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  1. Article ; Online: In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction.

    Silva-Arrieta, Sandra / Goulder, Philip J R / Brander, Christian

    PLoS pathogens

    2020  Volume 16, Issue 6, Page(s) e1008607

    MeSH term(s) Algorithms ; Amino Acid Motifs ; Antigen Presentation ; Betacoronavirus ; COVID-19 ; COVID-19 Vaccines ; Computational Biology ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Cross Reactions ; Epitopes, T-Lymphocyte/immunology ; Histocompatibility Antigens Class I/immunology ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Protein Binding ; SARS-CoV-2 ; Viral Vaccines/immunology ; Viral Vaccines/therapeutic use
    Chemical Substances COVID-19 Vaccines ; Epitopes, T-Lymphocyte ; Histocompatibility Antigens Class I ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1008607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction

    Silva-Arrieta, Sandra / Goulder, Philip J R / Brander, Christian

    PLoS Pathog

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #687901
    Database COVID19

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  3. Article ; Online: In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction

    Silva-Arrieta, Sandra / Goulder, Philip J. R. / Brander, Christian

    PLOS Pathogens

    2020  Volume 16, Issue 6, Page(s) e1008607

    Keywords Immunology ; Genetics ; Molecular Biology ; Microbiology ; Parasitology ; Virology ; covid19
    Language English
    Publisher Public Library of Science (PLoS)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1008607
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction

    Silva-Arrieta, Sandra / Goulder, Phillip J.R. / Brander, Christian.

    2020  

    Keywords COVID-19 ; SARS-CoV-2 ; Algorithms ; Amino Acid Motifs ; Antigen Presentation ; Betacoronavirus ; Computational Biology ; Coronavirus Infections ; Cross Reactions ; Epitopes ; T-Lymphocyte ; Histocompatibility Antigens Class I ; Humans ; Pandemics ; Pneumonia ; Viral ; Protein Binding ; Viral Vaccines ; covid19
    Language English
    Publishing country es
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction

    Silva-Arrieta, Sandra / Goulder, Philip J. R. / Brander, Christian

    PLoS pathogens, 16(6):e1008607

    2020  

    Keywords COVID-19 ; Immune response ; HIV vaccines ; T cells ; Vaccine development ; SARS-CoV-2 ; Viral vaccines ; Antigen-presenting cells ; covid19
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Novel Nested Peptide Epitopes Recognized by CD4

    Borthwick, Nicola / Silva-Arrieta, Sandra / Llano, Anuska / Takiguchi, Masafumi / Brander, Christian / Hanke, Tomáš

    Vaccines

    2020  Volume 8, Issue 1

    Abstract: ... ...

    Abstract CD4
    Language English
    Publishing date 2020-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines8010028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction.

    Sandra Silva-Arrieta / Philip J R Goulder / Christian Brander

    PLoS Pathogens, Vol 16, Iss 6, p e

    2020  Volume 1008607

    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Novel Nested Peptide Epitopes Recognized by CD4 + T Cells Induced by HIV-1 Conserved-Region Vaccines

    Nicola Borthwick / Sandra Silva-Arrieta / Anuska Llano / Masafumi Takiguchi / Christian Brander / Tomáš Hanke

    Vaccines, Vol 8, Iss 1, p

    2020  Volume 28

    Abstract: CD4 + T-cell responses play an important role in the immune control of the human immunodeficiency virus type 1 (HIV-1) infection and as such should be efficiently induced by vaccination. It follows that definition of HIV-1-derived peptides recognized by ... ...

    Abstract CD4 + T-cell responses play an important role in the immune control of the human immunodeficiency virus type 1 (HIV-1) infection and as such should be efficiently induced by vaccination. It follows that definition of HIV-1-derived peptides recognized by CD4 + T cells in association with HLA class II molecules will guide vaccine development. Here, we have characterized the fine specificity of CD4 + T cells elicited in human recipients of a candidate vaccine delivering conserved regions of HIV-1 proteins designated HIVconsv. The majority of these 19 most immunogenic regions contained novel epitopes, that is, epitopes not listed in the Los Alamos National Laboratory HIV Sequence Database, which were able in vitro to stimulate vaccinees’ CD4 + T cells to proliferate and produce interferon-γ and tumor necrosis factor-α. Accumulation of HLA class II epitopes will eventually accelerate development of HIV-1 prophylactic and therapeutic vaccines.
    Keywords hiv vaccine ; hivconsv ; conserved regions ; cd4 epitopes ; hla class ii epitopes ; t cell vaccine ; Medicine ; R
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction.

    Duran-Castells, Clara / Llano, Anuska / Kawana-Tachikawa, Ai / Prats, Anna / Martinez-Zalacain, Ignacio / Kobayashi-Ishihara, Mie / Oriol-Tordera, Bruna / Peña, Ruth / Gálvez, Cristina / Silva-Arrieta, Sandra / Clotet, Bonaventura / Riveira-Muñoz, Eva / Ballana, Esther / Prado, Julia G / Martinez-Picado, Javier / Sanchez, Jorge / Mothe, Beatriz / Hartigan-O'Connor, Dennis / Wyss-Coray, Tony /
    Meyerhans, Andreas / Gisslén, Magnus / Price, Richard W / Soriano-Mas, Carles / Muñoz-Moreno, José Antonio / Brander, Christian / Ruiz-Riol, Marta

    Journal of virology

    2023  Volume 97, Issue 2, Page(s) e0165522

    Abstract: The implementation and access to combined antiretroviral treatment (cART) have dramatically improved the quality of life of people living with HIV (PLWH). However, some comorbidities, such as neurological disorders associated with HIV infection still ... ...

    Abstract The implementation and access to combined antiretroviral treatment (cART) have dramatically improved the quality of life of people living with HIV (PLWH). However, some comorbidities, such as neurological disorders associated with HIV infection still represent a serious clinical challenge. Soluble factors in plasma that are associated with control of HIV replication and neurological dysfunction could serve as early biomarkers and as new therapeutic targets for this comorbidity. We used a customized antibody array for determination of blood plasma factors in 40 untreated PLWH with different levels of viremia and found sirtuin-2 (SIRT2), an NAD-dependent deacetylase, to be strongly associated with elevated viral loads and HIV provirus levels, as well as with markers of neurological damage (a-synuclein [SNCA], brain-derived neurotrophic factor [BDNF], microtubule-associated protein tau [MAPT], and neurofilament light protein [NFL]). Also, longitudinal analysis in HIV-infected individuals with immediate (
    MeSH term(s) Humans ; Biomarkers ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV-1 ; Neurofilament Proteins/metabolism ; Proviruses/metabolism ; Quality of Life ; Sirtuin 2/metabolism ; Nervous System Diseases/drug therapy ; Nervous System Diseases/etiology ; Nervous System Diseases/virology ; Viral Load
    Chemical Substances Biomarkers ; Neurofilament Proteins ; Sirtuin 2 (EC 3.5.1.-)
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.01655-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Vagus nerve dysfunction in the post-COVID-19 condition: a pilot cross-sectional study.

    Lladós, Gemma / Massanella, Marta / Coll-Fernández, Roser / Rodríguez, Raúl / Hernández, Electra / Lucente, Giuseppe / López, Cristina / Loste, Cora / Santos, José Ramón / España-Cueto, Sergio / Nevot, Maria / Muñoz-López, Francisco / Silva-Arrieta, Sandra / Brander, Christian / Durà, Maria José / Cuadras, Patricia / Bechini, Jordi / Tenesa, Montserrat / Martinez-Piñeiro, Alicia /
    Herrero, Cristina / Chamorro, Anna / Garcia, Anna / Grau, Eulalia / Clotet, Bonaventura / Paredes, Roger / Mateu, Lourdes

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 30, Issue 4, Page(s) 515–521

    Abstract: Objectives: The post-COVID-19 condition (PCC) is a disabling syndrome affecting at least 5%-10% of subjects who survive COVID-19. SARS-CoV-2 mediated vagus nerve dysfunction could explain some PCC symptoms, such as dysphonia, dysphagia, dyspnea, ... ...

    Abstract Objectives: The post-COVID-19 condition (PCC) is a disabling syndrome affecting at least 5%-10% of subjects who survive COVID-19. SARS-CoV-2 mediated vagus nerve dysfunction could explain some PCC symptoms, such as dysphonia, dysphagia, dyspnea, dizziness, tachycardia, orthostatic hypotension, gastrointestinal disturbances, or neurocognitive complaints.
    Methods: We performed a cross-sectional pilot study in subjects with PCC with symptoms suggesting vagus nerve dysfunction (n = 30) and compared them with subjects fully recovered from acute COVID-19 (n = 14) and with individuals never infected (n = 16). We evaluated the structure and function of the vagus nerve and respiratory muscles.
    Results: Participants were mostly women (24 of 30, 80%), and the median age was 44 years (interquartile range [IQR] 35-51 years). Their most prevalent symptoms were cognitive dysfunction 25 of 30 (83%), dyspnea 24 of 30 (80%), and tachycardia 24 of 30 (80%). Compared with COVID-19-recovered and uninfected controls, respectively, subjects with PCC were more likely to show thickening and hyperechogenic vagus nerve in neck ultrasounds (cross-sectional area [CSA] [mean ± standard deviation]: 2.4 ± 0.97mm2 vs. 2 ± 0.52mm2 vs. 1.9 ± 0.73 mm2; p 0.08), reduced esophageal-gastric-intestinal peristalsis (34% vs. 0% vs. 21%; p 0.02), gastroesophageal reflux (34% vs. 19% vs. 7%; p 0.13), and hiatal hernia (25% vs. 0% vs. 7%; p 0.05). Subjects with PCC showed flattening hemidiaphragms (47% vs. 6% vs. 14%; p 0.007), and reductions in maximum inspiratory pressure (62% vs. 6% vs. 17%; p ≤ 0.001), indicating respiratory muscle weakness. The latter findings suggest additional involvement of the phrenic nerve.
    Discussion: Vagus and phrenic nerve dysfunction contribute to the complex and multifactorial pathophysiology of PCC.
    MeSH term(s) Humans ; Female ; Adult ; Middle Aged ; Male ; COVID-19/complications ; Cross-Sectional Studies ; SARS-CoV-2 ; Pilot Projects ; Vagus Nerve ; Post-Acute COVID-19 Syndrome ; Dyspnea ; Tachycardia
    Language English
    Publishing date 2023-11-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 284: Show issues

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