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  1. Article ; Online: An atypical presentation of Leber's hereditary optic neuropathy in childhood.

    Ricciotti, G / De Negri, A M / Carta, A

    Journal francais d'ophtalmologie

    2024  Volume 47, Issue 3, Page(s) 104037

    MeSH term(s) Humans ; Optic Atrophy, Hereditary, Leber/complications ; Optic Atrophy, Hereditary, Leber/diagnosis ; Optic Atrophy, Hereditary, Leber/genetics ; DNA, Mitochondrial/genetics
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2024-02-19
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 426662-6
    ISSN 1773-0597 ; 0181-5512
    ISSN (online) 1773-0597
    ISSN 0181-5512
    DOI 10.1016/j.jfo.2023.104037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1417: Show issues Location:
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  2. Article ; Online: The cellular coding of temperature in the mammalian cortex.

    Vestergaard, M / Carta, M / Güney, G / Poulet, J F A

    Nature

    2023  Volume 614, Issue 7949, Page(s) 725–731

    Abstract: Temperature is a fundamental sensory modality separate from touch, with dedicated receptor channels and primary afferent neurons for cool and ... ...

    Abstract Temperature is a fundamental sensory modality separate from touch, with dedicated receptor channels and primary afferent neurons for cool and warm
    MeSH term(s) Animals ; Mice ; Cold Temperature ; Neurons/physiology ; Somatosensory Cortex/cytology ; Somatosensory Cortex/physiology ; Touch Perception/physiology ; Hot Temperature ; Skin Temperature/physiology ; Spatio-Temporal Analysis ; Insular Cortex/cytology ; Insular Cortex/physiology
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-05705-5
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    Zs.MO 244: Show issues

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  3. Article ; Online: Mechanochemically Induced Solid-State Transformations of Levofloxacin.

    Kadri, Lena / Carta, Maria / Lampronti, Giulio / Delogu, Francesco / Tajber, Lidia

    Molecular pharmaceutics

    2024  

    Abstract: Levofloxacin hemihydrate (LVXh) is a complex fluoroquinolone drug that exists in both hydrated and anhydrous/dehydrated forms. Due to the complexity of such a compound, the primary aim of this study was to investigate the amorphization capabilities and ... ...

    Abstract Levofloxacin hemihydrate (LVXh) is a complex fluoroquinolone drug that exists in both hydrated and anhydrous/dehydrated forms. Due to the complexity of such a compound, the primary aim of this study was to investigate the amorphization capabilities and solid-state transformations of LVXh when exposed to mechanical treatment using ball milling. Spray drying was utilized as a comparative method for investigating the capabilities of complete LVX amorphous (LVXam) formation. The solid states of the samples produced were comprehensively characterized by powder X-ray diffraction, thermal analysis, infrared spectroscopy, Rietveld method, and dynamic vapor sorption. The kinetics of the process and the quantification of phases at different time points were conducted by Rietveld refinement. The impact of the different mills, milling conditions, and parameters on the composition of the resulting powders was examined. A kinetic investigation of samples produced using both mills disclosed that it was in fact possible to partially amorphize LVXh upon mechanical treatment. It was discovered that LVXh first transformed to the anhydrous/dehydrated form γ (LVXγ), as an intermediate phase, before converting to LVXam. The mechanism of LVXam formation by ball milling was successfully revealed, and a new method of forming LVXγ and LVXam by mechanical forces was developed. Spray drying from water depicted that complete amorphization of LVXh was possible. The amorphous form of LVX had a glass transition temperature of 80 °C. The comparison of methods highlighted that the formation of LVXam is thus both mechanism- and process-dependent. Dynamic vapor sorption studies of both LVXam samples showed comparable stability properties and crystallized to the most stable hemihydrate form upon analysis. In summary, this work contributed to the detailed understanding of solid-state transformations of essential fluoroquinolones while employing greener and more sustainable manufacturing methods.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.4c00008
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  4. Article ; Online: Celebrating the centenary of Turan M. Itil and remembering his groundbreaking contributions to psychopharmacology and electroencephalography.

    Horato, Natia / Carta, Mauro G / Nardi, Antonio E

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2023  Volume 156, Page(s) 14–15

    Language English
    Publishing date 2023-09-30
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2023.09.008
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  5. Article ; Online: An AI-based approach driven by genotypes and phenotypes to uplift the diagnostic yield of genetic diseases.

    Zucca, S / Nicora, G / De Paoli, F / Carta, M G / Bellazzi, R / Magni, P / Rizzo, E / Limongelli, I

    Human genetics

    2024  

    Abstract: Identifying disease-causing variants in Rare Disease patients' genome is a challenging problem. To accomplish this task, we describe a machine learning framework, that we called "Suggested Diagnosis", whose aim is to prioritize genetic variants in an ... ...

    Abstract Identifying disease-causing variants in Rare Disease patients' genome is a challenging problem. To accomplish this task, we describe a machine learning framework, that we called "Suggested Diagnosis", whose aim is to prioritize genetic variants in an exome/genome based on the probability of being disease-causing. To do so, our method leverages standard guidelines for germline variant interpretation as defined by the American College of Human Genomics (ACMG) and the Association for Molecular Pathology (AMP), inheritance information, phenotypic similarity, and variant quality. Starting from (1) the VCF file containing proband's variants, (2) the list of proband's phenotypes encoded in Human Phenotype Ontology terms, and optionally (3) the information about family members (if available), the "Suggested Diagnosis" ranks all the variants according to their machine learning prediction. This method significantly reduces the number of variants that need to be evaluated by geneticists by pinpointing causative variants in the very first positions of the prioritized list. Most importantly, our approach proved to be among the top performers within the CAGI6 Rare Genome Project Challenge, where it was able to rank the true causative variant among the first positions and, uniquely among all the challenge participants, increased the diagnostic yield of 12.5% by solving 2 undiagnosed cases.
    Language English
    Publishing date 2024-03-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 223009-4
    ISSN 1432-1203 ; 0340-6717
    ISSN (online) 1432-1203
    ISSN 0340-6717
    DOI 10.1007/s00439-023-02638-x
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    Zs.A 256: Show issues Location:
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  6. Article: Stage 5 Chronic Kidney Disease: Epidemiological Analysis in a NorthEastern District of Italy Focusing on Access to Nephrological Care.

    Martino, Francesca K / Fanton, Giulia / Zanetti, Fiammetta / Carta, Mariarosa / Nalesso, Federico / Novara, Giacomo

    Journal of clinical medicine

    2024  Volume 13, Issue 4

    Abstract: Background: We conducted a retrospective epidemiological study about the prevalence of stage 5 chronic kidney disease (CKD) in a high-income district, comparing some demographic characteristics and outcomes of those patients who had nephrological ... ...

    Abstract Background: We conducted a retrospective epidemiological study about the prevalence of stage 5 chronic kidney disease (CKD) in a high-income district, comparing some demographic characteristics and outcomes of those patients who had nephrological consultations and those who had not.
    Results: In a district of 400,000 adult subjects in 2020, 925 patients had an estimated glomerular filtration rate (eGFR) under 15 mL/min and CKD. In the same period, 747 (80.4%) patients were assessed by nephrologists, while 178 (19.6%) were not. Age (88 vs. 75,
    Conclusions: About 20% of ESKD patients did not receive a nephrologist consultation. Older people and women were more likely not to be referred to nephrology clinics. Unfollowed patients with stage 5 CKD had a significantly higher death rate.
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13041144
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  7. Article ; Online: An update on the pharmacotherapeutic strategies for the treatment of dysthymic disorder: a systematic review.

    Quagliato, Laiana A / Primavera, Diego / Fornaro, Michele / Preti, Antonio / Carta, Mauro G / Nardi, Antonio E

    Expert opinion on pharmacotherapy

    2024  Volume 24, Issue 18, Page(s) 2035–2040

    Abstract: Introduction: Longer treatment times, more comorbidity, more severe impairments in social, psychological, and emotional functioning, increased healthcare use, and more hospitalizations are all factors that are related to dysthymia. Given the significant ...

    Abstract Introduction: Longer treatment times, more comorbidity, more severe impairments in social, psychological, and emotional functioning, increased healthcare use, and more hospitalizations are all factors that are related to dysthymia. Given the significant prevalence of dysthymia (including persistent depressive disorder) worldwide, its comorbidity with several mental disorders, and the detrimental effects of these comorbidities, it is important to conduct a systematic review to compare the effects of pharmacological acute and maintenance treatments for dysthymia with placebo and standard care in the last 10 years, based on the publication of DSM5.
    Areas covered: This systematic review was performed according to PRISMA guidelines. Databases, including PubMed and Cochrane Central Register of Controlled Trials, were searched to assess the effects of pharmacological acute and maintenance treatments for dysthymia in comparison with placebo and treatment as usual.
    Expert opinion: Our review shows that SSRIs and SNRIs present efficacy for dysthymia treatment, and L-Acetylcarnitine should be investigated further for this condition in elderly patients. The comparison of antidepressant medication versus placebo showed coherent results based on three studies favoring pharmacotherapy as an effective treatment for participants with dysthymia. However, the scarcity of research on continuation and maintenance therapy in people with dysthymia highlights the need for more primary research.
    MeSH term(s) Aged ; Humans ; Antidepressive Agents/therapeutic use ; Comorbidity ; Depressive Disorder/drug therapy ; Dysthymic Disorder/drug therapy ; Selective Serotonin Reuptake Inhibitors/therapeutic use ; Serotonin and Noradrenaline Reuptake Inhibitors/therapeutic use
    Chemical Substances Antidepressive Agents ; Selective Serotonin Reuptake Inhibitors ; Serotonin and Noradrenaline Reuptake Inhibitors
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2023.2265809
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    Zs.A 5130: Show issues Location:
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  8. Article ; Online: Facile Addition of B-H and B-B Bonds to an Iron(IV) Nitride Complex.

    Tran, Bao G / Carta, Veronica / Pink, Maren / Caulton, Kenneth G / Smith, Jeremy M

    Inorganic chemistry

    2022  Volume 61, Issue 49, Page(s) 19800–19805

    Abstract: The nitride ligand in the iron(IV) complex PhB( ...

    Abstract The nitride ligand in the iron(IV) complex PhB(
    Language English
    Publishing date 2022-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.2c02931
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  9. Article ; Online: Plasma glucose sampling using lyophilized citrate tubes: impact on the diagnosis of gestational diabetes mellitus.

    Carta, M / Bonetti, G / Giavarina, D

    Diabetic medicine : a journal of the British Diabetic Association

    2020  Volume 38, Issue 2, Page(s) e14422

    MeSH term(s) Blood Glucose ; Citrates ; Citric Acid ; Diabetes, Gestational/diagnosis ; Female ; Glucose Tolerance Test ; Humans ; Pregnancy
    Chemical Substances Blood Glucose ; Citrates ; Citric Acid (2968PHW8QP)
    Language English
    Publishing date 2020-11-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 605769-x
    ISSN 1464-5491 ; 0742-3071 ; 1466-5468
    ISSN (online) 1464-5491
    ISSN 0742-3071 ; 1466-5468
    DOI 10.1111/dme.14422
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  10. Article ; Online: A reagent for heteroatom borylation, including iron mediated reductive deoxygenation of nitrate yielding a dinitrosyl complex.

    Beagan, Daniel M / Carta, Veronica / Caulton, Kenneth G

    Dalton transactions (Cambridge, England : 2003)

    2020  Volume 49, Issue 5, Page(s) 1681–1687

    Abstract: 4,4'-Bipyridyl is shown to be a catalyst for transfer of pinacolboryl groups from (Bpin) ...

    Abstract 4,4'-Bipyridyl is shown to be a catalyst for transfer of pinacolboryl groups from (Bpin)
    Language English
    Publishing date 2020-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d0dt00077a
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