LIVIVO - Search results -

Search results

Result 1 - 10 of total 9281

Article ; Online: T

Damo, Martina / Joshi, Nikhil S

2019 Volume 20, Issue 6, Page(s) 674–675

MeSH term(s)	Adaptation, Physiological ; CD8-Positive T-Lymphocytes ; Humans ; Interleukin-10 ; Neoplasms ; T-Lymphocytes, Regulatory
Chemical Substances	Interleukin-10 (130068-27-8)
Language	English
Publishing date	2019-04-22
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-019-0389-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Relevance of lymphocyte proliferation to PHA in severe combined immunodeficiency (SCID) and T cell lymphopenia.

Abraham, Roshini S / Basu, Amrita / Heimall, Jennifer R / Dunn, Elizabeth / Yip, Alison / Kapadia, Malika / Kapoor, Neena / Satter, Lisa Forbes / Buckley, Rebecca / O'Reilly, Richard / Cuvelier, Geoffrey D E / Chandra, Sharat / Bednarski, Jeffrey / Chaudhury, Sonali / Moore, Theodore B / Haines, Hilary / Dávila Saldaña, Blachy J / Chellapandian, Deepakbabu / Rayes, Ahmad /

Chen, Karin / Caywood, Emi / Chandrakasan, Shanmuganathan / Lugt, Mark Thomas Vander / Ebens, Christen / Teira, Pierre / Shereck, Evan / Miller, Holly / Aquino, Victor / Eissa, Hesham / Yu, Lolie C / Gillio, Alfred / Madden, Lisa / Knutsen, Alan / Shah, Ami J / DeSantes, Kenneth / Barnum, Jessie / Broglie, Larisa / Joshi, Avni Y / Kleiner, Gary / Dara, Jasmeen / Prockop, Susan / Martinez, Caridad / Mousallem, Talal / Oved, Joseph / Burroughs, Lauri / Marsh, Rebecca / Torgerson, Troy R / Leiding, Jennifer W / Pai, Sung Yun / Kohn, Donald B / Pulsipher, Michael A / Griffith, Linda M / Notarangelo, Luigi D / Cowan, Morton J / Puck, Jennifer / Dvorak, Christopher C / Haddad, Elie

Clinical immunology (Orlando, Fla.)

2024 Volume 261, Page(s) 109942

Abstract: Severe combined immunodeficiency (SCID) is characterized by a severe deficiency in T cell numbers ... We analyzed data collected (n = 307) for PHA-based T cell proliferation from the PIDTC SCID protocol 6901, using ... 02). Further, in patients with CD3+ T cell counts between 51 and 300 cells/μL, there was a higher ...

Abstract	Severe combined immunodeficiency (SCID) is characterized by a severe deficiency in T cell numbers. We analyzed data collected (n = 307) for PHA-based T cell proliferation from the PIDTC SCID protocol 6901, using either a radioactive or flow cytometry method. In comparing the two groups, a smaller number of the patients tested by flow cytometry had <10% of the lower limit of normal proliferation as compared to the radioactive method (p = 0.02). Further, in patients with CD3+ T cell counts between 51 and 300 cells/μL, there was a higher proliferative response with the PHA flow assay compared to the
MeSH term(s)	Infant, Newborn ; Humans ; Severe Combined Immunodeficiency/diagnosis ; Lymphopenia/diagnosis ; Neonatal Screening/methods ; T-Lymphocytes ; Cell Proliferation
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2024.109942
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 880: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Perils and Problems in Bispecific T-Cell Engager Antibodies.

Khushboo, Bisht / Kumar, Joshi Rajat

Current drug safety

2024

Abstract: Bispecific antibodies (BsAbs) are promising immunotherapies for cancer treatment designed to engage both tumour and immune cells. However, their use is associated with potential toxicities, including cytokine release syndrome (CRS), neurotoxicity, and on- ...

Abstract	Bispecific antibodies (BsAbs) are promising immunotherapies for cancer treatment designed to engage both tumour and immune cells. However, their use is associated with potential toxicities, including cytokine release syndrome (CRS), neurotoxicity, and on-target, off-tumour toxicity. CRS, characterized by cytokine release, is the most common, potentially life-threatening toxicity. Neurotoxicity presents as neurological symptoms and on-target, off-tumour toxicity damages healthy cells. Incidence and severity vary based on BsAb type, dose, patient factors, and tumor characteristics. For this study, articles pertaining to BsAb toxicity were searched on PubMed. Moreover, the management involves early recognition, dose modification, supportive care, and, in severe cases, immunosuppressive therapy or treatment discontinuation. Clinicians must carefully assess risks and benefits, considering individual patient profiles. Close monitoring and multidisciplinary collaboration are crucial for effective BsAb therapy. All in all, while toxicity is a concern, with vigilant management, BsAbs remain a valuable cancer treatment option.
Language	English
Publishing date	2024-02-27
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2250840-5
ISSN	2212-3911 ; 1574-8863
ISSN (online)	2212-3911
ISSN	1574-8863
DOI	10.2174/0115748863286774240219094217
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6400: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Comprehensive genetic profiling reveals frequent alterations of driver genes on the X chromosome in extranodal NK/T-cell lymphoma.

Ito, Yuta / Marouf, Amira / Kogure, Yasunori / Koya, Junji / Liévin, Raphaël / Bruneau, Julie / Tabata, Mariko / Saito, Yuki / Shingaki, Sumito / Yuasa, Mitsuhiro / Yamaguchi, Kentaro / Murakami, Koichi / Weil, Robert / Vavasseur, Manon / Andrieu, Guillaume P / Latiri, Mehdi / Veleanu, Layla / Dussiot, Michaël / André, Isabelle /

Joshi, Akshay / Lagresle-Peyrou, Chantal / Magerus, Aude / Chaubard, Sammara / Lavergne, David / Bachy, Emmanuel / Brunet, Erika / Fataccioli, Virginie / Brouzes, Chantal / Laurent, Camille / De Leval, Laurence / Traverse-Glehen, Alexandra / Bossard, Céline / Parrens, Marie-Cécile / Meignin, Véronique / Philippe, Laure / Rossignol, Julien / Suarez, Felipe / Michot, Jean-Marie / Tournilhac, Olivier / Damaj, Gandhi / Lemonnier, François / Bôle-Feysot, Christine / Nitschké, Patrick / Tesson, Bruno / Laurent, Cécile / Molina, Thierry / Asnafi, Vahid / Watatani, Yosaku / Chiba, Kenichi / Okada, Ai / Shiraishi, Yuichi / Tsukita, Sachiko / Izutsu, Koji / Miyoshi, Hiroaki / Ohshima, Koichi / Sakata, Seiji / Dobashi, Akito / Takeuchi, Kengo / Sanada, Masashi / Gaulard, Philippe / Jaccard, Arnaud / Ogawa, Seishi / Hermine, Olivier / Kataoka, Keisuke / Couronné, Lucile

Cancer research

2024

Abstract: Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male ...

Abstract	Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations and their functional roles in ENKTCL could help improve patient stratification and treatments. Here, we performed comprehensive genetic analysis of 177 ENKTCL cases to delineate the landscape of mutations, copy number alterations (CNAs), and structural variations, identifying 34 driver genes including six previously unappreciated ones, namely HLA-B, HLA-C, ROBO1, CD58, POT1, and MAP2K1. Among them, CD274 (24%) was the most frequently altered, followed by TP53 (20%), CDKN2A (19%), ARID1A (15%), HLA-A (15%), BCOR (14%), and MSN (14%). Chromosome X (chrX) losses were the most common arm-level CNAs in females (~40%), and alterations of four X-linked driver genes (MSN, BCOR, DDX3X, and KDM6A) were more frequent in males and females harboring chrX losses. Among X-linked drivers, MSN was the most recurrently altered, and its expression was lost in approximately one-third of cases using immunohistochemical analysis. Functional studies of human cell lines demonstrated that MSN disruption promoted cell proliferation and NF-κB activation. Moreover, MSN inactivation increased sensitivity to NF-κB inhibition in vitro and in vivo. In addition, recurrent deletions were observed at the origin of replication in the EBV genome (6%). Finally, by integrating the 34 drivers and 19 significant arm-level CNAs, non-negative matrix factorization and consensus clustering identified two molecular groups with different genetic features and prognosis irrespective of clinical prognostic factors. Together, these findings could help improve diagnostic and therapeutic strategies in ENKTCL.
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-24-0132
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.135/5: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: T-lymphoid progenitor-based immunotherapies: clinical perspectives for one and all.

Gaudeaux, P / Moirangthem, R D / Paillet, J / Martin-Corredera, M / Sadek, H / Rault, P / Joshi, A / Zuber, J / Soheili, T S / Negre, O / André, I

Cellular & molecular immunology

2022 Volume 19, Issue 12, Page(s) 1435–1438

MeSH term(s)	Immunotherapy ; B-Lymphocytes ; Cell Differentiation
Language	English
Publishing date	2022-09-30
Publishing country	China
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2435097-7
ISSN	2042-0226 ; 1672-7681
ISSN (online)	2042-0226
ISSN	1672-7681
DOI	10.1038/s41423-022-00927-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6681: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Cancer- and infection-induced T cell exhaustion are distinct.

Buck, Jessica / Joshi, Nikhil S

Nature immunology

2023 Volume 24, Issue 10, Page(s) 1604–1605

MeSH term(s)	Humans ; T-Cell Exhaustion ; CD8-Positive T-Lymphocytes ; Infections ; Neoplasms
Language	English
Publishing date	2023-09-12
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-023-01624-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Neoadjuvant chemotherapy enhances tumor-specific T cell immunity in patients with HPV-associated oropharyngeal cancer.

Samaniego, Christian / Friedman, Jay / Yang, Xinping / Badger, Christopher / Shaver, Timothy / Samankan, Shabnam / Thakkar, Punam / Goodman, Joseph / Joshi, Arjun / Allen, Clint T

Head & neck

2023 Volume 45, Issue 9, Page(s) 2294–2302

Abstract: ... HPV-specific T cell responses.: Methods: HPV-specific responses in tumor infiltrating lymphocytes ... induces HPV-specific tumor T cell responses in patients with newly diagnosed HPV-associated OPSCC ...

Abstract	Background: Treatment of patients with newly diagnosed HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) with neoadjuvant chemotherapy (NAC) results in a high rate of 5-year recurrence free survival with few patients requiring adjuvant treatment. We hypothesized that NAC enhances primary tumor HPV-specific T cell responses. Methods: HPV-specific responses in tumor infiltrating lymphocytes (TILs) before and after NAC were determined using autologous co-culture assays. Results: Greater HPV16-specific TIL responses, sometimes polyclonal, were observed after NAC compared to before in 8 of 10 patients (80%) with PCR-verified HPV16-positive tumors. A significant association was observed between net-negative change in HPV-specific TIL response and disease relapse (p = 0.04, Mann-Whitney test), whereas pathologic complete response at time of surgery did not correlate with recurrence. Conclusions: NAC induces HPV-specific tumor T cell responses in patients with newly diagnosed HPV-associated OPSCC; whereas lack of an increase following NAC may associate with risk of relapse.
MeSH term(s)	Humans ; T-Lymphocytes ; Prognosis ; Neoadjuvant Therapy/methods ; Papillomavirus Infections/complications ; Neoplasm Recurrence, Local ; Oropharyngeal Neoplasms/pathology ; Squamous Cell Carcinoma of Head and Neck/complications ; Head and Neck Neoplasms/complications
Language	English
Publishing date	2023-07-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27463
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1493: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Tracking down tumor-specific T cells.

Reading, James / Foster, Kane / Joshi, Kroopa / Chain, Benny

Cancer cell

2022 Volume 40, Issue 4, Page(s) 351–353

Abstract: ... which identifies tumor-specific T cells. ...

Abstract	Two papers published in this edition of Cancer Cell (Zheng et al., 2022 and Veatch et al., 2022) provide an elegant illustration of how single-cell sequencing can be used to define a molecular phenotype which identifies tumor-specific T cells.
MeSH term(s)	Humans ; Neoplasms/genetics ; Phenotype ; T-Lymphocytes
Language	English
Publishing date	2022-04-12
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2078448-X
ISSN	1878-3686 ; 1535-6108
ISSN (online)	1878-3686
ISSN	1535-6108
DOI	10.1016/j.ccell.2022.03.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5650: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 104: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: T follicular helper cells in cancer, tertiary lymphoid structures, and beyond.

Cui, Can / Craft, Joseph / Joshi, Nikhil S

Seminars in immunology

2023 Volume 69, Page(s) 101797

Abstract: ... focused on CD8 T cells, whose cytotoxic programs directly target tumor cells. However, the limited ... infiltrating immune cells, such as CD4 T cells and B cells, and how they interact with CD8 T ... cells in a coordinated network. Recent studies have demonstrated the potential therapeutic benefits of CD4 T follicular ...

Abstract	With the emergence and success of checkpoint blockade immunotherapy, immuno-oncology has primarily focused on CD8 T cells, whose cytotoxic programs directly target tumor cells. However, the limited response rate of current immunotherapy regimens has prompted investigation into other types of tumor-infiltrating immune cells, such as CD4 T cells and B cells, and how they interact with CD8 T cells in a coordinated network. Recent studies have demonstrated the potential therapeutic benefits of CD4 T follicular helper (TFH) cells and B cells in cancer, highlighting the important role of their crosstalk and interactions with other immune cell components in the tumor microenvironment. These interactions also occur in tumor-associated tertiary lymphoid structures (TLS), which resemble secondary lymphoid organs (SLOs) with orchestrated vascular, chemokine, and cellular infrastructures that support the developmental pathways of functional immune cells. In this review, we discuss recent breakthroughs on TFH biology and T cell-B cell interactions in tumor immunology, and their potential as novel therapeutic targets to advance cancer treatment.
MeSH term(s)	Humans ; Tertiary Lymphoid Structures ; T Follicular Helper Cells/metabolism ; T Follicular Helper Cells/pathology ; Neoplasms ; B-Lymphocytes ; CD8-Positive T-Lymphocytes ; Tumor Microenvironment
Language	English
Publishing date	2023-06-19
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1018141-6
ISSN	1096-3618 ; 1044-5323
ISSN (online)	1096-3618
ISSN	1044-5323
DOI	10.1016/j.smim.2023.101797
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2843: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Modulation of the skin microbiome in cutaneous T-cell lymphoma delays tumour growth and increases survival in the murine EL4 model.

Dey, Saptaswa / Vieyra-Garcia, Pablo Augusto / Joshi, Aaroh Anand / Trajanoski, Slave / Wolf, Peter

Frontiers in immunology

2024 Volume 15, Page(s) 1255859

Abstract: Cutaneous T-cell lymphomas (CTCL) are a group of lymphoproliferative disorders of skin-homing ... T cells causing chronic inflammation. These disorders cause impairment of the immune environment ... of the skin microbiota could beneficially affect the course of CTCL. EL4 T-cell lymphoma cells were ...

Abstract	Cutaneous T-cell lymphomas (CTCL) are a group of lymphoproliferative disorders of skin-homing T cells causing chronic inflammation. These disorders cause impairment of the immune environment, which leads to severe infections and/or sepsis due to dysbiosis. In this study, we elucidated the host-microbial interaction in CTCL that occurs during the phototherapeutic treatment regime and determined whether modulation of the skin microbiota could beneficially affect the course of CTCL. EL4 T-cell lymphoma cells were intradermally grafted on the back of C57BL/6 mice. Animals were treated with conventional therapeutics such as psoralen + UVA (PUVA) or UVB in the presence or absence of topical antibiotic treatment (neomycin, bacitracin, and polymyxin B sulphate) as an adjuvant. Microbial colonisation of the skin was assessed to correlate with disease severity and tumour growth. Triple antibiotic treatment significantly delayed tumour occurrence (
MeSH term(s)	Animals ; Microbiota/drug effects ; Mice ; Skin/microbiology ; Skin/pathology ; Skin/immunology ; Skin/drug effects ; Skin Neoplasms/microbiology ; Skin Neoplasms/immunology ; Skin Neoplasms/pathology ; Lymphoma, T-Cell, Cutaneous/microbiology ; Lymphoma, T-Cell, Cutaneous/pathology ; Lymphoma, T-Cell, Cutaneous/drug therapy ; Lymphoma, T-Cell, Cutaneous/therapy ; Mice, Inbred C57BL ; Disease Models, Animal ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/administration & dosage ; Cell Line, Tumor ; Female ; Humans
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-04-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1255859
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito