LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 38

Search options

  1. Article ; Online: Correction to: An insight into reactivity and bioactivity properties of quorum sensing peptides against PDE10A: a computational peptidology approach.

    Shreevatsa, Bhargav / Dharmashekara, Chandan / Jain, Anisha S / Amachawadi, Raghavendra / Achar, Raghu Ram / Syed, Asad / Shivamallu, Chandan / Kollur, Shiva Prasad / Frau, Juan / Flores-Holguín, Norma / Glossman-Mitnik, Daniel

    Journal of molecular modeling

    2022  Volume 28, Issue 11, Page(s) 347

    Language English
    Publishing date 2022-10-08
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1284729-X
    ISSN 0948-5023 ; 1610-2940
    ISSN (online) 0948-5023
    ISSN 1610-2940
    DOI 10.1007/s00894-022-05344-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Evaluating the Antimicrobial and Anti-Hemolytic Activity of Synthesized Pseudopeptide against

    Dharmashekar, Chandan / Shreevatsa, Bhargav / Jain, Anisha S / Harendra, Bhavana / Pradeep, Sushma / Vishwanath, Prashanth M / Singh, Pranav / V, Balamurugan / Kk, Vinod / Patil, Sharanagouda S / Shati, Ali A / Alfaifi, Mohammad Y / Elbehairi, Serag Eldin I / Amachawadi, Raghavendra G / Kollur, Shiva Prasad / Shivamallu, Chandan

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 3

    Abstract: Bacterial infections are one of the leading causes of morbidity, mortality, and healthcare complications in patients. Leptospirosis is found to be the most prevalent, re-emergent, and neglected tropical zoonotic disease worldwide. The adaptation to ... ...

    Abstract Bacterial infections are one of the leading causes of morbidity, mortality, and healthcare complications in patients. Leptospirosis is found to be the most prevalent, re-emergent, and neglected tropical zoonotic disease worldwide. The adaptation to various environmental conditions has made
    MeSH term(s) Animals ; Humans ; Anti-Infective Agents ; Endothelial Cells ; Leptospira/genetics ; Leptospirosis/drug therapy ; Leptospirosis/diagnosis ; Leptospirosis/microbiology ; Sphingomyelin Phosphodiesterase ; Hemostatics/pharmacology
    Chemical Substances Anti-Infective Agents ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12) ; Hemostatics
    Language English
    Publishing date 2023-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28031106
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Corrigendum: Everything Old Is New Again: Drug Repurposing Approach for Non-Small Cell Lung Cancer Targeting MAPK Signaling Pathway.

    Jain, Anisha S / Prasad, Ashwini / Pradeep, Sushma / Dharmashekar, Chandan / Achar, Raghu Ram / Silina, Ekaterina / Stupin, Victor / Amachawadi, Raghavendra G / Prasad, Shashanka K / Pruthvish, R / Syed, Asad / Shivamallu, Chandan / Kollur, Shiva Prasad

    Frontiers in oncology

    2021  Volume 11, Page(s) 822865

    Abstract: This corrects the article DOI: 10.3389/fonc.2021.741326.]. ...

    Abstract [This corrects the article DOI: 10.3389/fonc.2021.741326.].
    Language English
    Publishing date 2021-12-20
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.822865
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Overall Survival Prediction of Docetaxel-based Second-line Treatment for Advanced Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis.

    Nagaraju, Chaitra / Vaidya, Gayatri / Jain, Anisha S / Nair, Amrutha Puthiyidath / Chandrappa, Sahana / Srinivasa, Chandrashekar / Suresh, Kuralayanapalya Puttahonnappa / Patil, Sharanagouda S / Shivananda, Bindya / Kollur, Shiva Prasad / Shivamallu, Chandan

    Oman medical journal

    2022  Volume 37, Issue 5, Page(s) e419

    Abstract: Objectives: Non-small cell lung cancer (NSCLC) accounts for 75-85% of all lung cancer diagnoses. This meta-analysis sought to estimate the overall survival (OS) of NSCLC based on randomized control trials which had compared docetaxel with kinase ... ...

    Abstract Objectives: Non-small cell lung cancer (NSCLC) accounts for 75-85% of all lung cancer diagnoses. This meta-analysis sought to estimate the overall survival (OS) of NSCLC based on randomized control trials which had compared docetaxel with kinase inhibitors, antineoplastic agents, and monoclonal antibodies as second-line chemotherapy for advanced NSCLC.
    Methods: We selected 18 randomized control trials which used docetaxel as the standard treatment arm, while kinase inhibitors, antineoplastic agents, and monoclonal antibodies constituted the experimental arm. The methodological quality of the trial was classified according to the Modified Jadad score. Several steps were taken to reduce publication bias. A forest plot was used to graphically summarize the meta-analysis.
    Results: The Hedge's g value of antineoplastic agents was 0.11 (95% CI: -0.03-0.26), while for kinase inhibitors was 0.04 (95% CI: -0.10-0.17) and monoclonal antibodies was 0.05 (95% CI: -0.02-0.13). Forest plot showed a clear though only slightly higher overall survival using docetaxel compared to those of the antineoplastic agents, kinase inhibitors, and monoclonal antibodies, due to the existence of moderate heterogeneity and lower impact.
    Conclusions: Overall, the patients in these studies who were in the standard (docetaxel) treatment arm had slightly better OS than those in the intervention treatment arm. As per the results, docetaxel was more effective in the second-line treatment of advanced NSCLC than antineoplastic agents, monoclonal antibodies, and kinase inhibitors. We infer that docetaxel-based second-line therapy for patients with advanced NSCLC is supported by our meta-analysis.
    Language English
    Publishing date 2022-09-30
    Publishing country Oman
    Document type Journal Article
    ZDB-ID 2571431-4
    ISSN 2070-5204 ; 1999-768X
    ISSN (online) 2070-5204
    ISSN 1999-768X
    DOI 10.5001/omj.2022.86
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Evaluating the Antimicrobial and Anti-Hemolytic Activity of Synthesized Pseudopeptide against Leptospiral Species

    Chandan Dharmashekar / Bhargav Shreevatsa / Anisha S. Jain / Bhavana Harendra / Sushma Pradeep / Prashanth M. Vishwanath / Pranav Singh / Balamurugan V / Vinod KK / Sharanagouda S. Patil / Ali A. Shati / Mohammad Y. Alfaifi / Serag Eldin I. Elbehairi / Raghavendra G. Amachawadi / Shiva Prasad Kollur / Chandan Shivamallu

    Molecules, Vol 28, Iss 1106, p

    In Silico and In Vitro Approach

    2023  Volume 1106

    Abstract: Bacterial infections are one of the leading causes of morbidity, mortality, and healthcare complications in patients. Leptospirosis is found to be the most prevalent, re-emergent, and neglected tropical zoonotic disease worldwide. The adaptation to ... ...

    Abstract Bacterial infections are one of the leading causes of morbidity, mortality, and healthcare complications in patients. Leptospirosis is found to be the most prevalent, re-emergent, and neglected tropical zoonotic disease worldwide. The adaptation to various environmental conditions has made Leptospira acquire a large genome (~4.6 Mb) and a complex outer membrane, making it unique among bacteria that mimic the symptoms of jaundice and hemorrhage. Sph2 is another important virulence factor that enhances hemolytic sphingomyelinase—capable of moving inside mitochondria—which increases the ROS level and decreases the mitochondrial membrane potential, thereby leading to cell apoptosis. In the present study, 25 suspected bovine serum samples were subjected to the Microscopic Agglutination Test (MAT) across the Mysuru region. Different samples, such as urine, serum, and aborted materials from the confirmed MAT-positive animals, were used for isolation and genomic detection by conventional PCR targeting virulence gene, Lipl32, using specific primers. Further, in vitro and in silico studies were performed on isolated cultures to assess the anti-leptospiral, anti-hemolytic, and sphingomyelinase enzyme inhibition using novel pseudopeptides. The microdilution technique (MDT) and dark field microscope (DFM) assays revealed that at a concentration of 62.5 μg/mL, the pseudopeptide inhibited 100% of the growth of Leptospira spp., suggesting its efficiency in the treatment of leptospirosis. The flow cytometry analyses show the potency of the pseudopeptide against sphingomyelinase enzymes using human umbilical vein endothelial cells (HUVECs). Thus, the present study demonstrated the efficacy of the pseudopeptide in the inhibition of the growth of Leptospira , and therefore, this can be used as an alternative drug for the treatment of leptospirosis.
    Keywords Leptospira ; Microscopic Agglutination Test (MAT) ; pseudopeptide ; sphingomyelin enzymes ; molecular docking ; Organic chemistry ; QD241-441
    Subject code 630
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: Molecular docking analysis of phytocompounds from Acacia farnesiana with protein targets linked to bronchitis.

    Beelagi, Mallikarjun S / Bongale, Manoj Manjunath / Jain, Anisha S / Shiva Prasad, Kollur / Patil, Sharanagouda S / Mellappa, Govindappa / Dharmashekar, Chandan / Ashwini, P / Triveni, R / Shivamallu, Chandan / Srinivasa, Chandrashekar

    Bioinformation

    2021  Volume 17, Issue 5, Page(s) 557–567

    Abstract: Acute bronchitis is a lower respiratory tract lung infection that causes bronchial inflammation. The known protein drug targets are peptidoglycan D, D-transpeptidase, and DNA topoisomerase 4 subunit A for bronchitis linked infections. These are the ... ...

    Abstract Acute bronchitis is a lower respiratory tract lung infection that causes bronchial inflammation. The known protein drug targets are peptidoglycan D, D-transpeptidase, and DNA topoisomerase 4 subunit A for bronchitis linked infections. These are the membrane associated macromolecules which takes a major role in the formation of cell wall membrane by synthesising the cross-linked peptidoglycan. Therefore, it is of interest to design molecules with improved binding features with these protein targets. Hence, we document the molecular docking analysis data of four phytocompounds from Acacia farnesiana having optimal binding features with these targets linked to bronchitis for further consideration.
    Language English
    Publishing date 2021-05-31
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2203786-X
    ISSN 0973-2063
    ISSN 0973-2063
    DOI 10.6026/97320630017557
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Molecular insights into the

    Pradeep, Sushma / Patil, Shashank M / Dharmashekara, Chandan / Jain, Anisha / Ramu, Ramith / Shirahatti, Prithvi S / Mandal, Subhankar P / Reddy, Pruthvish / Srinivasa, Chandrashekar / Patil, Sharanagouda S / Ortega-Castro, Joaqúın / Frau, Juan / Flores-Holgúın, Norma / Shivamallu, Chandan / Kollur, Shiva Prasad / Glossman-Mitnik, Daniel

    Journal of biomolecular structure & dynamics

    2022  Volume 41, Issue 20, Page(s) 10869–10884

    Abstract: The spike (S) glycoprotein and nucleocapsid (N) proteins are the crucial pathogenic proteins ... potential dual inhibitor of S and N proteins from ...

    Abstract The spike (S) glycoprotein and nucleocapsid (N) proteins are the crucial pathogenic proteins of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) virus during its interaction with the host. Even FDA-approved drugs like dexamethasone and grazoprevir are not able to curb the viral progression inside the host and are reported with adverse effects on body metabolism. In this context, we aim to report corilagin a novel, potential dual inhibitor of S and N proteins from
    MeSH term(s) Terminalia ; SARS-CoV-2 ; Molecular Docking Simulation ; COVID-19 ; Molecular Dynamics Simulation ; Protease Inhibitors
    Chemical Substances corilagin (62LOS9TW6D) ; Protease Inhibitors
    Language English
    Publishing date 2022-12-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2022.2158943
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Alzheimer's Disease and Herbal Combination Therapy: A Comprehensive Review.

    Pradeep, Sushma / Jain, Anisha S / Dharmashekara, Chandan / Prasad, Shashanka K / Kollur, Shiva Prasad / Syed, Asad / Shivamallu, Chandan

    Journal of Alzheimer's disease reports

    2020  Volume 4, Issue 1, Page(s) 417–429

    Abstract: Alzheimer's disease (AD) was first described in 1907 and got its name after Alois Alzheimer, a German psychiatrist and neuropathologist. This disease starts slow, increasing gradually to worsen in the due course of time. AD is mainly characterized by the ...

    Abstract Alzheimer's disease (AD) was first described in 1907 and got its name after Alois Alzheimer, a German psychiatrist and neuropathologist. This disease starts slow, increasing gradually to worsen in the due course of time. AD is mainly characterized by the associated dementia, which is a decline of cognitive effects such as memory, praxis, and orientation. The dementia is further highlighted by the presence of psychological and behavioral symptoms. Additionally, AD is also associated with the multiple interconnected pathways linked neuropathological changes such as the formation of neurofibrillary tangles and amyloid-β plaques inside the brain. AD therapeutics have been of prime concern over the decades, resulting in the elucidation of promising therapeutic targets. The requirement of AD stage dependent optimized conditions has necessitated a combinatorial approach toward treatment. The priority in AD research has remained to develop disease-modifying and development-reducing drugs for treatment regimens followed during the early and later stages, respectively.
    Language English
    Publishing date 2020-10-24
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2542-4823
    ISSN (online) 2542-4823
    DOI 10.3233/ADR-200228
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Book ; Online: ReactGenie

    Yang, Jackie Junrui / Shi, Yingtian / Zhang, Yuhan / Li, Karina / Rosli, Daniel Wan / Jain, Anisha / Zhang, Shuning / Li, Tianshi / Landay, James A. / Lam, Monica S.

    A Development Framework for Complex Multimodal Interactions Using Large Language Models

    2023  

    Abstract: By combining voice and touch interactions, multimodal interfaces can surpass the efficiency of either modality alone. This paper targets complex interactions, where users can issue multimodal commands that translate into one of the possible exponential ... ...

    Abstract By combining voice and touch interactions, multimodal interfaces can surpass the efficiency of either modality alone. This paper targets complex interactions, where users can issue multimodal commands that translate into one of the possible exponential combinations of actions/function invocations. This paper presents ReactGenie, a programming framework where developers can code with simple object-oriented abstractions and labeled user-invocable primitives. ReactGenie translates multimodal user commands into ReactGenieDSL, a domain-specific language we created for this purpose, using a neural semantic parser based on large-language models. The ReactGenie runtime interprets the parsed ReactGenieDSL and composes primitives to implement complex user commands. As a result, ReactGenie provides an unprecedented level of richness in user interactions. Our evaluation showed that 12 developers can learn and build a ReactGenie application in under 2.5 hours on average. In addition, compared with a traditional GUI, end users can complete tasks faster and with less task load using ReactGenie apps.
    Keywords Computer Science - Human-Computer Interaction ; Computer Science - Computation and Language
    Subject code 004
    Publishing date 2023-06-16
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: N

    Mariwamy, Vinusha H / Kollur, Shiva Prasad / Shivananda, Bindya / Begum, Muneera / Shivamallu, Chandan / Dharmashekara, Chandan / Pradeep, Sushma / Jain, Anisha S / Prasad, Shashanka K / Syed, Asad / Elgorban, Abdallah M / Al-Rejaie, Salim / Ortega-Castro, Joaquín / Frau, Juan / Flores-Holguín, Norma / Glossman-Mitnik, Daniel

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 4

    Abstract: Researchers are interested in Schiff bases and their metal complexes because they offer a wide range of applications. The chemistry of Schiff bases of heterocompounds has got a lot of attention because of the metal's ability to coordinate with Schiff ... ...

    Abstract Researchers are interested in Schiff bases and their metal complexes because they offer a wide range of applications. The chemistry of Schiff bases of heterocompounds has got a lot of attention because of the metal's ability to coordinate with Schiff base ligands. In the current study, a new bidentate Schiff base ligand,
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/chemical synthesis ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Chemistry Techniques, Synthetic ; Cobalt/chemistry ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; Copper/chemistry ; Density Functional Theory ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Models, Chemical ; Models, Molecular ; Molecular Structure ; Schiff Bases/chemistry ; Spectrum Analysis
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Coordination Complexes ; Schiff Bases ; Cobalt (3G0H8C9362) ; Copper (789U1901C5)
    Language English
    Publishing date 2022-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27041436
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top