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  1. Article ; Online: Who's on first … Na

    Romero, Michael F

    The Journal of physiology

    2022  Volume 600, Issue 13, Page(s) 3005–3006

    MeSH term(s) Bicarbonates/metabolism ; Hydrogen-Ion Concentration ; Sodium/metabolism ; Sodium-Bicarbonate Symporters
    Chemical Substances Bicarbonates ; Sodium-Bicarbonate Symporters ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP282945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Publisher Correction: Drosophila melanogaster: a simple genetic model of kidney structure, function and disease.

    Dow, Julian A T / Simons, Matias / Romero, Michael F

    Nature reviews. Nephrology

    2023  Volume 20, Issue 1, Page(s) 70

    Language English
    Publishing date 2023-11-10
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-023-00788-9
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  3. Article ; Online: The role of Na

    Holmberg, Shannon R / Sakamoto, Yohei / Kato, Akira / Romero, Michael F

    Pflugers Archiv : European journal of physiology

    2024  Volume 476, Issue 4, Page(s) 479–503

    Abstract: Cellular and organism survival depends upon the regulation of pH, which is regulated by highly specialized cell membrane transporters, the solute carriers (SLC) (For a comprehensive list of the solute carrier family members, see: https://www.bioparadigms. ...

    Abstract Cellular and organism survival depends upon the regulation of pH, which is regulated by highly specialized cell membrane transporters, the solute carriers (SLC) (For a comprehensive list of the solute carrier family members, see: https://www.bioparadigms.org/slc/ ). The SLC4 family of bicarbonate (HCO
    MeSH term(s) Sodium-Bicarbonate Symporters/genetics ; Sodium-Bicarbonate Symporters/metabolism ; Bicarbonates/metabolism ; Sodium Bicarbonate ; Sodium/metabolism ; Membrane Transport Proteins ; Hydrogen-Ion Concentration
    Chemical Substances Sodium-Bicarbonate Symporters ; Bicarbonates ; Sodium Bicarbonate (8MDF5V39QO) ; Sodium (9NEZ333N27) ; Membrane Transport Proteins
    Language English
    Publishing date 2024-03-27
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-024-02937-w
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  4. Article ; Online: What is your diagnosis? Gallbladder mass from a dog.

    Hanson, Taylor A / Roady, Patrick J / Ruiz Romero, Jose de Jesus / Rosser, Michael F

    Veterinary clinical pathology

    2023  

    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2114702-4
    ISSN 1939-165X ; 0275-6382
    ISSN (online) 1939-165X
    ISSN 0275-6382
    DOI 10.1111/vcp.13262
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  5. Article ; Online: Drosophila ClC-c Is a Homolog of Human CLC-5 and a New Model for Dent Disease Type 1.

    Reynolds, Carmen J / Gillen, Christopher M / Burke, Richard / Tsering, Yula / Loucks, Emi / Judd-Mole, Sebastian / Dow, Julian A T / Romero, Michael F

    Kidney360

    2024  Volume 5, Issue 3, Page(s) 414–426

    MeSH term(s) Animals ; Humans ; Drosophila ; Dent Disease
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000352
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  6. Article ; Online: Drosophila melanogaster: a simple genetic model of kidney structure, function and disease.

    Dow, Julian A T / Simons, Matias / Romero, Michael F

    Nature reviews. Nephrology

    2022  Volume 18, Issue 7, Page(s) 417–434

    Abstract: Although the genetic basis of many kidney diseases is being rapidly elucidated, their experimental study remains problematic owing to the lack of suitable models. The fruitfly Drosophila melanogaster provides a rapid, ethical and cost-effective model ... ...

    Abstract Although the genetic basis of many kidney diseases is being rapidly elucidated, their experimental study remains problematic owing to the lack of suitable models. The fruitfly Drosophila melanogaster provides a rapid, ethical and cost-effective model system of the kidney. The unique advantages of D. melanogaster include ease and low cost of maintenance, comprehensive availability of genetic mutants and powerful transgenic technologies, and less onerous regulation, as compared with mammalian systems. Renal and excretory functions in D. melanogaster reside in three main tissues - the transporting renal (Malpighian) tubules, the reabsorptive hindgut and the endocytic nephrocytes. Tubules contain multiple cell types and regions and generate a primary urine by transcellular transport rather than filtration, which is then subjected to selective reabsorption in the hindgut. By contrast, the nephrocytes are specialized for uptake of macromolecules and equipped with a filtering slit diaphragm resembling that of podocytes. Many genes with key roles in the human kidney have D. melanogaster orthologues that are enriched and functionally relevant in fly renal tissues. This similarity has allowed investigations of epithelial transport, kidney stone formation and podocyte and proximal tubule function. Furthermore, a range of unique quantitative phenotypes are available to measure function in both wild type and disease-modelling flies.
    MeSH term(s) Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Humans ; Kidney/metabolism ; Kidney Calculi ; Mammals/metabolism ; Models, Genetic
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2022-04-11
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-022-00561-4
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  7. Article: Eigenvalue estimates for Fourier concentration operators on two domains.

    Marceca, Felipe / Romero, José Luis / Speckbacher, Michael

    Archive for rational mechanics and analysis

    2024  Volume 248, Issue 3, Page(s) 35

    Abstract: We study concentration operators associated with either the discrete or the continuous Fourier transform, that is, operators that incorporate a spatial cut-off and a subsequent frequency cut-off to the Fourier inversion formula. The spectral profiles of ... ...

    Abstract We study concentration operators associated with either the discrete or the continuous Fourier transform, that is, operators that incorporate a spatial cut-off and a subsequent frequency cut-off to the Fourier inversion formula. The spectral profiles of these operators describe the number of prominent degrees of freedom in problems where functions are assumed to be supported on a certain domain and their Fourier transforms are known or measured on a second domain. We derive eigenvalue estimates that quantify the extent to which Fourier concentration operators deviate from orthogonal projectors, by bounding the number of eigenvalues that are away from 0 and 1 in terms of the geometry of the spatial and frequency domains, and a factor that grows at most poly-logarithmically on the inverse of the spectral margin. The estimates are non-asymptotic in the sense that they are applicable to concrete domains and spectral thresholds, and almost match asymptotic benchmarks. Our work covers, for the first time, non-convex and non-symmetric spatial and frequency concentration domains, as demanded by numerous applications that exploit the expected approximate low dimensionality of the modeled phenomena. The proofs build on Israel's work on one dimensional intervals arXiv:1502.04404v1. The new ingredients are the use of redundant wave-packet expansions and a dyadic decomposition argument to obtain Schatten norm estimates for Hankel operators.
    Language English
    Publishing date 2024-04-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1458447-5
    ISSN 1432-0673 ; 0003-9527
    ISSN (online) 1432-0673
    ISSN 0003-9527
    DOI 10.1007/s00205-024-01979-9
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  8. Article: Membrane Transport Proteins Expressed in the Renal Tubular Epithelial Cells of Seawater and Freshwater Teleost Fishes.

    Kato, Akira / Nagashima, Ayumi / Hosono, Kohei / Romero, Michael F

    Frontiers in physiology

    2022  Volume 13, Page(s) 939114

    Abstract: The kidney is an important organ that maintains body fluid homeostasis in seawater and freshwater teleost fishes. Seawater teleosts excrete sulfate and magnesium in small amounts of isotonic urine, and freshwater teleosts excrete water in large amounts ... ...

    Abstract The kidney is an important organ that maintains body fluid homeostasis in seawater and freshwater teleost fishes. Seawater teleosts excrete sulfate and magnesium in small amounts of isotonic urine, and freshwater teleosts excrete water in large amounts of hypo-osmotic urine. The volume, osmolality, and ionic compositions of the urine are regulated mainly by membrane transport proteins expressed in the renal tubular epithelial cells. Gene expression, immunohistochemical, and functional analyses of the fish kidney identified membrane transport proteins involved in the secretion of sulfate and magnesium ions by the proximal tubules and reduction of urine volume by the collecting ducts in seawater teleosts, and excretion of water as hypotonic urine by the distal tubules and collecting ducts in freshwater teleosts. These studies promote an understanding of how the kidney contributes to the seawater and freshwater acclimation of teleosts at the molecular level.
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.939114
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  9. Article ; Online: Transporters and tubule crystals in the insect Malpighian tubule.

    Reynolds, Carmen J / Turin, Daniel R / Romero, Michael F

    Current opinion in insect science

    2021  Volume 47, Page(s) 82–89

    Abstract: The insect renal (Malpighian) tubules are functionally homologous to the mammalian kidney. Accumulating evidence indicates that renal tubule crystals form in a manner similar to mammalian kidney stones. In Drosophila melanogaster, crystals can be induced ...

    Abstract The insect renal (Malpighian) tubules are functionally homologous to the mammalian kidney. Accumulating evidence indicates that renal tubule crystals form in a manner similar to mammalian kidney stones. In Drosophila melanogaster, crystals can be induced by diet, toxic substances, or genetic mutations that reflect circumstances influencing or eliciting kidney stones in mammals. Incredibly, many mammalian proteins have distinct homologs in Drosophila, and the function of most homologs have been demonstrated to recapitulate their mammalian and human counterparts. Here, we discuss the present literature establishing Drosophila as a nephrolithiasis model. This insect model may be used to investigate and understand the etiology of kidney stone diseases, especially with regard to calcium oxalate, calcium phosphate and xanthine or urate crystallization.
    MeSH term(s) Animals ; Calcium Oxalate ; Disease Models, Animal ; Drosophila melanogaster/genetics ; Malpighian Tubules ; Nephrolithiasis
    Chemical Substances Calcium Oxalate (2612HC57YE)
    Language English
    Publishing date 2021-05-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2772833-X
    ISSN 2214-5753 ; 2214-5745
    ISSN (online) 2214-5753
    ISSN 2214-5745
    DOI 10.1016/j.cois.2021.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Acid-Base Basics.

    Romero, Michael F / Rossano, Adam J

    Seminars in nephrology

    2019  Volume 39, Issue 4, Page(s) 316–327

    Abstract: Although students initially learn of ionic buffering in basic chemistry, buffering and acid-base transport in biology often is relegated to specialized classes, discussions, or situations. That said, for physiology, nephrology, pulmonology, and ... ...

    Abstract Although students initially learn of ionic buffering in basic chemistry, buffering and acid-base transport in biology often is relegated to specialized classes, discussions, or situations. That said, for physiology, nephrology, pulmonology, and anesthesiology, these basic principles often are critically important for mechanistic understanding, medical treatments, and assessing therapy effectiveness. This short introductory perspective focuses on basic chemistry and transport of buffers and acid-base equivalents, provides an outline of basic science acid-base concepts, tools used to monitor intracellular pH, model cellular responses to pH buffer changes, and the more recent development and use of genetically encoded pH-indicators. Examples of newer genetically encoded pH-indicators (pHerry and pHire) are provided, and their use for in vitro, ex vivo, and in vivo experiments are described. The continued use and development of these basic tools provide increasing opportunities for both basic and potentially clinical investigations.
    MeSH term(s) Acid-Base Equilibrium/physiology ; Animals ; Biological Transport/physiology ; Buffers ; Humans ; Hydrogen/physiology ; Hydrogen-Ion Concentration ; Intracellular Fluid/physiology
    Chemical Substances Buffers ; Hydrogen (7YNJ3PO35Z)
    Language English
    Publishing date 2019-07-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2019.04.002
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