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Article ; Online: Biomolecular engineering of drugs loading in Riboflavin-targeted polymeric devices: simulation and experimental.

Khedri, Mohammad / Keshavarz Moraveji, Mostafa

2022 Volume 12, Issue 1, Page(s) 5119

Abstract: The synthesis of polymeric nanoparticles (NPs) with efficient drug loading content and targeting moieties is an attractive field and remains a challenge in drug delivery systems. Atomistic investigations can provide an in-depth understanding of delivery ... ...

Abstract	The synthesis of polymeric nanoparticles (NPs) with efficient drug loading content and targeting moieties is an attractive field and remains a challenge in drug delivery systems. Atomistic investigations can provide an in-depth understanding of delivery devices and reduce the number of expensive experiments. In this paper, we studied the self-assembly of poly (lactic-co-glycolic acid)-b-poly (ethylene glycol) with different molecular weights and surface compositions. The innovation of this molecular study is the loading of an antitumor drug (docetaxel) on a targeting ligand (riboflavin). According to this work, a novel, biocompatible and targeted system for cancer treatment has been developed. The obtained results revealed a correlation between polymer molecular weight and the stability of particles. In this line, samples including 20 and 10 w/w% moiety NPs formed from polymers with 3 and 4.5 kDa backbone sizes, respectively, are the stable models with the highest drug loading and entrapment efficiencies. Next, we evaluated NP morphology and found that NPs have a core/shell structure consisting of a hydrophobic core with a shell of poly (ethylene glycol) and riboflavin. Interestingly, morphology assessments confirmed that the targeting moiety located on the surface can improve drug delivery to receptors and cancerous cells. The developed models provided significant insight into the structure and morphology of NPs before the synthesis and further analysis of NPs in biological environments. However, in the best cases of this system, Dynamic Light Scattering (DLS) tests were also taken and the results were consistent with the results obtained from All Atom and Coarse Grained simulations.
MeSH term(s)	Docetaxel ; Drug Carriers/chemistry ; Drug Delivery Systems/methods ; Nanoparticles/chemistry ; Pharmaceutical Preparations ; Polyethylene Glycols/chemistry ; Polymers/chemistry ; Riboflavin
Chemical Substances	Drug Carriers ; Pharmaceutical Preparations ; Polymers ; Docetaxel (15H5577CQD) ; Polyethylene Glycols (3WJQ0SDW1A) ; Riboflavin (TLM2976OFR)
Language	English
Publishing date	2022-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-09164-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The effect of hesperetin on estrogen receptor gene expression and its relationship with the downstream pathways of estrogen receptor alpha.

Bideh, Milad / Safari, Samaneh / Khedri, Azam / Zangooei, Mohammad

Molecular biology reports

2023 Volume 50, Issue 9, Page(s) 7225–7236

Abstract: Background: Estrogen receptor (ER) is a transcription factor that affects the expression of some genes involved in the progression and development of breast cancer (BC). Hesperetin (Hst) is a flavonoid that inhibits the proliferation of BC cells. In ... ...

Abstract	Background: Estrogen receptor (ER) is a transcription factor that affects the expression of some genes involved in the progression and development of breast cancer (BC). Hesperetin (Hst) is a flavonoid that inhibits the proliferation of BC cells. In this study, we investigated the effect of Hst on the cell viability of MCF-7 cells and the gene expression of the ERα, ERβ, IL-6, Ps2, and Cyclin D1. Methods: In this study, cell viability was determined by MTT assay. The cells were seeded in RPMI-1640 medium and then exposed to different concentrations of Hst (0, 25, 50, 100, 200, and 400 µM) for 24 h, and IC50 was calculated. Real-time PCR was used to assess the expression of ERα, ERβ, pS2, Cyclin D1, and IL-6 mRNA. MCF-7 cells were seeded in RPMI-1640 medium and then exposed to different concentrations of Hst (0, 25, 50, 100, and 200 µM) for 24 h. Real-time PCR was carried out using a Step One Real-Time PCR System (ABI, USA) and Amplicon SYBR Green reagents. Results: The MTT assay revealed increased cytotoxicity with higher concentrations of Hst, and the IC Conclusions: The results of our study demonstrate that Hst has the ability to induce cell death in MCF-7 cells. Furthermore, it was observed that Hst reduces the expression of the ER gene and enhances its activity, which can affect the downstream pathways of the ER.
MeSH term(s)	Humans ; Female ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Receptors, Estrogen/metabolism ; Estrogen Receptor beta/genetics ; Estrogen Receptor beta/metabolism ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Interleukin-6/genetics ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Gene Expression ; Cell Proliferation ; Cell Line, Tumor
Chemical Substances	Estrogen Receptor alpha ; Receptors, Estrogen ; Estrogen Receptor beta ; Cyclin D1 (136601-57-5) ; hesperetin (Q9Q3D557F1) ; Interleukin-6
Language	English
Publishing date	2023-07-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-08616-w
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Article: Chewing lice of wild birds in Iran: new data and a checklist of avian louse species reported in Iran.

Bahiraei, Zahra / Sazmand, Alireza / Khedri, Javad / Babaei, Mohammad / Moeinifard, Erfan / Dik, Bilal

Frontiers in veterinary science

2024 Volume 10, Page(s) 1324619

Abstract: Between September 2019 and December 2023, a total of 612 wild birds representing 16 orders, 33 families, 60 genera, and 78 species from nine provinces of Iran with different climates namely Hamedan ( ...

Abstract	Between September 2019 and December 2023, a total of 612 wild birds representing 16 orders, 33 families, 60 genera, and 78 species from nine provinces of Iran with different climates namely Hamedan (
Language	English
Publishing date	2024-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2023.1324619
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Article ; Online: Biomolecular engineering of drugs loading in Riboflavin-targeted polymeric devices

Mohammad Khedri / Mostafa Keshavarz Moraveji

Scientific Reports, Vol 12, Iss 1, Pp 1-

simulation and experimental

2022 Volume 13

Abstract: Abstract The synthesis of polymeric nanoparticles (NPs) with efficient drug loading content and targeting moieties is an attractive field and remains a challenge in drug delivery systems. Atomistic investigations can provide an in-depth understanding of ... ...

Abstract	Abstract The synthesis of polymeric nanoparticles (NPs) with efficient drug loading content and targeting moieties is an attractive field and remains a challenge in drug delivery systems. Atomistic investigations can provide an in-depth understanding of delivery devices and reduce the number of expensive experiments. In this paper, we studied the self-assembly of poly (lactic-co-glycolic acid)-b-poly (ethylene glycol) with different molecular weights and surface compositions. The innovation of this molecular study is the loading of an antitumor drug (docetaxel) on a targeting ligand (riboflavin). According to this work, a novel, biocompatible and targeted system for cancer treatment has been developed. The obtained results revealed a correlation between polymer molecular weight and the stability of particles. In this line, samples including 20 and 10 w/w% moiety NPs formed from polymers with 3 and 4.5 kDa backbone sizes, respectively, are the stable models with the highest drug loading and entrapment efficiencies. Next, we evaluated NP morphology and found that NPs have a core/shell structure consisting of a hydrophobic core with a shell of poly (ethylene glycol) and riboflavin. Interestingly, morphology assessments confirmed that the targeting moiety located on the surface can improve drug delivery to receptors and cancerous cells. The developed models provided significant insight into the structure and morphology of NPs before the synthesis and further analysis of NPs in biological environments. However, in the best cases of this system, Dynamic Light Scattering (DLS) tests were also taken and the results were consistent with the results obtained from All Atom and Coarse Grained simulations.
Keywords	Medicine ; R ; Science ; Q
Subject code	540
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Status of ancillary services in the children section of public libraries and its relationship with loyalty of children aged 7-11 years

Mohammad Hassan Azimi / Maryam Khedri / Shahnaz Khademizadeh

تحقیقات اطلاع‌رسانی و کتابخانه‌های عمومی, Vol 29, Iss 1, Pp 88-

2023 Volume 106

Abstract: Purpose: The main purpose of this research is to investigate the status of ancillary services in the children’s department of public libraries in Khuzestan province, and in this regard, the sub-objectives of the research are as follows: identification of ...

Abstract	Purpose: The main purpose of this research is to investigate the status of ancillary services in the children’s department of public libraries in Khuzestan province, and in this regard, the sub-objectives of the research are as follows: identification of the ancillary services of the children’s department, investigating the status of providing ancillary services, investigating the level of satisfaction of the members of the children’s department, and investigating the relationship between satisfaction with the ancillary services provided and the loyalty of the members of the children’s section of the public libraries of Khuzestan province. Method: The research method is of mixed type (qualitative and quantitative) and has a combined mode. In the qualitative part of the research, by referring to the public libraries of Khuzestan province and reviewing the regulations, a checklist including ancillary services for children has been presented. Then in the quantitative part of the research, using the customer loyalty evaluation questionnaire (Moghimi and Ramadan, 2010, Moon Q and Lawrence, 2001), the studied variables were measured, and the research questions were answered using quantitative methods. The statistical population of this research includes all the 7-11-year-old members of public libraries in Khuzestan province in 2019, out of which 380 people were determined as the statistical sample of the research population by the cluster sampling method. Descriptive statistics and inferential statistics were used to analyze the data. Findings: The results showed that according to the checklist of the research, 27 secondary services should be implemented in the public libraries of the province, and among the services listed in this list, three services are not being implemented, which are: providing services to special groups, holding national and religious festivals, and inviting actors and artists to the libraries. In the field of descriptive information about the knowledge of the library’s ancillary services, only ...
Keywords	ancillary services ; loyalty ; public libraries ; satisfaction ; children ; khuzestan province ; Bibliography. Library science. Information resources ; Z ; Information technology ; T58.5-58.64
Subject code	020
Language	Persian
Publishing date	2023-04-01T00:00:00Z
Publisher	Iran Public Libraries Foundation
Document type	Article ; Online
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Article: Genotyping of Environmental Isolates of

Khedri, Maryam / Fallah, Mohammad / Saidijam, Massoud / Matini, Mohammad / Bazzazi, Nooshin / Maghsood, Amir Hossein

Iranian journal of parasitology

2022 Volume 18, Issue 1, Page(s) 1–9

Abstract: Background: Different genotypes of : Methods: During 2018-2020, a total of 104 environmental samples including, water, soil, and dust and 16 corneal scraping samples were collected and investigated for the presence of : Results: The presence of !## ...

Abstract	Background: Different genotypes of Methods: During 2018-2020, a total of 104 environmental samples including, water, soil, and dust and 16 corneal scraping samples were collected and investigated for the presence of Results: The presence of Conclusion: The widespread occurrence of this potentially pathogenic amoeba in most hospital wards and environmental resources and areas of the region highlights a strong need to increase awareness regarding this ubiquitous amoeba among susceptible individuals, such as immunocompromised patients and contact lens wearers.
Language	English
Publishing date	2022-11-21
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2388453-8
ISSN	2008-238X ; 1735-7020
ISSN (online)	2008-238X
ISSN	1735-7020
DOI	10.18502/ijpa.v18i1.12374
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Article ; Online: Bisphenol A adsorption using modified aloe vera leaf-wastes derived bio-sorbents from aqueous solution: kinetic, isotherm, and thermodynamic studies.

Hashemzadeh, Farzad / Derakhshandeh, Seyed Hamed / Soori, Mohammad Mahdi / Khedri, Fereshteh / Rajabi, Saeed

International journal of environmental health research

2023 Volume 34, Issue 4, Page(s) 2031–2051

Abstract: Reactive-oxygen-species are produced more often in the body when bisphenol A (BPA), an endocrine-disrupting-substance, is present. In this investigation, bio-sorbents from an aqueous solution adapted from Aloe-vera were used to survey BPA removal. Aloe- ... ...

Abstract	Reactive-oxygen-species are produced more often in the body when bisphenol A (BPA), an endocrine-disrupting-substance, is present. In this investigation, bio-sorbents from an aqueous solution adapted from Aloe-vera were used to survey BPA removal. Aloe-vera leaf wastes were used to create activated carbon, which was then analyzed using Fourier transform infrared (FTIR), Field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), Thermogravimetric analysis (TGA), Zeta potential, and Brunauer-Emmett-Teller (BET) techniques. It was revealed that the adsorption process adheres to the Freundlich isotherm model with R
MeSH term(s)	Adsorption ; Aloe ; Thermodynamics ; Plant Leaves/chemistry ; Water Pollutants, Chemical/analysis ; Benzhydryl Compounds ; Phenols
Chemical Substances	bisphenol A (MLT3645I99) ; Water Pollutants, Chemical ; Benzhydryl Compounds ; Phenols
Language	English
Publishing date	2023-05-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1104887-6
ISSN	1369-1619 ; 0960-3123
ISSN (online)	1369-1619
ISSN	0960-3123
DOI	10.1080/09603123.2023.2208536
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Article ; Online: Physico-chemical characterization and anti-laryngeal cancer effects of the gold nanoparticles

Maoyu Jiang / Li Zhang / Li Liang / Mohammad Reza Khedri

Arabian Journal of Chemistry, Vol 16, Iss 4, Pp 104545- (2023)

2023

Abstract: Most recently, gold nanoparticles due to anticancer properties have been considered in medical science. So the aim of the study was green synthesis of gold nanoparticles using Ocimum basilicum extract and its anticancer activity. The prepared Au ... ...

Abstract	Most recently, gold nanoparticles due to anticancer properties have been considered in medical science. So the aim of the study was green synthesis of gold nanoparticles using Ocimum basilicum extract and its anticancer activity. The prepared Au nanoparticles were characterized by advanced physicochemical techniques like Fourier Transformed Infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray spectroscopy (EDX), X-ray Diffraction (XRD) and UV–vis spectroscopy study. It has been established that Au nanoparticles have a spherical shape with a mean diameter from 19 to 44 nm. In the cellular and molecular part of the recent study, the treated cells with Au nanoparticles were assessed by MTT assay for 48 h about the cytotoxicity and anti-human laryngeal cancer properties on normal (HUVEC) and cancer (HEp-2, TU212, KB, UM-SCC-5, UM-SCC-11A and UM-SCC-11B) cell lines. In the antioxidant test, the IC50 of Au nanoparticles and BHT against DPPH free radicals were 228 and 208 µg/mL, respectively. The IC50 of Au nanoparticles were 174, 231, 179, 143, 230, and 216 µg/mL against HEp-2, TU212, KB, UM-SCC-5, UM-SCC-11A and UM-SCC-11B cell lines, respectively. The viability of malignant cell lines reduced dose-dependently in the presence of Au nanoparticles. It appears that the anti-cancer effect of Au nanoparticles e to their antioxidant effects.
Keywords	Gold nanoparticles ; Anti-cancer properties ; Antioxidant properties ; Chemistry ; QD1-999
Subject code	500
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Gastrointestinal helminths infection of free-roaming cats (Felis catus) in Southeast Iran.

Nourollahi Fard, Saeid Reza / Akhtardanesh, Baharak / Sadr, Soheil / Khedri, Javad / Radfar, Mohammad Hossein / Shadmehr, Mehdi

Veterinary medicine and science

2023 Volume 10, Issue 3, Page(s) e1422

Abstract: Background: Cats in Iran are definitive hosts for several zoonotic intestinal helminths, such as Toxocara cati, Dipylidium caninum, Toxascaris leonina, Physaloptera praeputialis and Diplopylidium nolleri.: Objective: This study aimed to determine the ...

Abstract	Background: Cats in Iran are definitive hosts for several zoonotic intestinal helminths, such as Toxocara cati, Dipylidium caninum, Toxascaris leonina, Physaloptera praeputialis and Diplopylidium nolleri. Objective: This study aimed to determine the prevalence of intestinal helminth infection in free-roaming cats in southeast Iran, a region with a high free-roaming cat population. Methods: From January 2018 to December 2021, 153 cadavers of free-roaming cats from Southeast Iran were necropsied for intestinal helminth infections. The carcasses were dissected, and the digestive systems were removed. The esophagus, stomach, small intestine, caecum and colon were tightly ligated. All adult helminths were collected, preserved and identified. Results: The prevalence of gastrointestinal helminth infections was 80.39% (123/153). Of the cats from Kerman, 73% (73/100) were infected with at least one helminth, including D. caninum 70% (70/100), T. leonina 8% (8/100) and P. praeputialis 17% (17/100). Concurrent infection with two helminth species was found in 16% (16/100) and of three species infections was found in 3% (3/100) of the cats. Of the cats from Zabol, 94.33% (50/53) were infected with at least one of the helminths, including D. caninum 69.81% (37/53), T. leonina 11.32% (6/53), P. praeputialis 37.73% (20/53) and T. cati 5.66% (3/53). Concurrent infection with two helminth species was found in 28.3% (15/53), and three species were found in 1.88% (1/53) of the cats. Helminth infections were more prevalent in older cats. There was no association between sex and infection rate. Conclusion: Based on the very high prevalence of zoonotic intestinal helminth infections in free-roaming cats in southeast Iran, the potential public health risk emphasizes the need for intersectoral collaboration, particularly the provision of health and hygiene education to high-risk populations, such as pre-school and school-age children.
MeSH term(s)	Animals ; Cats ; Iran/epidemiology ; Helminthiasis, Animal/epidemiology ; Helminthiasis, Animal/parasitology ; Helminths ; Intestinal Diseases, Parasitic/epidemiology ; Intestinal Diseases, Parasitic/veterinary ; Intestinal Diseases, Parasitic/parasitology ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/veterinary ; Gastrointestinal Diseases/parasitology ; Cadaver ; Cat Diseases/epidemiology ; Helminthiasis
Language	English
Publishing date	2023-11-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2819409-3
ISSN	2053-1095 ; 2053-1095
ISSN (online)	2053-1095
ISSN	2053-1095
DOI	10.1002/vms3.1422
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Article ; Online: Intestinal parasitic infection among mentally handicapped students in the Islamic Republic of Iran.

Khedri, Maryam / Piri, Mina / Matini, Mohammad

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit

2021 Volume 27, Issue 9, Page(s) 868–873

Abstract: Background: Intestinal parasitic infections are among the most common public health problems in populations with poor hygiene. Consequently, mental retardation increases the risk of infection.: Aims: The aim of this study was to investigate the ... ...

Abstract	Background: Intestinal parasitic infections are among the most common public health problems in populations with poor hygiene. Consequently, mental retardation increases the risk of infection. Aims: The aim of this study was to investigate the prevalence of intestinal parasitic infections among mentally disabled young people in Hamadan, western Islamic Republic of Iran. Methods: This descriptive cross-sectional study was conducted on 318 students in 9 special schools in 2017. Triplicate faecal specimens for each student were subjected to stool analysis using direct wet mount, sedimentation concentration, and permanent staining technique. Chi-squared or Fisher's exact test were used for statistical analysis. Results: Out of 318 students, 135 (42.5%, 95% CI: 37.1-47.9) were infected with intestinal parasites. Prevalence rates for females and males were 45.2% (61/135) and 40.4% (74/183) respectively. Protozoan infections (42.5%, 135) were more numerous than helminthiasis (0.6%, 2). Blastocystis hominis (28%, 89) was the most common parasite, followed by Giardia lamblia (9.7%, 31), Entamoeba coli (9.1%, 29) and Trichomonas hominis (6%, 19). Conclusions: The high prevalence rate of intestinal protozoan infection reflects poor personal hygiene among the students and inappropriate environmental conditions. Therefore, specific public health measures are required for the mentally handicapped students in special schools.
MeSH term(s)	Adolescent ; Cross-Sectional Studies ; Feces ; Female ; Humans ; Intestinal Diseases, Parasitic/epidemiology ; Iran/epidemiology ; Male ; Persons with Mental Disabilities ; Prevalence ; Students
Language	English
Publishing date	2021-09-21
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	1291071-5
ISSN	1687-1634 ; 1020-3397
ISSN (online)	1687-1634
ISSN	1020-3397
DOI	10.26719/emhj.21.039
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