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  1. Article ; Online: Arylative Methylation of 2,3-Dihydropyrazines and Pyrazinones Using Dimethyl Sulfoxide as a C1 Source.

    Palit, Kuntal / Sepay, Nayim / Panda, Niranjan

    The Journal of organic chemistry

    2023  Volume 88, Issue 5, Page(s) 2931–2941

    Abstract: Divergent synthesis of α-C-H methylated pyrazines and pyrazinones using dimethyl sulfoxide as a nonconventional methylating agent under metal-free conditions was reported. Dimethyl sulfoxide-coordinated bromine cation pools generated from the treatment ... ...

    Abstract Divergent synthesis of α-C-H methylated pyrazines and pyrazinones using dimethyl sulfoxide as a nonconventional methylating agent under metal-free conditions was reported. Dimethyl sulfoxide-coordinated bromine cation pools generated from the treatment of dimethyl sulfoxide and 1,2-dibromoethane undergo Pummerer-type fragmentation to afford an electrophilic methyl(methylene)sulfonium ion for reaction with a carbon nucleophile followed by aromatization to afford α-methylated pyrazines and pyrazinones.
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c02675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Entropy-Enthalpy Compensation in Solvent Geometry Regulated Supramolecular Polymerization of Luminescent Napthalimide via a Non-Cooperative, Isodesmic Mechanism.

    Ali, Sk Mursed / Sk, Sujauddin / Sepay, Nayim / Molla, Mijanur Rahaman

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 13, Page(s) e202303587

    Abstract: Supramolecular polymers of π-conjugated systems are an important class of materials with fascinating functions and properties originated from the dynamic behavior and highly ordered molecular organizations. Here, a donor-π-acceptor based functionalized ... ...

    Abstract Supramolecular polymers of π-conjugated systems are an important class of materials with fascinating functions and properties originated from the dynamic behavior and highly ordered molecular organizations. Here, a donor-π-acceptor based functionalized luminescent napthalene monoimide (NMI) undergoes J-type self-assembly by non-covalent interactions via a non-cooperative, isodesmic mechanism to form supramolecular 1D nanowire. The fundamental insights into the thermodynamics regulating the supramolecular polymerization were derived through the fitting of the isodesmic model to variable temperature UV/Vis data in linear (dodecane) and nonliner hydrocarbon (decalin) based solvents. This shows a significant role of entropy-enthalpy compensation in solvent geometry-regulated formation and stabilization of supramolecular polymer. Furthermore, we have quantitively estimated the influence of solvent geometry and found that NMI forms stronger self-assembly and spontaneous gel in linear hydrocarbon based solvent compared to nonliner one and thereby substantially increases the degree of polymerization in linear hydrocarbon solvent (dodecane). This is accredited to the effective influence of the linear hydrocarbon solvent molecules in the polymerization process by favourable van der waals interactions with the peripheral alkyl chains of the NMI monomers in contrast to unfavourable interaction of nonliner hydrocarbon solvent due to geometry mismatch.
    Language English
    Publishing date 2024-01-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202303587
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  3. Article ; Online: ß-Sheet Induced Helical Self-Assembly Structure Formation by Dityrosine Dipeptide: Crystallographic Evidence and Other Biophysical Studies.

    Majumder, Leena / Sepay, Nayim / Banerji, Biswadip

    The journal of physical chemistry. B

    2022  Volume 126, Issue 28, Page(s) 5207–5218

    Abstract: Self-assembled structures derived from short peptides are a versatile class of organic building blocks which have shown great potential in a wide range of domains. In the current study, side-chain protected dityrosine based short peptide ( ...

    Abstract Self-assembled structures derived from short peptides are a versatile class of organic building blocks which have shown great potential in a wide range of domains. In the current study, side-chain protected dityrosine based short peptide (
    MeSH term(s) Dipeptides ; Hydrogen Bonding ; Peptides/chemistry ; Protein Conformation, alpha-Helical ; Tyrosine/analogs & derivatives
    Chemical Substances Dipeptides ; Peptides ; Tyrosine (42HK56048U) ; dityrosine (CJ9XG8HS20)
    Language English
    Publishing date 2022-07-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.2c02681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Identification of 4-acrylamido-

    Sepay, Nayim / Chakrabarti, Sukanya / Afzal, Mohd / Alarifi, Abdullah / Mal, Dasarath

    RSC advances

    2022  Volume 12, Issue 37, Page(s) 24178–24186

    Abstract: Omicron is one of the variants of COVID-19 and continuing member of a pandemic. There are several types of vaccines that were developed around the globe to fight against the virus. However, the world is suffering to find suitable drug candidates for the ... ...

    Abstract Omicron is one of the variants of COVID-19 and continuing member of a pandemic. There are several types of vaccines that were developed around the globe to fight against the virus. However, the world is suffering to find suitable drug candidates for the virus. The main protease (M
    Language English
    Publishing date 2022-08-25
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra04333e
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  5. Article: Anti-HSV nucleoside and non-nucleoside analogues: spectroscopic characterisation of naphthyl and coumarinyl amides and their mode and mechanism of antiviral action.

    Das Mahapatra, Ananya / Patra, Chiranjit / Sepay, Nayim / Sinha, Chittaranjan / Chattopadhyay, Debprasad

    3 Biotech

    2023  Volume 13, Issue 7, Page(s) 245

    Abstract: Nucleoside analogues acyclovir, valaciclovir, and famciclovir are the preferred drugs against human Herpes Simplex Viruses (HSVs). However, the viruses rapidly develop resistance against these analogues which demand safer, more efficient, and nontoxic ... ...

    Abstract Nucleoside analogues acyclovir, valaciclovir, and famciclovir are the preferred drugs against human Herpes Simplex Viruses (HSVs). However, the viruses rapidly develop resistance against these analogues which demand safer, more efficient, and nontoxic antiviral agents. We have synthesized two non-nucleoside amide analogues, 2-Oxo-2H-chromene-3-carboxylic acid [2-(pyridin-2-yl methoxy)-phenyl]-amide (
    Supplementary information: The online version contains supplementary material available at 10.1007/s13205-023-03658-0.
    Language English
    Publishing date 2023-06-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-023-03658-0
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  6. Article ; Online: Urea-Promoted Neat Synthesis of Fused Dihydroisoquinolines and Disubstituted Pyridines: A Mechanistic Observation with Molecular-Sensing Studies.

    Azad, Sk Abulkalam / Bera, Anirban / Samanta, Jayanta / Sepay, Nayim / Jana, Rathin / Pal, Chandan Kumar / Molla, Mijanur Rahaman / Maiti, Debabrata / Samanta, Shubhankar

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 13, Page(s) e202303287

    Abstract: An efficient and short synthesis of fused dihydroisoquinolines, diaryl substituted pyridine derivatives in good to high yields has been established by using an environmentally safe, solvent-metal-oxidant-free tandem approach. In this article, we discuss ... ...

    Abstract An efficient and short synthesis of fused dihydroisoquinolines, diaryl substituted pyridine derivatives in good to high yields has been established by using an environmentally safe, solvent-metal-oxidant-free tandem approach. In this article, we discuss how the electrocyclic reaction is more pronounced in the solid phase in the presence of urea, whereas the typical aza-Michael addition is more prominent in presence of arylamine in the solution phase for 3-(2-formylcycloalkenyl)acrylic ester derivative substrates. The wide range of substrates and urea-promoted neat synthesis made our approach more significant in medical and also analytical science. Moreover, an isoquinoline alkaloid decumbenine B analogue has been synthesized by using our newly developed neat methodology. We have also investigated the photophysical properties of the synthesized fused dihydroisoquinoline derivatives. One of the synthesized molecules was used as a sensor for the selective detection of toxic picric acid. Therefore, the effective neat synthesis and molecular sensing applications of these compounds made our approach more exciting in the field of heterocyclic chemistry.
    Language English
    Publishing date 2024-01-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202303287
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  7. Article ; Online: A novel nickel(II) complex with N,S donor Schiff base: Structural characterisation, DFT, TD-DFT study and catalytic investigation.

    Chowdhury, Manas / Biswas, Niladri / Saha, Sandeepta / Zangrando, Ennio / Sepay, Nayim / Roy Choudhury, Chirantan

    Acta chimica Slovenica

    2023  Volume 70, Issue 4, Page(s) 479–488

    Abstract: One new mononuclear nickel(II) thiosemicarbazone complex (1), has been synthesised from the Schiff base ligand derived from p-anisaldehyde and thiosemicarbazide. Complex 1 is characterized by using different spectroscopic techniques and single crystal X- ... ...

    Abstract One new mononuclear nickel(II) thiosemicarbazone complex (1), has been synthesised from the Schiff base ligand derived from p-anisaldehyde and thiosemicarbazide. Complex 1 is characterized by using different spectroscopic techniques and single crystal X-ray structure analysis. Time dependent density functional theory (TD-DFT) was performed to simulate the electronic spectra of the complex 1 with the help of Polarizable Continuum Model (PCM) model. Complex 1 acts as functional models. The catalytic property has been evaluated from Lineweaver-Burk plot using the Michaelis-Menten approach of enzyme catalysis with a kcat value of the order of 708 h-1.
    Language English
    Publishing date 2023-11-04
    Publishing country Slovenia
    Document type Journal Article
    ZDB-ID 2029709-9
    ISSN 1580-3155 ; 1318-0207
    ISSN (online) 1580-3155
    ISSN 1318-0207
    DOI 10.17344/acsi.2023.8136
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  8. Article ; Online: Comparative study on Antibacterial efficacy of a series of chromone sulfonamide derivatives against drug-resistant and MDR-isolates.

    Das Mahapatra, Ananya / Patra, Chiranjit / Sepay, Nayim / Sinha, Chittaranjan / Chattopadhyay, Debprasad

    Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

    2023  Volume 55, Issue 1, Page(s) 343–355

    Abstract: Sulfonamide derivatives have numerous pharmaceutical applications having antiviral, antibacterial, antifungal, antimalarial, anticancer, and antidepressant activities. The structural flexibility of sulfonamide derivatives makes them an excellent ... ...

    Abstract Sulfonamide derivatives have numerous pharmaceutical applications having antiviral, antibacterial, antifungal, antimalarial, anticancer, and antidepressant activities. The structural flexibility of sulfonamide derivatives makes them an excellent candidate for the development of new multi-target agents, although long-time exposure to sulfonamide drugs results in many toxic impacts on human health. However, sulfonamides may be functionalized for developing less toxic and more competent drugs. In this work, sulfonamides including Sulfapyridine (a), Sulfathiazole (b), Sulfamethoxazole (c), and Sulfamerazine (d) are used to synthesize Schiff bases of 7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbalde-hyde (1a-1d). The synthesized compounds were spectroscopically characterized and tested against hospital isolates of three Gram-positive (Methicillin-resistant Staphylococcus aureus PH217, Ampicillin-resistant Coagulase-negative Staphylococcus aureus, multidrug-resistant (MDR) Enterococcus faecalis PH007
    MeSH term(s) Humans ; Staphylococcus aureus ; Methicillin-Resistant Staphylococcus aureus ; Molecular Docking Simulation ; Chromones/pharmacology ; Escherichia coli ; Schiff Bases/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Sulfanilamide ; Ampicillin/pharmacology ; Sulfonamides/pharmacology ; Microbial Sensitivity Tests
    Chemical Substances Chromones ; Schiff Bases ; Anti-Bacterial Agents ; Sulfanilamide (21240MF57M) ; Ampicillin (7C782967RD) ; Sulfonamides
    Language English
    Publishing date 2023-12-08
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2017175-4
    ISSN 1678-4405 ; 1517-8382
    ISSN (online) 1678-4405
    ISSN 1517-8382
    DOI 10.1007/s42770-023-01194-w
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  9. Article ; Online: Synthesis of Multifused Pyrrolo[1,2-

    Bera, Anirban / Azad, Sk Abulkalam / Patra, Prasanta / Sepay, Nayim / Jana, Rathin / Das, Tapas / Saha, Amit / Samanta, Shubhankar

    The Journal of organic chemistry

    2023  Volume 88, Issue 9, Page(s) 5622–5638

    Abstract: Herein, we have presented a weak acid-promoted tandem aza-Michael-aldol strategy for the synthesis of diversely fused pyrrolo[1,2- ...

    Abstract Herein, we have presented a weak acid-promoted tandem aza-Michael-aldol strategy for the synthesis of diversely fused pyrrolo[1,2-
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c00109
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  10. Article ; Online: Structural, Theoretical Investigations, Hirshfeld Surface Analysis, and Cytotoxicity Profile of a Neocuproine-Co(II)-Based Discrete Homodinuclear Complex.

    Muslim, Mohd / Naz, Farha / Alarifi, Abdullah / Afzal, Mohd / Sepay, Nayim / Ahmad, Musheer

    Applied biochemistry and biotechnology

    2022  Volume 195, Issue 2, Page(s) 871–888

    Abstract: In this work, we aimed to synthesize a new cobalt(II) complex, namely [ ... ...

    Abstract In this work, we aimed to synthesize a new cobalt(II) complex, namely [Co
    MeSH term(s) Molecular Docking Simulation ; Phenanthrolines/chemistry ; Phenanthrolines/pharmacology ; Crystallography, X-Ray ; Cell Line
    Chemical Substances neocuproine (8E7D2SH3BV) ; Phenanthrolines
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-022-04180-4
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    Zs.A 3053: Show issues Location:
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