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Article ; Online: Exploration of Anti-plasmodial Activity of Prunus cerasoides Buch.-Ham. ex D. Don (family: Rosaceae) and Its Wood Chromatographic Fractions.

Sachdeva, Cheryl / Kumar, Sandeep / Kaushik, Naveen K

2020 Volume 66, Issue 1, Page(s) 205–212

Abstract: Purpose: Increasing resistance to the currently available antimalarial drugs is a leading cause of failure to control malaria. Plant-based medicines are commonly used to manage numerous infections, making medicinal plants the best possible source of ... ...

Abstract	Purpose: Increasing resistance to the currently available antimalarial drugs is a leading cause of failure to control malaria. Plant-based medicines are commonly used to manage numerous infections, making medicinal plants the best possible source of alternative antimalarial drugs. The objective of this study is therefore to identify antimalarial potential of Prunus cerasoides. Methods: Here, anti-plasmodial activity of crude methanolic and aqueous extracts of Prunus cerasoides and fractions obtained by reverse-phase high performance liquid chromatography (RPHPLC) were tested for in vitro activity against chloroquine sensitive Plasmodium falciparum 3D7 and chloroquine resistant INDO & Dd2 strains using SYBR Green I assay. The cytotoxic activity of active extracts/fractions was evaluated against mammalian cell lines-HeLa using MTT assay. Results: Aqueous extracts of leaves, wood, bark and fruit of P. cerasoides showed poor to no activity up to 100 µg/ml, however methanolic extract showed moderate (IC Conclusion: Findings of this study elucidate the anti-plasmodial potential of P. cerasoides and validate its traditional usage suggesting that it could be a possible source of a drug candidate in combating this disease.
MeSH term(s)	Animals ; Antimalarials/pharmacology ; Humans ; Plant Extracts/pharmacology ; Plasmodium falciparum ; Prunus ; Rosaceae ; Wood
Chemical Substances	Antimalarials ; Plant Extracts
Language	English
Publishing date	2020-09-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1132735-2
ISSN	1896-1851 ; 0065-1478 ; 1230-2821
ISSN (online)	1896-1851
ISSN	0065-1478 ; 1230-2821
DOI	10.1007/s11686-020-00272-5
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Article ; Online: Assessment of in vitro and in vivo antimalarial efficacy and GC-fingerprints of selected medicinal plant extracts.

Sachdeva, Cheryl / Mohanakrishnan, Dinesh / Kumar, Sandeep / Kaushik, Naveen Kumar

Experimental parasitology

2020 Volume 219, Page(s) 108011

Abstract: A hallmark of mortality and morbidity, malaria is affecting nearly half of the world's population. Emergence of drug-resistant strains of malarial parasite prompts identification and evaluation of medicinal plants and their constituents that may hold the ...

Abstract	A hallmark of mortality and morbidity, malaria is affecting nearly half of the world's population. Emergence of drug-resistant strains of malarial parasite prompts identification and evaluation of medicinal plants and their constituents that may hold the key to a new and effective anti-malarial drug. In this context, nineteen methanolic extracts from seventeen medicinal plants were evaluated for anti-plasmodial potential against Plasmodium falciparum strain 3D7 (Chloroquine (CQ) sensitive) and INDO (CQ resistant) using fluorescence based SYBR-Green assay and for cytotoxic effects against mammalian cell lines. Leaf extract of two plants showed promising in vitro anti-malarial activity (Pf3D7 IC
MeSH term(s)	Acacia/chemistry ; Animals ; Antimalarials/classification ; Antimalarials/pharmacology ; Antimalarials/toxicity ; Chromatography, High Pressure Liquid ; Dose-Response Relationship, Drug ; Ethnopharmacology ; Female ; Gas Chromatography-Mass Spectrometry ; HEK293 Cells ; Humans ; India ; Inhibitory Concentration 50 ; Medicine, East Asian Traditional ; Mice ; Mice, Inbred BALB C ; Plant Extracts/pharmacology ; Plant Extracts/toxicity ; Plant Leaves/chemistry ; Plants, Medicinal/chemistry ; Plants, Medicinal/classification ; Plasmodium berghei/drug effects ; Plasmodium falciparum/drug effects ; Rubus/chemistry ; Syzygium/chemistry
Chemical Substances	Antimalarials ; Plant Extracts
Language	English
Publishing date	2020-09-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	391089-1
ISSN	1090-2449 ; 0014-4894
ISSN (online)	1090-2449
ISSN	0014-4894
DOI	10.1016/j.exppara.2020.108011
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Article: Assessment of in vitro and in vivo antimalarial efficacy and GC-fingerprints of selected medicinal plant extracts

Sachdeva, Cheryl / Mohanakrishnan, Dinesh / Kumar, Sandeep / Kaushik, Naveen Kumar

Experimental parasitology. 2020 Dec., v. 219

2020

Abstract	A hallmark of mortality and morbidity, malaria is affecting nearly half of the world's population. Emergence of drug-resistant strains of malarial parasite prompts identification and evaluation of medicinal plants and their constituents that may hold the key to a new and effective anti-malarial drug. In this context, nineteen methanolic extracts from seventeen medicinal plants were evaluated for anti-plasmodial potential against Plasmodium falciparum strain 3D7 (Chloroquine (CQ) sensitive) and INDO (CQ resistant) using fluorescence based SYBR-Green assay and for cytotoxic effects against mammalian cell lines. Leaf extract of two plants showed promising in vitro anti-malarial activity (Pf3D7 IC₅₀ ≤ 10 μg/ml); one plant extract showed good activity (Pf3D7 IC₅₀ = 10.1–20 μg/ml); seven were moderately active (IC₅₀ = 20.1–50 μg/ml), four plant extracts showed poor activity (PfD7 IC₅₀ = 50.1–100 μg/ml) and five extracts showed no activity up to IC₅₀ = 100 μg/ml. Further, six extracts were found equipotent to PfINDO (resistance index ranging 0.4–2) and relatively nontoxic to mammalian cell lines HEK293 (cytotoxicity index ranging 1.4–12.5). Based on good resistance and selectivity indices, three extracts were evaluated for in vivo activity in Plasmodium berghei ANKA infected mice at a dose of 500 mg/kg and they showed significant suppression of P. berghei parasitemia. Further, these active plant extracts were fractionated using silica-gel chromatography and their fractions were evaluated for anti-plasmodial action. Obtained fractions showed enrichment in antimalarial activity. Active fractions were analyzed by gas chromatography and mass-spectrometery. Results suggests that the three active plant extracts could serve as potent source of anti-malarial agent and therefore require further analysis.
Keywords	Plasmodium berghei ; Plasmodium falciparum ; chloroquine ; cytotoxicity ; drug resistance ; fluorescence ; gas chromatography ; leaf extracts ; malaria ; medicinal plants ; morbidity ; mortality ; parasitemia ; parasites ; parasitology ; silica gel
Language	English
Dates of publication	2020-12
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	391089-1
ISSN	1090-2449 ; 0014-4894
ISSN (online)	1090-2449
ISSN	0014-4894
DOI	10.1016/j.exppara.2020.108011
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: In silico

Sachdeva, Cheryl / Wadhwa, Anju / Kumari, Anita / Hussain, Firasat / Jha, Preeti / Kaushik, Naveen K

Omics : a journal of integrative biology

2020 Volume 24, Issue 10, Page(s) 568–580

Abstract: Although the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is wreaking havoc and resulting in mortality and morbidity across the planet, novel treatments are urgently needed. Drug ... ...

Abstract	Although the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is wreaking havoc and resulting in mortality and morbidity across the planet, novel treatments are urgently needed. Drug repurposing offers an innovative approach in this context. We report here new findings on the
MeSH term(s)	Antimalarials/chemistry ; Antimalarials/pharmacology ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Betacoronavirus/chemistry ; Betacoronavirus/drug effects ; Binding Sites ; Computer Simulation ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Cysteine Endopeptidases/chemistry ; Cysteine Endopeptidases/drug effects ; Doxycycline/chemistry ; Doxycycline/pharmacology ; Drug Evaluation, Preclinical ; Drug Repositioning/methods ; Humans ; Molecular Docking Simulation ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/drug effects ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/drug effects
Chemical Substances	Antimalarials ; Antiviral Agents ; Spike Glycoprotein, Coronavirus ; Viral Nonstructural Proteins ; spike protein, SARS-CoV-2 ; 3C-like proteinase, Coronavirus (EC 3.4.22.-) ; Cysteine Endopeptidases (EC 3.4.22.-) ; Doxycycline (N12000U13O)
Keywords	covid19
Language	English
Publishing date	2020-07-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2030312-9
ISSN	1557-8100 ; 1536-2310
ISSN (online)	1557-8100
ISSN	1536-2310
DOI	10.1089/omi.2020.0071
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Article ; Online: In silico Potential of Approved Antimalarial Drugs for Repurposing Against COVID-19

Sachdeva, Cheryl / Wadhwa, Anju / Kumari, Anita / Hussain, Firasat / Jha, Preeti / Kaushik, Naveen K.

OMICS: A Journal of Integrative Biology

2020 Volume 24, Issue 10, Page(s) 568–580

Keywords	covid19
Language	English
Publisher	Mary Ann Liebert Inc
Publishing country	us
Document type	Article ; Online
ZDB-ID	2030312-9
ISSN	1557-8100 ; 1536-2310
ISSN (online)	1557-8100
ISSN	1536-2310
DOI	10.1089/omi.2020.0071
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Impact of Coronavirus Disease 2019 Pandemic on U.S. and Canadian PICUs.

Sachdeva, Ramesh / Rice, Tom B / Reisner, Brian / Brundage, Nancy / Hulbert, Cheryl / Kaminski, Alex / Wetzel, Randall C

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2020 Volume 21, Issue 9, Page(s) e643–e650

Abstract: Objectives: There are limited reports of the impact of the coronavirus disease 2019 pandemic focused on U.S. and Canadian PICUs. This hypothesis-generating report aims to identify the United States and Canadian trends of coronavirus disease 2019 in ... ...

Abstract	Objectives: There are limited reports of the impact of the coronavirus disease 2019 pandemic focused on U.S. and Canadian PICUs. This hypothesis-generating report aims to identify the United States and Canadian trends of coronavirus disease 2019 in PICUs. Design and setting: To better understand how the coronavirus disease 2019 pandemic was affecting U.S. and Canadian PICUs, an open voluntary daily data collection process of Canadian and U.S. PICUs was initiated by Virtual Pediatric Systems, LLC (Los Angeles, CA; http://www.myvps.org) in mid-March 2020. Information was made available online to all PICUs wishing to participate. A secondary data collection was performed to follow-up on patients discharged from those PICUs reporting coronavirus disease 2019 positive patients. Measurements and main results: To date, over 180 PICUs have responded detailing 530 PICU admissions requiring over 3,467 days of PICU care with 30 deaths. The preponderance of cases was in the eastern regions. Twenty-four percent of the patients admitted to the PICUs were over 18 years old. Fourteen percent of admissions were under 2 years old. Nearly 60% of children had comorbidities at admission with the average length of stay increasing by age and by severity of comorbidity. Advanced respiratory support was necessary during 67% of the current days of care, with 69% being conventional mechanical ventilation. Conclusions: PICUs have been significantly impacted by the pandemic. They have provided care not only for children but also adults. Patients with coronavirus disease 2019 have a high frequency of comorbidities, require longer stays, more ventilatory support than usual PICU admissions. These data suggest several avenues for further exploration.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Betacoronavirus ; COVID-19 ; Canada/epidemiology ; Child ; Child, Preschool ; Comorbidity ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Humans ; Infant ; Intensive Care Units, Pediatric/statistics & numerical data ; Length of Stay/statistics & numerical data ; Pandemics ; Patient Admission ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Respiration, Artificial/statistics & numerical data ; SARS-CoV-2 ; Severity of Illness Index ; United States/epidemiology ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-07-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000002510
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Article: In silico Potential of Approved Antimalarial Drugs for Repurposing Against COVID-19

Sachdeva, Cheryl / Wadhwa, Anju / Kumari, Anita / Hussain, Firasat / Jha, Preeti / Kaushik, Naveen K

OMICS

Abstract	Although the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is wreaking havoc and resulting in mortality and morbidity across the planet, novel treatments are urgently needed. Drug repurposing offers an innovative approach in this context. We report here new findings on the in silico potential of several antimalarial drugs for repurposing against COVID-19. We conducted analyses by docking the compounds against two SARS-CoV-2-specific targets: (1) the receptor binding domain spike protein and (2) the main protease of the virus (MPro) using the Schrödinger software. Importantly, the docking analysis revealed that doxycycline (DOX) showed the most effective binding to the spike protein of SARS-CoV-2, whereas halofantrine and mefloquine bound effectively with the main protease among the antimalarial drugs evaluated in the present study. The in silico approach reported here suggested that DOX could potentially be a good candidate for repurposing for COVID-19. In contrast, to decipher the actual potential of DOX and halofantrine against COVID-19, further in vitro and in vivo studies are called for. Drug repurposing warrants consideration as a viable research and innovation avenue as planetary health efforts to fight the COVID-19 continue.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #696599
Database	COVID19

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Article: The Impact of Coronavirus Disease 2019 Pandemic on U.S. and Canadian PICUs

Sachdeva, Ramesh / Rice, Tom B / Reisner, Brian / Brundage, Nancy / Hulbert, Cheryl / Kaminski, Alex / Wetzel, Randall C

Pediatr Crit Care Med

Abstract: OBJECTIVES: There are limited reports of the impact of the coronavirus disease 2019 pandemic focused on U.S. and Canadian PICUs. This hypothesis-generating report aims to identify the United States and Canadian trends of coronavirus disease 2019 in PICUs. ...

Abstract	OBJECTIVES: There are limited reports of the impact of the coronavirus disease 2019 pandemic focused on U.S. and Canadian PICUs. This hypothesis-generating report aims to identify the United States and Canadian trends of coronavirus disease 2019 in PICUs. DESIGN AND SETTING: To better understand how the coronavirus disease 2019 pandemic was affecting U.S. and Canadian PICUs, an open voluntary daily data collection process of Canadian and U.S. PICUs was initiated by Virtual Pediatric Systems, LLC (Los Angeles, CA; http://www.myvps.org) in mid-March 2020. Information was made available online to all PICUs wishing to participate. A secondary data collection was performed to follow-up on patients discharged from those PICUs reporting coronavirus disease 2019 positive patients. MEASUREMENTS AND MAIN RESULTS: To date, over 180 PICUs have responded detailing 530 PICU admissions requiring over 3,467 days of PICU care with 30 deaths. The preponderance of cases was in the eastern regions. Twenty-four percent of the patients admitted to the PICUs were over 18 years old. Fourteen percent of admissions were under 2 years old. Nearly 60% of children had comorbidities at admission with the average length of stay increasing by age and by severity of comorbidity. Advanced respiratory support was necessary during 67% of the current days of care, with 69% being conventional mechanical ventilation. CONCLUSIONS: PICUs have been significantly impacted by the pandemic. They have provided care not only for children but also adults. Patients with coronavirus disease 2019 have a high frequency of comorbidities, require longer stays, more ventilatory support than usual PICU admissions. These data suggest several avenues for further exploration.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #639368
Database	COVID19

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Article ; Online: Top-down controls on bacterial community structure: microbial network analysis of bacteria, T4-like viruses and protists.

Chow, Cheryl-Emiliane T / Kim, Diane Y / Sachdeva, Rohan / Caron, David A / Fuhrman, Jed A

The ISME journal

2013 Volume 8, Issue 4, Page(s) 816–829

Abstract: Characterizing ecological relationships between viruses, bacteria and protists in the ocean are critical to understanding ecosystem function, yet these relationships are infrequently investigated together. We evaluated these relationships through ... ...

Abstract	Characterizing ecological relationships between viruses, bacteria and protists in the ocean are critical to understanding ecosystem function, yet these relationships are infrequently investigated together. We evaluated these relationships through microbial association network analysis of samples collected approximately monthly from March 2008 to January 2011 in the surface ocean (0-5 m) at the San Pedro Ocean Time series station. Bacterial, T4-like myoviral and protistan communities were described by Automated Ribosomal Intergenic Spacer Analysis and terminal restriction fragment length polymorphism of the gene encoding the major capsid protein (g23) and 18S ribosomal DNA, respectively. Concurrent shifts in community structure suggested similar timing of responses to environmental and biological parameters. We linked T4-like myoviral, bacterial and protistan operational taxonomic units by local similarity correlations, which were then visualized as association networks. Network links (correlations) potentially represent synergistic and antagonistic relationships such as viral lysis, grazing, competition or other interactions. We found that virus-bacteria relationships were more cross-linked than protist-bacteria relationships, suggestive of increased taxonomic specificity in virus-bacteria relationships. We also found that 80% of bacterial-protist and 74% of bacterial-viral correlations were positive, with the latter suggesting that at monthly and seasonal timescales, viruses may be following their hosts more often than controlling host abundance.
MeSH term(s)	Bacteria/genetics ; Bacteria/metabolism ; Bacterial Physiological Phenomena ; Bacteriophage T4/genetics ; Bacteriophage T4/physiology ; Capsid Proteins/genetics ; Ecosystem ; Eukaryota/genetics ; Eukaryota/physiology ; Oceans and Seas ; Polymorphism, Restriction Fragment Length ; RNA, Ribosomal, 18S/genetics ; Water Microbiology
Chemical Substances	Capsid Proteins ; RNA, Ribosomal, 18S
Language	English
Publishing date	2013-11-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2406536-5
ISSN	1751-7370 ; 1751-7362
ISSN (online)	1751-7370
ISSN	1751-7362
DOI	10.1038/ismej.2013.199
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Article ; Online: Abiraterone acetate plus prednisolone with or without enzalutamide for patients with metastatic prostate cancer starting androgen deprivation therapy: final results from two randomised phase 3 trials of the STAMPEDE platform protocol.

Attard, Gerhardt / Murphy, Laura / Clarke, Noel W / Sachdeva, Ashwin / Jones, Craig / Hoyle, Alex / Cross, William / Jones, Robert J / Parker, Christopher C / Gillessen, Silke / Cook, Adrian / Brawley, Chris / Gilson, Clare / Rush, Hannah / Abdel-Aty, Hoda / Amos, Claire L / Murphy, Claire / Chowdhury, Simon / Malik, Zafar /

Russell, J Martin / Parkar, Nazia / Pugh, Cheryl / Diaz-Montana, Carlos / Pezaro, Carmel / Grant, Warren / Saxby, Helen / Pedley, Ian / O'Sullivan, Joe M / Birtle, Alison / Gale, Joanna / Srihari, Narayanan / Thomas, Carys / Tanguay, Jacob / Wagstaff, John / Das, Prantik / Gray, Emma / Alzouebi, Mymoona / Parikh, Omi / Robinson, Angus / Montazeri, Amir H / Wylie, James / Zarkar, Anjali / Cathomas, Richard / Brown, Michael D / Jain, Yatin / Dearnaley, David P / Mason, Malcolm D / Gilbert, Duncan / Langley, Ruth E / Millman, Robin / Matheson, David / Sydes, Matthew R / Brown, Louise C / Parmar, Mahesh K B / James, Nicholas D

The Lancet. Oncology

2023 Volume 24, Issue 5, Page(s) 443–456

Abstract: Background: Abiraterone acetate plus prednisolone (herein referred to as abiraterone) or enzalutamide added at the start of androgen deprivation therapy improves outcomes for patients with metastatic prostate cancer. Here, we aimed to evaluate long-term ...

Abstract	Background: Abiraterone acetate plus prednisolone (herein referred to as abiraterone) or enzalutamide added at the start of androgen deprivation therapy improves outcomes for patients with metastatic prostate cancer. Here, we aimed to evaluate long-term outcomes and test whether combining enzalutamide with abiraterone and androgen deprivation therapy improves survival. Methods: We analysed two open-label, randomised, controlled, phase 3 trials of the STAMPEDE platform protocol, with no overlapping controls, conducted at 117 sites in the UK and Switzerland. Eligible patients (no age restriction) had metastatic, histologically-confirmed prostate adenocarcinoma; a WHO performance status of 0-2; and adequate haematological, renal, and liver function. Patients were randomly assigned (1:1) using a computerised algorithm and a minimisation technique to either standard of care (androgen deprivation therapy; docetaxel 75 mg/m Findings: Between Nov 15, 2011, and Jan 17, 2014, 1003 patients were randomly assigned to standard of care (n=502) or standard of care plus abiraterone (n=501) in the abiraterone trial. Between July 29, 2014, and March 31, 2016, 916 patients were randomly assigned to standard of care (n=454) or standard of care plus abiraterone and enzalutamide (n=462) in the abiraterone and enzalutamide trial. Median follow-up was 96 months (IQR 86-107) in the abiraterone trial and 72 months (61-74) in the abiraterone and enzalutamide trial. In the abiraterone trial, median overall survival was 76·6 months (95% CI 67·8-86·9) in the abiraterone group versus 45·7 months (41·6-52·0) in the standard of care group (hazard ratio [HR] 0·62 [95% CI 0·53-0·73]; p<0·0001). In the abiraterone and enzalutamide trial, median overall survival was 73·1 months (61·9-81·3) in the abiraterone and enzalutamide group versus 51·8 months (45·3-59·0) in the standard of care group (HR 0·65 [0·55-0·77]; p<0·0001). We found no difference in the treatment effect between these two trials (interaction HR 1·05 [0·83-1·32]; p Interpretation: Enzalutamide and abiraterone should not be combined for patients with prostate cancer starting long-term androgen deprivation therapy. Clinically important improvements in survival from addition of abiraterone to androgen deprivation therapy are maintained for longer than 7 years. Funding: Cancer Research UK, UK Medical Research Council, Swiss Group for Clinical Cancer Research, Janssen, and Astellas.
MeSH term(s)	Male ; Humans ; Abiraterone Acetate ; Prostatic Neoplasms/pathology ; Androgen Antagonists ; Androgens ; Prednisolone ; Docetaxel/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/pathology ; Randomized Controlled Trials as Topic ; Clinical Trials, Phase III as Topic ; Meta-Analysis as Topic
Chemical Substances	Abiraterone Acetate (EM5OCB9YJ6) ; Androgen Antagonists ; Androgens ; Prednisolone (9PHQ9Y1OLM) ; enzalutamide (93T0T9GKNU) ; Docetaxel (15H5577CQD)
Language	English
Publishing date	2023-05-05
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(23)00148-1
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