Article ; Online: Sleep loss disrupts decision-making ability and neuronal cytomorphology in zebrafish and the effects are mediated by noradrenaline acting on α1-adrenoceptor.
2024 Volume 247, Page(s) 109861
Abstract: Sleep is an instinct behavior, and its significance and functions are still an enigma. It is expressed throughout one's life and its loss affects psycho-somatic and physiological processes. We had proposed that it might maintain a fundamental property of ...
| Abstract | Sleep is an instinct behavior, and its significance and functions are still an enigma. It is expressed throughout one's life and its loss affects psycho-somatic and physiological processes. We had proposed that it might maintain a fundamental property of the neurons and the brain. In that context, it was shown that sleep, rapid eye movement sleep (REMS) in particular, by regulating noradrenaline (NA), maintains the brain excitability. It was also reported that sleep-loss affected memory, reaction time and decision-making ability among others. However, as there was lack of clarity on the cause-and-effect relationship as to how the sleep-loss could affect these basic behaviors, their association was questioned and it was difficult to propose a cure or at least ways and means to ameliorate the symptoms. Also, we wanted to conduct the studies in a simpler model system so that conducting future molecular studies might be easier. Hence, using zebrafish as a model we evaluated if sleep-loss affected the basic decision-making ability, a cognitive process and if the effect was induced by NA. Indeed, our findings confirmed that upon sleep-deprivation, the cognitive decision-making ability of the prey zebrafish was compromised to protect itself by running away from the reach of the exposed predator Tiger Oscar (TO) fish. Also, we observed that upon sleep-loss the axonal arborization of the prey zebrafish brain was reduced. Interestingly, the effects were prevented by prazosin (PRZ), an α1-adrenoceptor (AR) antagonist and when the zebrafish recovered from the lost sleep. |
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| MeSH term(s) | Animals ; Norepinephrine/pharmacology ; Zebrafish ; Sleep Deprivation ; Sleep ; Neurons ; Receptors, Adrenergic, alpha-1/physiology |
| Chemical Substances | Norepinephrine (X4W3ENH1CV) ; Receptors, Adrenergic, alpha-1 |
| Language | English |
| Publishing date | 2024-02-07 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 218272-5 |
| ISSN | 1873-7064 ; 0028-3908 |
| ISSN (online) | 1873-7064 |
| ISSN | 0028-3908 |
| DOI | 10.1016/j.neuropharm.2024.109861 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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