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Article ; Online: In silico approach of secondary metabolites from Brazilian herbal medicines to search for potential drugs against SARS-CoV-2.

Amparo, Tatiane R / Seibert, Janaína B / Almeida, Tamires C / Costa, Fernanda S F / Silveira, Benila M / da Silva, Glenda N / Dos Santos, Orlando D H / de Souza, Gustavo H B

Phytotherapy research : PTR

2021 Volume 35, Issue 8, Page(s) 4297–4308

Abstract: The new severe acute respiratory syndrome coronavirus (SARS-CoV-2) recently emerged as a worrying pandemic, with many confirmed cases and deaths globally. Therefore, there is a clear need for identifying effective therapeutic options and a review of ... ...

Abstract	The new severe acute respiratory syndrome coronavirus (SARS-CoV-2) recently emerged as a worrying pandemic, with many confirmed cases and deaths globally. Therefore, there is a clear need for identifying effective therapeutic options and a review of secondary metabolites related to Brazilian herbal medicines was performed as a strategy for the discovery of new antiviral agents. To confirm this potential, an in silico screening of the identified compounds identified was also evaluated. The review was performed by the PubMed database and the selected natural compounds were subjected to in silico analysis such as QSAR, molecular docking and ADMET. 497 secondary metabolites were identified from 23 species. The in silico assays indicated 19 potential anti-SARS-CoV-2 compounds, being triterpenes and phenolic compounds. The indicated compounds showed a high affinity with proteins considered as the main molecular targets against SARS-CoV-2 and parameters indicated low toxicity. In addition to Brazilian medicinal plants, these compounds can be found in other species and they can be a base for the synthesis of other anti-COVID-19 drugs. Therefore, this review is important to conduct researches that address the emerging need for drugs in COVID-19 treatment.
MeSH term(s)	Antiviral Agents/pharmacology ; COVID-19/drug therapy ; Humans ; Molecular Docking Simulation ; Phytochemicals/pharmacology ; Plant Preparations/pharmacology ; Plants, Medicinal/chemistry ; SARS-CoV-2/drug effects
Chemical Substances	Antiviral Agents ; Phytochemicals ; Plant Preparations
Language	English
Publishing date	2021-04-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7097
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Article: In silico approach of secondary metabolites from Brazilian herbal medicines to search for potential drugs against SARS‐CoV‐2

Amparo, Tatiane R. / Seibert, Janaína B. / Almeida, Tamires C. / Costa, Fernanda S. F. / Silveira, Benila M. / da Silva, Glenda N. / dos Santos, Orlando D. H. / de Souza, Gustavo H. B.

Phytotherapy research. 2021 Aug., v. 35, no. 8

2021

Abstract: The new severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) recently emerged as a worrying pandemic, with many confirmed cases and deaths globally. Therefore, there is a clear need for identifying effective therapeutic options and a review of ... ...

Abstract	The new severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) recently emerged as a worrying pandemic, with many confirmed cases and deaths globally. Therefore, there is a clear need for identifying effective therapeutic options and a review of secondary metabolites related to Brazilian herbal medicines was performed as a strategy for the discovery of new antiviral agents. To confirm this potential, an in silico screening of the identified compounds identified was also evaluated. The review was performed by the PubMed database and the selected natural compounds were subjected to in silico analysis such as QSAR, molecular docking and ADMET. 497 secondary metabolites were identified from 23 species. The in silico assays indicated 19 potential anti‐SARS‐CoV‐2 compounds, being triterpenes and phenolic compounds. The indicated compounds showed a high affinity with proteins considered as the main molecular targets against SARS‐CoV‐2 and parameters indicated low toxicity. In addition to Brazilian medicinal plants, these compounds can be found in other species and they can be a base for the synthesis of other anti‐COVID‐19 drugs. Therefore, this review is important to conduct researches that address the emerging need for drugs in COVID‐19 treatment.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus ; Severe acute respiratory syndrome coronavirus 2 ; computer simulation ; databases ; pandemic ; phytotherapy ; research ; secondary metabolites ; toxicity ; triterpenoids
Language	English
Dates of publication	2021-08
Size	p. 4297-4308.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	REVIEW
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7097
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Melaleuca leucadendra Essential Oil Promotes Loss of Cell Membrane and Wall Integrity and Inhibits Bacterial Growth: An In Silico and In Vitro Approach.

Bautista-Silva, Jessica P / Seibert, Janaína B / Amparo, Tatiane R / Rodrigues, Ivanildes V / Teixeira, Luiz Fernando M / Souza, Gustavo Henrique B / Dos Santos, Orlando D H

Current microbiology

2020 Volume 77, Issue 9, Page(s) 2181–2191

Abstract: Essential oils are potential antimicrobial agents and can be used as active ingredients in the pharmaceutical, food and cosmetics industries. This work intends to evaluate the antibacterial activity and design a strategy for the proposition of the ... ...

Abstract	Essential oils are potential antimicrobial agents and can be used as active ingredients in the pharmaceutical, food and cosmetics industries. This work intends to evaluate the antibacterial activity and design a strategy for the proposition of the mechanism of action of Melaleuca leucadendra essential oil. Optimum concentration of the bacteria and the phase where they had the highest pathogenic activity were determined. Results show that for each microorganism it is necessary to use a different concentration at the time of adjusting the initial inoculum, and that the time to achieve exponential growth phase varies from one to the other. M. leucadendra essential oil demonstrated in vitro antimicrobial properties. This oil was chemically characterized and the main compounds were evaluated by their mechanism of antibacterial action based on structure-activity analysis. The mechanism is related to the increase of bacteria cell membrane permeability. This indication was confirmed by flow cytometry and transmission electronic microscopy. Thus, in silico analysis is an important tool in the search for new antimicrobial agents and these results showed that M. leucadendra essential oil may be useful on the development of new chemotherapies or food preservation systems.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents ; Cell Membrane ; Computer Simulation ; Melaleuca ; Microbial Sensitivity Tests ; Oils, Volatile/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Oils, Volatile
Language	English
Publishing date	2020-05-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-020-02024-0
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Article ; Online: Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays.

Pinto, Isabelle C / Seibert, Janaína B / Pinto, Luciano S / Santos, Vagner R / de Sousa, Rafaela F / Sousa, Lucas R D / Amparo, Tatiane R / Dos Santos, Viviane M R / do Nascimento, Andrea M / de Souza, Gustavo Henrique Bianco / Vasconcellos, Walisson A / Vieira, Paula M A / Andrade, Ângela L

Scientific reports

2020 Volume 10, Issue 1, Page(s) 22312

Abstract: Plants may contain beneficial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against pathogenic ... ...

Abstract	Plants may contain beneficial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against pathogenic microorganisms of the oral cavity, along with its in vitro biocompatibility. The ethanolic Brazilian pepper extract (BPE), the glass-ionomer cement (GIC) and the composite GIC-BPE were characterized by scanning electron microscopy, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and thermal analysis. The BPE compounds were identified by UPLC-QTOF-MS/MS. The release profile of flavonoids and the mechanical properties of the GIC-BPE composite were assessed. The flavonoids were released through a linear mechanism governing the diffusion for the first 48 h, as evidenced by the M
MeSH term(s)	Anacardiaceae/chemistry ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Brazil ; Compressive Strength ; Fruit/chemistry ; Glass Ionomer Cements/chemical synthesis ; Glass Ionomer Cements/chemistry ; Glass Ionomer Cements/pharmacology ; Humans ; Materials Testing ; Microscopy, Electron, Scanning ; Mouth/chemistry ; Mouth/drug effects ; Mouth/microbiology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	Biocompatible Materials ; Glass Ionomer Cements ; Plant Extracts
Language	English
Publishing date	2020-12-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-79257-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Melaleuca leucadendra Essential Oil Promotes Loss of Cell Membrane and Wall Integrity and Inhibits Bacterial Growth: An In Silico and In Vitro Approach

Bautista-Silva, Jessica P / Seibert, Janaína B / Amparo, Tatiane R / Rodrigues, Ivanildes V / Teixeira, Luiz Fernando M / Souza, Gustavo Henrique B / dos Santos, Orlando D. H

Current microbiology. 2020 Sept., v. 77, no. 9

2020

Abstract	Essential oils are potential antimicrobial agents and can be used as active ingredients in the pharmaceutical, food and cosmetics industries. This work intends to evaluate the antibacterial activity and design a strategy for the proposition of the mechanism of action of Melaleuca leucadendra essential oil. Optimum concentration of the bacteria and the phase where they had the highest pathogenic activity were determined. Results show that for each microorganism it is necessary to use a different concentration at the time of adjusting the initial inoculum, and that the time to achieve exponential growth phase varies from one to the other. M. leucadendra essential oil demonstrated in vitro antimicrobial properties. This oil was chemically characterized and the main compounds were evaluated by their mechanism of antibacterial action based on structure–activity analysis. The mechanism is related to the increase of bacteria cell membrane permeability. This indication was confirmed by flow cytometry and transmission electronic microscopy. Thus, in silico analysis is an important tool in the search for new antimicrobial agents and these results showed that M. leucadendra essential oil may be useful on the development of new chemotherapies or food preservation systems.
Keywords	Melaleuca leucadendra ; antibacterial properties ; bacterial growth ; cell membranes ; computer simulation ; cosmetics ; essential oils ; flow cytometry ; food preservation ; inoculum ; mechanism of action ; membrane permeability ; oils ; transmission electron microscopy
Language	English
Dates of publication	2020-09
Size	p. 2181-2191.
Publishing place	Springer US
Document type	Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-020-02024-0
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Nanostructured Systems Improve the Antimicrobial Potential of the Essential Oil from

Seibert, Janaína B / Viegas, Juliana S R / Almeida, Tamires C / Amparo, Tatiane R / Rodrigues, Ivanildes V / Lanza, Juliane S / Frézard, Frédéric J G / Soares, Rodrigo D O A / Teixeira, Luiz Fernando M / de Souza, Gustavo H B / Vieira, Paula M A / Barichello, José M / Dos Santos, Orlando D H

Journal of natural products

2019 Volume 82, Issue 12, Page(s) 3208–3220

Abstract: The physicochemical characteristics of nanostructured suspensions are important prerequisites for the success of new drug development. This work aimed to develop nanometric systems ... ...

Abstract	The physicochemical characteristics of nanostructured suspensions are important prerequisites for the success of new drug development. This work aimed to develop nanometric systems containing
MeSH term(s)	Animals ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Bacteria/drug effects ; Cell Line ; Cell Membrane Permeability/drug effects ; Cymbopogon/chemistry ; Drug Screening Assays, Antitumor ; Fungi/drug effects ; Gas Chromatography-Mass Spectrometry ; Hydrogen-Ion Concentration ; Mice ; Microbial Sensitivity Tests ; Microscopy, Electron, Transmission ; Nanostructures ; Oils, Volatile/chemistry ; Oils, Volatile/pharmacology ; Particle Size ; Plant Leaves/chemistry ; Quantitative Structure-Activity Relationship
Chemical Substances	Anti-Infective Agents ; Oils, Volatile
Language	English
Publishing date	2019-12-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.8b00870
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits

Isabelle C. Pinto / Janaína B. Seibert / Luciano S. Pinto / Vagner R. Santos / Rafaela F. de Sousa / Lucas R. D. Sousa / Tatiane R. Amparo / Viviane M. R. dos Santos / Andrea M. do Nascimento / Gustavo Henrique Bianco de Souza / Walisson A. Vasconcellos / Paula M. A. Vieira / Ângela L. Andrade

Scientific Reports, Vol 10, Iss 1, Pp 1-

chemical and biological assays

2020 Volume 13

Abstract: Abstract Plants may contain beneficial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against ... ...

Abstract	Abstract Plants may contain beneficial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against pathogenic microorganisms of the oral cavity, along with its in vitro biocompatibility. The ethanolic Brazilian pepper extract (BPE), the glass-ionomer cement (GIC) and the composite GIC-BPE were characterized by scanning electron microscopy, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and thermal analysis. The BPE compounds were identified by UPLC–QTOF–MS/MS. The release profile of flavonoids and the mechanical properties of the GIC-BPE composite were assessed. The flavonoids were released through a linear mechanism governing the diffusion for the first 48 h, as evidenced by the Mt/M∞ relatively to $$\sqrt t$$ t , at a diffusion coefficient of 1.406 × 10–6 cm2 s−1. The ATR-FTIR analysis indicated that a chemical bond between the GIC and BPE components may have occurred, but the compressive strength of GIC-BPE does not differ significantly from that of this glass-ionomer. The GIC-BPE sample revealed an ample bacterial activity at non-cytotoxic concentrations for the human fibroblast MRC-5 cells. These results suggest that the prepared composite may represent an alternative agent for endodontic treatment.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Photoprotective activity and increase of SPF in sunscreen formulation using lyophilized red propolis extracts from Alagoas

Almeida, Wanessa A. da S / Amparo, Tatiane Roquete / Andrade, Ângela L / Antunes, Amanda dos Santos / Cazati, Thiago / Correa, Helen S. da G / Freitas, Kátia Michelle / Nascimento, Andrea M. do / Penido, Ricardo G / Santos, Orlando David Henrique dos / Santos, Vagner R / Santos, Viviane M. R. dos / Sousa, Lucas Resende Dutra / Souza, Gustavo Henrique Bianco de

Sociedade Brasileira de Farmacognosia Revista Brasileira de Farmacognosia. 2019 May, June, v. 29, no. 3

2019

Abstract: The excessive sun exposure, coupled with lack of sun protection represents one of the biggest risks to the occurrence of skin cancer and photoaging. Recent strategies for photoprotection have included the incorporation of natural antioxidant and anti- ... ...

Abstract	The excessive sun exposure, coupled with lack of sun protection represents one of the biggest risks to the occurrence of skin cancer and photoaging. Recent strategies for photoprotection have included the incorporation of natural antioxidant and anti-inflammatory compounds, into sunscreens, and the oral administration of natural antioxidant extracts. In this work, we use Brazilian red propolis extract because its antioxidant and anti-inflammatory activities. The aim of this work was to evaluate the sun protection factor and antioxidant activity of different hydroalcoholic extracts of red propolis (70% and 75%) prepared from lyophilized red propolis at room and high temperatures. The sun protection factor in vitro was determined by a spectrophotometric method developed by Mansur. The hydroalcoholic extracts of red propolis incorporated with Filter UVA-UVB 5% Gel Permulem TR-1 presented absorption in the UVB region. Also, the in vitro capacity of the hydroalcoholic extracts of red propolis to increase photoprotective activity of Filter UVA-UVB 5% Gel was evaluated. The hydroalcoholic extracts of red propolis incorporated presented higher values of sun protection factor and showed synergism in the photoprotective activity of Filter UVA-UVB 5% Gel Permulem TR-1. The antioxidant activity and sun protection factor are correlated with total phenolics content of the extracts and the hydroalcoholic extract of red propolis 75% at room temperature was choosen. The formulation developed with Filter UVA-UVB 5% Gel Permulem TR-1 with this hydroalcoholic extract of red propolis showed safe to be applied on the skin according HET-CAM test. Suggests indication of hydroalcoholic extract of red propolis (75% – room temperature) associated to photoprotective formulations for use in photoprotective products.
Keywords	absorption ; ambient temperature ; anti-inflammatory activity ; antioxidants ; freeze drying ; isoflavonoids ; oral administration ; photoaging ; photostability ; propolis ; risk ; skin neoplasms ; spectrophotometers ; sunscreens ; synergism ; Brazil
Language	English
Dates of publication	2019-05
Size	p. 373-380.
Publishing place	Elsevier Editora Ltda.
Document type	Article
ISSN	0102-695X
DOI	10.1016/j.bjp.2019.02.003
Database	NAL-Catalogue (AGRICOLA)

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Article: Nanostructured Systems Improve the Antimicrobial Potential of the Essential Oil from Cymbopogon densiflorus Leaves

Seibert, Janaína B / Viegas, Juliana S. R / Almeida, Tamires C / Amparo, Tatiane R / Rodrigues, Ivanildes V / Lanza, Juliane S / Frézard, Frédéric J. G / Soares, Rodrigo D. O. A / Teixeira, Luiz Fernando M / de Souza, Gustavo H. B / Vieira, Paula M. A / Barichello, José M / dos Santos, Orlando D. H

Journal of natural products. 2019 Dec. 09, v. 82, no. 12

2019

Abstract: The physicochemical characteristics of nanostructured suspensions are important prerequisites for the success of new drug development. This work aimed to develop nanometric systems containing Cymbopogon densiflorus leaf essential oil and to evaluate ... ...

Abstract	The physicochemical characteristics of nanostructured suspensions are important prerequisites for the success of new drug development. This work aimed to develop nanometric systems containing Cymbopogon densiflorus leaf essential oil and to evaluate their antimicrobial activity. The essential oil was isolated by hydrodistillation from leaves and analyzed by GC-MS. The main constituents were found to be trans-p-mentha-2,8-dien-1-ol, cis-p-mentha-2,8-dien-1-ol, trans-p-mentha-1(7),8-dien-2-ol, cis-piperitol, and cis-p-mentha-1(7),8-dien-2-ol. In silico prediction analysis suggested that this oil possesses antimicrobial potential and the main mechanism of action might be the peptidoglycan glycosyltransferase inhibition. Nanoemulsions were prepared by the phase inversion method, and liposomes were made by the film hydration method. Qualitative evaluation of the antimicrobial activity was performed by the diffusion disk assay with 24 microorganisms; all of them were found to be sensitive to the essential oil. Subsequently, this property was quantified by the serial microdilution technique, where the nanoformulations demonstrated improved activity in comparison with the free oil. Bactericidal action was tested by the propidium iodide method, which revealed that free essential oil and nanoemulsion increased cytoplasmic membrane permeability, while no difference was observed between negative control and liposome. These results were confirmed by images obtained using transmission electron microscopy. This study has shown an optimization in the antimicrobial activity of C. densiflorus essential oil by a nanoemulsion and a liposomal formulation of the active substances.
Keywords	Cymbopogon ; active ingredients ; antimicrobial properties ; cell membranes ; drug development ; enzyme inhibition ; essential oils ; gas chromatography-mass spectrometry ; hydrodistillation ; leaves ; mechanism of action ; membrane permeability ; microorganisms ; nanoemulsions ; oils ; peptidoglycans ; physicochemical properties ; prediction ; propidium ; transferases ; transmission electron microscopy
Language	English
Dates of publication	2019-1209
Size	p. 3208-3220.
Publishing place	American Chemical Society and American Society of Pharmacognosy
Document type	Article
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.8b00870
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Métodos para avaliação in vitro da atividade antimicrobiana de plantas medicinais

Tatiane Roquete AMPARO / Vanessa Cristina Carvalho BRAGA / Janaína Brandão SEIBERT / Gustavo Henrique Bianco de SOUZA / Luiz Fernando Medeiros TEIXEIRA

Infarma: Pharmaceutical Sciences, Vol 30, Iss 1, Pp 50-

a necessidade da padronização

2018 Volume 59

Abstract: A crescente incidência de patógenos resistentes aos medicamentos atuais incentiva a busca de novos agentes antimicrobianos. Neste contexto, as plantas medicinais se destacam, sendo uma importante fonte de novos fármacos. Existem diversos métodos para ... ...

Abstract	A crescente incidência de patógenos resistentes aos medicamentos atuais incentiva a busca de novos agentes antimicrobianos. Neste contexto, as plantas medicinais se destacam, sendo uma importante fonte de novos fármacos. Existem diversos métodos para avaliar a atividade antibacteriana e antifúngica de extratos, frações, óleos essenciais e substâncias isoladas de vegetais. Os mais conhecidos incluem métodos de difusão, diluição e bioautografia. A proposta desse trabalho é apresentar os métodos mais utilizados atualmente, juntamente com suas vantagens, desvantagens e fatores interferentes. Entre os artigos indexados na biblioteca SciELO, abrangendo os últimos dez anos, somente 4,4% das pesquisas com plantas medicinais estão relacionadas com atividade antimicrobiana. O método mais utilizado foi a microdiluição (57,9%), o mais recomendado devido à alta sensibilidade, à quantidade mínima de reagentes e amostra e à possibilidade de um maior número de réplicas. Nos trabalhos que utilizaram esse método, foram verificadas divergências de fatores que podem interferir nos resultados. A fim de facilitar a obtenção de resultados comparáveis e reprodutíveis, se faz necessária a padronização dos métodos utilizados pelos pesquisadores. Recomenda-se utilizar como A crescente incidência de patógenos resistentes aos medicamentos atuais incentiva a busca de novos agentes antimicrobianos. Neste contexto, as plantas medicinais se destacam, sendo uma importante fonte de novos fármacos. Existem diversos métodos para avaliar a atividade antibacteriana e antifúngica de extratos, frações, óleos essenciais e substâncias isoladas de vegetais. Os mais conhecidos incluem métodos de difusão, diluição e bioautografia. A proposta desse trabalho é apresentar os métodos mais utilizados atualmente, juntamente com suas vantagens, desvantagens e fatores interferentes. Entre os artigos indexados na biblioteca SciELO, abrangendo os últimos dez anos, somente 4,4% das pesquisas com plantas medicinais estão relacionadas com atividade antimicrobiana. O ...
Keywords	plantas medicinais ; microbiologia ; testes de sensibilidade microbiana ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Language	English
Publishing date	2018-04-01T00:00:00Z
Publisher	Federal Council of Pharmacy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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