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Article ; Online: Mistletoe infested

Oyeniran, Olubukola H / Oboh, Ganiyu / Ademiluyi, Adedayo O / Umar, Haruna I

Food chemistry. Molecular sciences

2022 Volume 5, Page(s) 100124

Abstract: Moringa and Almond are common plants of medicinal and economic value which are often infested with mistletoe. Host plants' infestation could result in major differences in their phytoconstituents and biological activities. Thus, effects of mistletoe ... ...

Abstract	Moringa and Almond are common plants of medicinal and economic value which are often infested with mistletoe. Host plants' infestation could result in major differences in their phytoconstituents and biological activities. Thus, effects of mistletoe infestation on Moringa and Almond host plants supplemented diets on mRNA expression levels of
Language	English
Publishing date	2022-07-26
Publishing country	England
Document type	Journal Article
ISSN	2666-5662
ISSN (online)	2666-5662
DOI	10.1016/j.fochms.2022.100124
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Article ; Online: Utilization of Mobile Reminders in Improving the Completeness and Timeliness of Routine Childhood Immunization in Kano Metropolis, Nigeria: A Randomized Controlled Trial.

Yunusa, Umar / Garba, Saleh Ngaski / MacDonald, Shannon E / Bello, Umar Lawal / Ibrahim, Abdullahi Haruna / Abdulrashid, Idris / Dalhatu, Adamu / Ladan, Muhammad Awwal

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners

2024

Abstract: Introduction: This study examined the effectiveness of mobile phone reminders in improving the completeness and timeliness of childhood immunization.: Method: We conducted a parallel arm cluster randomized controlled trial in four primary health care ...

Abstract	Introduction: This study examined the effectiveness of mobile phone reminders in improving the completeness and timeliness of childhood immunization. Method: We conducted a parallel arm cluster randomized controlled trial in four primary health care facilities in Nigeria. Reminders were sent to eligible participants in the intervention group at specific intervals when their children were scheduled to receive the vaccines administered at the sixth, 10, and 14 weeks after birth. Immunization records of all participants' children were then tracked to assess their immunization status. Results: The immunization status of the intervention (n = 275) and control (n = 261) arms was analyzed. Completeness and timeliness of the vaccine series were significantly higher (p < .001) among children of participants in the intervention (n = 169, 61.5% and n = 138, 50.2%) than those in the control group (n = 35, 13.4% and n = 13, 5%) arm. Discussion: Mobile phone reminders were established to be effective in increasing the completeness and timeliness of childhood immunization.
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036356-7
ISSN	1532-656X ; 0891-5245
ISSN (online)	1532-656X
ISSN	0891-5245
DOI	10.1016/j.pedhc.2024.03.002
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Article ; Online: Assessment of Legibility of Handwritten Prescriptions and Adherence to W.H.O. Prescription Writing Guidelines in Ahmadu Bello University Teaching Hospital Zaria - Kaduna State, Nigeria.

Khalid Abdullahi, Abba / Senire Fatima, Ibrahim / Abdurrahaman, Umar / Isa Sa'adatu, Salihu / Bukhari Hafsat, Abubakar / Abdullahi Abdulrasheed, Haruna / Abubakar, Umar / Dorcas, Igashi / Hameed Kehinde, Sanni / Ibrahim Bashir, Adam / Kabir Musa, Muhammad

Innovations in pharmacy

2023 Volume 14, Issue 1

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-10-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2689516-X
ISSN	2155-0417 ; 2155-0417
ISSN (online)	2155-0417
ISSN	2155-0417
DOI	10.24926/iip.v14i1.5164
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Article: Socio-economic and Lifestyle Determinants of Functional Capacity of the Senior Attendees of an Outpatient Clinic in Northern Nigeria: A Cross-Sectional Study.

Olawumi, A L / Grema, B A / Suleiman, A K / Michael, G C / Umar, Z A / Damagum, F M / Haruna, A I / Abdulkadir, Z / Kwaku, A

West African journal of medicine

2023 Volume 40, Issue 6, Page(s) 581–589

Abstract: Background: Typical ageing changes and the associated health concerns frequently manifest themselves as reduction in their efficiency and functional capacity.: Objective: To identify the socioeconomic and lifestyle determinants of the functional ... ...

Abstract	Background: Typical ageing changes and the associated health concerns frequently manifest themselves as reduction in their efficiency and functional capacity. Objective: To identify the socioeconomic and lifestyle determinants of the functional capacity of elderly patients. Methods: A cross-sectional study involving 329 patients aged ≥ 60 years who presented to the General Outpatient Clinic. Data on socioeconomic, lifestyle, and functional capacity were collected. The functional capacity was assessed by the self-reported questionnaires: the Lawton and Katz indexes for the activity of daily living (ADL) and instrumental activity of daily living (IADL) respectively. The chi-square test and logistic regression analysis were used to determine associations between the variables. The level of significance was set at a p-value ≤ 0.05. Results: A total of 312 respondents completed the study, with 59.6% females and a mean age of 67.67 ± 7.69 years. The majority of the respondents (76.3%) belong to the low socioeconomic status (classes V and VI). The prevalence of functional dependence was 21.5% and 44.2% for ADL and IADL respectively. The disability in continence and food preparation had the highest prevalence among the components of ADL and IADL respectively. Advancing age, Hausa/Fulani tribe, polygamy, poor social support, and chronic pain were the determinants of functional dependence in ADL while age, female gender, marital status, and Fulani tribe were the determinants of functional dependence in IADL among the respondents. CONCLUSION: The identified determinants of functional capacity among the older persons should be considered when assessing their functional capacity in the primary care or similar settings.
MeSH term(s)	Aged ; Humans ; Female ; Aged, 80 and over ; Middle Aged ; Male ; Cross-Sectional Studies ; Nigeria/epidemiology ; Ambulatory Care Facilities ; Life Style ; Low Socioeconomic Status
Language	English
Publishing date	2023-06-29
Publishing country	Nigeria
Document type	Journal Article
ZDB-ID	1132088-6
ISSN	0189-160X
ISSN	0189-160X
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Article ; Online: The influence of the Community-based Health Planning and Services (CHPS) program on community health sustainability in the Upper West Region of Ghana.

Woods, Hannah / Haruna, Umar / Konkor, Irenius / Luginaah, Isaac

The International journal of health planning and management

2018 Volume 34, Issue 1, Page(s) e802–e816

Abstract: Ghana introduced Community-based Health Planning and Services (CHPS) to improve primary health care in rural areas. The extension of health care services to rural areas has the potential to increase sustainability of community health. Drawing on the ... ...

Abstract	Ghana introduced Community-based Health Planning and Services (CHPS) to improve primary health care in rural areas. The extension of health care services to rural areas has the potential to increase sustainability of community health. Drawing on the capitals framework, this study aims to understand the contribution of CHPS to the sustainability of community health in the Upper West Region of Ghana-the poorest region in the country. We conducted in-depth interviews with community members (n = 25), key informant interviews with health officials (n = 8), and focus group discussions (n = 12: made up of six to eight participants per group) in six communities from two districts. Findings show that through their mandate of primary health care provision, CHPS contributed directly to improvement in community health (eg, access to family planning services) and indirectly through strengthening social, human, and economic capital and thereby improving social cohesion, awareness of health care needs, and willingness to take action at the community level. Despite the current contributions of CHPS in improving the sustainability of community health, there are several challenges, based on which we recommend, that government should increase staffing and infrastructure in order to strengthen and maintain the functionality of CHPS.
MeSH term(s)	Community Health Services ; Female ; Focus Groups ; Ghana ; Health Planning ; Health Services Accessibility ; Humans ; Interviews as Topic ; Male ; Population Health ; Primary Health Care ; Qualitative Research ; Rural Health Services ; Social Capital
Language	English
Publishing date	2018-11-15
Publishing country	England
Document type	Journal Article
ZDB-ID	632786-2
ISSN	1099-1751 ; 0749-6753
ISSN (online)	1099-1751
ISSN	0749-6753
DOI	10.1002/hpm.2694
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Article ; Online: Hesperetin protects against diesel exhaust particles-induced cardiovascular oxidative stress and inflammation in Wistar rats.

Olumegbon, Lateefat T / Lawal, Akeem O / Oluyede, Dare M / Adebimpe, Monsurat O / Elekofehinti, Olusola O / I Umar, Haruna

Environmental science and pollution research international

2022 Volume 29, Issue 35, Page(s) 52574–52589

Abstract: Air particulate matter exposure has been linked to cardiovascular and atherosclerosis as a result of increase oxidative stress and inflammatory response. This study aims to determine the effect of the use of hesperetin (HESP) as a therapeutic agent to ... ...

Abstract	Air particulate matter exposure has been linked to cardiovascular and atherosclerosis as a result of increase oxidative stress and inflammatory response. This study aims to determine the effect of the use of hesperetin (HESP) as a therapeutic agent to mitigate the cardiovascular oxidative and pro-inflammatory effects of diesel exhaust particles in Wistar rats. DEP was collected from an Iveco cargo engine truck, and n-hexane fraction (hDEP) was obtained. Forty Wistar strains of male albino rats (6 weeks) were divided into 8 groups: control group received DMSO and CMC-Na; other groups received either n-hexane extract of DEP (0.064 or 0.640 mg/kg hDEP) or Standard Reference Material 2975 (0.064 mg/kg hSRM) in the presence or absence of 200 mg/kg HESP. Extracts were administered orally. Serum lipids, lipid peroxidation (LPO), conjugated dienes (CDs), and GSH levels were determined. Also, inflammatory cytokines, PCSK-9, LDL-receptor, and antioxidant genes expression were assessed by RT-PCR in both the heart and aorta. The molecular interaction of targeted proteins with HESP was assessed by the in silico approach. Extracts of DEP caused a significant (p < 0.001) increase in serum lipids but significantly decreased HDL-CHOL. It also increased CDs and MDA levels but decreased GSH levels. In addition, the particulate extracts caused a significant (p < 0.001) increase in pro-inflammatory genes expression in the heart and aorta but significantly decreased IL-10 and LDL-R gene expressions. Pre-treatment with hesperetin significantly reversed all these effects. This study shows that hesperetin has the ability to protect against DEP-induced oxidative stress and inflammation in the cardiovascular system.
MeSH term(s)	Animals ; Cardiovascular System ; Hesperidin ; Inflammation/chemically induced ; Lipids ; Male ; Oxidative Stress ; Particulate Matter/pharmacology ; Rats ; Rats, Wistar ; Vehicle Emissions/toxicity
Chemical Substances	Lipids ; Particulate Matter ; Vehicle Emissions ; Hesperidin (E750O06Y6O) ; hesperetin (Q9Q3D557F1)
Language	English
Publishing date	2022-03-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-19494-3
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Article ; Online: In silico molecular modeling and simulations of black tea theaflavins revealed theaflavin-3'-gallate as putative liver X receptor-beta agonist.

Adigun, Temidayo O / Danazumi, Ammar U / Umar, Haruna I / Na'Allah, Asiat / Alabi, Mutiu A / Joel, Wisdom O / Aberuagba, Adepeju / Alejolowo, Omokolade O / Bamidele, Joy O / Omotayo, Olakunle S / Medayedupin, Oluwatobi A

Journal of biomolecular structure & dynamics

2023 Volume 41, Issue 22, Page(s) 13015–13028

Abstract: The low constitutive activation of Liver X receptor, an endogenous nuclear receptor with two subtypes (α and β), is a condition lying at the crossroad of cancer and cardiovascular disease. Both natural and synthetic Liver X receptor agonists have ... ...

Abstract	The low constitutive activation of Liver X receptor, an endogenous nuclear receptor with two subtypes (α and β), is a condition lying at the crossroad of cancer and cardiovascular disease. Both natural and synthetic Liver X receptor agonists have reportedly shown remarkable antiproliferative and atheroprotective effects but the repeated doses of its synthetic ones are also paradoxically associated with hyperlipidaemic effects and neurotoxicity, though attributed to the alpha subtype. This highlights the need for novel, safe, and potent LXR-beta-selective agonists. Hypocholesterolaemic effects of black theaflavins have been widely reported, but data on the exact theaflavin compound (s) responsible for these effects is currently lacking. Neither is information on the possible modulatory effects of the compound (s) on LXR-beta nor its possible implications in the context of drug development for cardiovascular diseases and cancers is explored. On this account, we investigated the potential interaction of four main theaflavin monomers (TF1, TF2A, TF2B & TF3) with human LXR-beta through robust computational modelling that entails molecular docking, free energy calculations and molecular dynamics simulations. The ligands were further profiled (
MeSH term(s)	Humans ; Tea ; Liver X Receptors ; Molecular Docking Simulation ; Camellia sinensis ; Antioxidants/pharmacology ; Molecular Dynamics Simulation
Chemical Substances	Tea ; Liver X Receptors ; theaflavin (1IA46M0D13) ; Antioxidants ; theaflavine gallate (31629-79-5)
Language	English
Publishing date	2023-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2175264
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Article: Marble Powder as a Soil Stabilizer: An Experimental Investigation of the Geotechnical Properties and Unconfined Compressive Strength Analysis.

Umar, Ibrahim Haruna / Lin, Hang

Materials (Basel, Switzerland)

2024 Volume 17, Issue 5

Abstract: Fine-grained soils present engineering challenges. Stabilization with marble powder has shown promise for improving engineering properties. Understanding the temporal evolution of Unconfined Compressive Strength (UCS) and geotechnical properties in ... ...

Abstract	Fine-grained soils present engineering challenges. Stabilization with marble powder has shown promise for improving engineering properties. Understanding the temporal evolution of Unconfined Compressive Strength (UCS) and geotechnical properties in stabilized soils could aid strength assessment. This study investigates the stabilization of fine-grained clayey soils using waste marble powder as an alternative binder. Laboratory experiments were conducted to evaluate the geotechnical properties of soil-marble powder mixtures, including Atterberg's limits, compaction characteristics, California Bearing Ratio (CBR), Indirect Tensile Strength (ITS), and Unconfined Compressive Strength (UCS). The effects of various factors, such as curing time, molding water content, and composition ratios, on UCS, were analyzed using Exploratory Data Analysis (EDA) techniques, including histograms, box plots, and statistical modeling. The results show that the CBR increased from 10.43 to 22.94% for unsoaked and 4.68 to 12.46% for soaked conditions with 60% marble powder, ITS rose from 100 to 208 kN/m
Language	English
Publishing date	2024-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17051208
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Article: Hesperetin protects against diesel exhaust particles-induced cardiovascular oxidative stress and inflammation in Wistar rats

Olumegbon, Lateefat T. / Lawal, Akeem O. / Oluyede, Dare M. / Adebimpe, Monsurat O. / Elekofehinti, Olusola O. / I. Umar, Haruna

Environmental science and pollution research. 2022 July, v. 29, no. 35

2022

Abstract	Air particulate matter exposure has been linked to cardiovascular and atherosclerosis as a result of increase oxidative stress and inflammatory response. This study aims to determine the effect of the use of hesperetin (HESP) as a therapeutic agent to mitigate the cardiovascular oxidative and pro-inflammatory effects of diesel exhaust particles in Wistar rats. DEP was collected from an Iveco cargo engine truck, and n-hexane fraction (hDEP) was obtained. Forty Wistar strains of male albino rats (6 weeks) were divided into 8 groups: control group received DMSO and CMC-Na; other groups received either n-hexane extract of DEP (0.064 or 0.640 mg/kg hDEP) or Standard Reference Material 2975 (0.064 mg/kg hSRM) in the presence or absence of 200 mg/kg HESP. Extracts were administered orally. Serum lipids, lipid peroxidation (LPO), conjugated dienes (CDs), and GSH levels were determined. Also, inflammatory cytokines, PCSK-9, LDL-receptor, and antioxidant genes expression were assessed by RT-PCR in both the heart and aorta. The molecular interaction of targeted proteins with HESP was assessed by the in silico approach. Extracts of DEP caused a significant (p < 0.001) increase in serum lipids but significantly decreased HDL-CHOL. It also increased CDs and MDA levels but decreased GSH levels. In addition, the particulate extracts caused a significant (p < 0.001) increase in pro-inflammatory genes expression in the heart and aorta but significantly decreased IL-10 and LDL-R gene expressions. Pre-treatment with hesperetin significantly reversed all these effects. This study shows that hesperetin has the ability to protect against DEP-induced oxidative stress and inflammation in the cardiovascular system.
Keywords	air ; albino ; antioxidants ; aorta ; atherosclerosis ; blood serum ; computer simulation ; heart ; hesperetin ; hexane ; inflammation ; interleukin-10 ; lipid peroxidation ; males ; oxidative stress ; particulates ; pollution ; research ; therapeutics
Language	English
Dates of publication	2022-07
Size	p. 52574-52589.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-19494-3
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Article ; Online: In-silico analysis of the inhibition of the SARS-CoV-2 main protease by some active compounds from selected African plants.

Umar, Haruna I / Josiah, Sunday S / Saliu, Tolulope P / Jimoh, Tajudeen O / Ajayi, Adeola / Danjuma, Jamilu B

Journal of Taibah University Medical Sciences

2021 Volume 16, Issue 2, Page(s) 162–176

Abstract: Objectives: Over the years, : Methods: The crystal structure of Mpro was retrieved from the Protein Data Bank, while the plant bioactive compounds were retrieved from Pubchem. Drug-likeness of the selected compounds and a control drug ( ... ...

Abstract	Objectives: Over the years, Methods: The crystal structure of Mpro was retrieved from the Protein Data Bank, while the plant bioactive compounds were retrieved from Pubchem. Drug-likeness of the selected compounds and a control drug (hydroxychloroquine) were assessed, and the compounds that satisfied the drug-likeness rule were docked against Mpro. The docked complexes were analyzed using LigPlot and the protein-ligand profiler server. The top five compound hits were subjected to ADMET screening using the ADMETSar server. Results: A total of 17 out of 22 screened compounds passed Lipinski's assessment. Additionally, the most active compounds from the investigated plants exhibited relative inhibitory potentials against Mpro compared with hydroxychloroquine, which alludes to their possible involvement in inhibiting the SARS-CoV-2 main protease replication process. Conclusions: In our study, most of the active phytocomponents of the investigated plants exhibited relative inhibitory potentials against Mpro of SARS-CoV-2 and preferred pharmacological features when compared with hydroxychloroquine. These findings indicate these compounds are potentially antiviral candidates against SARS-CoV-2.
Language	English
Publishing date	2021-01-06
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2817396-X
ISSN	1658-3612 ; 1658-3612
ISSN (online)	1658-3612
ISSN	1658-3612
DOI	10.1016/j.jtumed.2020.12.005
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