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  1. Article: Molecular Pathogenesis and New Therapeutic Dimensions for Spinal Muscular Atrophy.

    López-Cortés, Andrés / Echeverría-Garcés, Gabriela / Ramos-Medina, María José

    Biology

    2022  Volume 11, Issue 6

    Abstract: The condition known as 5q spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease caused by a deficiency of the ubiquitous protein survival of motor neuron (SMN), which is encoded by ... ...

    Abstract The condition known as 5q spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease caused by a deficiency of the ubiquitous protein survival of motor neuron (SMN), which is encoded by the
    Language English
    Publishing date 2022-06-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11060894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Molecular Pathogenesis and New Therapeutic Dimensions for Spinal Muscular Atrophy

    López-Cortés, Andrés / Echeverría-Garcés, Gabriela / Ramos-Medina, María José

    Biology. 2022 June 10, v. 11, no. 6

    2022  

    Abstract: The condition known as 5q spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease caused by a deficiency of the ubiquitous protein survival of motor neuron (SMN), which is encoded by the SMN1 and SMN2 genes. It is one of ... ...

    Abstract The condition known as 5q spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease caused by a deficiency of the ubiquitous protein survival of motor neuron (SMN), which is encoded by the SMN1 and SMN2 genes. It is one of the most common pediatric recessive genetic diseases, and it represents the most common cause of hereditary infant mortality. After decades of intensive basic and clinical research efforts, and improvements in the standard of care, successful therapeutic milestones have been developed, delaying the progression of 5q SMA and increasing patient survival. At the same time, promising data from early-stage clinical trials have indicated that additional therapeutic options are likely to emerge in the near future. Here, we provide updated information on the molecular underpinnings of SMA; we also provide an overview of the rapidly evolving therapeutic landscape for SMA, including SMN-targeted therapies, SMN-independent therapies, and combinational therapies that are likely to be key for the development of treatments that are effective across a patient’s lifespan.
    Keywords biomedical research ; infant mortality ; landscapes ; longevity ; motor neurons ; muscular atrophy ; pathogenesis ; patients ; therapeutics
    Language English
    Dates of publication 2022-0610
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11060894
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Molecular Pathogenesis and New Therapeutic Dimensions for Spinal Muscular Atrophy

    Andrés López-Cortés / Gabriela Echeverría-Garcés / María José Ramos-Medina

    Biology, Vol 11, Iss 894, p

    2022  Volume 894

    Abstract: The condition known as 5q spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease caused by a deficiency of the ubiquitous protein survival of motor neuron (SMN), which is encoded by the SMN1 and SMN2 genes. It is one of ... ...

    Abstract The condition known as 5q spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease caused by a deficiency of the ubiquitous protein survival of motor neuron (SMN), which is encoded by the SMN1 and SMN2 genes. It is one of the most common pediatric recessive genetic diseases, and it represents the most common cause of hereditary infant mortality. After decades of intensive basic and clinical research efforts, and improvements in the standard of care, successful therapeutic milestones have been developed, delaying the progression of 5q SMA and increasing patient survival. At the same time, promising data from early-stage clinical trials have indicated that additional therapeutic options are likely to emerge in the near future. Here, we provide updated information on the molecular underpinnings of SMA; we also provide an overview of the rapidly evolving therapeutic landscape for SMA, including SMN-targeted therapies, SMN-independent therapies, and combinational therapies that are likely to be key for the development of treatments that are effective across a patient’s lifespan.
    Keywords spinal muscular atrophy ; SMN1 ; SMN2 ; recessive genetic disease ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Editorial: Pharmacogenetics and pharmacogenomics in Latin America: ethnic variability, new insights in advances and perspectives: a RELIVAF-CYTED initiative, Volume II.

    López-Cortés, Andrés / Esperón, Patricia / Martínez, Matías F / Redal, María A / Lazarowski, Alberto / Varela, Nelson M / Lares-Asseff, Ismael / Quiñones, Luis A

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1211712

    Language English
    Publishing date 2023-05-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1211712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Biological role of fructose in the male reproductive system: Potential implications for prostate cancer.

    Echeverría, Carolina E / Oyarzún, Vanessa I / López-Cortés, Andrés / Cancino, Jorge / Sotomayor, Paula C / Goncalves, Marcus D / Godoy, Alejandro S

    The Prostate

    2023  Volume 84, Issue 1, Page(s) 8–24

    Abstract: Background: Over the last 20 years, fructose has gradually emerged as a potential metabolic substrate capable of promoting the growth and progression of various cancers, including prostate cancer (PCa). The biological and molecular mechanisms that ... ...

    Abstract Background: Over the last 20 years, fructose has gradually emerged as a potential metabolic substrate capable of promoting the growth and progression of various cancers, including prostate cancer (PCa). The biological and molecular mechanisms that underlie the effects of fructose on cancer are beginning to be elucidated.
    Methods: This review summarizes the biological function of fructose as a potential carbon source for PCa cells and its role in the functionality of the male reproductive tract under normal conditions.
    Results: The most recent biological advances related to fructose transport and metabolism as well as their implications in PCa growth and progression suggest that fructose represent a potential carbon source for PCa cells. Consequently, fructose derivatives may represent efficient radiotracers for obtaining PCa images via positron emission tomography and fructose transporters/fructose-metabolizing enzymes could be utilized as potential diagnostic and/or predictive biomarkers for PCa.
    Conclusion: The existing data suggest that restriction of fructose from the diet could be a useful therapeutic strategy for patients with PCa.
    MeSH term(s) Humans ; Male ; Fructose ; Prostatic Neoplasms/metabolism ; Positron-Emission Tomography ; Genitalia, Male ; Carbon
    Chemical Substances Fructose (30237-26-4) ; Carbon (7440-44-0)
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604707-5
    ISSN 1097-0045 ; 0270-4137
    ISSN (online) 1097-0045
    ISSN 0270-4137
    DOI 10.1002/pros.24631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Article: Data mining identifies novel RNA-binding proteins involved in colon and rectal carcinomas.

    García-Cárdenas, Jennyfer M / Armendáriz-Castillo, Isaac / García-Cárdenas, Nathali / Pesantez-Coronel, David / López-Cortés, Andrés / Indacochea, Alberto / Guerrero, Santiago

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1088057

    Abstract: Colorectal adenocarcinoma (COREAD) is the second most deadly cancer and third most frequently encountered malignancy worldwide. Despite efforts in molecular subtyping and subsequent personalized COREAD treatments, multidisciplinary evidence suggests ... ...

    Abstract Colorectal adenocarcinoma (COREAD) is the second most deadly cancer and third most frequently encountered malignancy worldwide. Despite efforts in molecular subtyping and subsequent personalized COREAD treatments, multidisciplinary evidence suggests separating COREAD into colon cancer (COAD) and rectal cancer (READ). This new perspective could improve diagnosis and treatment of both carcinomas. RNA-binding proteins (RBPs), as critical regulators of every hallmark of cancer, could fulfill the need to identify sensitive biomarkers for COAD and READ separately. To detect new RBPs involved in COAD and READ progression, here we used a multidata integration strategy to prioritize tumorigenic RBPs. We analyzed and integrated 1) RBPs genomic and transcriptomic alterations from 488 COAD and 155 READ patients, 2) ∼ 10,000 raw associations between RBPs and cancer genes, 3) ∼ 15,000 immunostainings, and 4) loss-of-function screens performed in 102 COREAD cell lines. Thus, we unraveled new putative roles of NOP56, RBM12, NAT10, FKBP1A, EMG1, and CSE1L in COAD and READ progression. Interestingly, FKBP1A and EMG1 have never been related with any of these carcinomas but presented tumorigenic features in other cancer types. Subsequent survival analyses highlighted the clinical relevance of FKBP1A, NOP56, and NAT10 mRNA expression to predict poor prognosis in COREAD and COAD patients. Further research should be performed to validate their clinical potential and to elucidate their molecular mechanisms underlying these malignancies.
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1088057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates.

    Kyriakidis, Nikolaos C / López-Cortés, Andrés / González, Eduardo Vásconez / Grimaldos, Alejandra Barreto / Prado, Esteban Ortiz

    NPJ vaccines

    2021  Volume 6, Issue 1, Page(s) 28

    Abstract: The new SARS-CoV-2 virus is an RNA virus that belongs to the Coronaviridae family and causes COVID-19 disease. The newly sequenced virus appears to originate in China and rapidly spread throughout the world, becoming a pandemic that, until January 5th, ... ...

    Abstract The new SARS-CoV-2 virus is an RNA virus that belongs to the Coronaviridae family and causes COVID-19 disease. The newly sequenced virus appears to originate in China and rapidly spread throughout the world, becoming a pandemic that, until January 5th, 2021, has caused more than 1,866,000 deaths. Hence, laboratories worldwide are developing an effective vaccine against this disease, which will be essential to reduce morbidity and mortality. Currently, there more than 64 vaccine candidates, most of them aiming to induce neutralizing antibodies against the spike protein (S). These antibodies will prevent uptake through the human ACE-2 receptor, thereby limiting viral entrance. Different vaccine platforms are being used for vaccine development, each one presenting several advantages and disadvantages. Thus far, thirteen vaccine candidates are being tested in Phase 3 clinical trials; therefore, it is closer to receiving approval or authorization for large-scale immunizations.
    Language English
    Publishing date 2021-02-22
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-021-00292-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  8. Article: Editorial: Pharmacogenetics and Pharmacogenomics in Latin America: Ethnic Variability, New Insights in Advances and Perspectives: A RELIVAF-CYTED Initiative.

    Esperón, Patricia / Martínez, Matías F / Redal, María A / Lazarowski, Alberto / López-Cortés, Andrés / Varela, Nelson M / Quiñones, Luis A

    Frontiers in pharmacology

    2022  Volume 12, Page(s) 833000

    Language English
    Publishing date 2022-01-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.833000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Data mining identifies novel RNA-binding proteins involved in colon and rectal carcinomas

    Jennyfer M. García-Cárdenas / Isaac Armendáriz-Castillo / Nathali García-Cárdenas / David Pesantez-Coronel / Andrés López-Cortés / Alberto Indacochea / Santiago Guerrero

    Frontiers in Cell and Developmental Biology, Vol

    2023  Volume 11

    Abstract: Colorectal adenocarcinoma (COREAD) is the second most deadly cancer and third most frequently encountered malignancy worldwide. Despite efforts in molecular subtyping and subsequent personalized COREAD treatments, multidisciplinary evidence suggests ... ...

    Abstract Colorectal adenocarcinoma (COREAD) is the second most deadly cancer and third most frequently encountered malignancy worldwide. Despite efforts in molecular subtyping and subsequent personalized COREAD treatments, multidisciplinary evidence suggests separating COREAD into colon cancer (COAD) and rectal cancer (READ). This new perspective could improve diagnosis and treatment of both carcinomas. RNA-binding proteins (RBPs), as critical regulators of every hallmark of cancer, could fulfill the need to identify sensitive biomarkers for COAD and READ separately. To detect new RBPs involved in COAD and READ progression, here we used a multidata integration strategy to prioritize tumorigenic RBPs. We analyzed and integrated 1) RBPs genomic and transcriptomic alterations from 488 COAD and 155 READ patients, 2) ∼ 10,000 raw associations between RBPs and cancer genes, 3) ∼ 15,000 immunostainings, and 4) loss-of-function screens performed in 102 COREAD cell lines. Thus, we unraveled new putative roles of NOP56, RBM12, NAT10, FKBP1A, EMG1, and CSE1L in COAD and READ progression. Interestingly, FKBP1A and EMG1 have never been related with any of these carcinomas but presented tumorigenic features in other cancer types. Subsequent survival analyses highlighted the clinical relevance of FKBP1A, NOP56, and NAT10 mRNA expression to predict poor prognosis in COREAD and COAD patients. Further research should be performed to validate their clinical potential and to elucidate their molecular mechanisms underlying these malignancies.
    Keywords RNA-binding proteins (RBPs) ; colorectal adenocarcinoma (COREAD) ; rectum ; colon ; biomarkers ; cancer ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Integrated In Silico Analyses Identify PUF60 and SF3A3 as New Spliceosome-Related Breast Cancer RNA-Binding Proteins.

    García-Cárdenas, Jennyfer M / Armendáriz-Castillo, Isaac / Pérez-Villa, Andy / Indacochea, Alberto / Jácome-Alvarado, Andrea / López-Cortés, Andrés / Guerrero, Santiago

    Biology

    2022  Volume 11, Issue 4

    Abstract: More women are diagnosed with breast cancer (BC) than any other type of cancer. Although large-scale efforts have completely redefined cancer, a cure remains unattainable. In that respect, new molecular functions of the cell should be investigated, such ... ...

    Abstract More women are diagnosed with breast cancer (BC) than any other type of cancer. Although large-scale efforts have completely redefined cancer, a cure remains unattainable. In that respect, new molecular functions of the cell should be investigated, such as post-transcriptional regulation. RNA-binding proteins (RBPs) are emerging as critical post-transcriptional modulators of tumorigenesis, but only a few have clear roles in BC. To recognize new putative breast cancer RNA-binding proteins, we performed integrated in silico analyses of all human RBPs (
    Language English
    Publishing date 2022-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11040481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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