 days.

    Singh, Ameeta

    Annals of internal medicine

    2021  Volume 174, Issue 1, Page(s) JC3

    Abstract: Source citation: RECOVERY Collaborative Group. ...

    Abstract Source citation: RECOVERY Collaborative Group.
    MeSH term(s) Administration, Oral ; Aged ; Antiviral Agents/administration & dosage ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/mortality ; Drug Combinations ; Female ; Hospitalization ; Humans ; Lopinavir/administration & dosage ; Lopinavir/therapeutic use ; Male ; Multicenter Studies as Topic ; Randomized Controlled Trials as Topic ; Ritonavir/administration & dosage ; Ritonavir/therapeutic use ; SARS-CoV-2 ; United Kingdom
    Chemical Substances Antiviral Agents ; Drug Combinations ; Lopinavir (2494G1JF75) ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2021-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJ202101190-003
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  2. Article ; Online: Rapid POC tests have low sensitivity for

    Singh, Ameeta

    Annals of internal medicine

    2020  Volume 172, Issue 12, Page(s) JC69

    Abstract: Source citation: Grillo-Ardila CF, Torres M, Gaitan HG. ...

    Abstract Source citation: Grillo-Ardila CF, Torres M, Gaitan HG.
    MeSH term(s) Chlamydia Infections/diagnosis ; Chlamydia trachomatis ; Female ; Humans ; Male ; Point-of-Care Systems
    Language English
    Publishing date 2020-06-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJ202006160-069
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  3. Article ; Online: Ocular and neurosyphilis: epidemiology and approach to management.

    Singh, Ameeta E

    Current opinion in infectious diseases

    2019  Volume 33, Issue 1, Page(s) 66–72

    Abstract: Purpose of review: In the context of a resurgence of syphilis worldwide, it can be anticipated that a rise in cases of ocular, otic, and neurosyphilis will also be seen. This article reviews the current epidemiology, manifestations, and approach to ... ...

    Abstract Purpose of review: In the context of a resurgence of syphilis worldwide, it can be anticipated that a rise in cases of ocular, otic, and neurosyphilis will also be seen. This article reviews the current epidemiology, manifestations, and approach to management and treatment.
    Recent findings: Although studies continue investigating alternate approaches and new diagnostic tests for ocular and neurosyphilis, few data exist to change current diagnostic algorithms and approaches to diagnosis, management, or follow up.
    Summary: The diagnosis of neurologic and eye/ear involvement with syphilis may be delayed because of a lack of specificity of findings, low suspicion for syphilis, fluctuation in symptoms, and/or similarities in presentation to other diseases. A high index of suspicion for syphilis and re-education about the protean manifestations of syphilis by all clinicians is required provide timely diagnosis and management of ocular, otic, and neurosyphilis.
    MeSH term(s) Eye Infections, Bacterial/cerebrospinal fluid ; Eye Infections, Bacterial/diagnosis ; Eye Infections, Bacterial/epidemiology ; Eye Infections, Bacterial/etiology ; Humans ; Neurosyphilis/cerebrospinal fluid ; Neurosyphilis/diagnosis ; Neurosyphilis/epidemiology ; Neurosyphilis/therapy ; Syphilis/epidemiology ; Treponema pallidum/isolation & purification ; Treponema pallidum/pathogenicity
    Language English
    Publishing date 2019-12-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000617
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  4. Article ; Online: Neurosyphilis and Lyme neuroborreliosis.

    Dersch, Rick / Singh, Ameeta E

    Current opinion in neurology

    2021  Volume 34, Issue 3, Page(s) 403–409

    Abstract: Purpose of review: Neurosyphilis (NS) and Lyme neuroborreliosis (LNB) are spirochetal diseases with distinct clinical manifestations. The diagnosis of NS remains challenging due to imperfect diagnostic criteria and testing modalities. With LNB, ... ...

    Abstract Purpose of review: Neurosyphilis (NS) and Lyme neuroborreliosis (LNB) are spirochetal diseases with distinct clinical manifestations. The diagnosis of NS remains challenging due to imperfect diagnostic criteria and testing modalities. With LNB, misconceptions about diagnosis and treatment lead to considerable morbidity and drug related adverse effects.
    Recent findings: Although studies continue investigating alternate approaches and new diagnostic tests for NS, few data exist to change current approaches to diagnosis, management or follow up. In the diagnosis of LNB, the chemokine CXCL13 shows promising diagnostic accuracy. A systematic review discourages the use of cell-based assays when investigating Lyme disease. Clinical studies show no benefit from extended antibiotic treatment for patients with unspecific symptoms labelled as having Lyme disease.
    Summary: The diagnosis of NS may be delayed due to a lack of specificity of findings, low suspicion for syphilis, and/or similarities in presentation to other diseases. A high index of suspicion for syphilis is required provide timely diagnosis and management of NS. Fortunately, penicillin remains the treatment of choice. Overdiagnosis and overtreatment in patients labelled as having Lyme disease can be avoided by an evidence-based approach towards diagnosis and treatment.
    MeSH term(s) Chemokine CXCL13 ; Humans ; Lyme Neuroborreliosis/diagnosis ; Lyme Neuroborreliosis/drug therapy ; Neurosyphilis/diagnosis ; Neurosyphilis/drug therapy ; Neurosyphilis/epidemiology
    Chemical Substances Chemokine CXCL13
    Language English
    Publishing date 2021-03-11
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000000923
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  5. Article ; Online: In adults exposed to COVID-19, hydroxychloroquine did not reduce confirmed or probable COVID-19; trial stopped for futility.

    Singh, Ameeta / Sonpar, Ashlesha

    Annals of internal medicine

    2020  Volume 173, Issue 8, Page(s) JC41

    Abstract: Source citation: Boulware DR, Pullen MF, Bangdiwala AS, et al. ...

    Abstract Source citation: Boulware DR, Pullen MF, Bangdiwala AS, et al.
    MeSH term(s) Adult ; Betacoronavirus ; Coronavirus Infections/drug therapy ; Humans ; Hydroxychloroquine/adverse effects ; Medical Futility ; Pandemics ; Pneumonia, Viral
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Keywords covid19
    Language English
    Publishing date 2020-10-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJ202010200-041
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  6. Article ; Online: The return of syphilis in Canada: A failed plan to eliminate this infection.

    Singh, Ameeta E / Romanowski, Barbara

    Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada

    2019  Volume 4, Issue 4, Page(s) 215–217

    Language English
    Publishing date 2019-11-29
    Publishing country Canada
    Document type Journal Article
    ISSN 2371-0888
    ISSN (online) 2371-0888
    DOI 10.3138/jammi.2019-08-22
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  7. Article ; Online: Tetrahydropalmatine from medicinal plants activates human glucokinase to regulate glucose homeostasis.

    Singh, Sweta / Ghosh, Payel / Sharma, Shilpy / Bhargava, Shobha / Kumar, Ameeta Ravi

    Biotechnology and applied biochemistry

    2023  Volume 71, Issue 2, Page(s) 295–313

    Abstract: Many synthetic glucokinase activators (GKAs), modulating glucokinase (GK), an important therapeutic target in diabetes have failed to clear clinical trials. In this study, an in silico structural similarity search with differing scaffolds of reference ... ...

    Abstract Many synthetic glucokinase activators (GKAs), modulating glucokinase (GK), an important therapeutic target in diabetes have failed to clear clinical trials. In this study, an in silico structural similarity search with differing scaffolds of reference GKAs have been used to identify derivatives from natural product databases. Ten molecules with good binding score and similar interactions to that in the co-crystallized GK as well good activation against recombinant human GK experimentally were identified. Tetrahydropalmatine, an alkaloid present in formulations and drugs from medicinal plants, has not been explored as an antidiabetic agent and no information regarding its mechanism of action or GK activation exists. Tetrahydropalmatine activates GK with EC
    MeSH term(s) Humans ; Berberine Alkaloids ; Glucokinase/genetics ; Glucokinase/metabolism ; Glucose ; Homeostasis ; Plants, Medicinal
    Chemical Substances Berberine Alkaloids ; Glucokinase (EC 2.7.1.2) ; Glucose (IY9XDZ35W2) ; tetrahydropalmatine (3X69CO5I79)
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 883433-7
    ISSN 1470-8744 ; 0885-4513
    ISSN (online) 1470-8744
    ISSN 0885-4513
    DOI 10.1002/bab.2541
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  8. Article ; Online: Is It Time for the United States and Canada to Reconsider Macrolides as the First-line Empiric Treatment for Males With Symptomatic Urethritis?

    Singh, Ameeta E / Manhart, Lisa

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2019  Volume 70, Issue 5, Page(s) 811–813

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Canada ; Gonorrhea ; Humans ; Macrolides/therapeutic use ; Male ; Mycoplasma genitalium ; United States ; Urethritis/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Macrolides
    Language English
    Publishing date 2019-04-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciz297
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  9. Article: Is Ultrasound-Guided Transversus Abdominis Plane Block Superior to a Caudal Epidural or Wound Infiltration for Intraoperative and Postoperative Analgesia in Children Undergoing Unilateral Infraumbilical Surgery? A Double-blind Randomized Trial.

    Rautela, Mukesh Singh / Sahni, Ameeta / Dalal, Niti

    Journal of Indian Association of Pediatric Surgeons

    2022  Volume 27, Issue 3, Page(s) 323–328

    Abstract: Background and aim: Caudal block (CB) is the standard of care in pediatric surgeries. Ultrasound (USG) transversus abdominis plane (TAP) block has also been used as an effective regional anesthesia technique. We compared the duration of postoperative ... ...

    Abstract Background and aim: Caudal block (CB) is the standard of care in pediatric surgeries. Ultrasound (USG) transversus abdominis plane (TAP) block has also been used as an effective regional anesthesia technique. We compared the duration of postoperative and intraoperative analgesia between TAP block, CB, and local wound infiltration (LI) in children undergoing unilateral infraumbilical abdominal surgery.
    Materials and methods: One hundred and twenty children, 3-10 years old and American Society of Anesthesiologists Grade I and II, undergoing elective unilateral infraumbilical abdominal surgery were allocated to three groups. Group TAP: USG-guided TAP block with 0.5 ml/kg of 0.25% bupivacaine; Group CB: CB with 0.75 ml/kg of 0.25% bupivacaine; and Group LI: Local wound infiltration along the incision with 0.5 ml/kg of 0.25% bupivacaine. The primary outcome was the efficacy of postoperative analgesia using modified objective pain score (MOPS), and the secondary outcome was to determine intraoperative analgesia with fentanyl requirement and minimum alveolar concentration (MAC) hour of isoflurane among the three groups.
    Results: The MOPS was statistically better in Group TAP compared to group CB and group LI at 8 and 24 h postoperatively. The mean ± standard deviation duration of postoperative analgesia in groups CB, LI, and TAP was 6.84 ± 0.47, 2.3 ± 1.26, and 9.78 ± 1.02 h, respectively. The intraoperative requirement of fentanyl and MAC hour was least in Group CB.
    Conclusion: We found that USG-guided TAP block is a good alternative, with longer and effective postoperative analgesia compared to CB. However, the quality of intraoperative analgesia was best in group CB. Local infiltration was a poor alternative.
    Language English
    Publishing date 2022-05-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 2164528-0
    ISSN 1998-3891 ; 0971-9261
    ISSN (online) 1998-3891
    ISSN 0971-9261
    DOI 10.4103/jiaps.JIAPS_54_21
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  10. Article ; Online: Serologic follow-up of solid organ transplant recipients who received organs from donors with reactive syphilis tests: A retrospective cohort study.

    Fernández García, Oscar A / Singh, Ameeta E / Gratrix, Jennifer / Smyczek, Petra / Doucette, Karen

    Clinical transplantation

    2023  Volume 37, Issue 2, Page(s) e14896

    Abstract: The increased procurement of organs from donors with risk factors for blood-borne diseases and the expanding syphilis epidemic have resulted in a growing number of organs transplanted from donors with reactive syphilis serology in our center. Based on ... ...

    Abstract The increased procurement of organs from donors with risk factors for blood-borne diseases and the expanding syphilis epidemic have resulted in a growing number of organs transplanted from donors with reactive syphilis serology in our center. Based on guidelines, recipients typically receive therapy shortly after the transplant, but data on outcomes are limited. The primary objective of this study was to determine syphilis seroconversion rates at three months post-transplant in recipients of solid organs procured from donors with reactive syphilis serology. Organ donors and recipients were tested for syphilis antibody; positive results were confirmed with Treponema pallidum Particle Agglutination (TPPA). Eleven donors with reactive syphilis antibody donated organs to 25 syphilis negative recipients. Three recipients seroconverted at post-transplant month 3. All of them had received therapy shortly after transplant. TPPA was negative in all 3. Despite post-transplant treatment, 3 of 25 (12%) syphilis negative recipients of organs from syphilis positive donors seroconverted at 3 months. All remained TPPA negative possibly reflecting passive antibody transfer or differing test sensitivity to low level treponemal antibodies. Further studies are needed to assess optimal syphilis transmission prevention strategies and follow up recipient testing in organ transplantation.
    MeSH term(s) Humans ; Syphilis/diagnosis ; Syphilis/epidemiology ; Retrospective Studies ; Follow-Up Studies ; Treponema pallidum ; Tissue Donors ; Organ Transplantation/adverse effects ; Organ Transplantation/methods ; Transplant Recipients ; Antibodies
    Chemical Substances Antibodies
    Language English
    Publishing date 2023-01-09
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.14896
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