Article ; Online: Antiviral mechanisms of sorafenib against foot-and-mouth disease virus via c-RAF and AKT/PI3K pathways.
Veterinary research communications
2023 Volume 48, Issue 1, Page(s) 329–343
Abstract: Foot-and-mouth disease virus (FMDV) is a highly contagious pathogen that poses a significant threat to the global livestock industry. However, specific antiviral treatments against FMDV are currently unavailable. This study aimed to evaluate the ... ...
Abstract | Foot-and-mouth disease virus (FMDV) is a highly contagious pathogen that poses a significant threat to the global livestock industry. However, specific antiviral treatments against FMDV are currently unavailable. This study aimed to evaluate the antiviral activity of anticancer drugs, including kinase and non-kinase inhibitors against FMDV replication in BHK-21 cells. Sorafenib, a multi-kinase inhibitor, demonstrated a significant dose-dependent reduction in FMDV replication. It exhibited a half maximal effective concentration (EC50) value of 2.46 µM at the pre-viral entry stage and 2.03 µM at the post-viral entry stage. Further intracellular assays revealed that sorafenib effectively decreased 3D |
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MeSH term(s) | Animals ; Foot-and-Mouth Disease Virus ; Sorafenib/pharmacology ; Sorafenib/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol 3-Kinases/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-akt/pharmacology ; Foot-and-Mouth Disease ; Molecular Docking Simulation ; Cell Line ; Antiviral Agents/pharmacology ; Virus Replication |
Chemical Substances | Sorafenib (9ZOQ3TZI87) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Antiviral Agents |
Language | English |
Publishing date | 2023-09-11 |
Publishing country | Switzerland |
Document type | Journal Article |
ZDB-ID | 406735-6 |
ISSN | 1573-7446 ; 0165-7380 |
ISSN (online) | 1573-7446 |
ISSN | 0165-7380 |
DOI | 10.1007/s11259-023-10211-0 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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